CA2768041A1 - Prodrugs of desazadesferrothiocin polyether analogues as metal chelation agents - Google Patents

Info

Publication number

CA2768041A1

CA2768041A1 CA2768041A CA2768041A CA2768041A1 CA 2768041 A1 CA2768041 A1 CA 2768041A1 CA 2768041 A CA2768041 A CA 2768041A CA 2768041 A CA2768041 A CA 2768041A CA 2768041 A1 CA2768041 A1 CA 2768041A1

Authority

CA

Canada

Prior art keywords

chosen

recited

compound

hydrogen

alkyl

Prior art date

2009-07-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 229910052751 metal Inorganic materials 0.000 title claims abstract description 34
• 239000002184 metal Substances 0.000 title claims abstract description 34
• 239000002738 chelating agent Substances 0.000 title abstract description 17
• 229920000570 polyether Polymers 0.000 title abstract description 13
• 239000004721 Polyphenylene oxide Substances 0.000 title abstract description 9
• 239000000651 prodrug Substances 0.000 title description 48
• 229940002612 prodrug Drugs 0.000 title description 48
• 150000001875 compounds Chemical class 0.000 claims abstract description 183
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 80
• 238000000034 method Methods 0.000 claims abstract description 41
• 229910052742 iron Inorganic materials 0.000 claims abstract description 39
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 27
• 201000010099 disease Diseases 0.000 claims abstract description 12
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 10
• 230000009920 chelation Effects 0.000 claims abstract description 9
• 239000001257 hydrogen Substances 0.000 claims description 91
• 229910052739 hydrogen Inorganic materials 0.000 claims description 91
• 125000000217 alkyl group Chemical group 0.000 claims description 82
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 77
• 150000002431 hydrogen Chemical class 0.000 claims description 69
• 125000003118 aryl group Chemical group 0.000 claims description 43
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 33
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 31
• 125000001072 heteroaryl group Chemical group 0.000 claims description 26
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• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 18
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 16
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 16
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
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