CA2822939A1 - A cross-linking polypeptide that induces apoptosis - Google Patents

A cross-linking polypeptide that induces apoptosis Download PDF

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Publication number
CA2822939A1
CA2822939A1 CA2822939A CA2822939A CA2822939A1 CA 2822939 A1 CA2822939 A1 CA 2822939A1 CA 2822939 A CA2822939 A CA 2822939A CA 2822939 A CA2822939 A CA 2822939A CA 2822939 A1 CA2822939 A1 CA 2822939A1
Authority
CA
Canada
Prior art keywords
peptide
mec
cells
polypeptide according
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2822939A
Other languages
English (en)
French (fr)
Inventor
Ralph Alexander Willemsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
APO-T BV
Original Assignee
APO-T BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by APO-T BV filed Critical APO-T BV
Publication of CA2822939A1 publication Critical patent/CA2822939A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2822939A 2010-12-27 2011-12-22 A cross-linking polypeptide that induces apoptosis Abandoned CA2822939A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061460213P 2010-12-27 2010-12-27
US61/460,213 2010-12-27
US201161572318P 2011-07-13 2011-07-13
US61/572,318 2011-07-13
PCT/NL2011/050893 WO2012091564A2 (en) 2010-12-27 2011-12-22 A cross-linking polypeptide that induces apoptosis

Publications (1)

Publication Number Publication Date
CA2822939A1 true CA2822939A1 (en) 2012-07-05

Family

ID=45771867

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2822939A Abandoned CA2822939A1 (en) 2010-12-27 2011-12-22 A cross-linking polypeptide that induces apoptosis

Country Status (7)

Country Link
US (3) US9512231B2 (ja)
EP (2) EP3613773A1 (ja)
JP (1) JP6177137B2 (ja)
AU (1) AU2011353197B2 (ja)
CA (1) CA2822939A1 (ja)
DK (1) DK2658873T3 (ja)
WO (1) WO2012091564A2 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9821073B2 (en) * 2010-12-27 2017-11-21 Apo-T B.V. Polypeptide that binds aberrant cells and induces apoptosis
EP3613773A1 (en) 2010-12-27 2020-02-26 Apo-T B.V. A cross linking polypeptide comprising an hexameric single chain antibody binding mhc-mage complex that induces apoptosis
EP2760892A1 (en) * 2011-09-29 2014-08-06 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
US20130183307A1 (en) 2012-01-13 2013-07-18 Johan Renes Aberrant cell-restricted immunoglobulins provided with a toxic moiety
US9732146B2 (en) * 2012-03-30 2017-08-15 The United States Of America As Represented By The Department Of Veterans Affairs Antibody-mediated transduction of heat shock proteins into living cells
AU2013281327A1 (en) 2012-06-26 2015-01-22 Apo-T B.V. Binding molecules targeting pathogens
JP6705746B2 (ja) * 2013-12-06 2020-06-03 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 治療用ペプチド
WO2015123359A1 (en) * 2014-02-11 2015-08-20 Albany Medical College Multi-functional mucosal vaccine platform
CN108650886B (zh) 2015-07-23 2022-07-05 英伊布里克斯公司 多价和多特异性gitr-结合融合蛋白
US20210041435A1 (en) * 2018-01-31 2021-02-11 Tohoku University Method for regulating antigen-specific mhc expression
US11713345B2 (en) * 2018-10-22 2023-08-01 Janssen Sciences Ireland Unlimited Company Glucagon like peptide 1 (GLP1)-growth differentiation factor 15 (GDF15) fusion proteins and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7527787B2 (en) 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
WO2003070752A2 (en) * 2002-02-20 2003-08-28 Dyax Corporation Mhc-peptide complex binding ligands
ATE328906T1 (de) * 2002-06-28 2006-06-15 Domantis Ltd Dual-specifische liganden mit erhöhter halbwertszeit
JP2006523437A (ja) * 2002-12-03 2006-10-19 アヴィデックス リミテッド レセプター複合体
US20100062001A1 (en) * 2004-06-09 2010-03-11 Technion Research & Development Antibodies for selective apoptosis of cells
US20090208502A1 (en) 2005-12-20 2009-08-20 Ralph Alexander Willemsen Apoptosis-inducing protein complexes and therapeutic use thereof
US9821073B2 (en) * 2010-12-27 2017-11-21 Apo-T B.V. Polypeptide that binds aberrant cells and induces apoptosis
EP3613773A1 (en) 2010-12-27 2020-02-26 Apo-T B.V. A cross linking polypeptide comprising an hexameric single chain antibody binding mhc-mage complex that induces apoptosis
EP2760892A1 (en) * 2011-09-29 2014-08-06 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
US20130183307A1 (en) * 2012-01-13 2013-07-18 Johan Renes Aberrant cell-restricted immunoglobulins provided with a toxic moiety

Also Published As

Publication number Publication date
AU2011353197B2 (en) 2017-04-20
JP6177137B2 (ja) 2017-08-09
AU2011353197A8 (en) 2013-12-19
AU2011353197A1 (en) 2013-07-18
EP2658873A2 (en) 2013-11-06
EP3613773A1 (en) 2020-02-26
US20190085090A1 (en) 2019-03-21
WO2012091564A3 (en) 2012-08-23
US20170114144A1 (en) 2017-04-27
EP2658873B1 (en) 2019-08-21
US9512231B2 (en) 2016-12-06
WO2012091564A2 (en) 2012-07-05
DK2658873T3 (da) 2019-11-25
JP2014505471A (ja) 2014-03-06
US20140120090A1 (en) 2014-05-01

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20161205

FZDE Discontinued

Effective date: 20220426

FZDE Discontinued

Effective date: 20220426