CA2774375C - Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury - Google Patents

Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury Download PDF

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Publication number
CA2774375C
CA2774375C CA2774375A CA2774375A CA2774375C CA 2774375 C CA2774375 C CA 2774375C CA 2774375 A CA2774375 A CA 2774375A CA 2774375 A CA2774375 A CA 2774375A CA 2774375 C CA2774375 C CA 2774375C
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Prior art keywords
disease
hepes
composition
demyelination
diseases
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CA2774375A
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English (en)
French (fr)
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CA2774375A1 (en
Inventor
Ivan E. Danhof
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Bespoke Bioscience LLC
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Bespoke Bioscience LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2774375A 2009-09-17 2010-09-17 Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury Active CA2774375C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2977918A CA2977918C (en) 2009-09-17 2010-09-17 Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24346409P 2009-09-17 2009-09-17
US61/243,464 2009-09-17
PCT/US2010/049405 WO2011035212A2 (en) 2009-09-17 2010-09-17 Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2977918A Division CA2977918C (en) 2009-09-17 2010-09-17 Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Publications (2)

Publication Number Publication Date
CA2774375A1 CA2774375A1 (en) 2011-03-24
CA2774375C true CA2774375C (en) 2018-02-13

Family

ID=43757159

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2774375A Active CA2774375C (en) 2009-09-17 2010-09-17 Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury
CA3122553A Pending CA3122553A1 (en) 2009-09-17 2010-09-17 Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury
CA2977918A Active CA2977918C (en) 2009-09-17 2010-09-17 Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Family Applications After (2)

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CA3122553A Pending CA3122553A1 (en) 2009-09-17 2010-09-17 Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury
CA2977918A Active CA2977918C (en) 2009-09-17 2010-09-17 Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Country Status (18)

Country Link
US (4) US8883855B2 (OSRAM)
EP (3) EP2835133B1 (OSRAM)
JP (4) JP2013505264A (OSRAM)
KR (1) KR101737775B1 (OSRAM)
CN (4) CN107260740A (OSRAM)
AR (1) AR078290A1 (OSRAM)
AU (1) AU2010295445B2 (OSRAM)
BR (1) BR112012006155A2 (OSRAM)
CA (3) CA2774375C (OSRAM)
HK (1) HK1199621A1 (OSRAM)
IL (2) IL264055B2 (OSRAM)
IN (1) IN2012DN02499A (OSRAM)
MX (2) MX2012003212A (OSRAM)
MY (2) MY159626A (OSRAM)
NZ (1) NZ598861A (OSRAM)
SG (3) SG10202100421XA (OSRAM)
TW (2) TWI494106B (OSRAM)
WO (1) WO2011035212A2 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012003212A (es) * 2009-09-17 2012-09-07 North Texas Medical Ass Papel del acido n-2-hidroxi-etil-piperazina-n´-2-etano sulfonico (hepes) en el control del dolor y reversion de lesiones por desmielinizacion.
WO2016014419A1 (en) 2014-07-21 2016-01-28 Glia, Llc Method for treating radiotherapy-and-chemotherapy associated cognitive or emotional impairment with cannabinoids
EP3288637B1 (en) * 2015-04-28 2022-09-14 NewSouth Innovations Pty Limited Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641529B2 (en) 1990-07-30 1993-09-23 Bloomfield D.A. Zwitterionic compounds and their N-halo derivatives for use in the treatment of clinical conditions
US5840294A (en) * 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
US5643562A (en) * 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5792881A (en) 1995-07-06 1998-08-11 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Thiolsilanes, method of their production and of their use
US5716959A (en) * 1996-02-13 1998-02-10 T. Ronald Theodore Method of treating disease with piperazine zwitterion compounds
IL137751A0 (en) * 1998-02-11 2001-10-31 Neurochem Inc Method for modulating macrophage activation
CA2585983C (en) 2004-11-10 2014-03-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases
US9308260B2 (en) * 2007-07-05 2016-04-12 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anticonvulsive pharmaceutical compositions
EP2011491A1 (en) 2007-07-05 2009-01-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anticonvulsive pharmaceutical compositions
EP2163246A1 (en) * 2008-09-12 2010-03-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Taurine or taurine-like substances for the prevention of the irreversible visual effects of vigabatrin
JP2013504151A (ja) 2009-09-04 2013-02-04 ビーエーエスエフ ソシエタス・ヨーロピア 色素増感太陽電池
MX2012003212A (es) 2009-09-17 2012-09-07 North Texas Medical Ass Papel del acido n-2-hidroxi-etil-piperazina-n´-2-etano sulfonico (hepes) en el control del dolor y reversion de lesiones por desmielinizacion.
AU2014206220B2 (en) 2009-09-17 2016-09-29 Bespoke Bioscience, Llc Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Also Published As

Publication number Publication date
TWI562777B (en) 2016-12-21
IL218677B (en) 2019-01-31
EP2477626A2 (en) 2012-07-25
MX360190B (es) 2018-10-24
BR112012006155A2 (pt) 2016-06-28
HK1199621A1 (en) 2015-07-10
NZ598861A (en) 2013-01-25
EP3520794A2 (en) 2019-08-07
JP6347807B2 (ja) 2018-06-27
EP2477626A4 (en) 2013-05-22
KR101737775B1 (ko) 2017-05-19
AU2010295445B2 (en) 2014-09-25
JP2015052006A (ja) 2015-03-19
CN103977405A (zh) 2014-08-13
MX2012003212A (es) 2012-09-07
US20180028530A1 (en) 2018-02-01
TWI494106B (zh) 2015-08-01
JP2013505264A (ja) 2013-02-14
JP2016216493A (ja) 2016-12-22
US20110071157A1 (en) 2011-03-24
CA2977918C (en) 2021-08-10
AR078290A1 (es) 2011-10-26
MY174012A (en) 2020-03-03
MY159626A (en) 2017-01-13
US8883855B2 (en) 2014-11-11
US10213425B2 (en) 2019-02-26
US9867820B2 (en) 2018-01-16
AU2010295445A1 (en) 2012-04-12
JP5974062B2 (ja) 2016-08-23
WO2011035212A3 (en) 2011-07-14
EP2835133A1 (en) 2015-02-11
SG10202100421XA (en) 2021-02-25
US20190142825A1 (en) 2019-05-16
CA2774375A1 (en) 2011-03-24
WO2011035212A2 (en) 2011-03-24
EP3520794A3 (en) 2019-11-20
SG179191A1 (en) 2012-04-27
IL264055A (en) 2019-01-31
SG10201500510YA (en) 2015-03-30
US20140378467A1 (en) 2014-12-25
IL218677A0 (en) 2012-05-31
IN2012DN02499A (OSRAM) 2015-08-28
CA3122553A1 (en) 2011-03-24
CA2977918A1 (en) 2011-03-24
IL264055B2 (en) 2024-09-01
KR20120081151A (ko) 2012-07-18
CN109224077A (zh) 2019-01-18
EP2835133B1 (en) 2019-04-24
TW201117813A (en) 2011-06-01
IL264055B1 (en) 2024-05-01
CN102612366A (zh) 2012-07-25
JP2015129150A (ja) 2015-07-16
TW201440769A (zh) 2014-11-01
CN107260740A (zh) 2017-10-20

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