CA2813013C - Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain - Google Patents

Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain Download PDF

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Publication number
CA2813013C
CA2813013C CA2813013A CA2813013A CA2813013C CA 2813013 C CA2813013 C CA 2813013C CA 2813013 A CA2813013 A CA 2813013A CA 2813013 A CA2813013 A CA 2813013A CA 2813013 C CA2813013 C CA 2813013C
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CA
Canada
Prior art keywords
meteorin
allodynia
polypeptide
treatment
hyperalgesia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2813013A
Other languages
English (en)
French (fr)
Other versions
CA2813013A1 (en
Inventor
Teit E. Johansen
Lars Ulrik Wahlberg
Jesper Roland Jorgensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoba Therapeutics Aps
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Hoba Therapeutics Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoba Therapeutics Aps filed Critical Hoba Therapeutics Aps
Publication of CA2813013A1 publication Critical patent/CA2813013A1/en
Application granted granted Critical
Publication of CA2813013C publication Critical patent/CA2813013C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
CA2813013A 2010-10-01 2011-09-30 Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain Active CA2813013C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201070423 2010-10-01
DKPA201070423 2010-10-01
US39079110P 2010-10-07 2010-10-07
US61/390,791 2010-10-07
PCT/DK2011/050369 WO2012041328A1 (en) 2010-10-01 2011-09-30 Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain

Publications (2)

Publication Number Publication Date
CA2813013A1 CA2813013A1 (en) 2012-04-05
CA2813013C true CA2813013C (en) 2019-10-22

Family

ID=59278857

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2813013A Active CA2813013C (en) 2010-10-01 2011-09-30 Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain

Country Status (9)

Country Link
US (3) US8404642B2 (enExample)
EP (1) EP2621512B1 (enExample)
JP (2) JP6149226B2 (enExample)
KR (1) KR101886029B1 (enExample)
CN (2) CN103269708A (enExample)
AU (1) AU2011307488B2 (enExample)
CA (1) CA2813013C (enExample)
ES (1) ES2584068T3 (enExample)
WO (1) WO2012041328A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010009732A1 (en) 2008-07-24 2010-01-28 Nsgene A/S Therapeutic use of a growth factor, metrnl
ES2584068T3 (es) 2010-10-01 2016-09-23 Nsgene A/S Uso de meteorina para el tratamiento de alodinia, hiperalgesia, dolor espontáneo y dolor fantasma
WO2013034157A1 (en) * 2011-09-05 2013-03-14 Nsgene A/S Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain
CN103685771A (zh) * 2013-12-13 2014-03-26 苏州士丹尼信息技术有限公司 一种集成的信息交流系统
CN107184956B (zh) * 2016-03-14 2020-09-08 上海风劲生物医药科技有限公司 Metrnl蛋白或基因在防治脓毒血症方面的应用
WO2020163469A2 (en) 2019-02-08 2020-08-13 BioLegend, Inc. METHODS FOR DETECTING METEORIN-β ACTIVITY
US20240218033A1 (en) 2021-05-06 2024-07-04 Hoba Therapeutics Aps Prevention and treatment of chemotherapy-induced neuropathic pain
KR20240118796A (ko) 2021-12-10 2024-08-05 호바 세라퓨틱스 에이피에스 침해수용성 통증의 치료

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Also Published As

Publication number Publication date
US20130303459A1 (en) 2013-11-14
JP2013543378A (ja) 2013-12-05
US9314502B2 (en) 2016-04-19
AU2011307488B2 (en) 2015-08-20
EP2621512B1 (en) 2016-04-06
US8404642B2 (en) 2013-03-26
CN108079279A (zh) 2018-05-29
ES2584068T3 (es) 2016-09-23
EP2621512A1 (en) 2013-08-07
CN108079279B (zh) 2022-04-12
CN103269708A (zh) 2013-08-28
JP6247734B2 (ja) 2017-12-13
US20150202262A1 (en) 2015-07-23
US8815810B2 (en) 2014-08-26
CA2813013A1 (en) 2012-04-05
HK1186412A1 (zh) 2014-03-14
AU2011307488A1 (en) 2013-05-02
US20120108518A1 (en) 2012-05-03
JP2017052783A (ja) 2017-03-16
WO2012041328A1 (en) 2012-04-05
JP6149226B2 (ja) 2017-06-21
KR101886029B1 (ko) 2018-08-07
KR20130108380A (ko) 2013-10-02

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