CA2805078A1 - Derives d'imidazole - Google Patents

Derives d'imidazole Download PDF

Info

Publication number
CA2805078A1
CA2805078A1 CA2805078A CA2805078A CA2805078A1 CA 2805078 A1 CA2805078 A1 CA 2805078A1 CA 2805078 A CA2805078 A CA 2805078A CA 2805078 A CA2805078 A CA 2805078A CA 2805078 A1 CA2805078 A1 CA 2805078A1
Authority
CA
Canada
Prior art keywords
c6alkyl
compound
pharmaceutically acceptable
acceptable salt
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2805078A
Other languages
English (en)
Inventor
Jian Liu
Deodial Guiadeen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of CA2805078A1 publication Critical patent/CA2805078A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2805078A 2010-07-28 2011-07-22 Derives d'imidazole Abandoned CA2805078A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36837010P 2010-07-28 2010-07-28
US61/368,370 2010-07-28
PCT/US2011/045022 WO2012015693A1 (fr) 2010-07-28 2011-07-22 Dérivés d'imidazole

Publications (1)

Publication Number Publication Date
CA2805078A1 true CA2805078A1 (fr) 2012-02-02

Family

ID=45530455

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2805078A Abandoned CA2805078A1 (fr) 2010-07-28 2011-07-22 Derives d'imidazole

Country Status (3)

Country Link
AU (1) AU2011282989A1 (fr)
CA (1) CA2805078A1 (fr)
WO (1) WO2012015693A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5629380B2 (ja) 2010-12-17 2014-11-19 田辺三菱製薬株式会社 連続芳香環式化合物
WO2012164071A1 (fr) * 2011-06-02 2012-12-06 Intervet International B.V. Dérivés d'imidazole
ES2690315T3 (es) 2012-06-15 2018-11-20 Mitsubishi Tanabe Pharma Corporation Compuestos de imidazol y triazol como inhibidores de DGAT-1
WO2014140241A1 (fr) * 2013-03-15 2014-09-18 Intervet International B.V. Dérivés de pyridine en tant qu'inhibiteurs de dgat-1
WO2014181813A1 (fr) * 2013-05-10 2014-11-13 武田薬品工業株式会社 Composé hétérocyclique
CN105175414B (zh) * 2015-09-30 2017-12-05 山东大学 咪唑[4,5‑b]吡啶巯乙酰胺类衍生物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
KR20020020788A (ko) * 1999-07-21 2002-03-15 후지야마 아키라 벤즈이미다졸론 유도체 및 포스포디에스테라제억제제로서의 이의 용도

Also Published As

Publication number Publication date
AU2011282989A1 (en) 2013-01-10
WO2012015693A1 (fr) 2012-02-02

Similar Documents

Publication Publication Date Title
AU2011256444B2 (en) Spiro isoxazoline compounds as SSTR5 antagonists
CA2804970A1 (fr) Composes spirocycliques
US8742110B2 (en) Spiroxazolidinone compounds
AU2008276568A1 (en) Beta carboline derivatives as antidiabetic compounds
CA2805078A1 (fr) Derives d'imidazole
WO2013096093A1 (fr) Composés en tant qu'inhibiteurs de dgat-1
US10065945B2 (en) Isoquinoline derivatives as MGAT2 inhibitors
US10414775B2 (en) Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
WO2012044567A2 (fr) Dérivés d'imidazole
AU2011205483A1 (en) Oxadiazole beta carboline derivatives as antidiabetic compounds
WO2012024179A1 (fr) Dérivés d'amide substitués en tant qu'inhibiteurs de dgat-1
EP2760855B1 (fr) Composés de cyclopropyle substitués, compositions contenant ces composés ainsi que leur utilisation pour le traitement du diabète de type 2
WO2013074387A1 (fr) Dérivés d'imidazole
WO2012064569A1 (fr) Dérivés d'imidazole
WO2011127643A1 (fr) Dérivés de pyridone
WO2012096813A1 (fr) Dérivés d'imidazole
WO2012047772A2 (fr) Dérivés d'imidazole
US20140088124A1 (en) Imidazole derivatives
WO2013068328A1 (fr) Composés d'acide bicyclo[2.2.2]octan-1-ylcarboxylique comme inhibiteurs de la dgat-1
EP2931718A1 (fr) Nouveaux dérivés de pyridine -2-carboxamide, compositions contenant de tels composés et méthodes de traitement associées
WO2012112364A1 (fr) Dérivés de lactame en tant qu'inhibiteurs de dgat-1
WO2013130370A2 (fr) Composés en tant qu'inhibiteurs de dgat-1
WO2012122075A1 (fr) Dérivés de lactame en tant qu'inhibiteurs de dgat-1
WO2013068439A1 (fr) Composés 4-amino-5-oxo-7,8-dihydropyrimido[5, 4 -f] [1, 4] oxazépine comme inhibiteurs de dgat1

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20150722