CA2760166C - Derives d'isoxazole-pyridine - Google Patents

Derives d'isoxazole-pyridine Download PDF

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Publication number
CA2760166C
CA2760166C CA2760166A CA2760166A CA2760166C CA 2760166 C CA2760166 C CA 2760166C CA 2760166 A CA2760166 A CA 2760166A CA 2760166 A CA2760166 A CA 2760166A CA 2760166 C CA2760166 C CA 2760166C
Authority
CA
Canada
Prior art keywords
lower alkyl
pyridine
disorder
carboxylic acid
isoxazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2760166A
Other languages
English (en)
Other versions
CA2760166A1 (fr
Inventor
Roland Jakob-Roetne
Matthew C. Lucas
Andrew Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2760166A1 publication Critical patent/CA2760166A1/fr
Application granted granted Critical
Publication of CA2760166C publication Critical patent/CA2760166C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2760166A 2009-05-05 2010-04-28 Derives d'isoxazole-pyridine Expired - Fee Related CA2760166C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09159457.2 2009-05-05
EP09159457 2009-05-05
PCT/EP2010/055695 WO2010127976A1 (fr) 2009-05-05 2010-04-28 Dérivés d'isoxazole-pyridine

Publications (2)

Publication Number Publication Date
CA2760166A1 CA2760166A1 (fr) 2010-11-11
CA2760166C true CA2760166C (fr) 2017-07-18

Family

ID=42371365

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2760166A Expired - Fee Related CA2760166C (fr) 2009-05-05 2010-04-28 Derives d'isoxazole-pyridine

Country Status (12)

Country Link
US (1) US8415379B2 (fr)
EP (1) EP2427456B1 (fr)
JP (1) JP5466292B2 (fr)
KR (1) KR101367012B1 (fr)
CN (1) CN102414206B (fr)
AU (1) AU2010244553A1 (fr)
BR (1) BRPI1013844A2 (fr)
CA (1) CA2760166C (fr)
IL (1) IL216007A0 (fr)
MX (1) MX2011011489A (fr)
SG (1) SG175867A1 (fr)
WO (1) WO2010127976A1 (fr)

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PL2635277T3 (pl) * 2010-11-05 2019-05-31 Hoffmann La Roche Zastosowanie aktywnych związków farmaceutycznych w leczeniu schorzeń ośrodkowego układu nerwowego
EP2457569A1 (fr) * 2010-11-05 2012-05-30 F. Hoffmann-La Roche AG Utilisation de composés pharmaceutiques actifs pour le traitement de conditions du système nerveux central
CA2840396C (fr) * 2011-06-27 2020-07-14 Merial Limited Composes et compositions d'amidopyridylether et leur utilisation contre des parasites
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014001280A1 (fr) 2012-06-26 2014-01-03 Aniona Aps Dérivé de phényle triazole et son utilisation pour moduler le complexe du récepteur gabaa
WO2014001278A1 (fr) 2012-06-26 2014-01-03 Aniona Aps Dérivé de phényle triazole et son utilisation pour moduler le complexe du récepteur gabaa
WO2014001279A1 (fr) 2012-06-26 2014-01-03 Aniona Aps Dérivé de phényle triazole et son utilisation pour moduler le complexe du récepteur gabaa
WO2014001281A1 (fr) 2012-06-26 2014-01-03 Aniona Aps Dérivé de phényle triazole et son utilisation pour moduler le complexe du récepteur gabaa
EP2885290B1 (fr) 2012-06-26 2017-10-18 Saniona A/S Un dérivé de phényl triazole et son utilisation pour moduler le complexe du récepteur gabaa
CA2915561C (fr) 2013-06-21 2020-09-22 Zenith Epigenetics Corp. Nouveaux composes bicycliques substitues utilises comme inhibiteurs de bromodomaines
WO2015002754A2 (fr) 2013-06-21 2015-01-08 Zenith Epigenetics Corp. Nouveaux inhibiteurs de bromodomaines bicycliques
CN105593224B (zh) 2013-07-31 2021-05-25 恒元生物医药科技(苏州)有限公司 作为溴结构域抑制剂的新型喹唑啉酮类化合物
EP3227281A4 (fr) 2014-12-01 2018-05-30 Zenith Epigenetics Ltd. Pyridinones substituées utilisées comme inhibiteurs de bromodomaines
EP3227280B1 (fr) 2014-12-01 2019-04-24 Zenith Epigenetics Ltd. Pyridines substituées comme inhibiteurs de bromodomaine
WO2016092375A1 (fr) 2014-12-11 2016-06-16 Zenith Epigenetics Corp. Hétérocycles substitués à titre d'inhibiteurs de bromodomaines
WO2016097863A1 (fr) 2014-12-17 2016-06-23 Zenith Epigenetics Corp. Inhibiteurs de bromodomaines
AU2017287716B2 (en) * 2016-06-27 2019-08-08 Korea Research Institute Of Chemical Technology Pyridine-based compound including isoxazoline ring, and use thereof as herbicide
ES2910110T3 (es) 2016-12-08 2022-05-11 Hoffmann La Roche Nuevos derivados de isoxazolil-éter como PAM de alfa 5 GABA A
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
WO2022234271A1 (fr) 2021-05-05 2022-11-10 University College Cardiff Consultants Limited Composés hétéroaryle pouvant être utilisés dans le traitement de troubles cognitifs

Family Cites Families (31)

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DE3525205A1 (de) 1984-09-11 1986-03-20 Hoechst Ag, 6230 Frankfurt Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols
GB9808663D0 (en) 1998-04-23 1998-06-24 Merck Sharp & Dohme Therapeutic agents
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
IT1314191B1 (it) 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
EP1228069B1 (fr) 1999-11-12 2003-04-02 Neurogen Corporation Composes heteroaromatiques bicycliques et tricycliques
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
MXPA03011886A (es) 2001-07-05 2005-03-07 Lundbeck & Co As H Piperidinias anilinicas sustituidas como antagonistas selectivos de mch.
ATE381542T1 (de) 2001-08-13 2008-01-15 Phenex Pharmaceuticals Ag Nr1h4-kern-rezeptor-bindende verbindungen
WO2003044017A1 (fr) 2001-11-20 2003-05-30 Eli Lilly And Company Agonistes beta 3 adrenergiques
GB0128160D0 (en) 2001-11-23 2002-01-16 Merck Sharp & Dohme Novel compounds
EP1562915A1 (fr) 2002-11-22 2005-08-17 SmithKline Beecham Corporation Agonistes de recepteur farnesoide x
GB0318447D0 (en) 2003-08-05 2003-09-10 Merck Sharp & Dohme Therapeutic agents
PL1756086T3 (pl) 2004-06-01 2008-11-28 Hoffmann La Roche Pirydyn-4-ylo-etynylo-imidazole i pirazole jako antagoniści receptora mGlu5
US20080153869A1 (en) 2004-06-14 2008-06-26 Bressi Jerome C Kinase Inhibitors
CA2581945C (fr) 2004-10-01 2011-01-18 Henrietta Dehmlow Derives d'ether substitues par du hexafluoroisopropanol
EP1812427A4 (fr) 2004-10-15 2009-10-14 Scripps Research Inst Inhibiteurs oxadiazole cetone d'hydrolase d'amide d'acide gras
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KR100976675B1 (ko) * 2005-09-19 2010-08-18 에프. 호프만-라 로슈 아게 Ｇａｂａ ａ 알파5 역작용물질로서의 아이속사졸로 유도체
US7334639B2 (en) * 2005-09-30 2008-02-26 M-I Llc In-situ solidification of invert emulsion fluids to form gas tight annular barrier
WO2007052843A1 (fr) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited Compose amide heterocyclique et son utilisation
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EP1894924A1 (fr) 2006-08-29 2008-03-05 Phenex Pharmaceuticals AG Composés hétérocycliques de liason du FXR
EP1894928A1 (fr) 2006-08-29 2008-03-05 PheneX Pharmaceuticals AG Composes heterocycliques de liaison au fxr
DK2227467T3 (en) * 2007-12-04 2015-01-19 Hoffmann La Roche Isoxazolo-pyridine derivatives
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AU2008333320B2 (en) * 2007-12-04 2012-12-20 F. Hoffmann-La Roche Ag Isoxazolo-pyrazine derivatives

Also Published As

Publication number Publication date
CN102414206B (zh) 2014-11-05
KR20120018349A (ko) 2012-03-02
KR101367012B1 (ko) 2014-03-14
WO2010127976A1 (fr) 2010-11-11
US20100286132A1 (en) 2010-11-11
JP2012526071A (ja) 2012-10-25
US8415379B2 (en) 2013-04-09
AU2010244553A1 (en) 2011-12-01
MX2011011489A (es) 2011-11-18
BRPI1013844A2 (pt) 2016-04-12
JP5466292B2 (ja) 2014-04-09
SG175867A1 (en) 2011-12-29
EP2427456A1 (fr) 2012-03-14
CA2760166A1 (fr) 2010-11-11
IL216007A0 (en) 2012-01-31
EP2427456B1 (fr) 2020-02-05
CN102414206A (zh) 2012-04-11

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EEER Examination request

Effective date: 20150423

MKLA Lapsed

Effective date: 20190429