CA2832355A1 - Computer based system for predicting treatment outcomes - Google Patents
Computer based system for predicting treatment outcomes Download PDFInfo
- Publication number
- CA2832355A1 CA2832355A1 CA2832355A CA2832355A CA2832355A1 CA 2832355 A1 CA2832355 A1 CA 2832355A1 CA 2832355 A CA2832355 A CA 2832355A CA 2832355 A CA2832355 A CA 2832355A CA 2832355 A1 CA2832355 A1 CA 2832355A1
- Authority
- CA
- Canada
- Prior art keywords
- treatment
- benefit
- population
- function
- individuals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 740
- 230000008901 benefit Effects 0.000 claims abstract description 382
- 238000000034 method Methods 0.000 claims abstract description 293
- 239000000090 biomarker Substances 0.000 claims abstract description 145
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 74
- 230000006870 function Effects 0.000 claims description 247
- 230000000694 effects Effects 0.000 claims description 207
- 230000004075 alteration Effects 0.000 claims description 62
- 239000000470 constituent Substances 0.000 claims description 53
- 239000013598 vector Substances 0.000 claims description 34
- 238000012545 processing Methods 0.000 claims description 30
- 230000031018 biological processes and functions Effects 0.000 claims description 27
- 230000001413 cellular effect Effects 0.000 claims description 24
- 210000000056 organ Anatomy 0.000 claims description 13
- 238000004590 computer program Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 abstract description 180
- 229940079593 drug Drugs 0.000 abstract description 143
- 238000009509 drug development Methods 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 90
- 201000010099 disease Diseases 0.000 description 87
- 230000008569 process Effects 0.000 description 43
- 238000011161 development Methods 0.000 description 39
- 230000018109 developmental process Effects 0.000 description 39
- 230000036541 health Effects 0.000 description 38
- 239000003795 chemical substances by application Substances 0.000 description 33
- 210000004027 cell Anatomy 0.000 description 32
- 238000011156 evaluation Methods 0.000 description 31
- 108090000623 proteins and genes Proteins 0.000 description 28
- 238000004891 communication Methods 0.000 description 27
- 238000012544 monitoring process Methods 0.000 description 26
- 102000004169 proteins and genes Human genes 0.000 description 21
- 210000001519 tissue Anatomy 0.000 description 20
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 19
- 238000009826 distribution Methods 0.000 description 18
- 238000004088 simulation Methods 0.000 description 17
- 208000006011 Stroke Diseases 0.000 description 16
- 238000001727 in vivo Methods 0.000 description 16
- 150000002500 ions Chemical class 0.000 description 16
- 230000007246 mechanism Effects 0.000 description 16
- 206010002383 Angina Pectoris Diseases 0.000 description 15
- 241000282412 Homo Species 0.000 description 15
- 230000002596 correlated effect Effects 0.000 description 15
- 229940125681 anticonvulsant agent Drugs 0.000 description 14
- 239000001961 anticonvulsive agent Substances 0.000 description 14
- 230000006399 behavior Effects 0.000 description 14
- 230000003993 interaction Effects 0.000 description 14
- 230000003285 pharmacodynamic effect Effects 0.000 description 13
- 230000004044 response Effects 0.000 description 13
- 230000000699 topical effect Effects 0.000 description 13
- 241000769223 Thenea Species 0.000 description 12
- 230000004048 modification Effects 0.000 description 12
- 238000012986 modification Methods 0.000 description 12
- 230000000144 pharmacologic effect Effects 0.000 description 12
- 238000003860 storage Methods 0.000 description 12
- 230000002924 anti-infective effect Effects 0.000 description 11
- 229960005475 antiinfective agent Drugs 0.000 description 11
- 230000007321 biological mechanism Effects 0.000 description 11
- 230000000875 corresponding effect Effects 0.000 description 11
- 238000000338 in vitro Methods 0.000 description 11
- 230000037361 pathway Effects 0.000 description 10
- 241000283984 Rodentia Species 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 9
- 239000003112 inhibitor Substances 0.000 description 9
- 230000000391 smoking effect Effects 0.000 description 9
- 102000004310 Ion Channels Human genes 0.000 description 8
- 108090000862 Ion Channels Proteins 0.000 description 8
- 206010030113 Oedema Diseases 0.000 description 8
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 8
- 238000013500 data storage Methods 0.000 description 8
- 238000001647 drug administration Methods 0.000 description 8
- 230000000857 drug effect Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 210000002216 heart Anatomy 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 150000003431 steroids Chemical class 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 108010023302 HDL Cholesterol Proteins 0.000 description 7
- 108010052164 Sodium Channels Proteins 0.000 description 7
- 102000018674 Sodium Channels Human genes 0.000 description 7
- -1 antifungals Substances 0.000 description 7
- 238000013459 approach Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 7
- 230000034994 death Effects 0.000 description 7
- 231100000517 death Toxicity 0.000 description 7
- 206010012601 diabetes mellitus Diseases 0.000 description 7
- 230000035487 diastolic blood pressure Effects 0.000 description 7
- 238000007876 drug discovery Methods 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 229940088597 hormone Drugs 0.000 description 7
- 239000005556 hormone Substances 0.000 description 7
- 239000000543 intermediate Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 208000024172 Cardiovascular disease Diseases 0.000 description 6
- 230000006907 apoptotic process Effects 0.000 description 6
- 230000008238 biochemical pathway Effects 0.000 description 6
- 230000030833 cell death Effects 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 238000010946 mechanistic model Methods 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 229940126601 medicinal product Drugs 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 210000002569 neuron Anatomy 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 230000011664 signaling Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 230000036982 action potential Effects 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 239000000091 biomarker candidate Substances 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 229940000406 drug candidate Drugs 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 238000000099 in vitro assay Methods 0.000 description 5
- 208000028867 ischemia Diseases 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 206010008479 Chest Pain Diseases 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- 206010061818 Disease progression Diseases 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 102000003886 Glycoproteins Human genes 0.000 description 4
- 108090000288 Glycoproteins Proteins 0.000 description 4
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 4
- 229930182555 Penicillin Natural products 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 230000001078 anti-cholinergic effect Effects 0.000 description 4
- 230000003474 anti-emetic effect Effects 0.000 description 4
- 239000000935 antidepressant agent Substances 0.000 description 4
- 229940005513 antidepressants Drugs 0.000 description 4
- 239000002111 antiemetic agent Substances 0.000 description 4
- 239000000739 antihistaminic agent Substances 0.000 description 4
- 229940125715 antihistaminic agent Drugs 0.000 description 4
- 239000003430 antimalarial agent Substances 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 229940124630 bronchodilator Drugs 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 229940109239 creatinine Drugs 0.000 description 4
- 230000001186 cumulative effect Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 230000005750 disease progression Effects 0.000 description 4
- 230000002526 effect on cardiovascular system Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 239000003193 general anesthetic agent Substances 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 239000000193 iodinated contrast media Substances 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 150000002960 penicillins Chemical class 0.000 description 4
- 230000026731 phosphorylation Effects 0.000 description 4
- 238000006366 phosphorylation reaction Methods 0.000 description 4
- 230000035479 physiological effects, processes and functions Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000000241 respiratory effect Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000012795 verification Methods 0.000 description 4
- 108700028369 Alleles Proteins 0.000 description 3
- 108090001030 Lipoproteins Proteins 0.000 description 3
- 102000004895 Lipoproteins Human genes 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229940035676 analgesics Drugs 0.000 description 3
- 229940035674 anesthetics Drugs 0.000 description 3
- 239000000730 antalgic agent Substances 0.000 description 3
- 230000000118 anti-neoplastic effect Effects 0.000 description 3
- 239000003472 antidiabetic agent Substances 0.000 description 3
- 229940125683 antiemetic agent Drugs 0.000 description 3
- 229940121375 antifungal agent Drugs 0.000 description 3
- 239000000164 antipsychotic agent Substances 0.000 description 3
- 239000003443 antiviral agent Substances 0.000 description 3
- 239000002876 beta blocker Substances 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 229960000074 biopharmaceutical Drugs 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 239000000168 bronchodilator agent Substances 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 230000003177 cardiotonic effect Effects 0.000 description 3
- 230000001364 causal effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000005094 computer simulation Methods 0.000 description 3
- 239000000850 decongestant Substances 0.000 description 3
- 229940124581 decongestants Drugs 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000007877 drug screening Methods 0.000 description 3
- 230000002874 effect on oedema Effects 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 238000012854 evaluation process Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 210000002288 golgi apparatus Anatomy 0.000 description 3
- 239000003163 gonadal steroid hormone Substances 0.000 description 3
- 230000009931 harmful effect Effects 0.000 description 3
- 238000000126 in silico method Methods 0.000 description 3
- 238000005462 in vivo assay Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 210000003712 lysosome Anatomy 0.000 description 3
- 230000001868 lysosomic effect Effects 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000013178 mathematical model Methods 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 210000003470 mitochondria Anatomy 0.000 description 3
- 239000003607 modifier Substances 0.000 description 3
- 208000010125 myocardial infarction Diseases 0.000 description 3
- 239000003158 myorelaxant agent Substances 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 210000003463 organelle Anatomy 0.000 description 3
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000003705 ribosome Anatomy 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 230000019491 signal transduction Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- 230000002485 urinary effect Effects 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 229940078581 Bone resorption inhibitor Drugs 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229930186147 Cephalosporin Natural products 0.000 description 2
- 108091006146 Channels Proteins 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010028851 Necrosis Diseases 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 102000004257 Potassium Channel Human genes 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 229940100389 Sulfonylurea Drugs 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 2
- 230000001919 adrenal effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003732 agents acting on the eye Substances 0.000 description 2
- 239000002269 analeptic agent Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003178 anti-diabetic effect Effects 0.000 description 2
- 230000003276 anti-hypertensive effect Effects 0.000 description 2
- 230000000078 anti-malarial effect Effects 0.000 description 2
- 230000002682 anti-psoriatic effect Effects 0.000 description 2
- 230000002921 anti-spasmodic effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000003416 antiarrhythmic agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940125708 antidiabetic agent Drugs 0.000 description 2
- 239000003524 antilipemic agent Substances 0.000 description 2
- 229940034982 antineoplastic agent Drugs 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940125688 antiparkinson agent Drugs 0.000 description 2
- 239000000939 antiparkinson agent Substances 0.000 description 2
- 229940127218 antiplatelet drug Drugs 0.000 description 2
- 229940030999 antipsoriatics Drugs 0.000 description 2
- 229940005529 antipsychotics Drugs 0.000 description 2
- 229940124575 antispasmodic agent Drugs 0.000 description 2
- 229940121383 antituberculosis agent Drugs 0.000 description 2
- 229940121357 antivirals Drugs 0.000 description 2
- 239000002249 anxiolytic agent Substances 0.000 description 2
- 230000000949 anxiolytic effect Effects 0.000 description 2
- 229940005530 anxiolytics Drugs 0.000 description 2
- 210000001130 astrocyte Anatomy 0.000 description 2
- 229940125717 barbiturate Drugs 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 229940049706 benzodiazepine Drugs 0.000 description 2
- 229940097320 beta blocking agent Drugs 0.000 description 2
- 238000010256 biochemical assay Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 239000002617 bone density conservation agent Substances 0.000 description 2
- 210000004958 brain cell Anatomy 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000002327 cardiovascular agent Substances 0.000 description 2
- 229940125692 cardiovascular agent Drugs 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000003576 central nervous system agent Substances 0.000 description 2
- 229940125693 central nervous system agent Drugs 0.000 description 2
- 229940124587 cephalosporin Drugs 0.000 description 2
- 150000001780 cephalosporins Chemical class 0.000 description 2
- 230000007012 clinical effect Effects 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 238000002648 combination therapy Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 229940030606 diuretics Drugs 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 238000010304 firing Methods 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000013632 homeostatic process Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 229940047124 interferons Drugs 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 description 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 238000007620 mathematical function Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 229940125702 ophthalmic agent Drugs 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 229950000688 phenothiazine Drugs 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 108020001213 potassium channel Proteins 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 239000002464 receptor antagonist Substances 0.000 description 2
- 229940044551 receptor antagonist Drugs 0.000 description 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 2
- 238000011301 standard therapy Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000003860 topical agent Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 239000000814 tuberculostatic agent Substances 0.000 description 2
- 102000003390 tumor necrosis factor Human genes 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 210000004885 white matter Anatomy 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- NBGAYCYFNGPNPV-UHFFFAOYSA-N 2-aminooxybenzoic acid Chemical class NOC1=CC=CC=C1C(O)=O NBGAYCYFNGPNPV-UHFFFAOYSA-N 0.000 description 1
- ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 description 1
- WFFZGYRTVIPBFN-UHFFFAOYSA-N 3h-indene-1,2-dione Chemical class C1=CC=C2C(=O)C(=O)CC2=C1 WFFZGYRTVIPBFN-UHFFFAOYSA-N 0.000 description 1
- SWLAMJPTOQZTAE-UHFFFAOYSA-N 4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]benzoic acid Chemical class COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C(O)=O)C=C1 SWLAMJPTOQZTAE-UHFFFAOYSA-N 0.000 description 1
- 102000035037 5-HT3 receptors Human genes 0.000 description 1
- 108091005477 5-HT3 receptors Proteins 0.000 description 1
- 239000002677 5-alpha reductase inhibitor Substances 0.000 description 1
- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical compound C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 description 1
- RTAPDZBZLSXHQQ-UHFFFAOYSA-N 8-methyl-3,7-dihydropurine-2,6-dione Chemical class N1C(=O)NC(=O)C2=C1N=C(C)N2 RTAPDZBZLSXHQQ-UHFFFAOYSA-N 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 102100027211 Albumin Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 description 1
- 102000015427 Angiotensins Human genes 0.000 description 1
- 108010064733 Angiotensins Proteins 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 229940124290 BCR-ABL tyrosine kinase inhibitor Drugs 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 229940124292 CD20 monoclonal antibody Drugs 0.000 description 1
- 229940124294 CD33 monoclonal antibody Drugs 0.000 description 1
- 229940124296 CD52 monoclonal antibody Drugs 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- 102000005702 Calcium-Activated Potassium Channels Human genes 0.000 description 1
- 108010045489 Calcium-Activated Potassium Channels Proteins 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 229940122072 Carbonic anhydrase inhibitor Drugs 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 229940122444 Chemokine receptor antagonist Drugs 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000002330 Congenital Heart Defects Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 201000000057 Coronary Stenosis Diseases 0.000 description 1
- 102400000739 Corticotropin Human genes 0.000 description 1
- 101800000414 Corticotropin Proteins 0.000 description 1
- 102000013975 Delayed Rectifier Potassium Channels Human genes 0.000 description 1
- 108010050556 Delayed Rectifier Potassium Channels Proteins 0.000 description 1
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 description 1
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 description 1
- 108010049047 Echinocandins Proteins 0.000 description 1
- 229940102550 Estrogen receptor antagonist Drugs 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 229940123583 Factor Xa inhibitor Drugs 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 102100020948 Growth hormone receptor Human genes 0.000 description 1
- 229940125497 HER2 kinase inhibitor Drugs 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010058179 Hypertensive emergency Diseases 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010070070 Hypoinsulinaemia Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 108010041872 Islet Amyloid Polypeptide Chemical class 0.000 description 1
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 108010004718 Lipoglycopeptides Proteins 0.000 description 1
- 238000007476 Maximum Likelihood Methods 0.000 description 1
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 description 1
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 description 1
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 description 1
- 208000001089 Multiple system atrophy Diseases 0.000 description 1
- 229940124821 NNRTIs Drugs 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229940122313 Nucleoside reverse transcriptase inhibitor Drugs 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010031127 Orthostatic hypotension Diseases 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 108010087702 Penicillinase Proteins 0.000 description 1
- 102000003946 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 102000014128 RANK Ligand Human genes 0.000 description 1
- 108010025832 RANK Ligand Proteins 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 102000005157 Somatostatin Human genes 0.000 description 1
- 108010056088 Somatostatin Proteins 0.000 description 1
- 108010068542 Somatotropin Receptors Proteins 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- 241000287181 Sturnus vulgaris Species 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 229940123464 Thiazolidinedione Drugs 0.000 description 1
- 229940122388 Thrombin inhibitor Drugs 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- 229940116211 Vasopressin antagonist Drugs 0.000 description 1
- 102000002852 Vasopressins Human genes 0.000 description 1
- 108010004977 Vasopressins Proteins 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 description 1
- 229940124308 alpha-adrenoreceptor antagonist Drugs 0.000 description 1
- 229940126675 alternative medicines Drugs 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 239000002380 aminotransferase inhibitor Substances 0.000 description 1
- 229940124323 amoebicide Drugs 0.000 description 1
- 239000003263 anabolic agent Substances 0.000 description 1
- 229940070021 anabolic steroids Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 239000004004 anti-anginal agent Substances 0.000 description 1
- 230000001772 anti-angiogenic effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000001315 anti-hyperlipaemic effect Effects 0.000 description 1
- 230000002961 anti-hyperuricemic effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 239000000883 anti-obesity agent Substances 0.000 description 1
- 230000000244 anti-pseudomonal effect Effects 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 230000002365 anti-tubercular Effects 0.000 description 1
- 230000002303 anti-venom Effects 0.000 description 1
- 239000000059 antiamebic agent Substances 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 229940124345 antianginal agent Drugs 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 229940124286 antibiotics/antineoplastics Drugs 0.000 description 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 229940125714 antidiarrheal agent Drugs 0.000 description 1
- 239000003793 antidiarrheal agent Substances 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 229940075522 antidotes Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 description 1
- 239000002255 antigout agent Substances 0.000 description 1
- 229960002708 antigout preparations Drugs 0.000 description 1
- 239000003409 antileprotic agent Substances 0.000 description 1
- 229940033495 antimalarials Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 229940125684 antimigraine agent Drugs 0.000 description 1
- 239000002282 antimigraine agent Substances 0.000 description 1
- 229940124289 antineoplastic interferon Drugs 0.000 description 1
- 229940125710 antiobesity agent Drugs 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
- 239000003200 antithyroid agent Substances 0.000 description 1
- 229940043671 antithyroid preparations Drugs 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 239000003920 antivertigo agent Substances 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 239000003886 aromatase inhibitor Substances 0.000 description 1
- 229940046844 aromatase inhibitors Drugs 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000003693 atypical antipsychotic agent Substances 0.000 description 1
- 229940127236 atypical antipsychotics Drugs 0.000 description 1
- 230000003305 autocrine Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229960001212 bacterial vaccine Drugs 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 description 1
- 239000003781 beta lactamase inhibitor Substances 0.000 description 1
- 229940030611 beta-adrenergic blocking agent Drugs 0.000 description 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 description 1
- 229920000080 bile acid sequestrant Polymers 0.000 description 1
- 229940096699 bile acid sequestrants Drugs 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 229940082649 blood substitutes and perfusion irrigating solutions Drugs 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229940041011 carbapenems Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000008355 cartilage degradation Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 229940097228 centrally acting antiadrenergic agent Drugs 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 239000002559 chemokine receptor antagonist Substances 0.000 description 1
- 239000003467 chloride channel stimulating agent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001906 cholesterol absorption Effects 0.000 description 1
- 239000000064 cholinergic agonist Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 239000000544 cholinesterase inhibitor Substances 0.000 description 1
- 230000024321 chromosome segregation Effects 0.000 description 1
- 230000002057 chronotropic effect Effects 0.000 description 1
- 230000027288 circadian rhythm Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229940047120 colony stimulating factors Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000009850 completed effect Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 208000028831 congenital heart disease Diseases 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
- 229960000258 corticotropin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 125000000332 coumarinyl group Chemical class O1C(=O)C(=CC2=CC=CC=C12)* 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229940111134 coxibs Drugs 0.000 description 1
- 230000001955 cumulated effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- 239000003241 dermatological agent Substances 0.000 description 1
- 229940000033 dermatological agent Drugs 0.000 description 1
- 229940075527 detoxifying agent for antineoplastic treatment Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 235000021004 dietary regimen Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 description 1
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- 239000000221 dopamine uptake inhibitor Substances 0.000 description 1
- 230000003291 dopaminomimetic effect Effects 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 238000009513 drug distribution Methods 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 229940055061 drug used in alcohol dependence Drugs 0.000 description 1
- 239000002961 echo contrast media Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 229940121647 egfr inhibitor Drugs 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 206010014665 endocarditis Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 231100000317 environmental toxin Toxicity 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 229940066493 expectorants Drugs 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229940125753 fibrate Drugs 0.000 description 1
- 229940041006 first-generation cephalosporins Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940041010 fourth-generation cephalosporins Drugs 0.000 description 1
- 238000002825 functional assay Methods 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 230000028579 gamma-aminobutyric acid uptake involved in synaptic transmission Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229940125695 gastrointestinal agent Drugs 0.000 description 1
- 239000004083 gastrointestinal agent Substances 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 229940005494 general anesthetics Drugs 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 230000002518 glial effect Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 239000003933 gonadotropin antagonist Substances 0.000 description 1
- 229940094892 gonadotropins Drugs 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 238000009532 heart rate measurement Methods 0.000 description 1
- 208000018578 heart valve disease Diseases 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000002607 heparin antagonist Substances 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 description 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 229940124299 hormone/antineoplastic Drugs 0.000 description 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 1
- 229940091173 hydantoin Drugs 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 239000005554 hypnotics and sedatives Substances 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000035860 hypoinsulinemia Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 239000000677 immunologic agent Substances 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000011312 in silico drug discovery Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 239000000859 incretin Substances 0.000 description 1
- MGXWVYUBJRZYPE-YUGYIWNOSA-N incretin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=C(O)C=C1 MGXWVYUBJRZYPE-YUGYIWNOSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 229940125369 inhaled corticosteroids Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000004041 inotropic agent Substances 0.000 description 1
- 229940124525 integrase strand transfer inhibitor Drugs 0.000 description 1
- 210000002977 intracellular fluid Anatomy 0.000 description 1
- 230000031146 intracellular signal transduction Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000013010 irrigating solution Substances 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 239000003835 ketolide antibiotic agent Substances 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical class CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000002171 loop diuretic Substances 0.000 description 1
- 229940066294 lung surfactant Drugs 0.000 description 1
- 239000003580 lung surfactant Substances 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 229940124302 mTOR inhibitor Drugs 0.000 description 1
- 238000010801 machine learning Methods 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 229940116557 magnetic resonance imaging contrast media Drugs 0.000 description 1
- 201000005857 malignant hypertension Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229950004994 meglitinide Drugs 0.000 description 1
- 230000005055 memory storage Effects 0.000 description 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical class NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000002395 mineralocorticoid Substances 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 230000003990 molecular pathway Effects 0.000 description 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
- 230000000510 mucolytic effect Effects 0.000 description 1
- 229940066491 mucolytics Drugs 0.000 description 1
- 229940124303 multikinase inhibitor Drugs 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000002637 mydriatic agent Substances 0.000 description 1
- 230000002911 mydriatic effect Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000004084 narcotic analgesic agent Substances 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 229940037525 nasal preparations Drugs 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 238000002610 neuroimaging Methods 0.000 description 1
- 239000000842 neuromuscular blocking agent Substances 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 description 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940125703 otic agent Drugs 0.000 description 1
- COWNFYYYZFRNOY-UHFFFAOYSA-N oxazolidinedione Chemical compound O=C1COC(=O)N1 COWNFYYYZFRNOY-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000003076 paracrine Effects 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229940079358 peripheral opioid receptor antagonist Drugs 0.000 description 1
- 239000000810 peripheral vasodilating agent Substances 0.000 description 1
- 229960002116 peripheral vasodilator Drugs 0.000 description 1
- 229940097224 peripherally acting antiadrenergic agent Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000009521 phase II clinical trial Methods 0.000 description 1
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000010399 physical interaction Effects 0.000 description 1
- 238000005293 physical law Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229940037129 plain mineralocorticoids for systemic use Drugs 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 239000003286 potassium sparing diuretic agent Substances 0.000 description 1
- 229940097241 potassium-sparing diuretic Drugs 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 238000004632 predicting treatment efficacy Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 239000002379 progesterone receptor modulator Substances 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 description 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 239000002212 purine nucleoside Substances 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000002461 renin inhibitor Substances 0.000 description 1
- 229940086526 renin-inhibitors Drugs 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 239000003229 sclerosing agent Substances 0.000 description 1
- 229940041008 second-generation cephalosporins Drugs 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 description 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 description 1
- 230000002295 serotoninergic effect Effects 0.000 description 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000002911 sialidase inhibitor Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 229940125706 skeletal muscle relaxant agent Drugs 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000004895 subcellular structure Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 238000012706 support-vector machine Methods 0.000 description 1
- 229940094890 synthetic ovulation stimulants Drugs 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940127044 therapeutic radiopharmaceutical Drugs 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 150000005075 thioxanthenes Chemical class 0.000 description 1
- 229940041007 third-generation cephalosporins Drugs 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229960004089 tigecycline Drugs 0.000 description 1
- FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229940125712 tocolytic agent Drugs 0.000 description 1
- 239000003675 tocolytic agent Substances 0.000 description 1
- 229940026754 topical antivirals Drugs 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 229960003853 ultrasound contrast media Drugs 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000002432 uterotonic agent Substances 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000006441 vascular event Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000003038 vasopressin antagonist Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B5/20—Probabilistic models
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Data Mining & Analysis (AREA)
- Molecular Biology (AREA)
- Databases & Information Systems (AREA)
- Artificial Intelligence (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Probability & Statistics with Applications (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Software Systems (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32155510P | 2010-04-07 | 2010-04-07 | |
| US61/321,555 | 2010-04-07 | ||
| PCT/EP2011/001759 WO2011124385A1 (en) | 2010-04-07 | 2011-04-05 | Computer based system for predicting treatment outcomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2832355A1 true CA2832355A1 (en) | 2012-10-13 |
Family
ID=44477613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2832355A Abandoned CA2832355A1 (en) | 2010-04-07 | 2011-04-05 | Computer based system for predicting treatment outcomes |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20130041683A1 (enExample) |
| EP (1) | EP2556460A1 (enExample) |
| JP (1) | JP5970449B2 (enExample) |
| CN (1) | CN102822834B (enExample) |
| AU (1) | AU2011238099A1 (enExample) |
| CA (1) | CA2832355A1 (enExample) |
| RU (1) | RU2601197C2 (enExample) |
| WO (1) | WO2011124385A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10831863B2 (en) | 2016-03-24 | 2020-11-10 | Fujitsu Limited | System and a method for assessing patient risk using open data and clinician input |
| US10885150B2 (en) | 2016-03-24 | 2021-01-05 | Fujitsu Limited | System and a method for assessing patient treatment risk using open data and clinician input |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12324657B2 (en) | 2007-11-28 | 2025-06-10 | Intervet Inc. | System and method for diagnosis of bovine diseases using auscultation analysis |
| US8635183B1 (en) * | 2010-04-19 | 2014-01-21 | Bridgehealth Medical, Inc. | Method and apparatus to computer-process data to produce, store, and disseminate output related to medical or health information |
| JP5970449B2 (ja) * | 2010-04-07 | 2016-08-17 | ノヴァディスカバリー | 処置成果を予測するためのコンピュータベースシステム |
| US20200027181A1 (en) * | 2010-09-29 | 2020-01-23 | Dacadoo Ag | Automated health data acquisition, processing and communication system and method |
| US20130014061A1 (en) * | 2011-07-06 | 2013-01-10 | Lockheed Martin Corporation | Method and apparatus for time-based opportunity and risk management |
| US8992228B2 (en) * | 2012-06-19 | 2015-03-31 | MediResource Inc. | Automated system for delivery of targeted content based on behavior change models |
| EP3739596B1 (en) * | 2012-06-21 | 2024-04-24 | Battelle Memorial Institute | Clinical predictive analytics system |
| US9830423B2 (en) | 2013-03-13 | 2017-11-28 | Abhishek Biswas | Virtual communication platform for healthcare |
| US11694797B2 (en) | 2012-10-30 | 2023-07-04 | Neil S. Davey | Virtual healthcare communication platform |
| AU2014207327A1 (en) * | 2013-01-17 | 2015-08-06 | The Regents Of The University Of California | Rapid identification of optimized combinations of input parameters for a complex system |
| EP2951741A2 (en) * | 2013-02-03 | 2015-12-09 | Genelex Corporation | Systems and methods for quantification and presentation of medical risk arising from unknown factors |
| EP2953544B1 (en) * | 2013-02-06 | 2019-05-08 | Intervet Inc. | System for determining antibiotic effectiveness in respiratory diseased using auscultation analysis |
| US9864837B2 (en) * | 2013-02-28 | 2018-01-09 | Accenture Global Services Limited | Clinical quality analytics system with recursive, time sensitive event-based protocol matching |
| WO2014145705A2 (en) | 2013-03-15 | 2014-09-18 | Battelle Memorial Institute | Progression analytics system |
| CA2914534C (en) * | 2013-06-06 | 2023-07-18 | Timeless Veterinary Systems Inc. | Method and system for providing a treatment protocol |
| US9530095B2 (en) | 2013-06-26 | 2016-12-27 | International Business Machines Corporation | Method and system for exploring the associations between drug side-effects and therapeutic indications |
| EP3129507A4 (en) * | 2014-04-10 | 2017-12-06 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Methods and kits for determining a personalized treatment regimen for a subject suffering from a pathologic disorder |
| JP6324828B2 (ja) * | 2014-07-07 | 2018-05-16 | 株式会社日立製作所 | 薬効分析システム及び薬効分析方法 |
| US9349178B1 (en) * | 2014-11-24 | 2016-05-24 | Siemens Aktiengesellschaft | Synthetic data-driven hemodynamic determination in medical imaging |
| EP3051449A1 (de) * | 2015-01-29 | 2016-08-03 | Bayer Technology Services GmbH | Computerimplementiertes Verfahren zur Erstellung eines Fermentationsmodels |
| US10007762B2 (en) | 2015-04-17 | 2018-06-26 | Heartflow, Inc. | Systems and methods for assessment of tissue function based on vascular disease |
| RU2599350C1 (ru) * | 2015-06-04 | 2016-10-10 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Д. Гольдберга" | Способ прогнозирования индивидуальной эффективности лечения статинами (варианты) |
| US20170024539A1 (en) * | 2015-07-23 | 2017-01-26 | PrioBio, LLC | Enhancing blood cell estimation |
| US10825557B2 (en) * | 2015-09-04 | 2020-11-03 | Canon Medical Systems Corporation | Medical information processing apparatus |
| US11216478B2 (en) | 2015-10-16 | 2022-01-04 | o9 Solutions, Inc. | Plan model searching |
| US9906551B2 (en) * | 2016-02-09 | 2018-02-27 | International Business Machines Corporation | Forecasting and classifying cyber-attacks using crossover neural embeddings |
| US11039986B2 (en) * | 2016-02-25 | 2021-06-22 | Samsung Electronics Co., Ltd. | Chronotherapeutic dosing of medication and medication regimen adherence |
| WO2017201201A1 (en) * | 2016-05-18 | 2017-11-23 | Noar Mark D | Method and system for predicting successful treatment methods and outcomes of bodily tissue disorders based on energy activity of the tissue |
| JP6068715B1 (ja) * | 2016-07-06 | 2017-01-25 | 正彦 原 | 介入効果推測システム、介入効果推測方法、及び、介入効果推測システムに用いるプログラム |
| WO2019014366A1 (en) * | 2017-07-12 | 2019-01-17 | Fresenius Medical Care Holdings, Inc. | TECHNIQUES FOR PERFORMING VIRTUAL CLINICAL TRIALS |
| RU2675067C1 (ru) * | 2017-09-18 | 2018-12-14 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации | Способ прогнозирования возобновления клиники ишемической болезни сердца с помощью нейронных сетей у пациентов после эндоваскулярного вмешательства |
| EP3480823A1 (en) * | 2017-11-02 | 2019-05-08 | Koninklijke Philips N.V. | Clinical decision support |
| US11132621B2 (en) | 2017-11-15 | 2021-09-28 | International Business Machines Corporation | Correction of reaction rules databases by active learning |
| CN112074915B (zh) * | 2018-05-03 | 2024-02-02 | 豪夫迈·罗氏有限公司 | 生物医学预测的可视化 |
| AU2019277199B2 (en) * | 2018-05-31 | 2024-04-04 | Lynne Bilston | Systems, devices and methods for the treatment of oral and pharyngeal disorders |
| US11177028B2 (en) | 2018-12-06 | 2021-11-16 | International Business Machines Corporation | Extraction, representation, and cognitive interpretation of medically relevant evidence |
| US11605469B2 (en) * | 2018-12-13 | 2023-03-14 | International Business Machines Corporation | Cognitive analysis of data using granular review of documents |
| EP3673955A1 (en) * | 2018-12-24 | 2020-07-01 | Koninklijke Philips N.V. | Automated detection of lung conditions for monitoring thoracic patients undergoing external beam radiation therapy |
| SG11202109704UA (en) * | 2019-03-08 | 2021-10-28 | Diane Mould | Systems and methods for drug-agnostic patient-specific dosing regimens |
| US10515715B1 (en) | 2019-06-25 | 2019-12-24 | Colgate-Palmolive Company | Systems and methods for evaluating compositions |
| RU2736391C1 (ru) * | 2019-10-11 | 2020-11-16 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Способ прогноза терапевтической эффективности анксиолитика афобазола у больных с тревожными расстройствами |
| CN111166289B (zh) * | 2020-01-04 | 2023-02-24 | 山东大学齐鲁医院(青岛) | 一种远程内分泌紊乱检测设备 |
| RU2754884C2 (ru) * | 2020-02-03 | 2021-09-08 | Атлас Биомед Груп Лимитед | Определение фенотипа на основе неполных генетических данных |
| US11328796B1 (en) | 2020-02-25 | 2022-05-10 | Vignet Incorporated | Techniques for selecting cohorts for decentralized clinical trials for pharmaceutical research |
| CN111403040A (zh) * | 2020-06-04 | 2020-07-10 | 成都泰盟软件有限公司 | 基于虚拟标准病人的治疗模拟系统 |
| US12230406B2 (en) | 2020-07-13 | 2025-02-18 | Vignet Incorporated | Increasing diversity and engagement in clinical trails through digital tools for health data collection |
| US11854670B2 (en) * | 2020-08-18 | 2023-12-26 | International Business Machines Corporation | Running multiple experiments simultaneously on an array of chemical reactors |
| US12380968B2 (en) | 2020-08-18 | 2025-08-05 | International Business Machines Corporation | Multiple chemical programs for an array of chemical reactors with a single array of reactants |
| US11798652B2 (en) * | 2020-08-24 | 2023-10-24 | Kpn Innovations, Llc. | Method of and system for identifying and ameliorating body degradations |
| WO2022049606A1 (en) * | 2020-09-07 | 2022-03-10 | Theraindx Lifesciences Pvt Ltd | Systems and methods for identification of cell lines, biomarkers, and patients for drug response prediction |
| CN111956367B (zh) * | 2020-09-18 | 2024-09-27 | 上海中医药大学 | 一种治疗脑肿瘤的纳米给药系统 |
| CN112652368B (zh) * | 2020-12-31 | 2024-09-06 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | 一种数据分析的方法及装置 |
| CN112509669A (zh) * | 2021-02-01 | 2021-03-16 | 肾泰网健康科技(南京)有限公司 | 基于ai技术的肾脏病血液透析方案定制方法及系统 |
| US11196656B1 (en) | 2021-02-03 | 2021-12-07 | Vignet Incorporated | Improving diversity in cohorts for health research |
| US11789837B1 (en) | 2021-02-03 | 2023-10-17 | Vignet Incorporated | Adaptive data collection in clinical trials to increase the likelihood of on-time completion of a trial |
| US11521714B1 (en) | 2021-02-03 | 2022-12-06 | Vignet Incorporated | Increasing diversity of participants in health research using adaptive methods |
| US11361846B1 (en) | 2021-02-03 | 2022-06-14 | Vignet Incorporated | Systems and methods for customizing monitoring programs involving remote devices |
| US11296971B1 (en) | 2021-02-03 | 2022-04-05 | Vignet Incorporated | Managing and adapting monitoring programs |
| US11316941B1 (en) | 2021-02-03 | 2022-04-26 | Vignet Incorporated | Remotely managing and adapting monitoring programs using machine learning predictions |
| JP2022174614A (ja) * | 2021-05-11 | 2022-11-24 | 国立大学法人金沢大学 | プログラム、情報処理装置及び情報処理方法 |
| CA3258054A1 (en) * | 2022-06-02 | 2023-12-07 | Todra Capital Inc | SYSTEM, METHOD AND APPARATUS FOR EVALUATING THE EFFECTIVENESS OF NUTRACEUTICAL POLYPHENOLS USING AI |
| CN115270575B (zh) * | 2022-08-05 | 2025-09-05 | 江苏方天电力技术有限公司 | 一种变频凝结水泵结构优化设计方法 |
| CN115359921B (zh) * | 2022-10-20 | 2023-06-27 | 中融云尚科技有限公司 | 一种基于数据分析的医疗信息存储共享系统 |
| US20240419412A1 (en) * | 2023-06-13 | 2024-12-19 | 1370092 Ontario Ltd. | User interface support module and method of use |
| CN117238522B (zh) * | 2023-11-08 | 2024-10-11 | 查理高特(青岛)健康科技有限公司 | 一种非布司他的疗效预测系统、设备及介质 |
| CN117558460B (zh) * | 2024-01-11 | 2024-04-05 | 卓世未来(天津)科技有限公司 | 基于小样本学习和大语言模型的慢性病管理方法及系统 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6983227B1 (en) * | 1995-01-17 | 2006-01-03 | Intertech Ventures, Ltd. | Virtual models of complex systems |
| US5860917A (en) * | 1997-01-15 | 1999-01-19 | Chiron Corporation | Method and apparatus for predicting therapeutic outcomes |
| US6315720B1 (en) * | 2000-10-23 | 2001-11-13 | Celgene Corporation | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug |
| JP4284050B2 (ja) * | 2002-09-27 | 2009-06-24 | 株式会社東芝 | 治療法の有効性を予測するためのプログラム、データベース、システム及び方法 |
| CN1711361A (zh) * | 2002-10-15 | 2005-12-21 | 诺瓦提斯公司 | 预测药物治疗副效应水肿的方法 |
| US20040115647A1 (en) * | 2002-12-12 | 2004-06-17 | Paterson Thomas S. | Apparatus and method for identifying biomarkers using a computer model |
| NZ546089A (en) * | 2003-10-07 | 2008-04-30 | Entelos Inc | Simulating patient-specific outcomes using virtual patients and stimulation engine |
| CA2571856A1 (en) * | 2004-07-20 | 2006-02-09 | Wyeth | Methods of identifying patients at risk of developing encephalitis following immunotherapy for alzheimer's disease |
| NL1027047C2 (nl) * | 2004-09-15 | 2006-03-16 | Roderik Adriaan Kraaijenhagen | Computerinrichting voor het vaststellen van een diagnose. |
| WO2006113987A1 (en) * | 2005-04-25 | 2006-11-02 | Caduceus Information Systems Inc. | System for development of individualised treatment regimens |
| RU2322675C1 (ru) * | 2006-11-08 | 2008-04-20 | Андрей Александрович Темнов | Способ прогнозирования устойчивости организма к стрессорному воздействию |
| US20080140371A1 (en) * | 2006-11-15 | 2008-06-12 | General Electric Company | System and method for treating a patient |
| US20090177450A1 (en) * | 2007-12-12 | 2009-07-09 | Lawrence Berkeley National Laboratory | Systems and methods for predicting response of biological samples |
| WO2009079446A1 (en) * | 2007-12-14 | 2009-06-25 | Centocor, Inc. | Method and system for distributing information between patients, health care providers, caregivers, and payors |
| US20090164190A1 (en) * | 2007-12-19 | 2009-06-25 | Abbott Diabetes Care, Inc. | Physiological condition simulation device and method |
| US20090307181A1 (en) * | 2008-03-19 | 2009-12-10 | Brandon Colby | Genetic analysis |
| WO2009132239A2 (en) * | 2008-04-24 | 2009-10-29 | Trustees Of Boston University | A network biology approach for identifying targets for combination therapies |
| US8224665B2 (en) * | 2008-06-26 | 2012-07-17 | Archimedes, Inc. | Estimating healthcare outcomes for individuals |
| CA2736916A1 (en) * | 2008-10-06 | 2010-04-15 | Merck Sharp & Dohme Corp. | Devices and methods for determining a patient's propensity to adhere to a medication prescription |
| US8694300B2 (en) * | 2008-10-31 | 2014-04-08 | Archimedes, Inc. | Individualized ranking of risk of health outcomes |
| US20110105852A1 (en) * | 2009-11-03 | 2011-05-05 | Macdonald Morris | Using data imputation to determine and rank of risks of health outcomes |
| JP5970449B2 (ja) * | 2010-04-07 | 2016-08-17 | ノヴァディスカバリー | 処置成果を予測するためのコンピュータベースシステム |
-
2011
- 2011-04-05 JP JP2013503039A patent/JP5970449B2/ja active Active
- 2011-04-05 AU AU2011238099A patent/AU2011238099A1/en not_active Abandoned
- 2011-04-05 CN CN201180015982.6A patent/CN102822834B/zh active Active
- 2011-04-05 WO PCT/EP2011/001759 patent/WO2011124385A1/en not_active Ceased
- 2011-04-05 EP EP11713708A patent/EP2556460A1/en not_active Ceased
- 2011-04-05 US US13/636,737 patent/US20130041683A1/en not_active Abandoned
- 2011-04-05 CA CA2832355A patent/CA2832355A1/en not_active Abandoned
- 2011-04-05 RU RU2012133279/08A patent/RU2601197C2/ru active
-
2017
- 2017-05-17 US US15/597,661 patent/US20180039726A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10831863B2 (en) | 2016-03-24 | 2020-11-10 | Fujitsu Limited | System and a method for assessing patient risk using open data and clinician input |
| US10885150B2 (en) | 2016-03-24 | 2021-01-05 | Fujitsu Limited | System and a method for assessing patient treatment risk using open data and clinician input |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102822834A (zh) | 2012-12-12 |
| RU2012133279A (ru) | 2014-05-20 |
| JP5970449B2 (ja) | 2016-08-17 |
| US20180039726A1 (en) | 2018-02-08 |
| AU2011238099A1 (en) | 2012-11-29 |
| CN102822834B (zh) | 2020-09-25 |
| EP2556460A1 (en) | 2013-02-13 |
| JP2013524355A (ja) | 2013-06-17 |
| RU2601197C2 (ru) | 2016-10-27 |
| WO2011124385A1 (en) | 2011-10-13 |
| US20130041683A1 (en) | 2013-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20180039726A1 (en) | Computer based system for predicting treatment outcomes | |
| Yang et al. | DeepIDC: a prediction framework of injectable drug combination based on heterogeneous information and deep learning | |
| Sachdeva et al. | Advancements in myocardial infarction management: exploring novel approaches and strategies | |
| US20090150134A1 (en) | Simulating Patient-Specific Outcomes | |
| US20100324874A9 (en) | Simulating patient-specific outcomes | |
| US20070026365A1 (en) | Defining virtual patient populations | |
| HK1243509A1 (zh) | 基於患者数据的用於健康护理诊断和治疗的贝叶斯因果关系网络模型 | |
| Lecluse et al. | National registries of systemic treatment for psoriasis and the European ‘Psonet’initiative | |
| Manikiran et al. | Artificial intelligence: milestones and role in pharma and healthcare sector | |
| Boissel et al. | Bridging systems medicine and patient needs | |
| JP2022524083A (ja) | 薬物に依存しない患者固有の投薬レジメンのためのシステムおよび方法 | |
| WO2009148803A2 (en) | Methods and systems for integrated health systems | |
| Pollom et al. | A prospective study of electronic quality of life assessment using tablet devices during and after treatment of head and neck cancers | |
| Ponnarengan et al. | Data-Driven Healthcare: The Role of Computational Methods in Medical Innovation. | |
| Chen et al. | RareAgents: Advancing Rare Disease Care through LLM-Empowered Multi-disciplinary Team | |
| Wang et al. | From Bench to Bedside: A Review of Clinical Trials in Drug Discovery and Development | |
| CN105787261B (zh) | 一种基于分子指纹图谱快速评估药物不良反应的方法 | |
| Deorankar et al. | Optimizing Healthcare Throughput: The Role of Machine Learning and Data Analytics | |
| Usman et al. | Pharmacometrics and its application in clinical practice | |
| Surmann et al. | Digital Solutions and the Role of AI in Healthcare | |
| Yingngam | AI in Clinical Trial Design and Patient Recruitment | |
| Chen et al. | Comparative performance of machine learning and conventional scoring systems for neuroprognostication in out-of-hospital cardiac arrest survivors | |
| Eylenbosch et al. | From reactive to predictive: Advancing biologic dosing in dermatology | |
| Hamilton et al. | OP16 Environmental Sustainability Success Stories From the Pharmaceutical and Medtech Industries in Europe: A Targeted Literature Review | |
| Feinberg et al. | PCN325 real-world data describing the role of chemotherapy in the treatment of HR+/HER2-MBC patients: Divergence from evidence-based medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160324 |
|
| FZDE | Discontinued |
Effective date: 20200831 |