CA2788828A1 - Liquid milk beverage for toddlers - Google Patents
Liquid milk beverage for toddlers Download PDFInfo
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- CA2788828A1 CA2788828A1 CA2788828A CA2788828A CA2788828A1 CA 2788828 A1 CA2788828 A1 CA 2788828A1 CA 2788828 A CA2788828 A CA 2788828A CA 2788828 A CA2788828 A CA 2788828A CA 2788828 A1 CA2788828 A1 CA 2788828A1
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Abstract
Described herein are a liquid milk beverage for toddlers comprising non-hydrolyzed, non--fermented and protein-rebalanced cow's milk, processes for making same and methods of uses.
The non-hydrolyzed, non-fermented rebalanced cow's milk comprises a reduced weight/weight proportion of casein:whey proteins when compared to untreated cow's milk. The non--hydrolyzed, non-fermented rebalanced cow's milk may further comprises a reduced total protein concentration when compared to untreated cow's milk. The reduced proportion and/or reduced total concentration of proteins facilitate digestion of the liquid milk beverage by infant and toddlers. Also described are methods for providing nutrition to a toddler, methods for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk, and methods for increasing digestion of cow's milk in an individual.
The non-hydrolyzed, non-fermented rebalanced cow's milk comprises a reduced weight/weight proportion of casein:whey proteins when compared to untreated cow's milk. The non--hydrolyzed, non-fermented rebalanced cow's milk may further comprises a reduced total protein concentration when compared to untreated cow's milk. The reduced proportion and/or reduced total concentration of proteins facilitate digestion of the liquid milk beverage by infant and toddlers. Also described are methods for providing nutrition to a toddler, methods for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk, and methods for increasing digestion of cow's milk in an individual.
Description
LIQUID MILK BEVERAGE FOR TODDLERS
FIELD OF THE INVENTION
[0001] The invention relates to the field of nutrition and more particularly to liquid milk beverages.
BACKGROUND OF THE INVENTION
FIELD OF THE INVENTION
[0001] The invention relates to the field of nutrition and more particularly to liquid milk beverages.
BACKGROUND OF THE INVENTION
[0002] An important change in nutritional habits occurs during the transition from infancy to toddlerhood at about one year of age. During this period of time, toddlers gain independence by developing self-feeding skills and increasing control over food choices. The transition is accompanied by improved motor skills, awareness of table behaviours, appreciation for tastes and preferences, and increased in energy and nutrient requirements. In fact, the 3 first years of a child are crucial for physical and psychological development. Furthermore, the immune system of children under 3 years old is not totally developed which leaves children under 3 years old more at risk of various infections. Thought, special care for alimentation must be taken for children under 3 years old.
[0003] It is well recognized that maternal milk is the premium nutritional source for newborn children. However, for different reasons, mothers often cease breastfeeding early in child development and switch to infant formulas, follow-up formulas and later on to natural cow's homogenized milk to provide essential nutrients to their children.
[0004] Artificial starter infant formulas are roughly based on a mother's milk composition at approximately one to three months postpartum. They are generally well balanced in nutrients but are often made from chemical rather than natural ingredients. Most commonly used infant formulas contains purified cow's milk whey and casein as protein source, a blend of vegetable oils as fat source, lactose as a carbohydrate source, a vitamin-mineral mix, and other ingredients depending on the manufacturer. In addition, often infant formulas are not well accepted by children because of their taste. Furthermore infant formulas are very expensive and are not convenient since they are often only available in a powder form, which requires manipulation. Examples of infant formulas that exist today include Good Start (Nestle), EnfamilTM (Mead Johnson), and SimilacTM (Abbott).
DM_MTU 107794.00384/2876250.1 [0005] Follow-up formulas are intended for children after the age of four to six months (weaning formulas) who have begun a diversified diet. These formulas are closer in composition to cow's milk than starter formula but they differ from cow's milk in the following: they are enriched with essential fatty acids, they have higher vitamin E content and they are fortified in iron and vitamin D. They are also supplemented with essential fatty acids, vitamins and trace elements, especially vitamin D and iron. Examples of follow-up formulas that exist include Nestle Junior TM (Nestle), Milupa CroissanceTM (Milupa), Guigoz Premier pasTM
and Guigoz ConfortTM (Laboratoire Guigoz), and LemielT"' (Milupa).
DM_MTU 107794.00384/2876250.1 [0005] Follow-up formulas are intended for children after the age of four to six months (weaning formulas) who have begun a diversified diet. These formulas are closer in composition to cow's milk than starter formula but they differ from cow's milk in the following: they are enriched with essential fatty acids, they have higher vitamin E content and they are fortified in iron and vitamin D. They are also supplemented with essential fatty acids, vitamins and trace elements, especially vitamin D and iron. Examples of follow-up formulas that exist include Nestle Junior TM (Nestle), Milupa CroissanceTM (Milupa), Guigoz Premier pasTM
and Guigoz ConfortTM (Laboratoire Guigoz), and LemielT"' (Milupa).
[0006] Additional types of formulas include toddler's formulas which have been developed specifically to address diet concerns for child having about 10 to 36 months of age. These include EnfagrowO (Mead Johnson), Similac Go & GrowTM (Abbott), Follow-upO and NANO H.A.3 (Nestle), and the like. These formulas do not contain fresh cow's milk since they are typically in a powder form and they are made of non-fat or skim milk, skim milk powder, or enzymatically hydrolysed milk whey protein.
[0007] Natural liquid cow's milk is recognized as an important dietary component and it remains essential in the diet of most growing children, especially because of its high-quality proteins, its calcium and its vitamin A and D. It is also generally preferred by children over artificial formulas because it has a much richer enjoyable taste. However, liquid cow's milk comprises an elevated proportion of casein:whey proteins (about 80:20 weight/weight) and a too high total protein concentration compared to mother's milk, which renders it more difficult to digest, especially for infant and toddler. Natural liquid cow's milk is also poor in vitamin C, a vitamin known to be very important for absorption of iron in children. Because the milk industry is highly regulated in many countries (e.g. United States and Canada), natural liquid cow's milk cannot be easily modified to anyone desires since the final product has to remain entirely natural. Therefore, adding extraneous ingredients to milk for toddlers is not a trivial task.
[0008] There is therefore a need for a liquid milk beverage suitable for feeding toddlers of about 10 to 36 months of age. There is more particularly a need for a natural cow's milk liquid beverage having a reduced weight/weight proportion of casein:whey proteins compared to untreated cow's milk. There is also a need for a milk beverage and a method for increasing and/or facilitating digestion of cow's milk by toddlers (e.g. by reducing the proportion of casein:whey proteins).
DM_MTL/ 107794.00384/2876250.1 [0009] There is further a need for a natural cow's milk liquid beverage having a reduced total protein concentration when compared to untreated cow's milk. There is also a need for a cow's milk liquid beverage comprising liquid cow's milk and externally added natural source of vitamin C, and more particularly cow's milk with vitamin C effective in enhancing iron absorption from other foods consumed by toddlers. There is also a need for a milk beverage and a method for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk.
DM_MTL/ 107794.00384/2876250.1 [0009] There is further a need for a natural cow's milk liquid beverage having a reduced total protein concentration when compared to untreated cow's milk. There is also a need for a cow's milk liquid beverage comprising liquid cow's milk and externally added natural source of vitamin C, and more particularly cow's milk with vitamin C effective in enhancing iron absorption from other foods consumed by toddlers. There is also a need for a milk beverage and a method for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk.
[00010] The present invention addresses these needs and other needs as it will be apparent from review of the disclosure, drawings and description of the features of the invention hereinafter.
BRIEF SUMMARY OF THE INVENTION
BRIEF SUMMARY OF THE INVENTION
[00011] The invention concerns a liquid milk beverage for toddlers comprising non-hydrolyzed, non-fermented and protein-rebalanced cow's milk. The non-hydrolyzed, non-fermented rebalanced cow's milk comprises a reduced weight/weight proportion of casein:whey proteins when compared to untreated cow's milk (i.e. raw or pasteurized, whole or skimmed bovine whole milk). In a preferred embodiment, the non-hydrolyzed, non-fermented rebalanced cow's milk further comprises a reduced total protein concentration when compared to untreated cow's milk. The reduced proportion and/or reduced total concentration of proteins facilitate digestion of the liquid milk beverage by infant and toddlers.
[00012] The invention also concerns a cow's milk liquid beverage for toddlers, comprising protein-rebalanced cow's milk having a reduced proportion of casein:whey proteins when compared to untreated cow's milk, wherein the reduced proportion of casein:whey proteins is not achieved by hydrolyzing or fermenting the cow's milk or its proteins.
[00013] In a preferred embodiment, the liquid cow's milk beverage, comprises:
- fresh ultra-filtrated and Ultra High Temperature (UHT) pasteurized cow's milk, wherein the fresh ultra-filtrated cow's has been treated for having a weight/weight proportion of casein:whey proteins equal to or lower than about 50:50;
- externally added algal oil; and - externally added juice of acerola berries.
DM_MTL/ 107794.00384/2876250.1 [00014] The invention also concerns methods of uses, including a method for providing nutrition to a toddler, a method for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk, and a method for increasing digestion of cow's milk in an individual.
- fresh ultra-filtrated and Ultra High Temperature (UHT) pasteurized cow's milk, wherein the fresh ultra-filtrated cow's has been treated for having a weight/weight proportion of casein:whey proteins equal to or lower than about 50:50;
- externally added algal oil; and - externally added juice of acerola berries.
DM_MTL/ 107794.00384/2876250.1 [00014] The invention also concerns methods of uses, including a method for providing nutrition to a toddler, a method for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk, and a method for increasing digestion of cow's milk in an individual.
[00015] Yet, the invention further concerns processes for making liquid and protein-rebalanced cow's milk having a reduced weight/weight proportion of casein:whey proteins when compared to untreated liquid cow's milk.
[00016] An advantage of the present invention is that it provides cow's milk liquid beverages for toddlers which are much more tasteful and less expensive to manufacture than existing artificial formulas. It also provides one hundred percent natural cow's milk liquid beverages reduced in casein for an easier digestion for toddlers and enriched in vitamin C in order to enhance iron absorption by toddlers. The beverage of the invention also provides a nutritionally balanced milk for toddlers and provides a transition milk beverage particularly useful between the transition period of breastfeeding or infant formula towards drinking of commonly commercially available homogenized cow's milk.
[00017] Additional aspects, advantages and features of the present invention will become more apparent upon reading of the following non-restrictive description of preferred embodiments which are exemplary and should not be interpreted as limiting the scope of the invention.
BRIEF DESCRIPTION OF THE FIGURES
BRIEF DESCRIPTION OF THE FIGURES
[00018] In order that the invention may be readily understood, embodiments of the invention are illustrated by way of example in the accompanying drawings.
[00019] Figure 1 is a flowchart showing a process for making liquid and protein-rebalanced cow's milk according to a first embodiment of the invention.
[00020] Figure 2 is a flowchart showing a process for making liquid and protein-rebalanced cow's milk according to a second embodiment of the invention.
[00021] Figure 3 is a flowchart showing a process for making liquid and protein-rebalanced cow's milk according to a third embodiment of the invention.
DM_MTL/ 107794.00384/2876250.1 [00022] Figure 4 is a flowchart showing a process for making liquid and protein-rebalanced cow's milk according to a forth embodiment of the invention.
DM_MTL/ 107794.00384/2876250.1 [00022] Figure 4 is a flowchart showing a process for making liquid and protein-rebalanced cow's milk according to a forth embodiment of the invention.
[00023] Figure 5 is a flowchart showing a process for making liquid and protein-rebalanced cow's milk according to a fifth embodiment of the invention.
[00024] Further details of the invention and its advantages will be apparent from the detailed description included below.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
[00025] In the following description of the embodiments, references to the accompanying figures are by way of illustration of examples by which the invention may be practiced. It will be understood that other embodiments may be made without departing from the scope of the invention disclosed and claimed.
Protein-rebalanced cow's milk [00026] Many milk formulas exist today for different age ranges (see Table I
and Table 2).
Initially, infant formulas were based on unmodified cow milk protein and therefore these formulas had a protein profile comprising 20% of whey and 80% casein. Human milk, compare to bovine milk, is a dynamic fluid changing from a high whey-casein ratio (almost 80% whey) to a 60:40 whey:casein ratio from colostrum to mature milk, respectively. In extended lactation this ratio is more of 50:50 whey:casein. Having a reduced proportion of casein is preferable because it results in a lower mineral concentration and therefore it lowers the renal solute load delivered to the infant (i.e. the sum of solutes excreted by the kidney, primarily consisting of dietary non-metabolizable components such as ingested electrolytes in excess of needs, and metabolic end products, predominately excess nitrogen).
Protein-rebalanced cow's milk [00026] Many milk formulas exist today for different age ranges (see Table I
and Table 2).
Initially, infant formulas were based on unmodified cow milk protein and therefore these formulas had a protein profile comprising 20% of whey and 80% casein. Human milk, compare to bovine milk, is a dynamic fluid changing from a high whey-casein ratio (almost 80% whey) to a 60:40 whey:casein ratio from colostrum to mature milk, respectively. In extended lactation this ratio is more of 50:50 whey:casein. Having a reduced proportion of casein is preferable because it results in a lower mineral concentration and therefore it lowers the renal solute load delivered to the infant (i.e. the sum of solutes excreted by the kidney, primarily consisting of dietary non-metabolizable components such as ingested electrolytes in excess of needs, and metabolic end products, predominately excess nitrogen).
[00027] One aspect of the invention relates to a cow's milk liquid beverage which is more acceptable for toddlers of about 10 to about 36 months of age because this beverage comprises protein-rebalanced cow's milk. The protein-rebalanced cow's milk comprises a reduced weight/weight proportion of casein:whey proteins when compared to untreated cow's milk (i.e.
"natural" raw or pasteurized bovine whole or skimmed milk). In preferred embodiments, the liquid milk beverage of the invention further comprises a reduced total protein concentration when compared to untreated cow's milk. According to the invention, digestion by toddlers of the rebalanced cow's milk liquid milk beverage is facilitated because of the reduced weight/weight DM_MTL/ 107794.00384/2876250.1 proportion of casein:whey. Indeed, the gastric discharge of whey proteins is faster than casein and that the texture of the stomach acid curd from a whey protein-rebalanced product is softer and more liquid than the curd produced from bovine milk. Reducing the casein content of protein in cow's milk (typically about 80% w/w) also move closer the liquid milk beverage of the invention to human breast milk (about 40% w/w casein). Furthermore, the Biological Value (BV) of whey proteins is higher than casein, providing a better balanced protein intake for covering the needs of the infant in essential amino acids.
"natural" raw or pasteurized bovine whole or skimmed milk). In preferred embodiments, the liquid milk beverage of the invention further comprises a reduced total protein concentration when compared to untreated cow's milk. According to the invention, digestion by toddlers of the rebalanced cow's milk liquid milk beverage is facilitated because of the reduced weight/weight DM_MTL/ 107794.00384/2876250.1 proportion of casein:whey. Indeed, the gastric discharge of whey proteins is faster than casein and that the texture of the stomach acid curd from a whey protein-rebalanced product is softer and more liquid than the curd produced from bovine milk. Reducing the casein content of protein in cow's milk (typically about 80% w/w) also move closer the liquid milk beverage of the invention to human breast milk (about 40% w/w casein). Furthermore, the Biological Value (BV) of whey proteins is higher than casein, providing a better balanced protein intake for covering the needs of the infant in essential amino acids.
[00028] Accordingly, in various embodiments the proportion of casein:whey proteins in the liquid milk beverage of the invention is equal to or lower than about 70:30, or equal to or lower than about 60:40; or equal to or lower than about 55:45, or equal to or lower than about 50:50, or equal to or lower than about 45:55, or equal to or lower than about 40:60 (i.e. 40% w/w casein and 60% w/w whey proteins).
[00029] Accordingly, in various embodiments the reduced total protein concentration when compared to untreated cow's milk equal to or lower than about 3.0 % w/w or equal to or lower than about 2.6 % w/w, or equal to or lower than about 2.2 % w/w.
[00030] As described hereinafter, contrary to what is known in other formulas, the reduced proportion of casein:whey proteins is not achieved by hydrolyzing or by fermenting the cow's milk. Instead the reduced proportion of casein:whey proteins is obtained by mixing liquid cow's milk (fresh or pasteurized, whole or skimmed) with water, cream, whey protein concentrates (WPC), whey ingredients and/or milk permeate (e.g. milk ultrafiltration permeate) and/or modified milk ingredients. These ingredients are mixed in suitable quantities to obtain a protein-rebalanced cow's milk comprising a desired mineral, lipid and water content and also to obtain a desired weight/weight proportion of casein:whey proteins. Accordingly, in preferred embodiments the liquid milk beverage of the invention is entirely natural and it does not comprise hydrolyzed or fermented proteins. The Exemplification section and Figures 1-5 provides a few non-limitative examples of possible processes for making liquid and protein-rebalanced cow's milk according to various embodiments of the invention.
[00031] In preferred embodiments, the protein-rebalanced cow's milk origins from fresh cow's milk which has been collected, skimmed, ultra-filtrated or heat treated.
Thereafter, the ultra-filtered milk is mixed with the other ingredients to rebalance its protein concentration and proportion, as described herein.
DM_MTL/ 107794.00384/2876250.1 [00032] Preferably, the liquid milk beverage comprising the protein-rebalanced cow's milk is pasteurized before commercialization. Various known pasteurization process are acceptable and known to those skilled in the art. More preferably, the liquid milk beverage of the invention is pasteurized with a Ultra High Temperature (UHT) process (direct or indirect) or by using a High Temperature Short Time Sterilization (HTST) process. The UHT process allows a complete microbial destruction with a minimum loss in nutrients, more especially minimum loss of vitamin C and sulfurous amino acids. Given that the product is aseptically packaged after UHT, its shelf life can be of a few months at room temperature.
Thereafter, the ultra-filtered milk is mixed with the other ingredients to rebalance its protein concentration and proportion, as described herein.
DM_MTL/ 107794.00384/2876250.1 [00032] Preferably, the liquid milk beverage comprising the protein-rebalanced cow's milk is pasteurized before commercialization. Various known pasteurization process are acceptable and known to those skilled in the art. More preferably, the liquid milk beverage of the invention is pasteurized with a Ultra High Temperature (UHT) process (direct or indirect) or by using a High Temperature Short Time Sterilization (HTST) process. The UHT process allows a complete microbial destruction with a minimum loss in nutrients, more especially minimum loss of vitamin C and sulfurous amino acids. Given that the product is aseptically packaged after UHT, its shelf life can be of a few months at room temperature.
[00033] The liquid milk beverage of the invention may comprise additional ingredients to increase further its beneficial properties for toddlers. For instance, the liquid milk beverage may further comprises externally added ingredients including, but not limited to, vitamin(s) (e.g.
vitamin A, provitamin A, vitamin C, vitamin D, vitamin D2, vitamin D3, vitamin E, Folic acid, etc.), prebiotic(s) (e.g. linulin, fructo-oligosaccha rides (FOS), galacto-oligosaccharides (GOS), etc), probiotic(s) (e.g.Bifidobacterium bifidum BB-12, Bifidobacterium sp, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus reuteri), fiber(s) (e.g. inulin, polydextrose, pectine, etc), mineral(s) (e.g. calcium, iron, zinc, etc.), oils and lipids (e.g. algal oil, fish oil, marine oil, vegetable oil, etc.), selected essential fatty acid(s)s such as omega-3 (e.g.
Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Conjugated Linoleic acid (CLA), etc.), antioxidant(s) (e.g. green tea extracts, polyphenols, etc.), biologically active peptides, and other nutraceutical(s) and combinations thereof.
vitamin A, provitamin A, vitamin C, vitamin D, vitamin D2, vitamin D3, vitamin E, Folic acid, etc.), prebiotic(s) (e.g. linulin, fructo-oligosaccha rides (FOS), galacto-oligosaccharides (GOS), etc), probiotic(s) (e.g.Bifidobacterium bifidum BB-12, Bifidobacterium sp, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus reuteri), fiber(s) (e.g. inulin, polydextrose, pectine, etc), mineral(s) (e.g. calcium, iron, zinc, etc.), oils and lipids (e.g. algal oil, fish oil, marine oil, vegetable oil, etc.), selected essential fatty acid(s)s such as omega-3 (e.g.
Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Conjugated Linoleic acid (CLA), etc.), antioxidant(s) (e.g. green tea extracts, polyphenols, etc.), biologically active peptides, and other nutraceutical(s) and combinations thereof.
[00034] As it will be described herein after, the liquid milk beverage of invention preferably comprises externally added vitamin C, and more preferably vitamin C from a natural source such as acerola berries juice. In selected embodiments the cow's milk liquid beverage comprises about 0.5 mg/100 ml to about 4 mg/100 ml vitamin C, or about 1 mg/100 ml to about 4 mg/100 ml vitamin C, or about 2 mg/ml vitamin C.
[00035] Preferably, the liquid milk beverage of invention also comprises essential fatty acids including, but not limited to, omega-3, omega-6, conjugaged linoic acid (CLA).
A preferred source of omega-3 is Docosahexaenoic acid (DHA). The essential fatty acids may be provided by different types of natural oil including, but not limited to, algal oil, fish oil or other edible marine oil. For instance, the liquid milk beverage may comprises about 0.01%
w/w to about 0.25% w/w natural oil, or about 0.025% w/w to about 0.1% of natural oil.
According to some embodiments, the liquid milk beverage may comprises about 0.01% w/w to about 0.25% w/w DM_MTL/ 107794.00384/2876250.1 algal oil, or about 0.025% w/w to about 0.1% algal oil. In a preferred embodiment, the liquid milk beverage may comprises about 0.025% w/w algal oil and that natural oil provides a final concentration of about 100 mg/I Docosahexaenoic acid (DHA) in the liquid milk beverage. An example of a suitable algal oil according to the invention is the oil concentrated in DHA
commercialized by Martek Biosciences Corp. (Columbia, MD).
Method of making [00036] A related aspect of the invention concerns a process for making liquid and protein-rebalanced cow's milk having a reduced weight/weight proportion of casein:whey proteins when compared to untreated liquid cow's milk (e.g. proportion of casein:whey proteins lower than 70:30, or lower than 60:40, or lower than 55:45 or lower than 50:50).
Preferably, whole raw liquid cow's milk is used as the starting material and it is the standard used for comparing the reduced weight/weight proportion of casein:whey proteins according to the various embodiments of the invention. However, those skilled in the art will appreciate that other types of milk such as pasteurized or skimmed milk can also be used. Whole raw liquid cow's milk is also the preferred milk used as the standard for comparing the reduced weight/weight proportion of casein:whey proteins according to the various embodiments of the invention.
A preferred source of omega-3 is Docosahexaenoic acid (DHA). The essential fatty acids may be provided by different types of natural oil including, but not limited to, algal oil, fish oil or other edible marine oil. For instance, the liquid milk beverage may comprises about 0.01%
w/w to about 0.25% w/w natural oil, or about 0.025% w/w to about 0.1% of natural oil.
According to some embodiments, the liquid milk beverage may comprises about 0.01% w/w to about 0.25% w/w DM_MTL/ 107794.00384/2876250.1 algal oil, or about 0.025% w/w to about 0.1% algal oil. In a preferred embodiment, the liquid milk beverage may comprises about 0.025% w/w algal oil and that natural oil provides a final concentration of about 100 mg/I Docosahexaenoic acid (DHA) in the liquid milk beverage. An example of a suitable algal oil according to the invention is the oil concentrated in DHA
commercialized by Martek Biosciences Corp. (Columbia, MD).
Method of making [00036] A related aspect of the invention concerns a process for making liquid and protein-rebalanced cow's milk having a reduced weight/weight proportion of casein:whey proteins when compared to untreated liquid cow's milk (e.g. proportion of casein:whey proteins lower than 70:30, or lower than 60:40, or lower than 55:45 or lower than 50:50).
Preferably, whole raw liquid cow's milk is used as the starting material and it is the standard used for comparing the reduced weight/weight proportion of casein:whey proteins according to the various embodiments of the invention. However, those skilled in the art will appreciate that other types of milk such as pasteurized or skimmed milk can also be used. Whole raw liquid cow's milk is also the preferred milk used as the standard for comparing the reduced weight/weight proportion of casein:whey proteins according to the various embodiments of the invention.
[00037] In one embodiment, the process comprises mixing, in suitable quantities, a milk permeate, cream and raw or pasteurized liquid cow's milk in order to obtain a liquid and protein-rebalanced cow's milk having a desired reduced weight/weight proportion of casein:whey proteins (e.g. proportion of casein:whey proteins equal to or lower than about 70:30, or equal to or lower than about 60:40, or equal to or lower than about 55:45 or equal to or lower than about 50:50). Preferably, the mixing of the suitable quantities is such that a desired lipid, mineral and water content is obtained as well. In another embodiment, the process comprises mixing in suitable quantities liquid cow's milk with water, cream, whey protein concentrates (WPC) (powder or liquid), whey and/or milk ultrafiltration permeate. In additional embodiments, the process comprises further mixing in suitable quantities vitamin C (e.g.
acerola cherry extract in liquid (e.g. juice) or powder form). The Exemplification section and Figures 1-5 provides the steps of selected non-limitative examples of processes envisioned for making liquid and protein-rebalanced cow's milk according to various embodiments of the invention.
acerola cherry extract in liquid (e.g. juice) or powder form). The Exemplification section and Figures 1-5 provides the steps of selected non-limitative examples of processes envisioned for making liquid and protein-rebalanced cow's milk according to various embodiments of the invention.
[00038] In particular embodiments, the method further comprises agitation, one or more steps of homogenization, a preheating step for protein stabilization, a step of pasteurization and a packaging step.
DM_MTL/ 107794.00384/2876250.1 [00039] In a particular embodiment, the process comprises the steps of:
a) mixing sequentially the following ingredients according to the following proportions:
INGREDIENTS Desirable proportions Preferred proportions w/w % w/w Cow's milk (3.25 % w/w fat) 25.00 - 35.00 30.30 Cream (35% w/w fat) 7.000 - 10.000 8.430 WPC (80% w/w) 0.500 - 1.500 0.870 milk ultrafiltration permeate 55.00 - 65.00 60.31 Algal oil ** 0.050 - 0.025 0.025 Acerola *** 0.020 - 0.200 0.040 * facultative but preferred ingredients as source of omega-3;
**facultative but preferred ingredients as source of vitamin C.
b) agitation, preferably for about 30 min up to 60 min at 4 C;
c) homogenization of the ingredients (preferably multi-steps between 40 and 75 );
d) heating of the homogenized mixture between 60 C and 90 C for about 1 min in order to stabilize the proteins; and e) pasteurization, preferably by using a Ultra High Temperature (UHT) process (e.g. about 130-150 C for 2 to 10 sec, preferably about 138 C for 4 sec) in direct or indirect mode.
DM_MTL/ 107794.00384/2876250.1 [00039] In a particular embodiment, the process comprises the steps of:
a) mixing sequentially the following ingredients according to the following proportions:
INGREDIENTS Desirable proportions Preferred proportions w/w % w/w Cow's milk (3.25 % w/w fat) 25.00 - 35.00 30.30 Cream (35% w/w fat) 7.000 - 10.000 8.430 WPC (80% w/w) 0.500 - 1.500 0.870 milk ultrafiltration permeate 55.00 - 65.00 60.31 Algal oil ** 0.050 - 0.025 0.025 Acerola *** 0.020 - 0.200 0.040 * facultative but preferred ingredients as source of omega-3;
**facultative but preferred ingredients as source of vitamin C.
b) agitation, preferably for about 30 min up to 60 min at 4 C;
c) homogenization of the ingredients (preferably multi-steps between 40 and 75 );
d) heating of the homogenized mixture between 60 C and 90 C for about 1 min in order to stabilize the proteins; and e) pasteurization, preferably by using a Ultra High Temperature (UHT) process (e.g. about 130-150 C for 2 to 10 sec, preferably about 138 C for 4 sec) in direct or indirect mode.
[00040] Next, the pasteurized milk is packaged in any suitable container, preferably in an aseptic container such as Tetra BrikTM. Aseptic packaging is generally preferable since it provides an extended shelf-life and the possibility of storage at room temperature. However, may other types of packaging known to those skilled in the art may be suitable (e.g. monolayer or multilayer plastic jugs or bottles, gable top cardboard, polyethylene pouch, etc.).
[00041] Examples 1 to 5 hereinafter provide additional exemplary processes according to the invention.
Cow's milk enriched in Vitamin C
Cow's milk enriched in Vitamin C
[00042] As it is known, Vitamin C is an essential micronutrient required for normal metabolic functioning of the body. The chief biological function of vitamin C is as a water-soluble antioxidant. Reduction of iron by vitamin C has also been implicated in enhanced gastrointestinal absorption of dietary non-haem iron. At high enough concentration, vitamin C
can overcome the inhibitory effect of phytic acid in cereals toward the chelation of some minerals including iron. Other proposed activities include maintenance of enzyme thiols in a reduced state and sparing of glutathione. Finally, vitamin C has been implicated in strengthening of the immune system, something which is particularly important for children.
DM_MTL/ 107794.00384/2876250.1 [00043] There is increasing evidence that deficiencies of micronutrients, such as vitamin C, adversely affect the physical and mental growth of children. Vitamin C
supports growth via its role in collagen synthesis and, hence, the development of bone and soft tissues, and also indirectly by improving absorption of non-haem-iron, combating anaemia, another factor that negatively affects physical growth.
can overcome the inhibitory effect of phytic acid in cereals toward the chelation of some minerals including iron. Other proposed activities include maintenance of enzyme thiols in a reduced state and sparing of glutathione. Finally, vitamin C has been implicated in strengthening of the immune system, something which is particularly important for children.
DM_MTL/ 107794.00384/2876250.1 [00043] There is increasing evidence that deficiencies of micronutrients, such as vitamin C, adversely affect the physical and mental growth of children. Vitamin C
supports growth via its role in collagen synthesis and, hence, the development of bone and soft tissues, and also indirectly by improving absorption of non-haem-iron, combating anaemia, another factor that negatively affects physical growth.
[00044] Because the milk industry is highly regulated in many countries (both the source and the list of possible ingredients which can be added are controlled), cow's milk with vitamin C has not been commercialized yet. Indeed, most of available vitamin C is chemically synthesized and most countries do not authorize addition of chemically synthesized products to liquid milk. The present inventors have found acceptable natural source of vitamin C for supplementing milk, and more particularly acceptable source of vitamin C which can be incorporated into a cow's milk liquid beverage for toddlers.
[00045] Accordingly, an additional aspect of the invention relates to a cow's milk liquid beverage for infant, toddlers or adults comprising cow's milk and externally added vitamin C.
Preferably, the externally added vitamin C is from a natural source. In preferred embodiments, the cow's milk liquid beverage with vitamin C is a cow's milk liquid beverage for toddlers and the externally added vitamin C is present in an amount enhancing iron absorption from other foods consumed by toddlers. In embodiments, the cow's milk liquid beverage comprises about 0.5 mg/100 ml to about 4 mg/100 ml vitamin C, or about 1 mg/100 ml to about 4 mg/100 ml vitamin C, or about 2 mg/ml vitamin C.
Preferably, the externally added vitamin C is from a natural source. In preferred embodiments, the cow's milk liquid beverage with vitamin C is a cow's milk liquid beverage for toddlers and the externally added vitamin C is present in an amount enhancing iron absorption from other foods consumed by toddlers. In embodiments, the cow's milk liquid beverage comprises about 0.5 mg/100 ml to about 4 mg/100 ml vitamin C, or about 1 mg/100 ml to about 4 mg/100 ml vitamin C, or about 2 mg/ml vitamin C.
[00046] In preferred embodiments, the natural source for the externally added vitamin C is a plant extract (e.g. fruit juice (i.e. liquid), or powder concentrate). More preferably, the cow's milk liquid beverage of the invention comprises acerola berries juice as a natural source for the externally added vitamin C.
[00047] Acerola berries (Malphigia emarginata) are particularly known for their high vitamin C
content: 1 000 mg to 4 500 mg of vitamin C per 100 g of fruit, which is up to 90 times the vitamin C content of oranges. The concentration of Vitamin C in acerola berries is among the highest one can find in a berry grown on a commercial basis. For maximal vitamin C
concentration, the berries have to be harvested just before the optimal maturity of the fruit and transformed very rapidly into a juice or powder. Acerola has very high antioxidant potency with a Trolox equivalent antioxidant activity of 53.2 mmol/g. In addition, acerola berries have been DM_MTL/ 107794.00384/2876250.1 demonstrated to be a good source of provitamin A due to their content in carotenoids which is an important hormone-like growth factor for epithelial and other cells.
Although acerola juice has been used in various drinks, including baby food, juices and alcohol (Wikipedia), it has never been used in combination with milk. As used herein, the term "acerola berry' or "acerola berries"
refers to fruit of the tree Malpighia emarginata or Malpighia glabra also known as Barbados Cherry, West Indian Cherry and Wild Crapemyrtle.
content: 1 000 mg to 4 500 mg of vitamin C per 100 g of fruit, which is up to 90 times the vitamin C content of oranges. The concentration of Vitamin C in acerola berries is among the highest one can find in a berry grown on a commercial basis. For maximal vitamin C
concentration, the berries have to be harvested just before the optimal maturity of the fruit and transformed very rapidly into a juice or powder. Acerola has very high antioxidant potency with a Trolox equivalent antioxidant activity of 53.2 mmol/g. In addition, acerola berries have been DM_MTL/ 107794.00384/2876250.1 demonstrated to be a good source of provitamin A due to their content in carotenoids which is an important hormone-like growth factor for epithelial and other cells.
Although acerola juice has been used in various drinks, including baby food, juices and alcohol (Wikipedia), it has never been used in combination with milk. As used herein, the term "acerola berry' or "acerola berries"
refers to fruit of the tree Malpighia emarginata or Malpighia glabra also known as Barbados Cherry, West Indian Cherry and Wild Crapemyrtle.
[00048] Other possible sources of natural vitamin C may include camu camu (Myrciaria dubia), kakadu plum (Terminalia ferdinandiana), Rosehip (Rosa pomifera; cv Karpatia), Rosehip (Rosa sp; cv. Vitaminnyj). Other potential but less preferred sources include guava, papaya, strawberries, kiwi, cantaloupe, orange and grapefruit.
Nutritional Applications [00049] As described herein, the liquid milk beverages of the invention possess numerous advantages and thus find many beneficial applications.
Nutritional Applications [00049] As described herein, the liquid milk beverages of the invention possess numerous advantages and thus find many beneficial applications.
[00050] Accordingly, an additional aspect of the invention concerns a method for providing nutrition to a toddler of about 10 to about 36 months of age, comprising feeding the toddler with a liquid milk beverage as defined herein.
[00051] Another aspect of the invention concerns a method for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk, comprising: (i) providing a liquid milk beverage as defined herein; and (ii) incorporating to the child's diet increasing quantity of the liquid milk beverage. In particular embodiments, the method further comprises incorporating to the child's diet increasing quantity of cow's homogenized milk. Advantageously, the liquid milk beverage is mixed gradually with cereals, which may enhance absorption of the iron's cereal by the child.
[00052] Another related aspect of the invention concerns a method for increasing digestion of cow's milk in an individual, comprising: (1) rebalancing the protein content of raw or pasteurized liquid cow's milk to provide liquid rebalanced cow's milk having a reduced proportion of casein:whey proteins when compared to untreated "natural" liquid cow's milk;
and (2) feeding the individual with the liquid non-hydrolyzed, non-fermented rebalanced cow's milk. Contrary to other artificial infant formulas where the proportion of milk proteins has been modified, the reduced weight/weight proportion of casein:whey proteins in the beverage of the invention is not achieved by hydrolyzing or fermenting the cow's milk. In various embodiments, the proportion of DM_MTL/ 107794.00384/2876250.1 casein:whey proteins is equal to or lower than about 70:30, or equal to or lower than about 60:40, or equal to or lower than about 55:45 or equal to or lower than about 50:50.
Additional uses [00053] Those skilled in the art will appreciate the benefits of the milk beverage according to the invention and may readily identify additional uses. For instance the milk beverage according to the invention may be beneficial to elderly, people suffering from allergies or intolerance to milk proteins or for the prevention and/or treatment of various diseases or conditions associated with a lack of vitamin D, vitamin C, and/or omega-3 fatty acids.
Vitamin D
and (2) feeding the individual with the liquid non-hydrolyzed, non-fermented rebalanced cow's milk. Contrary to other artificial infant formulas where the proportion of milk proteins has been modified, the reduced weight/weight proportion of casein:whey proteins in the beverage of the invention is not achieved by hydrolyzing or fermenting the cow's milk. In various embodiments, the proportion of DM_MTL/ 107794.00384/2876250.1 casein:whey proteins is equal to or lower than about 70:30, or equal to or lower than about 60:40, or equal to or lower than about 55:45 or equal to or lower than about 50:50.
Additional uses [00053] Those skilled in the art will appreciate the benefits of the milk beverage according to the invention and may readily identify additional uses. For instance the milk beverage according to the invention may be beneficial to elderly, people suffering from allergies or intolerance to milk proteins or for the prevention and/or treatment of various diseases or conditions associated with a lack of vitamin D, vitamin C, and/or omega-3 fatty acids.
Vitamin D
[00054] Various studies suggest that poor vitamin D intake or status is associated with an increased risk of colon, breast and prostate cancer. Since milk is naturally rich (or may be enriched) in vitamin D, the milk beverage according to the invention may thus find useful applications in the prevention and/or treatment of these cancers and other cancers.
[00055] It also been suggested that Vitamin D is a prevention factor for a number of autoimmune diseases, including psoriasis. Results from epidemiological studies and evidence from animal models suggest that the risk of autoimmune diseases (e.g. multiple sclerosis, insulin-dependent diabetes mellitus, rheumatoid arthritis) may be decreased by adequate vitamin D intake. Therefore, the milk beverage according to the invention comprising natural or added vitamin D may thus helpful for the prevention and/or treatment of immune mediated diseases.
[00056] Vitamin D plays also an important role in the prevention of osteoporosis and vitamin D insufficiency can be an important contributing factor in this disease. Therefore, drinking the milk beverage according to the invention may slow bone density losses and may decrease the risks of osteoporotic fracture in men and women.
Vitamin C
Vitamin C
[00057] Dozens of prospective studies suggest that vitamin C plays a role in preventing a variety of diseases, including but not limited to cardiovascular diseases (CVD) (e.g. heart disease and stroke). Vitamin C may protect coronary arteries by reducing the build-up of plaque by preventing the oxidation of LDL cholesterol (the "bad" cholesterol) and/or by boosting blood levels of HDL cholesterol (the "good" cholesterol). Therefore, drinking a milk beverage DM_MTL/ 107794.00384/2876250.1 comprising externally added vitamin C according to the invention may have beneficial effects in the prevention and/or treatment of CVD and on blood cholesterol levels.
[00058] A number of studies have also associated higher intakes of vitamin C
with decreased incidence of cancers of the upper digestive tract, cervix, ovary, bladder, and colon. A cow's milk liquid beverage comprising cow's milk and externally added vitamin C according to the invention may thus decrease incidence of cancers.
with decreased incidence of cancers of the upper digestive tract, cervix, ovary, bladder, and colon. A cow's milk liquid beverage comprising cow's milk and externally added vitamin C according to the invention may thus decrease incidence of cancers.
[00059] Additional potential beneficial uses of vitamin C include: benefit in terms of the duration and severity of episodes of common cold; wound healing, prevention of infections and promotion of skin repair during a postoperative period; and improved dilation of blood vessels and lowering of blood pressure. Drinking a cow's milk liquid beverage according to the invention comprising externally added vitamin C may thus be beneficial for these particular indications.
Omega-3 (DHA) [00060] It is known that infants who are not breast fed are the most prominent group likely to be deficient in DHA. Omega-3 are also known to be important in adults and symptoms associated with a Omega-3 deficiency are reported to include poor neurological development, decreased concentration, dementia, depression, esp. postpartum depression, dyslexia, low serotonin levels, memory loss, and visual problems. A cow's milk liquid beverage according to the invention comprising cow's milk and externally added omega-3 (e.g. DHA) may thus have potential therapeutic uses for addressing these deficiencies and/or in the prevention and/or treatment of Alzheimer's disease, attention deficit disorder (ADD), high triglycerides, hyperactivity, learning disorders, neurological and visual development in infants.
Lactoferrin [00061] Lactoferrin is an iron-binding glycoprotein found in human milk in a greater concentration that in cow's milk. Its biological role has not been fully established but it is generally considered to act as a bacteriostatic agent by sequestering iron from iron-requiring bacteria. It is also suggested that it might promote iron absorption. On a protein basis, whey from bovine milk contains more lactoferrin than cow's milk. Therefore drinking a cow's milk liquid beverage with adjusted protein concentration and protein ratio according to the invention may thus be beneficial to individuals, for instance to increase lactoferrin levels in the body or to promote iron absorption.
DM_MTL/ 107794.00384/2876250.1 EXAMPLES
Example 1: Process for making liquid and protein-rebalanced cow's milk according to a first embodiment of the invention (Figure 1) Milk ultra-filtrated (UF) permeate preparation [00062] Whole milk 2 (raw or pasteurised) between 4 C and 50 C is skimmed 4 by a centrifugal separator to generate skim milk 6 and cream 8. One hundred kg of fresh skim milk 2 is concentrated to a concentration factor of 3x generating 33 kg of retentate 12 rich in proteins and 67 kg of permeate 10 containing water, lactose, soluble minerals and nitrogenous fractions (urea, proteose, peptones and others). The concentration 13 is done in a batch mode in close loop configuration using hollow fiber membrane of 10 000 Da molecular weight cut-off operated at 50 C. The permeate 10 is then cooled until further use and the retentate 12 can be used in cheese making, yogurt production or other dairy product.
Formulation of the product [00063] In order to make 100 kg of the desired formulation 1, three main components and are mixed in a double wall agitated tank: 60.1 kg of milk permeate 10, 30.3 kg of milk 2 (3,5 % fat) and 8.4 kg of cream 8 (35,0% fat). The resulting mixture is then agitated and heated by circulation of 80 C water in a jacket until it reaches 50 C.
Omega-3 (DHA) [00060] It is known that infants who are not breast fed are the most prominent group likely to be deficient in DHA. Omega-3 are also known to be important in adults and symptoms associated with a Omega-3 deficiency are reported to include poor neurological development, decreased concentration, dementia, depression, esp. postpartum depression, dyslexia, low serotonin levels, memory loss, and visual problems. A cow's milk liquid beverage according to the invention comprising cow's milk and externally added omega-3 (e.g. DHA) may thus have potential therapeutic uses for addressing these deficiencies and/or in the prevention and/or treatment of Alzheimer's disease, attention deficit disorder (ADD), high triglycerides, hyperactivity, learning disorders, neurological and visual development in infants.
Lactoferrin [00061] Lactoferrin is an iron-binding glycoprotein found in human milk in a greater concentration that in cow's milk. Its biological role has not been fully established but it is generally considered to act as a bacteriostatic agent by sequestering iron from iron-requiring bacteria. It is also suggested that it might promote iron absorption. On a protein basis, whey from bovine milk contains more lactoferrin than cow's milk. Therefore drinking a cow's milk liquid beverage with adjusted protein concentration and protein ratio according to the invention may thus be beneficial to individuals, for instance to increase lactoferrin levels in the body or to promote iron absorption.
DM_MTL/ 107794.00384/2876250.1 EXAMPLES
Example 1: Process for making liquid and protein-rebalanced cow's milk according to a first embodiment of the invention (Figure 1) Milk ultra-filtrated (UF) permeate preparation [00062] Whole milk 2 (raw or pasteurised) between 4 C and 50 C is skimmed 4 by a centrifugal separator to generate skim milk 6 and cream 8. One hundred kg of fresh skim milk 2 is concentrated to a concentration factor of 3x generating 33 kg of retentate 12 rich in proteins and 67 kg of permeate 10 containing water, lactose, soluble minerals and nitrogenous fractions (urea, proteose, peptones and others). The concentration 13 is done in a batch mode in close loop configuration using hollow fiber membrane of 10 000 Da molecular weight cut-off operated at 50 C. The permeate 10 is then cooled until further use and the retentate 12 can be used in cheese making, yogurt production or other dairy product.
Formulation of the product [00063] In order to make 100 kg of the desired formulation 1, three main components and are mixed in a double wall agitated tank: 60.1 kg of milk permeate 10, 30.3 kg of milk 2 (3,5 % fat) and 8.4 kg of cream 8 (35,0% fat). The resulting mixture is then agitated and heated by circulation of 80 C water in a jacket until it reaches 50 C.
[00064] To obtain the final desired milk formulation 1, other dry ingredients (e.g. 0.87 kg of dry whey protein concentrate (80% protein) and 40 g of acerola cherry powder) are added to mixture and dispersed by agitation.
Processing [00065] In order to improve the homogeneity of the formulation 1 prior its sterilization, the formulation I is homogenized 22 between 4 and 50 C at low pressure using a standard double valve homogenizer (100psi/500psi). The homogeneous dispersion is then heat treated 24 in an indirect heating UHT system (142 C, 4 sec) to ensure bacterial destruction, partially cooled to 70 C for homogenization 26 (500 psi/2500 psi) followed by final cooling and packaging 28 (e.g.
aseptic container, plastic jugs or bottles, gable top cardboard, polyethylene pouch, etc.). The packaged product can be stored 30 (at room temperature or in a cold room, as more appropriate) until its distribution 32.
DM_MTL/ 107794.00384/2876250.1 [00066] The milk beverage so obtained after the homogenization 26 and cooling steps was then analyzed and its properties were compared to breast milk and cow's milk as shown in Table 3.
Example 2: Process for making liquid and protein-rebalanced cow's milk according to a second embodiment of the invention (Figure 2).
Milk ultra-filtrated (UF) permeate preparation [00067] That step is carried out according to the procedure described in Example 1.
Preparation of the cream and other fat sources premix [00068] According to this Example, DHA rich algae oil 40 is added to the formulation 1. In order to prevent PUFA oxidation of the DHA rich algae oil, the oil 40 is dispersed in the cream 8:
0.25 kg of algae oil 40 is added to 8.4 kg of cream 8 (35% fat) and slowly stirred until well dispersed to obtain a cream premix 32.
Formulation [00069] In order to make 100 kg of the desired milk formulation 1, two main components are first mixed in an double wall agitated tank: 60.1 kg of milk permeate 10 and 30.3 kg of milk 2 (3,5 % fat). The cream 8 and DHA rich algae oil premix 42 are next added to the tank. The resulting mixture is then agitated and heated by circulation of 80 C water in a jacket until it reaches 50 C.
Processing [00065] In order to improve the homogeneity of the formulation 1 prior its sterilization, the formulation I is homogenized 22 between 4 and 50 C at low pressure using a standard double valve homogenizer (100psi/500psi). The homogeneous dispersion is then heat treated 24 in an indirect heating UHT system (142 C, 4 sec) to ensure bacterial destruction, partially cooled to 70 C for homogenization 26 (500 psi/2500 psi) followed by final cooling and packaging 28 (e.g.
aseptic container, plastic jugs or bottles, gable top cardboard, polyethylene pouch, etc.). The packaged product can be stored 30 (at room temperature or in a cold room, as more appropriate) until its distribution 32.
DM_MTL/ 107794.00384/2876250.1 [00066] The milk beverage so obtained after the homogenization 26 and cooling steps was then analyzed and its properties were compared to breast milk and cow's milk as shown in Table 3.
Example 2: Process for making liquid and protein-rebalanced cow's milk according to a second embodiment of the invention (Figure 2).
Milk ultra-filtrated (UF) permeate preparation [00067] That step is carried out according to the procedure described in Example 1.
Preparation of the cream and other fat sources premix [00068] According to this Example, DHA rich algae oil 40 is added to the formulation 1. In order to prevent PUFA oxidation of the DHA rich algae oil, the oil 40 is dispersed in the cream 8:
0.25 kg of algae oil 40 is added to 8.4 kg of cream 8 (35% fat) and slowly stirred until well dispersed to obtain a cream premix 32.
Formulation [00069] In order to make 100 kg of the desired milk formulation 1, two main components are first mixed in an double wall agitated tank: 60.1 kg of milk permeate 10 and 30.3 kg of milk 2 (3,5 % fat). The cream 8 and DHA rich algae oil premix 42 are next added to the tank. The resulting mixture is then agitated and heated by circulation of 80 C water in a jacket until it reaches 50 C.
[00070] To obtain the final desired milk formulation 1, other dry ingredients (e.g. 0.87 kg of dry whey protein concentrate (80% protein) and 40 g of acerola cherry powder) are added to mixture and dispersed by agitation.
Processing [00071] That step is carried out according to the procedure described in Example 1.
Example 3: Process for making liquid and protein-rebalanced cow's milk according to a third embodiment of the invention (Figure 3).
Milk ultra-filtrated (UF) preparation [00072] That step is carried out according to the procedure described in Example 1.
D M_MTL/ 107794.003 84/2 876250.1 Preparation of the cream and other fat sources premix [00073] That step is carried out according to the procedure described in Example 2.
Preparation of the protein rich pre-mix [00074] According to this Example, to facilitate the dispersion of dry powders to be part of the formulation 1, the WPC 80 powder and the acerola cherry powder are hydrated in milk prior their addition. Briefly, 15 kg of milk 46 (3,5% fat) is heated to 50 C in a double wall stirred tank.
The WPC 80 powder (0.87 kg) and the acerola cherry powder (40 g) are then added 20 and vigorously stirred until well dispersed to obtain a protein-rich premix 44.
Formulation [00075] In order to make 100 kg of the desired milk formulation 1, two main components are mixed in an double wall agitated tank: 60,1 kg of milk permeate 10 and the remaining of the milk 2 (15,3 kg at 3,5% fat). The cream premix 32 comprising the cream 8 and DHA rich algae oil 40 is next added to the tank. The protein-rich premix 44 is also added to the thank. The final desired milk formulation I is then agitated and heated by circulation of 80 C
water in the jacket until it reaches 50 C.
Processing [00076] That step is carried out according to the procedure described in Example 1.
Example 4: Process for making liquid and protein-rebalanced cow's milk according to a forth embodiment of the invention (Figure 4).
Milk ultra-filtrated (UF) permeate preparation [00077] That step is carried out according to the procedure described in Example 1.
Preparation of the cream and other fat sources premix [00078] That step is carried out according to the procedure described in Example 2.
Preparation of the protein rich pre-mix [00079] According to that Example, another way to facilitate the dispersion of dry powders to be part of the formulation 1, is to disperse the powdered ingredients in a portion of the milk UF
permeate 10 prior their incorporation to the formulation 1. For instance, 15 kg of milk UF
permeate 10 is heated to 50 C in a double wall stirred tank. The WPC 80 powder (0,87 kg) and DM_MTL/ 107794.00384/2876250.1 the acerola cherry powder (40 g) are then added 20 and vigorously stirred until well dispersed to obtain a protein-rich pre-mix 44.
Formulation [00080] That step is carried out according to the procedure described in Example 3.
Processing [00081] That step is carried out according to the procedure described in Example 1.
Example 5: Process for making liquid and protein-rebalanced cow's milk according to a fifth embodiment of the invention (Figure 5) Milk ultra-filtrated (UF) preparation [00082] Whole milk 2 (raw or pasteurized) between 4 C and 50 C is skimmed 4 by a centrifugal separator to generate skim milk 6 and cream 8. According to that Example, another way of obtaining the necessary milk UF permeate 10 is to concentrate 100 kg of fresh skim milk 2 (e.g. raw or pasteurised) to a factor of 3x generating 33 kg of retentate rich in proteins and 67 kg of permeate containing water, lactose, soluble minerals and nitrogenous fractions (urea, proteose peptones and others). The concentration is done in a batch mode in close loop configuration using a spiral wound UF membrane system 33. The membrane has a 10 000 Da molecular weight cut-off and the filtration is operated between 5 and 10 C.
The permeate 10 is then stored until further use and the retentate 12 can be used in cheese making, yogurt production or other dairy product.
Preparation of the cream and other fat sources premix [00083] That step is carried out according to the procedure described in Example 2.
Preparation of the protein rich pre-mix [00084] That step is carried out according to the procedure described in Example 4.
Formulation [00085] That step is carried out according to the procedure described in Example 4.
Processing [00086] That step is carried out according to the procedure described in Example 1.
DM_MTL/ 107794.00384/2876250.1 Table 1: Infant formulas composition compared to breast milk (source: Danone Institute).
STARTER INFANT FORMULAS
FORMULAS Adapted Protein Unchanged Protein Breast milk content content Per 100ml Infant Formulas Infant Formulas Powder (g) Liquid 12.7 to 14 (M: 13.3) 12.6 to 15 (M:13.7) Calories (kcal) 68 66 to 73 (M: 68.5) 66 to 72 (M: 69) Protein (g) 1.2 1.5 to 1.8 (M: 1.65) 1.6 to 1.9 (M: 1.8) Casein (%) 40 44 to 50 60 to 80 Lipids (g) 3.5 3.2 to 3.7 (M: 3.6) 2.6 to 3.8 (M: 3.3) Linoleic acid (mg) 350 370 to 670 (M: 520) 350 to 740 (M: 525) Linolenic acid (mg) 37 30 to 70 (M: 50) 30 to 100 (M: 55) Carbohydrates (g) 7.5 6.7 to 7.9 (M: 7.4) 6.8 to 9.5 (M: 7.9) Lactose (%) 85 71 to 100 (M: 77) 47 to 76.5 (M: 73) Malto-dexterin (g) 0 1.1 to 1.9 (M: 1.7) 1.8 to 2.6 (M: 2.1) Oligosaccha- Starch: Gui. C. PEL and Gal.
Other sugars * rides 0 Pre **
Sucrose LEM and PEL
Minerals (mg) 210 250 to 400 (M: 315) 250 to 500 (M: 400) Sodium (mg) 16 16 to 20 (M: 17.5) 16 to 28 (M: 23) Calcium (mg) 33 43 to 75 (M: 54.5) 50 to 93 (M: 70) Ca/P 2 1.4 to 2 (M: 1.7) 1.2 to 1.9 (M: 1.4) Iron (mg) 0.05 0.01 to 0.8 (M: 0.8) 0.7 to 1 (M: 0.8) M=mean `only lactose and malto-dextrin only **Gui C: GUIGOZ CONFORTTM; PEL; PELARGONTM; LEM: LEMIELT"'; Gal Pre:GALLIA
PREMIUMTM
DM_MTL/ 107794.00384/2876250.1 Table 2: Follow-up formulas compared to breast milk after 1 year (source:
Danone Institute).
FOLLOW-UP FORMULAS
FORMULAS
Breast milk Weaning follow-up Unchanged Protein content (after 1 year) formulas Infant Formulas Per 100m1 Powder (g) Liquid 13 to 16 (M: 14.7) Liquids (except MATERNA) Calories (kcal) 65 63 to 76 (M: 71) 63 to 71 (M: 66) Protein (g) 3.7 2 to 3 (M: 2.3) 2.2 to 3.2 (M: 2.6) Casein (%) 80 80 80 Lipids (g) 3.5 2.5 to 3.6 (M: 3.1) 2.4 to 3.5 (M: 2.8) Linoleic acid 90 400 to 690 (M: 515) 210 to 540 (M: 390) (mg) Linolenic acid traces 39 to 90 (M: 52) 38 to 100 (M: 58) (mg) Carbohydrates 4.5 6.2 to 9.1 (M: 8.1) 5.5 to 8.1 (M: 7.6) (g) Lactose (%) 100 42 to 88 41 to 100 Malto-dexterin 0 0.7 to 4.9 (M: 2.3) 0 to 3.2 (M: 1) (g) 0 Starch: Gui. C. LEM*. Starch : Mil Other sugars * Sucrose. Fructose. Sucrose: Gui. C. Nest*
Glucose: LEM *
Minerals (mg) 800 500 to 680 (M: 550) 520 to 800 (M: 670) Sodium (mg) 48 19 to 43 (M: 33) 32 to 42 (M: 37) Calcium (mg) 125 80 to 108 (M: 88) 95 to 111 (M: 102) Ca/P 1.25 1.17 to 1.7 (M: 1.3) 1.2 to 1.57 (M: 1.3) Iron (mg) 0.03 0.8 to 1.4 (M: 1.2) 1 to 1.4 (M: 1.2) M=mean *Gui C: GUIGOZ CONFORTTM; LEM: LEMIELTM; Nest : NESTLE JUNIORTM; Gui PP :
GUIGOZ Premier pasTM; Mil: MILUPA CROISSANCETM
DM_MTL/ 107794.00384/2876250.1 Table 3. Milk beverage according to the one embodiment of the invention compared to breast milk and cow's milk.
Nutrients Units Breast milk Cow's milk Milk beverage of 100) (3.25% fat) Example I
Calories Kcal 73.20 63.20 63.68 Proteins 1.10 3.40 2.00 Carbohydrates 7.20 4.80 4.77 Total fat 4.60 3.40 4.00 Saturated g 2.10 2.10 2.44 Monounsaturated g 1.70 0.90 0.88 Polyunsaturated g 0.50 0.10 0.17 18:3 ALA omega-3 g 0.10 0.00 0.00 18:2 AL omega-6 g 0.40 0.10 0.03 22:6 DHA omega-3 g 0.00 0.00 0.01 20:5 EPA omega-3 g 0.00 0.00 0.00 Cholesterol mg 14.00 14.0 13.24 Minerals Calcium mg 33.00 83.20 66.00 Iron mg 0.03 0.05 0.03 Magnesium mg 4.00 1.50 4.84 Phosphorus mg 14.00 88.00 54.99 Potassium mg 53.00 156.00 153.41 Sodium mg 18.00 51.20 42.49 Zinc mg 0.18 0.39 0.13 Copper mg 50.00 10.00 3.03 Manganese mg 0.03 0.00 0.00 Selenium 2.00 2.00 0.61 Vitamin C mg 5.00 1.00 2.00 Thiamine mg 0.01 0.04 0.01 Riboflavin mg 0.04 0.17 0.14 Niacin mg 0.50 0.90 0.28 Pantothenic acid mg 0.23 0.32 0.08 Vitamin B6 mg 0.01 0.04 0.01 Folate pg 5.00 5.00 1.60 Vitamin B12 pg 0.00 0.40 0.11 Vitamin A pg-EAR 64.00 31.20 45.94 Vitamin E mg-EAT 0.94 0.10 0.13 Vitamin D 0.10 1.14 0.86 DM_MTL/ 107794.00384/2876250.1 [00087] Headings are included herein for reference and to aid in locating certain sections These headings are not intended to limit the scope of the concepts described therein under, and these concepts may have applicability in other sections throughout the entire specification.
Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Processing [00071] That step is carried out according to the procedure described in Example 1.
Example 3: Process for making liquid and protein-rebalanced cow's milk according to a third embodiment of the invention (Figure 3).
Milk ultra-filtrated (UF) preparation [00072] That step is carried out according to the procedure described in Example 1.
D M_MTL/ 107794.003 84/2 876250.1 Preparation of the cream and other fat sources premix [00073] That step is carried out according to the procedure described in Example 2.
Preparation of the protein rich pre-mix [00074] According to this Example, to facilitate the dispersion of dry powders to be part of the formulation 1, the WPC 80 powder and the acerola cherry powder are hydrated in milk prior their addition. Briefly, 15 kg of milk 46 (3,5% fat) is heated to 50 C in a double wall stirred tank.
The WPC 80 powder (0.87 kg) and the acerola cherry powder (40 g) are then added 20 and vigorously stirred until well dispersed to obtain a protein-rich premix 44.
Formulation [00075] In order to make 100 kg of the desired milk formulation 1, two main components are mixed in an double wall agitated tank: 60,1 kg of milk permeate 10 and the remaining of the milk 2 (15,3 kg at 3,5% fat). The cream premix 32 comprising the cream 8 and DHA rich algae oil 40 is next added to the tank. The protein-rich premix 44 is also added to the thank. The final desired milk formulation I is then agitated and heated by circulation of 80 C
water in the jacket until it reaches 50 C.
Processing [00076] That step is carried out according to the procedure described in Example 1.
Example 4: Process for making liquid and protein-rebalanced cow's milk according to a forth embodiment of the invention (Figure 4).
Milk ultra-filtrated (UF) permeate preparation [00077] That step is carried out according to the procedure described in Example 1.
Preparation of the cream and other fat sources premix [00078] That step is carried out according to the procedure described in Example 2.
Preparation of the protein rich pre-mix [00079] According to that Example, another way to facilitate the dispersion of dry powders to be part of the formulation 1, is to disperse the powdered ingredients in a portion of the milk UF
permeate 10 prior their incorporation to the formulation 1. For instance, 15 kg of milk UF
permeate 10 is heated to 50 C in a double wall stirred tank. The WPC 80 powder (0,87 kg) and DM_MTL/ 107794.00384/2876250.1 the acerola cherry powder (40 g) are then added 20 and vigorously stirred until well dispersed to obtain a protein-rich pre-mix 44.
Formulation [00080] That step is carried out according to the procedure described in Example 3.
Processing [00081] That step is carried out according to the procedure described in Example 1.
Example 5: Process for making liquid and protein-rebalanced cow's milk according to a fifth embodiment of the invention (Figure 5) Milk ultra-filtrated (UF) preparation [00082] Whole milk 2 (raw or pasteurized) between 4 C and 50 C is skimmed 4 by a centrifugal separator to generate skim milk 6 and cream 8. According to that Example, another way of obtaining the necessary milk UF permeate 10 is to concentrate 100 kg of fresh skim milk 2 (e.g. raw or pasteurised) to a factor of 3x generating 33 kg of retentate rich in proteins and 67 kg of permeate containing water, lactose, soluble minerals and nitrogenous fractions (urea, proteose peptones and others). The concentration is done in a batch mode in close loop configuration using a spiral wound UF membrane system 33. The membrane has a 10 000 Da molecular weight cut-off and the filtration is operated between 5 and 10 C.
The permeate 10 is then stored until further use and the retentate 12 can be used in cheese making, yogurt production or other dairy product.
Preparation of the cream and other fat sources premix [00083] That step is carried out according to the procedure described in Example 2.
Preparation of the protein rich pre-mix [00084] That step is carried out according to the procedure described in Example 4.
Formulation [00085] That step is carried out according to the procedure described in Example 4.
Processing [00086] That step is carried out according to the procedure described in Example 1.
DM_MTL/ 107794.00384/2876250.1 Table 1: Infant formulas composition compared to breast milk (source: Danone Institute).
STARTER INFANT FORMULAS
FORMULAS Adapted Protein Unchanged Protein Breast milk content content Per 100ml Infant Formulas Infant Formulas Powder (g) Liquid 12.7 to 14 (M: 13.3) 12.6 to 15 (M:13.7) Calories (kcal) 68 66 to 73 (M: 68.5) 66 to 72 (M: 69) Protein (g) 1.2 1.5 to 1.8 (M: 1.65) 1.6 to 1.9 (M: 1.8) Casein (%) 40 44 to 50 60 to 80 Lipids (g) 3.5 3.2 to 3.7 (M: 3.6) 2.6 to 3.8 (M: 3.3) Linoleic acid (mg) 350 370 to 670 (M: 520) 350 to 740 (M: 525) Linolenic acid (mg) 37 30 to 70 (M: 50) 30 to 100 (M: 55) Carbohydrates (g) 7.5 6.7 to 7.9 (M: 7.4) 6.8 to 9.5 (M: 7.9) Lactose (%) 85 71 to 100 (M: 77) 47 to 76.5 (M: 73) Malto-dexterin (g) 0 1.1 to 1.9 (M: 1.7) 1.8 to 2.6 (M: 2.1) Oligosaccha- Starch: Gui. C. PEL and Gal.
Other sugars * rides 0 Pre **
Sucrose LEM and PEL
Minerals (mg) 210 250 to 400 (M: 315) 250 to 500 (M: 400) Sodium (mg) 16 16 to 20 (M: 17.5) 16 to 28 (M: 23) Calcium (mg) 33 43 to 75 (M: 54.5) 50 to 93 (M: 70) Ca/P 2 1.4 to 2 (M: 1.7) 1.2 to 1.9 (M: 1.4) Iron (mg) 0.05 0.01 to 0.8 (M: 0.8) 0.7 to 1 (M: 0.8) M=mean `only lactose and malto-dextrin only **Gui C: GUIGOZ CONFORTTM; PEL; PELARGONTM; LEM: LEMIELT"'; Gal Pre:GALLIA
PREMIUMTM
DM_MTL/ 107794.00384/2876250.1 Table 2: Follow-up formulas compared to breast milk after 1 year (source:
Danone Institute).
FOLLOW-UP FORMULAS
FORMULAS
Breast milk Weaning follow-up Unchanged Protein content (after 1 year) formulas Infant Formulas Per 100m1 Powder (g) Liquid 13 to 16 (M: 14.7) Liquids (except MATERNA) Calories (kcal) 65 63 to 76 (M: 71) 63 to 71 (M: 66) Protein (g) 3.7 2 to 3 (M: 2.3) 2.2 to 3.2 (M: 2.6) Casein (%) 80 80 80 Lipids (g) 3.5 2.5 to 3.6 (M: 3.1) 2.4 to 3.5 (M: 2.8) Linoleic acid 90 400 to 690 (M: 515) 210 to 540 (M: 390) (mg) Linolenic acid traces 39 to 90 (M: 52) 38 to 100 (M: 58) (mg) Carbohydrates 4.5 6.2 to 9.1 (M: 8.1) 5.5 to 8.1 (M: 7.6) (g) Lactose (%) 100 42 to 88 41 to 100 Malto-dexterin 0 0.7 to 4.9 (M: 2.3) 0 to 3.2 (M: 1) (g) 0 Starch: Gui. C. LEM*. Starch : Mil Other sugars * Sucrose. Fructose. Sucrose: Gui. C. Nest*
Glucose: LEM *
Minerals (mg) 800 500 to 680 (M: 550) 520 to 800 (M: 670) Sodium (mg) 48 19 to 43 (M: 33) 32 to 42 (M: 37) Calcium (mg) 125 80 to 108 (M: 88) 95 to 111 (M: 102) Ca/P 1.25 1.17 to 1.7 (M: 1.3) 1.2 to 1.57 (M: 1.3) Iron (mg) 0.03 0.8 to 1.4 (M: 1.2) 1 to 1.4 (M: 1.2) M=mean *Gui C: GUIGOZ CONFORTTM; LEM: LEMIELTM; Nest : NESTLE JUNIORTM; Gui PP :
GUIGOZ Premier pasTM; Mil: MILUPA CROISSANCETM
DM_MTL/ 107794.00384/2876250.1 Table 3. Milk beverage according to the one embodiment of the invention compared to breast milk and cow's milk.
Nutrients Units Breast milk Cow's milk Milk beverage of 100) (3.25% fat) Example I
Calories Kcal 73.20 63.20 63.68 Proteins 1.10 3.40 2.00 Carbohydrates 7.20 4.80 4.77 Total fat 4.60 3.40 4.00 Saturated g 2.10 2.10 2.44 Monounsaturated g 1.70 0.90 0.88 Polyunsaturated g 0.50 0.10 0.17 18:3 ALA omega-3 g 0.10 0.00 0.00 18:2 AL omega-6 g 0.40 0.10 0.03 22:6 DHA omega-3 g 0.00 0.00 0.01 20:5 EPA omega-3 g 0.00 0.00 0.00 Cholesterol mg 14.00 14.0 13.24 Minerals Calcium mg 33.00 83.20 66.00 Iron mg 0.03 0.05 0.03 Magnesium mg 4.00 1.50 4.84 Phosphorus mg 14.00 88.00 54.99 Potassium mg 53.00 156.00 153.41 Sodium mg 18.00 51.20 42.49 Zinc mg 0.18 0.39 0.13 Copper mg 50.00 10.00 3.03 Manganese mg 0.03 0.00 0.00 Selenium 2.00 2.00 0.61 Vitamin C mg 5.00 1.00 2.00 Thiamine mg 0.01 0.04 0.01 Riboflavin mg 0.04 0.17 0.14 Niacin mg 0.50 0.90 0.28 Pantothenic acid mg 0.23 0.32 0.08 Vitamin B6 mg 0.01 0.04 0.01 Folate pg 5.00 5.00 1.60 Vitamin B12 pg 0.00 0.40 0.11 Vitamin A pg-EAR 64.00 31.20 45.94 Vitamin E mg-EAT 0.94 0.10 0.13 Vitamin D 0.10 1.14 0.86 DM_MTL/ 107794.00384/2876250.1 [00087] Headings are included herein for reference and to aid in locating certain sections These headings are not intended to limit the scope of the concepts described therein under, and these concepts may have applicability in other sections throughout the entire specification.
Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
[00088] Although throughout this document reference is made to cow's milk, the invention is not limited to cow's milk only. Indeed, the principles of the invention are applicable to milk from other mammals including but not limited to goat, buffalo, ewe and camel.
Accordingly, the invention encompasses protein-rebalanced goat's milk, protein-rebalanced ewe's milk protein-rebalanced camel's milk and protein-rebalanced buffalo's milk. The invention also encompasses goat's milk, ewe's milk and buffalo's milk comprising externally added ingredients as described herein, and more particularity such milk comprising vitamin C
and/or comprising an acerola berries extract.
Accordingly, the invention encompasses protein-rebalanced goat's milk, protein-rebalanced ewe's milk protein-rebalanced camel's milk and protein-rebalanced buffalo's milk. The invention also encompasses goat's milk, ewe's milk and buffalo's milk comprising externally added ingredients as described herein, and more particularity such milk comprising vitamin C
and/or comprising an acerola berries extract.
[00089] As used herein and in the appended claims, the singular forms "a", "an", and "the"
include plural referents unless the context clearly indicates otherwise. Thus, for example, reference to "an ingredient" includes one or more of such compounds, and reference to "the method" or "the process" includes reference to equivalent steps and methods known to those of ordinary skill in the art that could be modified or substituted for the methods and processes described herein. Similarly, reference to "toddlers" (plural) encompasses a plurality or a single individual toddler.
include plural referents unless the context clearly indicates otherwise. Thus, for example, reference to "an ingredient" includes one or more of such compounds, and reference to "the method" or "the process" includes reference to equivalent steps and methods known to those of ordinary skill in the art that could be modified or substituted for the methods and processes described herein. Similarly, reference to "toddlers" (plural) encompasses a plurality or a single individual toddler.
[00090] It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the present invention and scope of the appended claims.
DM_MTL/ 107794.00384/2876250.1
DM_MTL/ 107794.00384/2876250.1
Claims (50)
1. A liquid milk beverage for toddlers comprising non-hydrolyzed, non-fermented and protein-rebalanced cow's milk, wherein said non-hydrolyzed, non-fermented and protein-rebalanced cow's milk comprises a reduced weight/weight proportion of casein:whey proteins when compared to untreated cow's milk.
2. The liquid milk beverage of claim 1, wherein the proportion of casein:whey proteins is equal to or lower than about 70:30.
3. The liquid milk beverage according to claim 1 or 2, wherein the proportion of casein:whey proteins is equal to or lower than about 60:40.
4. The liquid milk beverage according to any one of claims 1 to 3, wherein the proportion of casein:whey proteins is equal to or lower than about 55:45.
5. The liquid milk beverage according to any one of claims 1 to 4, wherein the proportion of casein:whey proteins is equal to or lower than about 50:50.
6. The liquid milk beverage according to any one of claims 1 to 5, wherein the proportion of casein:whey proteins is equal to or lower than about 45:55.
7. The liquid milk beverage according to any one of claims 1 to 6, wherein the proportion of casein:whey proteins is equal to or lower than about 40:60.
8. The liquid milk beverage according to any one of claims 1 to 7, wherein said reduced proportion of casein:whey proteins facilitates digestion of the cow's liquid milk beverage by toddlers.
9. The liquid milk beverage according to any one of claims 1 to 8, wherein said liquid milk beverage comprises a reduced total protein concentration when compared to untreated cow's milk.
10. The liquid milk beverage according to any one of claims 1 to 9, wherein said toddler is about 10 to about 36 months of age.
11. The liquid milk beverage according to any one of claims 1 to 10, wherein said liquid milk beverage further comprises externally added omega-3.
12. The liquid milk beverage of claim 11, wherein the externally added omega-3 is Docosahexaenoic acid (DHA).
13. The liquid milk beverage according to any one of claims 1 to 12, wherein said liquid milk beverage further comprises externally added vitamin C.
14. The liquid milk beverage of claim 13, wherein the externally added vitamin C is from a natural source.
15. The liquid milk beverage according to any one of claims 1 to 14, wherein said liquid milk beverage further comprises an acerola berry extract.
16. The liquid milk beverage according to any one of claims 1 to 15, wherein said liquid milk beverage further comprises externally added ingredients selected from the group consisting of vitamins, prebiotics probiotic, fibers, minerals, oil, essential fatty acids, antioxidants, biologically active peptides, and combinations thereof.
17. The liquid milk beverage according to any one of claims 1 to 16, wherein said protein-rebalanced cow's milk comprises fresh ultra-filtrated cow's milk.
18. The liquid milk beverage according to any one of claims 1 to 17, wherein said liquid milk beverage has been pasteurized by a Ultra High Temperature (UHT) process.
19. A cow's milk liquid beverage for toddlers comprising cow's milk and externally added vitamin C.
20. The cow's milk liquid beverage of claim 19, wherein said externally added vitamin C is present in an amount enhancing iron absorption of other foods consumed by said toddler.
21. The cow's milk liquid beverage according to claim 19 or 20, wherein said cow's milk liquid beverage comprises about 0.5 mg/100 ml to about 4 mg/100 ml externally added vitamin vitamin C.
22. The cow's milk liquid beverage according to any one of claims 19 to 21, wherein said cow's milk liquid beverage comprises about 1 mg/100 ml to about 4 mg/100 ml externally added vitamin.
23. The cow's milk liquid beverage according to any one of claims 19 to 22, wherein said cow's milk liquid beverage comprises about 2 mg/ml externally added vitamin.
24. The cow's milk liquid beverage of any one of claims 19 to 23, wherein said externally added vitamin C is from a natural source.
25. The cow's milk liquid beverage of claim 24, wherein the natural source for said externally added vitamin C is a plant extract.
26. The cow's milk liquid beverage of any one of claims 19 to 25, wherein said externally added vitamin C is from acerola berries.
27. A liquid cow's milk beverage, comprising:
- fresh ultra-filtrated and Ultra High Temperature (UHT) pasteurized cow's milk, wherein said fresh ultra-filtrated cow's has been protein-rebalanced for having a weight/weight proportion of casein:whey proteins equal to or lower than about 50:50;
- externally added algal oil; and - externally added juice of acerola berries.
- fresh ultra-filtrated and Ultra High Temperature (UHT) pasteurized cow's milk, wherein said fresh ultra-filtrated cow's has been protein-rebalanced for having a weight/weight proportion of casein:whey proteins equal to or lower than about 50:50;
- externally added algal oil; and - externally added juice of acerola berries.
28. The liquid cow's milk beverage of claim 27, wherein said liquid cow's milk beverage is especially formulated for feeding a toddler of about 10 to about 36 months of age.
29. The liquid cow's milk beverage of claim 27 or 28, wherein said cow's milk beverage further comprises externally added ingredients selected from the group consisting of vitamins, prebiotics probiotic, fibers, minerals, oil, essential fatty acids, antioxidants, biologically active peptides, and combinations thereof.
30. A method for providing nutrition to a toddler of about 10 to about 36 months of age, comprising feeding said toddler with a liquid milk beverage as defined in any one of claims 1 to 18.
31. A method for facilitating transition from breast feeding and/or artificial formula feeding of a child towards drinking of cow's homogenized milk, comprising: (i) providing a cow's milk liquid milk beverage as defined in any one of claims 1 to 18; and (ii) incorporating to the child's diet increasing quantity of said liquid milk beverage.
32. The method of claim 31, further comprising incorporating to the child's diet increasing quantity of cow's homogenized milk.
33. The method of claim 31 or 32, wherein said liquid milk beverage is mixed gradually with cereals.
34. A method for increasing digestion of cow's milk in an individual, comprising:
(1) rebalancing proteins content of liquid cow's milk to provide a liquid non-hydrolyzed, non-fermented rebalanced cow's milk having a reduced proportion of casein:whey proteins when compared to untreated liquid cow's milk, wherein said reduced weight/weight proportion of casein:whey proteins is equal to or lower than about 50:50; and (2) feeding said individual with said liquid non-hydrolyzed, non-fermented rebalanced cow's milk.
(1) rebalancing proteins content of liquid cow's milk to provide a liquid non-hydrolyzed, non-fermented rebalanced cow's milk having a reduced proportion of casein:whey proteins when compared to untreated liquid cow's milk, wherein said reduced weight/weight proportion of casein:whey proteins is equal to or lower than about 50:50; and (2) feeding said individual with said liquid non-hydrolyzed, non-fermented rebalanced cow's milk.
35. The method of claim 34, wherein reducing said weight/weight proportion of casein:whey proteins comprises mixing milk permeate, cream and milk obtained from liquid cow's milk.
36. The method of claim 34 or 35, wherein said liquid non-hydrolyzed, non-fermented rebalanced cow's milk comprises a reduced total protein concentration when compared to untreated fresh liquid cow's milk.
37. The method according to any one of claims 34 to 36, comprising using raw or pasteurized liquid cow's milk as a starting liquid cow's milk.
38. The method according to any one of claims 34 to 37, comprising using whole or skimmed liquid cow's milk as a starting liquid cow's milk.
39. A process for making fresh liquid and protein-rebalanced cow's milk having a reduced weight/weight proportion of casein:whey proteins when compared to untreated fresh liquid cow's milk, the process comprising mixing in suitable quantities a milk permeate, cream and fresh liquid cow's milk in order to obtain a fresh liquid and protein-rebalanced cow's milk having a desired lipid, mineral and water content and having a desired reduced weight/weight proportion of casein:whey proteins.
40. The process of claim 39, wherein the reduced weight/weight proportion of casein:whey proteins is equal to or lower than about 70:30.
41. The process of claim 40, wherein the reduced proportion of casein:whey proteins is equal to or lower than about 40:60.
42. Use of a liquid milk beverage according to any one of claims 1 to 18, for feeding milk to elderly, to people suffering from allergies or to people suffering from intolerance to milk proteins.
43. Use of a liquid milk beverage according to any one of claims 1 to 18, for the prevention and/or treatment of diseases or conditions associated with a lack of vitamin D, lack of vitamin C, and/or lack of omega-3 fatty acids.
44. Use of a liquid milk beverage according to any one of claims 1 to 18, prevention and/or treatment of cancer.
45. Use of a liquid milk beverage according to any one of claims 1 to 18, for the prevention and/or treatment of an immune mediated disease.
46. Use of a liquid milk beverage according to any one of claims 1 to 18, for slowing bone density losses and/or for decreasing the risks of osteoporotic fracture in men and women.
47. Use of a liquid milk beverage according to any one of claims 1 to 18, for the prevention and/or treatment of cardiovascular diseases (CVD) and/or for obtaining desirable blood cholesterol levels.
48. Use of a liquid milk beverage according to any one of claims 1 to 18, for the prevention and/or treatment of common cold and/or bacterial infections.
49. Use of a liquid milk beverage according to any one of claims 1 to 18, for addressing an omega-3 deficiency and/or for the prevention and/or treatment of attention deficit disorder (ADD), high triglycerides, hyperactivity, learning disorders, neurological and/or visual development in infants.
50. Use of a liquid milk beverage according to any one of claims 1 to 18, to increase lactoferrin levels in the body or to promote iron absorption.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161354101P | 2011-09-13 | 2011-09-13 | |
| US61/354,101 | 2011-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2788828A1 true CA2788828A1 (en) | 2013-03-13 |
Family
ID=47882079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2788828A Abandoned CA2788828A1 (en) | 2011-09-13 | 2012-09-06 | Liquid milk beverage for toddlers |
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| Country | Link |
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| CA (1) | CA2788828A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108713597A (en) * | 2018-06-01 | 2018-10-30 | 广州富诺营养科技有限公司 | A kind of the health modulation milk beverage and preparation method of addition algae oil DHA |
-
2012
- 2012-09-06 CA CA2788828A patent/CA2788828A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108713597A (en) * | 2018-06-01 | 2018-10-30 | 广州富诺营养科技有限公司 | A kind of the health modulation milk beverage and preparation method of addition algae oil DHA |
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