CA2783745C - Procede de mesure de concentration de substance a analyser dans echantillon liquide - Google Patents

Procede de mesure de concentration de substance a analyser dans echantillon liquide Download PDF

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Publication number
CA2783745C
CA2783745C CA2783745A CA2783745A CA2783745C CA 2783745 C CA2783745 C CA 2783745C CA 2783745 A CA2783745 A CA 2783745A CA 2783745 A CA2783745 A CA 2783745A CA 2783745 C CA2783745 C CA 2783745C
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CA
Canada
Prior art keywords
pulses
body fluid
applying
voltage
glucose concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2783745A
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English (en)
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CA2783745A1 (fr
Inventor
Georgeta Lica
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Individual
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2783745A1 publication Critical patent/CA2783745A1/fr
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Publication of CA2783745C publication Critical patent/CA2783745C/fr
Expired - Fee Related legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

Selon l'invention, la technique et le système d'analyse de la glycémie décrits par les présentes répondent au problème de l'interférence de l'hématocrite lors de la détection rapide de concentrations en glucose. Ils répondent à ce problème grâce à l'utilisation d'une technique de voltampérométrie d'impulsion différentielle dans laquelle des impulsions courtes de tension à haute fréquence sont appliquées pour maintenir la couche de diffusion au sein du réactif de l'électrode de travail et les impulsions sont appliquées sur une fenêtre (ou une plage) de tension limitée qui est au-dessous du courant limite de diffusion de crête. Les mesures au-dessous de la crête sont alors utilisées pour déterminer les concentrations en glucose. Grâce à cette technique, les concentrations en glucose peuvent être déterminées relativement rapidement (par exemple en 5 secondes) et indépendamment des niveaux d'hématocrite du fluide qui est analysé.
CA2783745A 2009-12-30 2010-12-23 Procede de mesure de concentration de substance a analyser dans echantillon liquide Expired - Fee Related CA2783745C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/649,929 US8691075B2 (en) 2009-12-30 2009-12-30 Method for measuring analyte concentration in a liquid sample
US12/649,929 2009-12-30
PCT/EP2010/007930 WO2011079937A2 (fr) 2009-12-30 2010-12-23 Procédé de mesure de concentration de substance à analyser dans échantillon liquide

Publications (2)

Publication Number Publication Date
CA2783745A1 CA2783745A1 (fr) 2011-07-07
CA2783745C true CA2783745C (fr) 2015-09-29

Family

ID=43661909

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2783745A Expired - Fee Related CA2783745C (fr) 2009-12-30 2010-12-23 Procede de mesure de concentration de substance a analyser dans echantillon liquide

Country Status (8)

Country Link
US (1) US8691075B2 (fr)
EP (1) EP2519817B1 (fr)
JP (1) JP5512825B2 (fr)
KR (1) KR101419625B1 (fr)
CN (1) CN102667475B (fr)
CA (1) CA2783745C (fr)
HK (1) HK1175840A1 (fr)
WO (1) WO2011079937A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2746759B1 (fr) * 2012-12-23 2016-09-07 Tyson Bioresearch, Inc. Procédé de détection d'une concentration d'un analyte d'un échantillon en utilisant d'une bande de test
DE102013227125B4 (de) 2013-12-23 2016-04-07 Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh Verfahren zur Bestimmung eines hämatokritabhängigen Messsignals bei der Bestimmung eines Analyten aus Vollblut unter Verwendung von enzymatisch-voltammetrischen Einmalgebrauchs-Sensoren
KR101666978B1 (ko) * 2014-09-17 2016-10-24 주식회사 아이센스 생체시료 내 분석대상물질의 농도측정방법 및 측정장치
CN104569102B (zh) * 2015-02-04 2018-04-06 苏州市玮琪生物科技有限公司 检测血液微量信号的生物传感电极和方法
TWI580958B (zh) 2015-04-28 2017-05-01 財團法人工業技術研究院 分析物濃度的檢測方法
CN108333236A (zh) * 2017-01-20 2018-07-27 长青生医科技股份有限公司 生物参数测量方法及其装置
CN109946337B (zh) * 2017-12-21 2022-01-04 王玉麟 血液检测方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
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US4805624A (en) * 1985-09-09 1989-02-21 The Montefiore Hospital Association Of Western Pa Low-potential electrochemical redox sensors
US4897162A (en) * 1986-11-14 1990-01-30 The Cleveland Clinic Foundation Pulse voltammetry
US5410474A (en) 1993-07-27 1995-04-25 Miles Inc. Buttonless memory system for an electronic measurement device
WO1997008544A1 (fr) * 1995-08-22 1997-03-06 Andcare, Inc. Dispositif de controle electrique manuel
US5980708A (en) * 1997-02-12 1999-11-09 Champagne; Gilles Y. High sensitivity multiple waveform voltammetric instrument
CN1122178C (zh) 1998-04-02 2003-09-24 松下电器产业株式会社 基质的定量方法
US6261780B1 (en) * 1999-01-06 2001-07-17 Fuji Photo Film Co., Ltd. Quantitative analysis of biochemical compound utilizing electrochemical reaction
US7045054B1 (en) * 1999-09-20 2006-05-16 Roche Diagnostics Corporation Small volume biosensor for continuous analyte monitoring
US6664407B2 (en) * 2000-12-04 2003-12-16 Beckman Coulter, Inc. Electrochemical saccharide sensor
US6872298B2 (en) * 2001-11-20 2005-03-29 Lifescan, Inc. Determination of sample volume adequacy in biosensor devices
US20030113933A1 (en) * 2001-12-18 2003-06-19 Rasmus Jansson Analysis of components in liquids
US6664776B2 (en) * 2001-12-18 2003-12-16 Otre Ab Method and system for voltammetric characterization of a liquid sample
US6743635B2 (en) * 2002-04-25 2004-06-01 Home Diagnostics, Inc. System and methods for blood glucose sensing
AU2003283935A1 (en) 2002-12-09 2004-06-30 Otre Ab Simplified signal processing method for voltammetry
GB0314944D0 (en) 2003-06-26 2003-07-30 Univ Cranfield Electrochemical detector for metabolites in physiological fluids
KR101258714B1 (ko) 2004-10-12 2013-04-26 바이엘 헬스케어 엘엘씨 샘플 내 분석물의 농도를 측정하기 위한 전기화학 시스템 및 전기화학 센서 스트립 및 이를 이용하는 방법
US20060096870A1 (en) * 2004-11-10 2006-05-11 Fwu-Shan Sheu Detection of biological molecules
JP2006242925A (ja) * 2005-03-07 2006-09-14 Seiko Epson Corp 電極基板、該基板を備える検出装置および該装置を含むキット、並びに該キットを用いた検出方法
KR101321296B1 (ko) * 2005-07-20 2013-10-28 바이엘 헬스케어 엘엘씨 게이트형 전류 측정법 온도 결정 방법
JP5671205B2 (ja) * 2005-09-30 2015-02-18 バイエル・ヘルスケア・エルエルシー ゲート化ボルタンメトリー
US20070235346A1 (en) * 2006-04-11 2007-10-11 Popovich Natasha D System and methods for providing corrected analyte concentration measurements
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WO2009119117A1 (fr) * 2008-03-27 2009-10-01 パナソニック株式会社 Dispositif de mesure, système de mesure et procédé de mesure de concentration

Also Published As

Publication number Publication date
EP2519817B1 (fr) 2014-10-22
JP2013516598A (ja) 2013-05-13
CN102667475A (zh) 2012-09-12
EP2519817A2 (fr) 2012-11-07
US8691075B2 (en) 2014-04-08
HK1175840A1 (en) 2013-07-12
US20110155588A1 (en) 2011-06-30
CN102667475B (zh) 2014-09-24
WO2011079937A3 (fr) 2011-09-09
KR101419625B1 (ko) 2014-07-15
KR20120094080A (ko) 2012-08-23
CA2783745A1 (fr) 2011-07-07
JP5512825B2 (ja) 2014-06-04
WO2011079937A2 (fr) 2011-07-07

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Effective date: 20210831

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