CA2831475C - Method and system for spectral unmixing of tissue images - Google Patents

Method and system for spectral unmixing of tissue images Download PDF

Info

Publication number
CA2831475C
CA2831475C CA2831475A CA2831475A CA2831475C CA 2831475 C CA2831475 C CA 2831475C CA 2831475 A CA2831475 A CA 2831475A CA 2831475 A CA2831475 A CA 2831475A CA 2831475 C CA2831475 C CA 2831475C
Authority
CA
Canada
Prior art keywords
distribution
spectral
image
intensity
data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2831475A
Other languages
English (en)
French (fr)
Other versions
CA2831475A1 (en
Inventor
Pascal Bamford
Ronald Kurnik
Michael Otter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
Original Assignee
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Medical Systems Inc filed Critical Ventana Medical Systems Inc
Publication of CA2831475A1 publication Critical patent/CA2831475A1/en
Application granted granted Critical
Publication of CA2831475C publication Critical patent/CA2831475C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361—Optical details, e.g. image relay to the camera or image sensor
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/58—Extraction of image or video features relating to hyperspectral data

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Image Input (AREA)
CA2831475A 2011-05-06 2012-05-04 Method and system for spectral unmixing of tissue images Active CA2831475C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161483202P 2011-05-06 2011-05-06
US61/483,202 2011-05-06
PCT/EP2012/058253 WO2012152693A1 (en) 2011-05-06 2012-05-04 Method and system for spectral unmixing of tissue images

Publications (2)

Publication Number Publication Date
CA2831475A1 CA2831475A1 (en) 2012-11-15
CA2831475C true CA2831475C (en) 2016-11-01

Family

ID=46149403

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2831475A Active CA2831475C (en) 2011-05-06 2012-05-04 Method and system for spectral unmixing of tissue images

Country Status (6)

Country Link
US (1) US9377613B2 (https=)
EP (1) EP2705463A1 (https=)
JP (1) JP2014525028A (https=)
AU (1) AU2012252564B2 (https=)
CA (1) CA2831475C (https=)
WO (1) WO2012152693A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2972227B1 (en) 2013-03-12 2020-05-06 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
AU2014230469B2 (en) * 2013-03-15 2017-07-13 Ventana Medical Systems, Inc. Spectral unmixing
CA2920492C (en) 2013-09-30 2019-08-13 Ventana Medical Systems, Inc. Systems and methods for adaptive histopathology image unmixing
WO2015101507A1 (en) 2013-12-31 2015-07-09 Ventana Medical Systems, Inc. Systems and methods for spectral unmixing of microscopic images using pixel grouping
JP6629762B2 (ja) 2014-05-23 2020-01-15 ベンタナ メディカル システムズ， インコーポレイテッド 画像内の生物学的構造及び／又はパターンの検出のためのシステム及び方法
WO2016189065A1 (en) 2015-05-26 2016-12-01 Ventana Medical Systems, Inc. Method and system for assessing stain quality for in-situ hybridization and immunohistochemistry
FR3091816B1 (fr) * 2019-01-18 2022-08-05 Fabre Pierre Dermo Cosmetique Dispositif pour la caractérisation et la comparaison de zones érythémales
CN116113098B (zh) * 2022-07-19 2025-10-24 漳州立达信光电子科技有限公司 光源控制方法、装置、照明设备和可读存储介质

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863504A (en) 1995-03-16 1999-01-26 Bio-Rad Laboratories, Inc. Fluorescence imaging instrument utilizing fish
JP2000098244A (ja) 1998-09-24 2000-04-07 Olympus Optical Co Ltd 蛍光顕微鏡
WO2004065997A2 (en) 2003-01-23 2004-08-05 Jobin Yvon Inc. Microscope for performing multiple frequency fluorometric measurements
US7321791B2 (en) * 2003-09-23 2008-01-22 Cambridge Research And Instrumentation, Inc. Spectral imaging of deep tissue
US20060126959A1 (en) * 2004-12-13 2006-06-15 Digitalglobe, Inc. Method and apparatus for enhancing a digital image
JP4537231B2 (ja) * 2005-03-07 2010-09-01 独立行政法人理化学研究所 多重蛍光からの蛍光色素濃度の推定方法および多重蛍光からの蛍光強度の推定方法
US8189191B2 (en) * 2005-07-26 2012-05-29 Tufts University Spectroscopic imaging microscopy
US8244021B2 (en) 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
JP4599519B2 (ja) 2007-03-07 2010-12-15 学校法人 芝浦工業大学 コンクリートの乾式吹き付けシステムおよびコンクリートの乾式吹き付け工法
JP2010020298A (ja) 2008-06-13 2010-01-28 Nikon Corp 結像装置及び顕微鏡
EP2451344B1 (en) * 2009-07-10 2019-02-20 Cas Medical Systems, Inc. Method for spectrophotometric blood oxygenation monitoring of the lower gastrointestinal tract
US9541504B2 (en) * 2010-08-05 2017-01-10 Cambridge Research & Instrumentation, Inc. Enhancing visual assessment of samples

Also Published As

Publication number Publication date
CA2831475A1 (en) 2012-11-15
AU2012252564A1 (en) 2013-09-26
AU2012252564B2 (en) 2015-11-26
EP2705463A1 (en) 2014-03-12
US20140078286A1 (en) 2014-03-20
US9377613B2 (en) 2016-06-28
WO2012152693A1 (en) 2012-11-15
JP2014525028A (ja) 2014-09-25

Similar Documents

Publication Publication Date Title
CA2831475C (en) Method and system for spectral unmixing of tissue images
JP5540102B2 (ja) 高められた病理学的決定のための複数モダリティコントラストおよび明視野コンテキスト表現、および組織内の複数検体検出
US10242248B2 (en) Image adaptive physiologically plausible color separation
US8379962B2 (en) Image classifier training
EP2972223B1 (en) Spectral unmixing
Adler et al. Colocalization analysis in fluorescence microscopy
EP3167278A1 (en) Pure spectrum extraction from biological samples
WO2019142136A1 (en) System and methods for real-time raman spectroscopy for cancer detection
Krafft et al. Advances in optical biopsy–correlation of malignancy and cell density of primary brain tumors using Raman microspectroscopic imaging
JP2010181833A (ja) 顕微鏡観察システム
Rodríguez et al. Automatic pseudo-coloring approaches to improve visual perception and contrast in polarimetric images of biological tissues
JP2023507587A (ja) 組織検出の改善のためにイメージングモダリティを組み合わせるシステムおよび方法
US20240393248A1 (en) Information processing device, biological sample observation system, and image generation method
US7045757B1 (en) Apparatus and method for chemical imaging of a biological sample
US7465911B2 (en) Apparatus and method for chemical imaging of a biological sample with at least two spectral images of the sample obtained simultaneously
US20240210321A1 (en) A smart tissue classification framework based on multi-classifier systems
JP7841533B2 (ja) 情報処理装置、生体試料観察システム及び画像生成方法
US20240035976A1 (en) Uv excited multi spectral fluorescence based tissue analysis with raman spectroscopy zoom-in scanning
US20230296519A1 (en) Autofluorescence-Based Targeting of Pathologically/Diagnostically Relevant Tissue Regions for Efficient and Accurate Omics Profiling
Xing et al. Combining multispectral reflectance and fluorescence imaging for identifying bruises and stem-end/calyx regions on Golden Delicious apples
US20240011969A1 (en) Multi-Modal Multi-Spectral Imaging System and Method for Characterizing Tissue Types in Bladder Specimens
Li et al. Hyperspectral Band Selection with Learnable Weights for Efficient Glioblastoma Detection
HK1171508A (en) Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue
HK1171508B (en) Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20141208

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD

Year of fee payment: 13

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250422

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250422