CA2761074A1 - 4 substituted pyrazolopyrimidines useful as pkc-theta inhibitors - Google Patents
4 substituted pyrazolopyrimidines useful as pkc-theta inhibitors Download PDFInfo
- Publication number
- CA2761074A1 CA2761074A1 CA2761074A CA2761074A CA2761074A1 CA 2761074 A1 CA2761074 A1 CA 2761074A1 CA 2761074 A CA2761074 A CA 2761074A CA 2761074 A CA2761074 A CA 2761074A CA 2761074 A1 CA2761074 A1 CA 2761074A1
- Authority
- CA
- Canada
- Prior art keywords
- independently
- compound
- halogen
- optionally
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2010/033711 WO2011139273A1 (en) | 2010-05-05 | 2010-05-05 | 4 substituted pyrazolopyrimidines useful as pkc-theta inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2761074A1 true CA2761074A1 (en) | 2011-11-10 |
Family
ID=42288734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2761074A Abandoned CA2761074A1 (en) | 2010-05-05 | 2010-05-05 | 4 substituted pyrazolopyrimidines useful as pkc-theta inhibitors |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2566866A1 (ja) |
JP (1) | JP2013525481A (ja) |
CN (1) | CN102471342A (ja) |
AU (1) | AU2010352577A1 (ja) |
CA (1) | CA2761074A1 (ja) |
WO (1) | WO2011139273A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104981247A (zh) * | 2012-09-06 | 2015-10-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
WO2016183071A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Hetero-tricyclic compounds and their use for the treatment of cancer |
WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
CA2995997A1 (en) * | 2015-08-26 | 2017-03-02 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
EP3377497A1 (en) | 2015-11-19 | 2018-09-26 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
US9981975B2 (en) | 2016-03-28 | 2018-05-29 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
SG11202002821UA (en) | 2017-09-27 | 2020-04-29 | Incyte Corp | Salts of pyrrolotriazine derivatives useful as tam inhibitors |
CN117771250A (zh) | 2018-06-29 | 2024-03-29 | 因赛特公司 | Axl/mer抑制剂的制剂 |
CN110833559A (zh) * | 2018-08-15 | 2020-02-25 | 广西梧州制药(集团)股份有限公司 | 吡唑并嘧啶衍生物在治疗急性肺损伤致肺纤维化的用途 |
US20240239794A1 (en) | 2021-05-06 | 2024-07-18 | Exscientia Ai Limited | PKC-Theta Modulators |
EP4333982A1 (en) | 2021-05-06 | 2024-03-13 | Exscientia Al Limited | Pkc-theta modulators |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1898243A (zh) * | 2003-12-23 | 2007-01-17 | 诺瓦提斯公司 | 二环杂环类p-38激酶抑制剂 |
WO2006073610A2 (en) * | 2004-11-23 | 2006-07-13 | Reddy Us Therapeutics, Inc. | Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them |
GB0608175D0 (en) * | 2006-04-25 | 2006-06-07 | Astex Therapeutics Ltd | Pharmaceutical Compounds |
MX2010004819A (es) * | 2007-11-02 | 2010-07-05 | Vertex Pharma | Derivados de [1h-pirazolo[3,4-b]piridin-4-il]-fenilo o piridin-2-ilo como proteina cinasa c-theta. |
US8987280B2 (en) * | 2008-01-30 | 2015-03-24 | Genentech, Inc. | Pyrazolopyrimidine PI3K inhibitor compounds and methods of use |
WO2010003133A2 (en) * | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
-
2010
- 2010-05-05 EP EP10721216A patent/EP2566866A1/en not_active Withdrawn
- 2010-05-05 AU AU2010352577A patent/AU2010352577A1/en not_active Abandoned
- 2010-05-05 JP JP2013509037A patent/JP2013525481A/ja active Pending
- 2010-05-05 CN CN201080030395XA patent/CN102471342A/zh active Pending
- 2010-05-05 WO PCT/US2010/033711 patent/WO2011139273A1/en active Application Filing
- 2010-05-05 CA CA2761074A patent/CA2761074A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN102471342A (zh) | 2012-05-23 |
AU2010352577A1 (en) | 2012-01-19 |
JP2013525481A (ja) | 2013-06-20 |
WO2011139273A1 (en) | 2011-11-10 |
EP2566866A1 (en) | 2013-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20140506 |