CA2789565A1 - Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens - Google Patents
Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens Download PDFInfo
- Publication number
- CA2789565A1 CA2789565A1 CA2789565A CA2789565A CA2789565A1 CA 2789565 A1 CA2789565 A1 CA 2789565A1 CA 2789565 A CA2789565 A CA 2789565A CA 2789565 A CA2789565 A CA 2789565A CA 2789565 A1 CA2789565 A1 CA 2789565A1
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- Prior art keywords
- coating
- polymer
- water
- iodine
- balloon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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| PCT/US2010/027731 WO2011106027A1 (en) | 2010-02-24 | 2010-03-17 | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
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| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8414909B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| EP2136853B1 (de) | 2007-01-21 | 2013-04-10 | Hemoteq AG | Medizinprodukt zur behandlung von verschlüssen von körperdurchgängen und zur prävention drohender wiederverschlüsse |
| US10010612B2 (en) | 2007-05-25 | 2018-07-03 | Indivior Uk Limited | Sustained delivery formulations of risperidone compounds |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| US8114429B2 (en) | 2008-09-15 | 2012-02-14 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| US8257722B2 (en) | 2008-09-15 | 2012-09-04 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| JP2012527493A (ja) * | 2009-04-22 | 2012-11-08 | トリオメッド・イノヴェーションズ・コーポレーション | 抗毒性材料層でエラストマー材料をコーティングする方法 |
| WO2011005421A2 (en) | 2009-07-10 | 2011-01-13 | Boston Scientific Scimed, Inc. | Use of nanocrystals for a drug delivery balloon |
| JP5933434B2 (ja) | 2009-07-17 | 2016-06-08 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 薬剤送達バルーンの製造方法 |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| CA2862611C (en) | 2011-02-24 | 2020-11-03 | Eximo Medical Ltd. | Hybrid catheter for tissue resection |
| US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
| US11883246B2 (en) | 2012-11-21 | 2024-01-30 | Trustees Of Boston University | Tissue markers and uses thereof |
| CN104174074B (zh) * | 2013-11-27 | 2016-05-18 | 浙江归创医疗器械有限公司 | 一种适用于涂在植入或介入医疗器械表面的药物涂层组合物 |
| US10525171B2 (en) * | 2014-01-24 | 2020-01-07 | The Spectranetics Corporation | Coatings for medical devices |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| ES2991421T3 (es) | 2014-05-18 | 2024-12-03 | Eximo Medical Ltd | Sistema para ablación de tejidos usando láser pulsado |
| CN104056341B (zh) * | 2014-06-24 | 2017-01-18 | 深圳市金瑞凯利生物科技有限公司 | 药物球囊制备方法 |
| WO2016037413A1 (zh) * | 2014-09-09 | 2016-03-17 | 浙江归创医疗器械有限公司 | 一种药物涂层组合物、其制备方法及利用其制成的植入或介入医疗器械 |
| JP2018504209A (ja) * | 2015-01-22 | 2018-02-15 | インターセクト エント， インコーポレイテッド | 薬物コーティングバルーン |
| US11969567B2 (en) | 2015-11-18 | 2024-04-30 | Spectranetics Llc | Balloon angioplasty catheter coating to encourage vessel repair and further reduce restenosis |
| CN109414292A (zh) | 2016-05-05 | 2019-03-01 | 爱克斯莫医疗有限公司 | 用于切除和/或消融不需要的组织的装置和方法 |
| DE102016110815B4 (de) * | 2016-06-13 | 2018-05-17 | Dot Gmbh | Beschichteter Ballonkatheter und Zusammensetzung zur Beschichtung des Ballonkatheters |
| CN109996569B (zh) * | 2016-12-22 | 2022-05-03 | 百多力股份公司 | 用于医疗装置的药物释放涂层及其制备方法 |
| CA3099368A1 (en) * | 2018-05-04 | 2019-11-07 | Advanced Medical Solutions Israel (Sealantis) Ltd | Reconstitution and mixing systems |
| US10688289B2 (en) | 2018-06-12 | 2020-06-23 | Intersect Ent, Inc. | Systems and methods for sinus access |
| US12239371B2 (en) | 2018-08-09 | 2025-03-04 | Koninklijke Philips N.V. | Treatment mode selection systems and laser catheter systems including same |
| US11672959B2 (en) | 2019-01-18 | 2023-06-13 | Intersect Ent, Inc. | Expandable member systems and methods for drug delivery |
| AU2020264747A1 (en) | 2019-05-02 | 2021-10-28 | Intersect ENT International GmbH | Balloon dilation device |
| US12376904B1 (en) | 2020-09-08 | 2025-08-05 | Angiodynamics, Inc. | Dynamic laser stabilization and calibration system |
| US11662126B2 (en) | 2021-06-17 | 2023-05-30 | Hewlett Packard Enterprise Development Lp | Leak mitigation system |
| US12038322B2 (en) | 2022-06-21 | 2024-07-16 | Eximo Medical Ltd. | Devices and methods for testing ablation systems |
| US20240408286A1 (en) * | 2023-06-08 | 2024-12-12 | Becton, Dickinson And Company | Tissue-plasminogen activator coated catheter with hydrogel-controlled elution |
Family Cites Families (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4010259A (en) | 1975-07-17 | 1977-03-01 | Johansson J A Olof | Disinfectants containing iodine complexed to a hydrophilic organic carrier |
| US4589873A (en) | 1984-05-29 | 1986-05-20 | Becton, Dickinson And Company | Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby |
| US5001009A (en) | 1987-09-02 | 1991-03-19 | Sterilization Technical Services, Inc. | Lubricious hydrophilic composite coated on substrates |
| US4950256A (en) | 1988-04-07 | 1990-08-21 | Luther Medical Products, Inc. | Non-thrombogenic intravascular time release catheter |
| US4847324A (en) | 1988-04-25 | 1989-07-11 | Hydromer, Inc. | Hydrophilic polyvinylbutyral alloys |
| US5328471A (en) * | 1990-02-26 | 1994-07-12 | Endoluminal Therapeutics, Inc. | Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens |
| US6146358A (en) | 1989-03-14 | 2000-11-14 | Cordis Corporation | Method and apparatus for delivery of therapeutic agent |
| US5525348A (en) | 1989-11-02 | 1996-06-11 | Sts Biopolymers, Inc. | Coating compositions comprising pharmaceutical agents |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| US5302392A (en) * | 1990-08-20 | 1994-04-12 | Becton, Dickinson And Company | Polyurethane sponge having rapid iodine release |
| JP3055796B2 (ja) | 1990-11-19 | 2000-06-26 | 善蔵 田村 | 殺菌消毒剤組成物 |
| US5762638A (en) | 1991-02-27 | 1998-06-09 | Shikani; Alain H. | Anti-infective and anti-inflammatory releasing systems for medical devices |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5302394A (en) * | 1992-07-14 | 1994-04-12 | Mcneil-Ppc, Inc. | Dextromethorphan continuous lozenge manufacturing process |
| US6680050B1 (en) * | 1992-09-16 | 2004-01-20 | Triosyn Holdings, Inc. | Iodine/resin disinfectant and a procedure for the preparation thereof |
| US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| DK0674510T3 (da) * | 1992-11-27 | 1999-05-10 | Napro Biotherapeutics Inc | Injicerbart præparat omfattende paclitaxel |
| EP2298310A3 (en) | 1993-01-28 | 2011-04-06 | Boston Scientific Limited | Therapeutic inhibitors of vascular smooth muscle cells |
| US6663881B2 (en) * | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| US6096331A (en) * | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| JPH08507715A (ja) | 1993-03-18 | 1996-08-20 | シーダーズ サイナイ メディカル センター | 生体人工部材のための薬剤導入性および放出性重合性コーティング |
| US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
| JP3423317B2 (ja) | 1993-07-19 | 2003-07-07 | アンジオジェネシス テクノロジーズ インコーポレイテッド | 抗−血管形成性組成物およびそれにより被覆されたステント |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| ES2210258T5 (es) | 1993-07-29 | 2009-01-16 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Procedimiento de tratamiento de la ateroesclerosis o reestenosis usando un agente estabilizante de microtubulos. |
| US5788979A (en) * | 1994-07-22 | 1998-08-04 | Inflow Dynamics Inc. | Biodegradable coating with inhibitory properties for application to biocompatible materials |
| US5828084A (en) * | 1995-03-27 | 1998-10-27 | Sony Corporation | High performance poly-SiGe thin film transistor |
| US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| US6120784A (en) * | 1996-02-20 | 2000-09-19 | Viro-Kote, Inc. | Anti-bacterial/anti-viral coatings, coating process and parameters thereof |
| ATE345682T1 (de) | 1996-05-01 | 2006-12-15 | Imarx Pharmaceutical Corp | In vitro verfahren zum einbringen von nukleinsäuren in eine zelle |
| US20030157187A1 (en) * | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
| US6491619B1 (en) * | 1997-01-31 | 2002-12-10 | Endologix, Inc | Radiation delivery catheters and dosimetry methods |
| US6159978A (en) | 1997-05-28 | 2000-12-12 | Aventis Pharmaceuticals Product, Inc. | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| US6110483A (en) | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
| AU8782098A (en) | 1997-08-13 | 1999-03-08 | Boston Scientific Limited | Loading and release of water-insoluble drugs |
| US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| US8257725B2 (en) * | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
| US6369039B1 (en) | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
| CA2340652C (en) | 1998-08-20 | 2013-09-24 | Cook Incorporated | Coated implantable medical device comprising paclitaxel |
| US20060240070A1 (en) | 1998-09-24 | 2006-10-26 | Cromack Keith R | Delivery of highly lipophilic agents via medical devices |
| US20050147690A1 (en) * | 1998-09-25 | 2005-07-07 | Masters David B. | Biocompatible protein particles, particle devices and methods thereof |
| US6299980B1 (en) | 1998-09-29 | 2001-10-09 | Medtronic Ave, Inc. | One step lubricious coating |
| DE19858534A1 (de) | 1998-12-18 | 2000-06-21 | Bosch Gmbh Robert | Elektrischer Verbinder |
| US6419692B1 (en) | 1999-02-03 | 2002-07-16 | Scimed Life Systems, Inc. | Surface protection method for stents and balloon catheters for drug delivery |
| US6673053B2 (en) | 1999-05-07 | 2004-01-06 | Scimed Life Systems, Inc. | Hydrophilic lubricity coating for medical devices comprising an antiblock agent |
| DE19949897A1 (de) | 1999-10-15 | 2001-04-19 | Rainer Rogasch | Formkörper und Verfahren zu dessen Herstellung |
| AU2002239436B2 (en) | 2000-10-31 | 2007-04-26 | Cook Medical Technologies Llc | Coated implantable medical device |
| US6545097B2 (en) | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
| GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| GB0100760D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| US7179251B2 (en) * | 2001-01-17 | 2007-02-20 | Boston Scientific Scimed, Inc. | Therapeutic delivery balloon |
| US7771468B2 (en) | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
| DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
| US7879267B2 (en) * | 2001-08-02 | 2011-02-01 | J&J Vision Care, Inc. | Method for coating articles by mold transfer |
| EP1435908A4 (en) | 2001-09-13 | 2006-03-15 | Korea Inst Sci & Tech | Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof |
| CA2458828A1 (en) | 2001-09-24 | 2003-05-01 | James J. Barry | Optimized dosing for drug coated stents |
| US6753071B1 (en) * | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
| US7488313B2 (en) * | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
| US20030225451A1 (en) * | 2002-01-14 | 2003-12-04 | Rangarajan Sundar | Stent delivery system, device, and method for coating |
| US7291165B2 (en) | 2002-01-31 | 2007-11-06 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
| US7008979B2 (en) * | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
| US6835387B2 (en) | 2002-06-11 | 2004-12-28 | Scimed Life Systems, Inc. | Sustained release of superoxide dismutase mimics from implantable or insertable medical devices |
| US20030236513A1 (en) * | 2002-06-19 | 2003-12-25 | Scimed Life Systems, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| US7105175B2 (en) | 2002-06-19 | 2006-09-12 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| DK1521603T3 (da) | 2002-07-12 | 2011-04-18 | Cook Inc | Coated medicinsk anordning |
| DE10244847A1 (de) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
| US6926919B1 (en) | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
| US8313759B2 (en) | 2003-03-06 | 2012-11-20 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent |
| US7241455B2 (en) | 2003-04-08 | 2007-07-10 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent |
| US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
| US7407507B2 (en) * | 2003-06-18 | 2008-08-05 | Nipro Corporation | Balloon catheter suited to kissing techniques |
| US7790141B2 (en) * | 2003-08-11 | 2010-09-07 | Pathak Holdings, Llc | Radio-opaque compounds, compositions containing same and methods of their synthesis and use |
| US7736362B2 (en) * | 2003-09-15 | 2010-06-15 | Boston Scientific Scimed, Inc. | Catheter balloons |
| US20050064223A1 (en) | 2003-09-22 | 2005-03-24 | Bavaro Vincent Peter | Polymeric marker with high radiopacity |
| US20100030183A1 (en) * | 2004-03-19 | 2010-02-04 | Toner John L | Method of treating vascular disease at a bifurcated vessel using a coated balloon |
| US20060034769A1 (en) | 2004-08-13 | 2006-02-16 | Rutgers, The State University | Radiopaque polymeric stents |
| US20060212106A1 (en) | 2005-03-21 | 2006-09-21 | Jan Weber | Coatings for use on medical devices |
| US20090216317A1 (en) * | 2005-03-23 | 2009-08-27 | Cromack Keith R | Delivery of Highly Lipophilic Agents Via Medical Devices |
| US20070021282A1 (en) * | 2005-07-19 | 2007-01-25 | Karp Shaun A | Abdominal exercising and strength testing systems |
| JP5226517B2 (ja) | 2005-09-21 | 2013-07-03 | サーモディクス，インコーポレイティド | 天然生分解性多糖類を含む生体内形成マトリックス、及びそれらの眼の使用 |
| CN101309709A (zh) | 2005-09-21 | 2008-11-19 | 苏尔莫迪克斯公司 | 包含天然生物可降解的多糖的涂层和物品 |
| US8137735B2 (en) * | 2005-11-10 | 2012-03-20 | Allegiance Corporation | Elastomeric article with antimicrobial coating |
| ES2809173T3 (es) * | 2006-02-09 | 2021-03-03 | Braun Melsungen Ag | Método de revestimiento de balón plegable |
| US8021678B2 (en) | 2006-02-10 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics |
| US8585753B2 (en) * | 2006-03-04 | 2013-11-19 | John James Scanlon | Fibrillated biodegradable prosthesis |
| US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
| US7914806B2 (en) * | 2006-06-01 | 2011-03-29 | Boston Scientific Scimed, Inc. | Medical devices having improved performance |
| US20080124372A1 (en) | 2006-06-06 | 2008-05-29 | Hossainy Syed F A | Morphology profiles for control of agent release rates from polymer matrices |
| MX374806B (es) * | 2006-07-03 | 2025-03-06 | Hemoteq Ag | Metodo, fabricacion y uso de productos medicos que liberan sustancia activa para mantener vasos sanguineos abiertos |
| JP5499321B2 (ja) * | 2006-09-13 | 2014-05-21 | ディーエスエム アイピー アセッツ ビー．ブイ． | 医療コーティングのためのコーティング調合物 |
| US8561614B2 (en) * | 2006-09-28 | 2013-10-22 | Covidien Lp | Multi-layer cuffs for medical devices |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080140002A1 (en) * | 2006-12-06 | 2008-06-12 | Kamal Ramzipoor | System for delivery of biologically active substances with actuating three dimensional surface |
| US20080146489A1 (en) * | 2006-12-15 | 2008-06-19 | Pacetti Stephen D | Regional delivery of therapeutic agents for the treatment of vascular diseases |
| BRPI0808118A2 (pt) * | 2007-02-28 | 2014-06-17 | Dsm Ip Assets Bv | Revestimento hidrófilo |
| US8221783B2 (en) * | 2007-09-10 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical devices with triggerable bioadhesive material |
| US20090112239A1 (en) * | 2007-10-31 | 2009-04-30 | Specialized Vascular Technologies, Inc. | Sticky dilatation balloon and methods of using |
| US20090186414A1 (en) * | 2008-01-18 | 2009-07-23 | Deepak Srivastava | Methods of Generating Cardiomyocytes and Cardiac Progenitors and Compositions |
| EP2594311A3 (en) * | 2008-03-06 | 2013-07-10 | Boston Scientific Scimed, Inc. | Balloon catheter devices with sheath covering |
| US20090297584A1 (en) * | 2008-04-18 | 2009-12-03 | Florencia Lim | Biosoluble coating with linear over time mass loss |
| US8298607B2 (en) * | 2008-05-15 | 2012-10-30 | Abbott Cardiovascular Systems Inc. | Method for electrostatic coating of a medical device |
| WO2010009335A1 (en) * | 2008-07-17 | 2010-01-21 | Micell Technologies, Inc. | Drug delivery medical device |
| US8367090B2 (en) * | 2008-09-05 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Coating on a balloon comprising a polymer and a drug |
| US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| DE102008044316A1 (de) * | 2008-12-03 | 2010-06-10 | Biotronik Vi Patent Ag | Wirkstoffbeschichtetes Medizinprodukt, Verfahren zu dessen Herstellung und dessen Verwendungen |
| JP2012527493A (ja) * | 2009-04-22 | 2012-11-08 | トリオメッド・イノヴェーションズ・コーポレーション | 抗毒性材料層でエラストマー材料をコーティングする方法 |
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| US20120078228A1 (en) | 2012-03-29 |
| EP2538990B1 (en) | 2018-10-03 |
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| US20100198190A1 (en) | 2010-08-05 |
| JP5781548B2 (ja) | 2015-09-24 |
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