CA2823460A1 - Diagnostic method - Google Patents
Diagnostic method Download PDFInfo
- Publication number
- CA2823460A1 CA2823460A1 CA2823460A CA2823460A CA2823460A1 CA 2823460 A1 CA2823460 A1 CA 2823460A1 CA 2823460 A CA2823460 A CA 2823460A CA 2823460 A CA2823460 A CA 2823460A CA 2823460 A1 CA2823460 A1 CA 2823460A1
- Authority
- CA
- Canada
- Prior art keywords
- mcm
- cells
- bladder cancer
- sample
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000002405 diagnostic procedure Methods 0.000 title description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims abstract description 121
- 206010005003 Bladder cancer Diseases 0.000 claims abstract description 120
- 201000005112 urinary bladder cancer Diseases 0.000 claims abstract description 120
- 238000000034 method Methods 0.000 claims abstract description 89
- 230000009870 specific binding Effects 0.000 claims abstract description 60
- 230000027455 binding Effects 0.000 claims abstract description 49
- 210000001124 body fluid Anatomy 0.000 claims abstract description 25
- 239000010839 body fluid Substances 0.000 claims abstract description 25
- 229920001184 polypeptide Polymers 0.000 claims abstract description 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 21
- 238000012423 maintenance Methods 0.000 claims abstract description 18
- 210000004027 cell Anatomy 0.000 claims description 276
- 206010028980 Neoplasm Diseases 0.000 claims description 82
- 210000002700 urine Anatomy 0.000 claims description 44
- 201000011510 cancer Diseases 0.000 claims description 40
- 208000006750 hematuria Diseases 0.000 claims description 40
- 238000005259 measurement Methods 0.000 claims description 20
- 208000024891 symptom Diseases 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 238000000684 flow cytometry Methods 0.000 claims description 3
- 210000000349 chromosome Anatomy 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 description 104
- 230000035945 sensitivity Effects 0.000 description 47
- 230000036210 malignancy Effects 0.000 description 28
- 206010044412 transitional cell carcinoma Diseases 0.000 description 24
- 210000001519 tissue Anatomy 0.000 description 23
- 239000000427 antigen Substances 0.000 description 20
- 102000036639 antigens Human genes 0.000 description 20
- 108091007433 antigens Proteins 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 238000002574 cystoscopy Methods 0.000 description 12
- 238000010186 staining Methods 0.000 description 12
- 239000000872 buffer Substances 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
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- 238000011835 investigation Methods 0.000 description 9
- 238000012552 review Methods 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 102100030960 DNA replication licensing factor MCM2 Human genes 0.000 description 7
- 101000583807 Homo sapiens DNA replication licensing factor MCM2 Proteins 0.000 description 7
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- SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
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- 208000015181 infectious disease Diseases 0.000 description 4
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- 239000006228 supernatant Substances 0.000 description 4
- 208000014001 urinary system disease Diseases 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 206010071289 Lower urinary tract symptoms Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000003339 best practice Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000019206 urinary tract infection Diseases 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- WZUVPPKBWHMQCE-XJKSGUPXSA-N (+)-haematoxylin Chemical compound C12=CC(O)=C(O)C=C2C[C@]2(O)[C@H]1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-XJKSGUPXSA-N 0.000 description 2
- 101100236724 Caenorhabditis elegans mcm-5 gene Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Natural products C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 208000029162 bladder disease Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000011976 chest X-ray Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
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- 238000001990 intravenous administration Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 206010029446 nocturia Diseases 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
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- 230000001105 regulatory effect Effects 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- BUFQZEHPOKLSTP-UHFFFAOYSA-M sodium;oxido hydrogen sulfate Chemical compound [Na+].OS(=O)(=O)O[O-] BUFQZEHPOKLSTP-UHFFFAOYSA-M 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 208000026533 urinary bladder disease Diseases 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 101100023997 Caenorhabditis elegans mom-2 gene Proteins 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 102100034001 DNA replication licensing factor MCM5 Human genes 0.000 description 1
- 101001017545 Homo sapiens DNA replication licensing factor MCM5 Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000003794 Mini-chromosome maintenance proteins Human genes 0.000 description 1
- 108090000159 Mini-chromosome maintenance proteins Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000577979 Peromyscus spicilegus Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108010004729 Phycoerythrin Proteins 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 208000026723 Urinary tract disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
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- 239000000654 additive Substances 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000003443 bladder cell Anatomy 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 238000009535 clinical urine test Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 238000004163 cytometry Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005274 electronic transitions Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 239000000990 laser dye Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000005291 magnetic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1100223.5 | 2011-01-07 | ||
| GBGB1100223.5A GB201100223D0 (en) | 2011-01-07 | 2011-01-07 | Diagnostic method |
| PCT/GB2012/000008 WO2012093251A1 (en) | 2011-01-07 | 2012-01-06 | Diagnostic method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2823460A1 true CA2823460A1 (en) | 2012-07-12 |
Family
ID=43663908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2823460A Abandoned CA2823460A1 (en) | 2011-01-07 | 2012-01-06 | Diagnostic method |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10107814B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3214445B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2014501929A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012204796A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2823460A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201100223D0 (cg-RX-API-DMAC7.html) |
| IL (1) | IL227295A0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012093251A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11054426B2 (en) * | 2011-01-07 | 2021-07-06 | Cytosystems Ltd | Diagnostic method |
| EP3304084B1 (en) | 2015-06-08 | 2022-03-23 | Arquer Diagnostics Limited | Methods and kits |
| CN107771285A (zh) | 2015-06-08 | 2018-03-06 | 阿奎尔诊断有限公司 | 方法 |
| GB201511196D0 (en) | 2015-06-25 | 2015-08-12 | Cytosystems Ltd | Monoclonal antibodies |
| US20230204582A1 (en) * | 2020-05-28 | 2023-06-29 | Cytobay Inc. | Cytopathological staining |
| EP4217746A1 (en) * | 2020-09-24 | 2023-08-02 | Cytosystems Limited | Diagnosis of cancer by imaging flow cytometry |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303323B1 (en) * | 1997-10-21 | 2001-10-16 | Cancer Research Campaign Technology Limited | Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies |
| JP5086241B2 (ja) * | 2005-04-21 | 2012-11-28 | カリフォルニア インスティチュート オブ テクノロジー | パリレンメンブレンフィルターの使用 |
-
2011
- 2011-01-07 GB GBGB1100223.5A patent/GB201100223D0/en not_active Ceased
-
2012
- 2012-01-06 EP EP16205472.0A patent/EP3214445B1/en not_active Not-in-force
- 2012-01-06 CA CA2823460A patent/CA2823460A1/en not_active Abandoned
- 2012-01-06 EP EP12701160.9A patent/EP2661628B1/en not_active Not-in-force
- 2012-01-06 AU AU2012204796A patent/AU2012204796A1/en not_active Abandoned
- 2012-01-06 JP JP2013547903A patent/JP2014501929A/ja active Pending
- 2012-01-06 US US13/512,585 patent/US10107814B2/en active Active
- 2012-01-06 WO PCT/GB2012/000008 patent/WO2012093251A1/en not_active Ceased
-
2013
- 2013-07-02 IL IL227295A patent/IL227295A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012093251A1 (en) | 2012-07-12 |
| GB201100223D0 (en) | 2011-02-23 |
| IL227295A0 (en) | 2013-09-30 |
| JP2014501929A (ja) | 2014-01-23 |
| US20130059930A1 (en) | 2013-03-07 |
| AU2012204796A1 (en) | 2013-08-01 |
| EP2661628B1 (en) | 2016-12-21 |
| US10107814B2 (en) | 2018-10-23 |
| EP3214445A1 (en) | 2017-09-06 |
| EP2661628A1 (en) | 2013-11-13 |
| EP3214445B1 (en) | 2018-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20160106 |