CA2776954A1 - Banques combinatoires basees sur le domaine lectine de type c - Google Patents
Banques combinatoires basees sur le domaine lectine de type c Download PDFInfo
- Publication number
- CA2776954A1 CA2776954A1 CA2776954A CA2776954A CA2776954A1 CA 2776954 A1 CA2776954 A1 CA 2776954A1 CA 2776954 A CA2776954 A CA 2776954A CA 2776954 A CA2776954 A CA 2776954A CA 2776954 A1 CA2776954 A1 CA 2776954A1
- Authority
- CA
- Canada
- Prior art keywords
- loop
- amino acid
- ctld
- library
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4726—Lectins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/577,067 | 2009-10-09 | ||
US12/577,067 US20100105620A1 (en) | 2008-10-10 | 2009-10-09 | Polypeptides that bind Trail-R1 and Trail-R2 |
USPCT/US2009/060271 | 2009-10-09 | ||
PCT/US2009/060271 WO2010042890A2 (fr) | 2008-10-10 | 2009-10-09 | Polypeptides qui se lient à trail-ri et trail-r2 |
PCT/US2010/023803 WO2011043834A1 (fr) | 2009-10-09 | 2010-02-10 | Banques combinatoires basées sur le domaine lectine de type c |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2776954A1 true CA2776954A1 (fr) | 2011-04-14 |
Family
ID=42103903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2776954A Abandoned CA2776954A1 (fr) | 2009-10-09 | 2010-02-10 | Banques combinatoires basees sur le domaine lectine de type c |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2486132A1 (fr) |
JP (1) | JP2013507123A (fr) |
CN (1) | CN102686727A (fr) |
CA (1) | CA2776954A1 (fr) |
WO (1) | WO2011043834A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2347775T (pt) | 2005-12-13 | 2020-07-14 | The President And Fellows Of Harvard College | Estruturas em andaime para transplante celular |
WO2012048165A2 (fr) | 2010-10-06 | 2012-04-12 | President And Fellows Of Harvard College | Hydrogels injectable, gélifiants pour des thérapies cellulaires à base de matériaux |
CA2870309C (fr) | 2012-04-16 | 2024-02-20 | President And Fellows Of Harvard College | Compositions de silice mesoporeuse pour moduler les reponses immunitaires |
US20160039877A1 (en) | 2013-03-15 | 2016-02-11 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
WO2016123573A1 (fr) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Matériaux péritumoraux et intratumoraux pour traitement anticancéreux |
US11150242B2 (en) | 2015-04-10 | 2021-10-19 | President And Fellows Of Harvard College | Immune cell trapping devices and methods for making and using the same |
CN104961833B (zh) * | 2015-07-21 | 2018-08-03 | 中国科学技术大学 | 一种人源NKp80-Fc融合蛋白及其制备方法和在肿瘤治疗中的应用 |
CN115531609A (zh) | 2016-02-06 | 2022-12-30 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
CN108697778B (zh) * | 2016-02-16 | 2023-10-03 | 哈佛学院院长等 | 病原体疫苗及其生产和使用方法 |
CN115305229A (zh) | 2016-07-13 | 2022-11-08 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ526312A (en) * | 2000-12-13 | 2004-11-26 | Borean Pharma As | Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains |
-
2010
- 2010-02-10 CN CN2010800560215A patent/CN102686727A/zh active Pending
- 2010-02-10 CA CA2776954A patent/CA2776954A1/fr not_active Abandoned
- 2010-02-10 EP EP10704873A patent/EP2486132A1/fr not_active Withdrawn
- 2010-02-10 JP JP2012533143A patent/JP2013507123A/ja active Pending
- 2010-02-10 WO PCT/US2010/023803 patent/WO2011043834A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN102686727A (zh) | 2012-09-19 |
JP2013507123A (ja) | 2013-03-04 |
EP2486132A1 (fr) | 2012-08-15 |
WO2011043834A1 (fr) | 2011-04-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20110086770A1 (en) | Combinatorial Libraries Based on C-type Lectin-like Domain | |
CA2776954A1 (fr) | Banques combinatoires basees sur le domaine lectine de type c | |
EP1341912B1 (fr) | Methode pour l'identification et l'isolation des polypeptides de bibliotheques combinatoires de proteines presentant la structure en echafaudage des domaines lectonoides de type c | |
US20110028403A1 (en) | HSP70-Based Treatment for Autoimmune Diseases and Cancer | |
RU2556820C2 (ru) | Модифицированные убиквитиновые белки со специфической связывающей активностью для экстрадомена "в" фибронектина | |
JP5291279B2 (ja) | 反復モジュールを含む反復タンパク質の集合体 | |
AU2002221568A1 (en) | Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains | |
EP2284270A2 (fr) | Procédé d'identification et d'isolation des polypeptides de liaison à partir des bibliothèques combinatoires de protéines dotées d'une structure d'échafaudage des domaines par exemple de la lectine de type C | |
JP2008516210A (ja) | 治療、診断およびクロマトグラフィーに使用するためのタンパク質複合体 | |
WO2012171541A1 (fr) | Protéines hybrides humaines comportant des interférons et des protéines hétérodimériques modifiées par ubiquitine | |
KR20150016585A (ko) | 비-천연 컨센서스 알부민 결합 도메인 | |
WO2003091429A1 (fr) | Polypeptide microbicide et ses utilisations | |
AU2010303879A1 (en) | Combinatorial libraries based on C-type lectin domain | |
AU2015305220B2 (en) | Affinity proteins and uses thereof | |
US20110086806A1 (en) | Polypeptides that Bind IL-23R | |
EP2486050A1 (fr) | Polypeptides qui se lient à l'il-23r | |
US20090203541A1 (en) | Msp and its domains as frameworks for novel binding molecules | |
EP1225181A1 (fr) | Expression protéique et résolution structurale au moyen de vecteurs de fusion specifiques | |
Class et al. | Patent application title: HSP70-Based Treatment for Autoimmune Diseases and Cancer Inventors: Isabelle Caroline Le Poole (Downers Grove, IL, US) Josephus Dirk Nieland (Arhus C, DK) Thor Las Holtet (Ronde, DK) Thor Las Holtet (Ronde, DK) | |
CN113811542A (zh) | 包含细胞因子和支架蛋白的融合蛋白 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |
Effective date: 20140211 |