CA2785168C - Swallowable drug delivery device and methods of drug delivery - Google Patents

Swallowable drug delivery device and methods of drug delivery Download PDF

Info

Publication number
CA2785168C
CA2785168C CA2785168A CA2785168A CA2785168C CA 2785168 C CA2785168 C CA 2785168C CA 2785168 A CA2785168 A CA 2785168A CA 2785168 A CA2785168 A CA 2785168A CA 2785168 C CA2785168 C CA 2785168C
Authority
CA
Canada
Prior art keywords
tissue penetrating
capsule
penetrating member
therapeutic agent
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2785168A
Other languages
English (en)
French (fr)
Other versions
CA2785168A1 (en
Inventor
Mir Imran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rani Therapeutics LLC
Original Assignee
Rani Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44196421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2785168(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rani Therapeutics LLC filed Critical Rani Therapeutics LLC
Publication of CA2785168A1 publication Critical patent/CA2785168A1/en
Application granted granted Critical
Publication of CA2785168C publication Critical patent/CA2785168C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/06Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A61B5/065Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/073Intestinal transmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A61M2005/14284Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation with needle insertion means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Human Computer Interaction (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2785168A 2009-12-24 2010-12-23 Swallowable drug delivery device and methods of drug delivery Active CA2785168C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US28476609P 2009-12-24 2009-12-24
US61/284,766 2009-12-24
US34033110P 2010-03-15 2010-03-15
US61/340,331 2010-03-15
US39530410P 2010-05-10 2010-05-10
US61/395,304 2010-05-10
PCT/US2010/062070 WO2011079302A2 (en) 2009-12-24 2010-12-23 Swallowable drug delivery device and methods of drug delivery

Publications (2)

Publication Number Publication Date
CA2785168A1 CA2785168A1 (en) 2011-06-30
CA2785168C true CA2785168C (en) 2018-04-17

Family

ID=44196421

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2785168A Active CA2785168C (en) 2009-12-24 2010-12-23 Swallowable drug delivery device and methods of drug delivery

Country Status (11)

Country Link
EP (4) EP2515992B2 (OSRAM)
JP (7) JP2013515576A (OSRAM)
CN (2) CN102905753B (OSRAM)
AU (5) AU2010336330B2 (OSRAM)
CA (1) CA2785168C (OSRAM)
DK (3) DK3756657T3 (OSRAM)
ES (2) ES2804716T3 (OSRAM)
FI (1) FI3756657T3 (OSRAM)
PL (2) PL3461478T3 (OSRAM)
PT (1) PT3756657T (OSRAM)
WO (1) WO2011079302A2 (OSRAM)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5854513B2 (ja) 2009-08-03 2016-02-09 インキューブ ラブズ, エルエルシー 腸管内でインクレチン生産を刺激するための嚥下可能カプセルおよび方法
DK3756657T3 (da) 2009-12-24 2025-06-02 Rani Therapeutics Llc Synkbar anordning til lægemiddelfremføring
US8562589B2 (en) 2009-12-24 2013-10-22 Rani Therapeutics, Llc Swallowable drug delivery device and method of delivery
CN103025319B (zh) * 2010-03-10 2015-07-01 因卡伯实验室有限责任公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8740927B2 (en) 2011-01-21 2014-06-03 Obalon Therapeutics Inc. Intragastric device
PT2726091T (pt) * 2011-06-29 2020-04-22 Rani Therapeutics Llc Preparações de agentes terapêuticos para administração num lúmen do trato intestinal utilizando um dispositivo de administração de fármacos de engolir
DK3653223T3 (da) * 2011-06-29 2021-11-15 Rani Therapeutics Llc Enhed til oral levering af terapeutiske forbindelser
CA3240667A1 (en) * 2013-03-15 2014-10-02 Rani Therapeutics, Llc Device for oral delivery of therapeutic compounds
US20150064241A1 (en) * 2013-09-05 2015-03-05 Google Inc. Delivery of Functionalized Particles
CN103479401B (zh) * 2013-09-29 2015-08-19 中山大学附属第一医院 一种肠道生物标志物采样器
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10039810B2 (en) 2014-05-15 2018-08-07 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising anti-interleukin antibodies
JP2017519003A (ja) * 2014-06-11 2017-07-13 マサチューセッツ インスティテュート オブ テクノロジー 自己集合滞留デバイスおよび関連方法
WO2016155671A1 (zh) * 2015-04-02 2016-10-06 傅君志 可吞咽式装置
EP3294273A4 (en) * 2015-05-08 2018-12-05 Incube Labs, LLC Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
JP2018526403A (ja) * 2015-09-08 2018-09-13 インキューブ ラブズ, エルエルシー 嚥下可能な薬物送達デバイスを使用する腸管の管腔中への送達のためのpcsk9抗体製剤
US10220003B2 (en) * 2016-03-09 2019-03-05 Incube Labs, Llc Methods and articles for delivering viable cells into solid tissue
EP3509469A1 (en) 2016-09-09 2019-07-17 Progenity, Inc. Electromechanical ingestible device for delivery of a dispensable substance
FR3059553B1 (fr) * 2016-12-07 2021-04-23 Univ Grenoble Alpes Dispositif implantable
EP3554346B1 (en) * 2016-12-14 2024-01-31 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
CN107050578A (zh) * 2017-05-04 2017-08-18 梁曦 一种药物自动注射装置
WO2018213600A1 (en) * 2017-05-17 2018-11-22 Massachusetts Institute Of Technology Self-righting systems and related components and methods
AU2018269045B2 (en) * 2017-05-19 2023-08-31 Envivo Bio Inc Devices and methods for collecting gastrointestinal samples
EP3638111A4 (en) * 2017-06-12 2021-04-07 InCube Labs, LLC INGERABLE CAPSULE, SYSTEM AND METHOD OF MEASURING GASTRIC DRAIN PARAMETERS
CN108324231A (zh) * 2018-03-14 2018-07-27 潍坊学院 一种自清洁上药胶囊内镜
CN112218617A (zh) 2018-04-10 2021-01-12 潘纳西亚比奥马特斯公司 利用附加制造技术制备个性化营养配方和药物配方的方法和系统
US10675248B2 (en) * 2018-08-14 2020-06-09 Alma Therapeutics Ltd. Expandable pill
CN120837821A (zh) * 2018-08-15 2025-10-28 林德拉治疗公司 用于治疗剂的肠递送的系统
WO2020041774A1 (en) * 2018-08-23 2020-02-27 Baywind Bioventures Capsule device for delivery of active agent to gastrointestinal tract
US12128133B2 (en) * 2018-09-25 2024-10-29 Rani Therapeutics, Llc Ingestible device with expandable enclosure
WO2020106750A1 (en) * 2018-11-19 2020-05-28 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
EP3917598B1 (en) * 2019-02-01 2025-10-29 Massachusetts Institute of Technology Systems for liquid injection
US12121688B2 (en) 2019-02-01 2024-10-22 Novo Nordisk A/S Medical device with actuation mechanism
US11833319B2 (en) * 2019-03-01 2023-12-05 Rani Therapeutics, Llc Propulsive drug delivery from a swallowable device into a patients intestinal tract
WO2020245448A1 (en) * 2019-06-07 2020-12-10 Novo Nordisk A/S Ingestible device with delivery member detachment
US11793980B2 (en) * 2019-08-31 2023-10-24 Celero Systems, Inc. Intestinal attachment device
BR112022006750A2 (pt) * 2019-10-08 2022-06-28 Incube Labs Llc Dispositivo de entrega, dispositivo de entrega para controlar um perfil de entrega de uma substância terapêutica, e método para formar um dispositivo de entrega
EP3870261B1 (en) 2019-12-13 2024-01-31 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
CA3167324A1 (en) * 2020-01-14 2021-07-22 Rani Therapeutics, Llc Swallowable devices for drug delivery in an intestinal tract
BR112022016147A2 (pt) * 2020-02-18 2022-10-25 Rani Therapeutics Llc Injeção de uma formulação terapêutica para dentro de uma parede do trato gastrointestinal
US20240000708A1 (en) * 2020-03-31 2024-01-04 Danmarks Tekniske Universitet A flexible foil for the delivery of therapeutic cargos
EP4171715A4 (en) * 2020-06-29 2024-07-24 The Governing Council of the University of Toronto MAGNETICALLY ACTUATED CAPSULE
CN111772589B (zh) * 2020-08-04 2022-07-12 重庆金山医疗技术研究院有限公司 一种判断胶囊内镜是否适用的检测系统及其探路胶囊
AU2021343442B2 (en) * 2020-09-16 2024-08-15 Eli Lilly And Company Oral drug delivery device with expanding arms
US20240358629A1 (en) * 2021-07-19 2024-10-31 Cochlear Limited Self-propelled pharmaceutical delivery capsules
CN113598690B (zh) * 2021-08-10 2023-07-28 安徽光阵光电科技有限公司 一种用于人体体内医疗的内窥镜药丸
KR20240151199A (ko) * 2022-02-21 2024-10-17 라니 테라퓨틱스, 엘엘씨 유체 제제를 위장관 내로 전달하기 위한 디바이스, 조립체, 및 방법
CN119424884B (zh) * 2024-09-29 2025-10-10 北京水木金昇医疗科技服务有限公司 一种递送注射药物的微针胶囊及其应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5217449A (en) * 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
DK42093D0 (da) * 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
CA2380111A1 (en) 1999-08-03 2001-02-08 Smith & Nephew, Inc. Controlled release implantable devices
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
JP4643089B2 (ja) * 2001-09-27 2011-03-02 オリンパス株式会社 カプセル型医療装置
JP2002186672A (ja) * 2001-09-28 2002-07-02 Olympus Optical Co Ltd 医療用カプセル装置
FR2835730B1 (fr) * 2002-02-11 2004-12-10 C T M Ct De Transfert Des Micr Dispositif pour la delivrance de substances et le prelevement intracorporel
ES2607128T3 (es) 2002-06-25 2017-03-29 Theraject, Inc. Microperforador de rápida disolución para administración de medicamentos y otras aplicaciones
US7118531B2 (en) * 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
ATE547976T1 (de) * 2002-12-26 2012-03-15 Given Imaging Ltd Immobilisierbare in-vivo messvorrichtung
JP2006517827A (ja) 2003-01-29 2006-08-03 イー−ピル・ファーマ・リミテッド 胃腸管内における活性薬物の送達
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
JP2005021677A (ja) * 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベース、及び注射針
US8000784B2 (en) * 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
DE102004026615A1 (de) * 2004-06-01 2005-12-29 Siemens Ag Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels
US20060153894A1 (en) * 2004-06-30 2006-07-13 Ragae Ghabrial Multi-compartment delivery system
US7430998B2 (en) * 2004-09-13 2008-10-07 Luk Lamellen Und Kupplungsbau Beteiligungs Kg Method for positional determination of an EC motor
WO2006035446A2 (en) * 2004-09-30 2006-04-06 Duocure, Inc. Device and method for treating weight disorders
JP2008532568A (ja) * 2005-01-18 2008-08-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 電子制御されるカプセル
WO2006126653A1 (ja) * 2005-05-27 2006-11-30 Olympus Corporation 被検体内導入装置
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
JP4402648B2 (ja) * 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
ES2747956T3 (es) 2005-12-30 2020-03-12 Rdd Pharma Ltd Dispositivo para tratar el esfínter anal
GB0603252D0 (en) * 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
US7741273B2 (en) 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
DE102006047537B4 (de) * 2006-10-07 2024-05-16 Sanofi-Aventis Deutschland Gmbh Verfahren und Vorrichtung zur Bestimmung der Position eines Stopfens einer Ampulle für ein Arzneimittel in einem medizinischen Gerät sowie deren Verwendung, ein entsprechendes medizinisches Gerät sowie Herstellung eines medizinischen Geräts
US20080214919A1 (en) * 2006-12-26 2008-09-04 Lifescan, Inc. System and method for implementation of glycemic control protocols
CN101808567B (zh) * 2007-09-26 2012-09-05 奥林巴斯医疗株式会社 被检体内导入系统
DK3756657T3 (da) 2009-12-24 2025-06-02 Rani Therapeutics Llc Synkbar anordning til lægemiddelfremføring

Also Published As

Publication number Publication date
EP3756657B1 (en) 2025-03-05
CN105999526A (zh) 2016-10-12
WO2011079302A2 (en) 2011-06-30
JP7616937B2 (ja) 2025-01-17
DK4056173T3 (da) 2025-08-25
EP3461478A1 (en) 2019-04-03
DK3461478T3 (da) 2020-07-27
JP2020058871A (ja) 2020-04-16
JP6484208B2 (ja) 2019-03-13
AU2018203418A1 (en) 2018-06-07
JP2023116591A (ja) 2023-08-22
JP2018110907A (ja) 2018-07-19
AU2016208382A1 (en) 2016-08-18
AU2020203067B2 (en) 2022-08-04
EP3756657A1 (en) 2020-12-30
FI3756657T3 (fi) 2025-05-30
EP2515992B1 (en) 2018-10-10
AU2010336330A1 (en) 2012-07-12
EP4056173A2 (en) 2022-09-14
CA2785168A1 (en) 2011-06-30
CN102905753B (zh) 2016-06-29
PT3756657T (pt) 2025-06-06
JP2021112609A (ja) 2021-08-05
EP2515992A2 (en) 2012-10-31
AU2010336330B2 (en) 2016-04-28
WO2011079302A3 (en) 2011-11-17
JP7590811B2 (ja) 2024-11-27
JP2015186590A (ja) 2015-10-29
EP2515992A4 (en) 2013-08-28
ES2804716T3 (es) 2021-02-09
CN105999526B (zh) 2019-07-05
EP2515992B2 (en) 2024-11-06
CN102905753A (zh) 2013-01-30
DK3756657T3 (da) 2025-06-02
AU2016208382B2 (en) 2018-02-15
AU2018203418B2 (en) 2020-02-27
EP4056173A3 (en) 2022-11-23
EP4056173B1 (en) 2025-06-25
PL3756657T3 (pl) 2025-07-07
ES3031275T3 (en) 2025-07-07
AU2022263569A1 (en) 2022-12-08
JP2013515576A (ja) 2013-05-09
AU2022263569B2 (en) 2025-03-06
AU2020203067A1 (en) 2020-05-28
PL3461478T3 (pl) 2020-09-21
EP3461478B1 (en) 2020-04-22
JP2017014274A (ja) 2017-01-19

Similar Documents

Publication Publication Date Title
AU2022263569B2 (en) Swallowable drug delivery device and methods of drug delivery
US12268831B2 (en) Swallowable drug delivery device and methods of drug delivery
HK40044998A (en) Swallowable drug delivery device
HK40077106A (en) Swallowable drug delivery device
HK40077106B (en) Swallowable drug delivery device
HK40044998B (en) Swallowable drug delivery device

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151218