CA2827600C - Compositions de microgel - Google Patents
Compositions de microgel Download PDFInfo
- Publication number
- CA2827600C CA2827600C CA2827600A CA2827600A CA2827600C CA 2827600 C CA2827600 C CA 2827600C CA 2827600 A CA2827600 A CA 2827600A CA 2827600 A CA2827600 A CA 2827600A CA 2827600 C CA2827600 C CA 2827600C
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- Prior art keywords
- microgel
- microgel particles
- particles
- group
- cross
- Prior art date
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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- QGYLTGSHWIGJJD-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine Chemical compound C1=CC(F)=CC=C1C1=CSC2=NC=NC(NCC=3C=C4OCOC4=CC=3)=C12 QGYLTGSHWIGJJD-UHFFFAOYSA-N 0.000 description 1
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 description 1
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- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000004038 photonic crystal Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
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- 230000002787 reinforcement Effects 0.000 description 1
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- 206010039722 scoliosis Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
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- 208000005801 spondylosis Diseases 0.000 description 1
- 150000003440 styrenes Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000003115 supporting electrolyte Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 238000005287 template synthesis Methods 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1804—C4-(meth)acrylate, e.g. butyl (meth)acrylate, isobutyl (meth)acrylate or tert-butyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
- C08F265/04—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
- C08F265/06—Polymerisation of acrylate or methacrylate esters on to polymers thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
- C08F299/02—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates
- C08F299/022—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates from polycondensates with side or terminal unsaturations
- C08F299/024—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates from polycondensates with side or terminal unsaturations the unsaturation being in acrylic or methacrylic groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
- C08L33/062—Copolymers with monomers not covered by C08L33/06
- C08L33/064—Copolymers with monomers not covered by C08L33/06 containing anhydride, COOH or COOM groups, with M being metal or onium-cation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/04—Polymer mixtures characterised by other features containing interpenetrating networks
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des compositions de microgel et, en particulier, des compositions de gel obtenues en liant ensemble une pluralité de particules individuelles de microgel. La présente invention concerne également des procédés de préparation de ces compositions et leur utilisation dans des applications particulières, notamment des applications médicales telles que la réparation d'un tissu porteur lésé, dégénéré ou malformé (par exemple des disques intervertébraux).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1002862.9A GB201002862D0 (en) | 2010-02-19 | 2010-02-19 | Microgel compositions |
| GB1002862.9 | 2010-02-19 | ||
| PCT/GB2011/050329 WO2011101684A1 (fr) | 2010-02-19 | 2011-02-18 | Compositions de microgel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2827600A1 CA2827600A1 (fr) | 2011-08-25 |
| CA2827600C true CA2827600C (fr) | 2018-04-24 |
Family
ID=42114092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2827600A Active CA2827600C (fr) | 2010-02-19 | 2011-02-18 | Compositions de microgel |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10660989B2 (fr) |
| EP (3) | EP2542620B1 (fr) |
| CA (1) | CA2827600C (fr) |
| DK (2) | DK2542620T3 (fr) |
| ES (2) | ES2590685T3 (fr) |
| GB (1) | GB201002862D0 (fr) |
| WO (1) | WO2011101684A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120209396A1 (en) | 2008-07-07 | 2012-08-16 | David Myung | Orthopedic implants having gradient polymer alloys |
| GB201002862D0 (en) | 2010-02-19 | 2010-04-07 | Univ Manchester | Microgel compositions |
| AU2011248537B2 (en) | 2010-04-28 | 2014-04-17 | University Of Georgia Research Foundation, Inc. | Photochemical cross-linkable polymers, methods of marking photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers |
| EP3357518B1 (fr) | 2011-10-03 | 2020-12-02 | Hyalex Orthopaedics, Inc. | Adhésif polymère pour ancrage de matériaux conformes à une autre surface |
| US9839213B2 (en) | 2011-10-14 | 2017-12-12 | The University Of Georgia Research Foundation, Inc. | Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers |
| WO2016011387A1 (fr) * | 2014-07-17 | 2016-01-21 | The Regents Of The University Of California | Particules de microgel auto-recuites contrôlables pour des applications biomédicales |
| EP3240583B1 (fr) * | 2015-01-02 | 2019-05-08 | James Ankrum | Compositions de comblement tissulaire réticulables |
| US11046828B2 (en) * | 2015-04-21 | 2021-06-29 | Trustees Of Tufts College | Fabrication of macroporous monodisperse hydrogel microspheres |
| EP4227363A1 (fr) * | 2015-08-10 | 2023-08-16 | Hyalex Orthopaedics, Inc. | Réseaux polymères interpénétrés |
| US11077228B2 (en) | 2015-08-10 | 2021-08-03 | Hyalex Orthopaedics, Inc. | Interpenetrating polymer networks |
| WO2017055629A1 (fr) * | 2015-10-02 | 2017-04-06 | Dsm Ip Assets B.V. | Polymères multiréseau à base de particules |
| US11931480B2 (en) | 2016-02-16 | 2024-03-19 | The Regents Of The University Of California | Microporous annealed particle gels and methods of use |
| WO2018136205A1 (fr) | 2016-12-29 | 2018-07-26 | Tempo Therapeutics, Inc. | Procédés et systèmes de traitement d'un site d'implant médical |
| US10869950B2 (en) | 2018-07-17 | 2020-12-22 | Hyalex Orthopaedics, Inc. | Ionic polymer compositions |
| GB2586577B (en) * | 2019-06-14 | 2024-03-27 | Gelmetix Ltd | Diagnosis and treatment |
| CN113117140B (zh) * | 2021-04-07 | 2022-04-12 | 西安理工大学 | 双刺激协同响应多孔水凝胶改性丙烯酸骨水泥的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508325A (en) * | 1995-01-19 | 1996-04-16 | The Glidden Company | Aqueous dispersed, acrylic grafted epoxy microgel protective coatings |
| US6428576B1 (en) * | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
| US6608134B1 (en) | 1999-05-07 | 2003-08-19 | Avery Dennison Corporation | Adhesives and method for making same |
| US20030138490A1 (en) * | 2001-09-08 | 2003-07-24 | Zhibing Hu | Synthesis and uses of polymer gel nanoparticle networks |
| GB0523999D0 (en) * | 2005-11-25 | 2006-01-04 | Univ Manchester | Microgel particle |
| GB0912768D0 (en) | 2009-07-22 | 2009-08-26 | Glaxo Group Ltd | Novel composition |
| GB201002862D0 (en) | 2010-02-19 | 2010-04-07 | Univ Manchester | Microgel compositions |
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2010
- 2010-02-19 GB GBGB1002862.9A patent/GB201002862D0/en not_active Ceased
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- 2011-02-18 WO PCT/GB2011/050329 patent/WO2011101684A1/fr active Application Filing
- 2011-02-18 DK DK11707214.0T patent/DK2542620T3/en active
- 2011-02-18 EP EP11707214.0A patent/EP2542620B1/fr active Active
- 2011-02-18 DK DK16169236.3T patent/DK3095817T3/da active
- 2011-02-18 EP EP16169236.3A patent/EP3095817B1/fr active Active
- 2011-02-18 EP EP20213614.9A patent/EP3854845A1/fr active Pending
- 2011-02-18 ES ES11707214.0T patent/ES2590685T3/es active Active
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2011101684A1 (fr) | 2011-08-25 |
| EP2542620A1 (fr) | 2013-01-09 |
| US20120308508A1 (en) | 2012-12-06 |
| ES2861002T3 (es) | 2021-10-05 |
| US10660989B2 (en) | 2020-05-26 |
| DK3095817T3 (da) | 2021-03-15 |
| EP3095817A1 (fr) | 2016-11-23 |
| DK2542620T3 (en) | 2016-09-19 |
| EP2542620B1 (fr) | 2016-06-08 |
| GB201002862D0 (en) | 2010-04-07 |
| CA2827600A1 (fr) | 2011-08-25 |
| ES2590685T3 (es) | 2016-11-23 |
| US11197947B2 (en) | 2021-12-14 |
| EP3854845A1 (fr) | 2021-07-28 |
| US20190151512A1 (en) | 2019-05-23 |
| EP3095817B1 (fr) | 2020-12-16 |
| US20190224372A1 (en) | 2019-07-25 |
| US20220202993A1 (en) | 2022-06-30 |
| US10695465B2 (en) | 2020-06-30 |
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