CA2820435C - Glycomimetic compounds as anti-infectious against pathogens lectins - Google Patents
Glycomimetic compounds as anti-infectious against pathogens lectins Download PDFInfo
- Publication number
- CA2820435C CA2820435C CA2820435A CA2820435A CA2820435C CA 2820435 C CA2820435 C CA 2820435C CA 2820435 A CA2820435 A CA 2820435A CA 2820435 A CA2820435 A CA 2820435A CA 2820435 C CA2820435 C CA 2820435C
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- calixarene
- glycosylated compound
- formula
- based glycosylated
- Prior art date
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- 108090001090 Lectins Proteins 0.000 title claims abstract description 36
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- 244000052769 pathogen Species 0.000 title claims abstract description 12
- 230000002924 anti-infective effect Effects 0.000 title claims description 10
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 14
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 7
- 125000003277 amino group Chemical group 0.000 claims abstract description 6
- 125000003118 aryl group Chemical group 0.000 claims abstract description 6
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- 125000005843 halogen group Chemical group 0.000 claims abstract description 4
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- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2010/055741 WO2012076934A1 (en) | 2010-12-10 | 2010-12-10 | Glycomimetic compounds as anti-infectious against pathogens lectins |
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| CA2820435A1 CA2820435A1 (en) | 2012-06-14 |
| CA2820435C true CA2820435C (en) | 2017-11-28 |
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| CA2820435A Active CA2820435C (en) | 2010-12-10 | 2010-12-10 | Glycomimetic compounds as anti-infectious against pathogens lectins |
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| WO (1) | WO2012076934A1 (enExample) |
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| EP2851371A1 (en) * | 2013-09-23 | 2015-03-25 | Centre National de la Recherche Scientifique (CNRS) | Glycoclusters and their pharmaceutical use as antibacterials |
| GB2525384A (en) * | 2014-04-14 | 2015-10-28 | Calixar | Synthesis of amphiphilic calixarene glycoside detergents and use of same for extracting and stabilizing native functional membrane proteins |
| CN104311546A (zh) * | 2014-09-12 | 2015-01-28 | 三峡大学 | 一种杯芳烃稀土配合物,杯芳烃稀土配合物的制备方法及其应用 |
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| WO2005089733A2 (en) | 2004-03-23 | 2005-09-29 | Vib Vzw | Anti-adhesive compounds to prevent and treat bacterial infections |
| CA2618638C (en) | 2005-08-09 | 2014-03-11 | Glycomimetics, Inc. | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
| US20090176717A1 (en) | 2006-06-01 | 2009-07-09 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
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| ES2524363T3 (es) | 2014-12-05 |
| JP5774120B2 (ja) | 2015-09-02 |
| EP2649085A1 (en) | 2013-10-16 |
| US9023814B2 (en) | 2015-05-05 |
| JP2013544876A (ja) | 2013-12-19 |
| WO2012076934A1 (en) | 2012-06-14 |
| US20130252910A1 (en) | 2013-09-26 |
| EP2649085B1 (en) | 2014-08-20 |
| CA2820435A1 (en) | 2012-06-14 |
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