CA2787978A1 - Interferon-beta for anti-virus therapy for respiratory diseases - Google Patents
Interferon-beta for anti-virus therapy for respiratory diseases Download PDFInfo
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- CA2787978A1 CA2787978A1 CA2787978A CA2787978A CA2787978A1 CA 2787978 A1 CA2787978 A1 CA 2787978A1 CA 2787978 A CA2787978 A CA 2787978A CA 2787978 A CA2787978 A CA 2787978A CA 2787978 A1 CA2787978 A1 CA 2787978A1
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Landscapes
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| GB0405634.7 | 2004-03-12 | ||
| CA2558212A CA2558212C (en) | 2004-03-12 | 2005-03-07 | Interferon-beta for anti-virus therapy for respiratory diseases |
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| CA2558212A Division CA2558212C (en) | 2004-03-12 | 2005-03-07 | Interferon-beta for anti-virus therapy for respiratory diseases |
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| CA2787978A Abandoned CA2787978A1 (en) | 2004-03-12 | 2005-03-07 | Interferon-beta for anti-virus therapy for respiratory diseases |
| CA2558212A Expired - Lifetime CA2558212C (en) | 2004-03-12 | 2005-03-07 | Interferon-beta for anti-virus therapy for respiratory diseases |
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| CA2558212A Expired - Lifetime CA2558212C (en) | 2004-03-12 | 2005-03-07 | Interferon-beta for anti-virus therapy for respiratory diseases |
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| JP (2) | JP4807526B2 (enExample) |
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| ES (1) | ES2343732T3 (enExample) |
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| PL (1) | PL1734987T3 (enExample) |
| PT (1) | PT1734987E (enExample) |
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| GB0405634D0 (en) | 2004-03-12 | 2004-04-21 | Univ Southampton | Anti-virus therapy for respiratory diseases |
| US8318423B2 (en) * | 2004-07-06 | 2012-11-27 | Focus Diagnostics, Inc. | Methods and compositions for detecting rhinoviruses |
| JP5172679B2 (ja) * | 2005-09-09 | 2013-03-27 | インペリアル イノベーションズ リミテッド | 呼吸器疾患の治療のためのインターフェロン−λ療法 |
| CA2622987C (en) * | 2005-09-20 | 2018-02-27 | New York University | Method of treating pulmonary disease with interferons |
| DE102006022877B4 (de) | 2006-05-15 | 2009-01-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Bestimmung der Viabilität von Zellen in Zellkulturen |
| US7871603B2 (en) | 2007-05-18 | 2011-01-18 | Synairgen Research Limited | Interferon-beta and/or lambda for use in treating rhinovirus infection in the elderly |
| GB0713402D0 (en) * | 2007-07-11 | 2007-08-22 | Cardiff & Vale Nhs Trust | A method of diagnosing a condition using a neural network |
| EP2220115A2 (en) * | 2007-12-13 | 2010-08-25 | Glaxo Group Limited | Polypeptides, antibody variable domains & antagonists |
| JP2012512883A (ja) * | 2008-12-19 | 2012-06-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ウイルス感染の治療における上皮成長因子阻害剤の使用 |
| CA2782512A1 (en) * | 2009-12-02 | 2011-06-09 | Neetour Medical Ltd. | Hemodynamics-based monitoring and evaluation of a respiratory condition |
| US9421243B2 (en) * | 2010-03-12 | 2016-08-23 | Synairgen Research Limited | Therapy for influenza like illness |
| CA2811957C (en) | 2010-09-22 | 2019-04-16 | The University Of Melbourne | Soluble tlr2 moiety for use in the treatment or prevention of respiratory conditions associated with infectious agents |
| CN109293782A (zh) | 2014-01-08 | 2019-02-01 | 德益阳光生物技术（北京）有限责任公司 | 融合多肽及使用方法 |
| CN111148509A (zh) * | 2017-07-24 | 2020-05-12 | 诺瓦瓦克斯股份有限公司 | 治疗呼吸系统疾病的方法和组合物 |
| IL275360B2 (en) | 2017-12-21 | 2023-10-01 | Axelia Oncology Pty Ltd | Optimal compounds |
| EP3923975A4 (en) * | 2019-02-13 | 2023-04-19 | University of Florida Research Foundation, Inc. | TARGETING A LUNG-RESIDENT TNFR2 + CDC2 (R2D2) SUBPULATION FOR THE TREATMENT OF ASTHMA |
| NZ783377A (en) | 2019-06-26 | 2026-03-27 | Ena Respiratory Pty Ltd | Pegylated novel molecules for agonising tlr2 |
| EP4181944A1 (en) | 2020-07-20 | 2023-05-24 | Synairgen Research Limited | Inhaled interferon-beta for improving outcome in sars-cov-2 infected patients |
| GB202014114D0 (en) * | 2020-09-08 | 2020-10-21 | Synairgen Res Ltd | Use of inhaled interferon-beta to treat virus-induced exacerbations in copd patients undergoing treatment with a systemic corticosteroid |
| EP4240396B1 (en) * | 2020-11-04 | 2025-01-01 | Ethris GmbH | Ifn-lambda mrna for treating viral infections |
| WO2022154542A1 (ko) * | 2021-01-13 | 2022-07-21 | 에이비온 주식회사 | 잠재적인 호흡기바이러스 감염 개체에 인터페론-베타를 투여하는 것을 포함하는 호흡기바이러스에 대한 예방적 투여 방법 |
Family Cites Families (14)
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| US6596260B1 (en) * | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
| AU696387B2 (en) * | 1994-05-18 | 1998-09-10 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
| US6030609A (en) | 1995-05-19 | 2000-02-29 | Case Western Reserve University | Method and composition for treating paramyxovirus |
| US20010031253A1 (en) * | 1996-07-24 | 2001-10-18 | Gruenberg Micheal L. | Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease |
| AU780270B2 (en) * | 2000-02-23 | 2005-03-10 | Association Francaise Contre Les Myopathies | Treatment of immune diseases |
| GB2362884A (en) | 2000-05-30 | 2001-12-05 | Isis Innovation | Extended duration of airway gene therapy |
| WO2002036628A2 (en) | 2000-11-02 | 2002-05-10 | Maxygen Aps | New multimeric interferon beta polypeptides |
| US20030091544A1 (en) * | 2001-03-13 | 2003-05-15 | Vical Incorporated | Interferon-Beta polynucleotide therapy for autoimmune and inflammatory diseases |
| WO2003066002A2 (en) | 2002-02-08 | 2003-08-14 | University Of Medicine And Dentistry Of New Jersey | IFN-a/b-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION |
| US20040037809A1 (en) * | 2002-06-28 | 2004-02-26 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon beta |
| CA2503305A1 (en) | 2002-10-23 | 2004-05-06 | Zymogenetics, Inc. | Methods for treating viral infection using il-28 and il-29 |
| JP4808157B2 (ja) | 2003-08-07 | 2011-11-02 | ザイモジェネティクス リミテッド ライアビリティ カンパニー | Ｉｌ−２８およびｉｌ−２９の均一な調製物 |
| GB0405634D0 (en) | 2004-03-12 | 2004-04-21 | Univ Southampton | Anti-virus therapy for respiratory diseases |
| AU2005231476B2 (en) | 2004-04-02 | 2011-09-01 | Zymogenetics, Inc. | Il-28 and il-29 cysteine mutants for treating viral infection |
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- 2005-03-07 CA CA2787978A patent/CA2787978A1/en not_active Abandoned
- 2005-03-07 PL PL05708482T patent/PL1734987T3/pl unknown
- 2005-03-07 DK DK05708482.4T patent/DK1734987T3/da active
- 2005-03-07 WO PCT/GB2005/050031 patent/WO2005087253A2/en not_active Ceased
- 2005-03-07 CA CA2558212A patent/CA2558212C/en not_active Expired - Lifetime
- 2005-03-07 PT PT05708482T patent/PT1734987E/pt unknown
- 2005-03-07 ES ES05708482T patent/ES2343732T3/es not_active Expired - Lifetime
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- 2005-03-07 JP JP2007502414A patent/JP4807526B2/ja not_active Expired - Fee Related
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| PT1734987E (pt) | 2010-07-06 |
| EP2206512A2 (en) | 2010-07-14 |
| WO2005087253A3 (en) | 2005-11-24 |
| US20090257980A1 (en) | 2009-10-15 |
| GB0405634D0 (en) | 2004-04-21 |
| JP2011144201A (ja) | 2011-07-28 |
| EP1734987A2 (en) | 2006-12-27 |
| ATE466591T1 (de) | 2010-05-15 |
| US9089535B2 (en) | 2015-07-28 |
| JP2007528890A (ja) | 2007-10-18 |
| CA2558212C (en) | 2012-11-27 |
| PL1734987T3 (pl) | 2010-10-29 |
| EP1734987B1 (en) | 2010-05-05 |
| US20130209399A1 (en) | 2013-08-15 |
| DK1734987T3 (da) | 2010-08-30 |
| DE602005021078D1 (de) | 2010-06-17 |
| EP2206512A3 (en) | 2013-01-09 |
| ES2343732T3 (es) | 2010-08-09 |
| CA2558212A1 (en) | 2005-09-22 |
| JP4807526B2 (ja) | 2011-11-02 |
| US7569216B2 (en) | 2009-08-04 |
| WO2005087253A2 (en) | 2005-09-22 |
| US8273342B2 (en) | 2012-09-25 |
| HK1097181A1 (en) | 2007-06-22 |
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