CA2759984A1 - Formulation of tocotrienol quinones for the treatment of ophthalmic diseases - Google Patents
Formulation of tocotrienol quinones for the treatment of ophthalmic diseases Download PDFInfo
- Publication number
- CA2759984A1 CA2759984A1 CA2759984A CA2759984A CA2759984A1 CA 2759984 A1 CA2759984 A1 CA 2759984A1 CA 2759984 A CA2759984 A CA 2759984A CA 2759984 A CA2759984 A CA 2759984A CA 2759984 A1 CA2759984 A1 CA 2759984A1
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- Prior art keywords
- formulation
- deficiency
- tocotrienol quinone
- disease
- complex
- Prior art date
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Landscapes
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| US61/318,737 | 2010-03-29 | ||
| PCT/US2010/032621 WO2010126909A1 (en) | 2009-04-28 | 2010-04-27 | Formulation of tocotrienol quinones for the treatment of ophthalmic diseases |
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| WO2005033093A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| DK2471530T3 (en) * | 2005-06-01 | 2017-04-10 | Edison Pharmaceuticals Inc | REDOXACTIVE THERAPEUTIC AGENTS FOR THE TREATMENT OF MITOCONDARY DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS |
| EP1986636B1 (en) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
| HUE028502T2 (en) | 2007-11-06 | 2016-12-28 | Edison Pharmaceuticals Inc | 4- (P-Quinonyl) -2-hydroxybutanamide derivatives for the treatment of mitochondrial diseases |
| EP2237664A4 (en) * | 2008-01-08 | 2013-05-22 | Edison Pharmaceuticals Inc | (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES |
| US8716527B2 (en) | 2008-03-05 | 2014-05-06 | Edison Pharmaceuticals, Inc. | 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases |
| US8716486B2 (en) * | 2008-06-25 | 2014-05-06 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
| US10039722B2 (en) | 2008-10-14 | 2018-08-07 | Bioelectron Technology Corporation | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| ES2553557T3 (es) | 2008-10-28 | 2015-12-10 | Edison Pharmaceuticals, Inc. | Proceso para la producción de alfa-tocotrienol y derivados |
| HUE037574T2 (hu) | 2009-04-28 | 2018-09-28 | Bioelectron Tech Corp | Leber-féle örökletes optikus neuropátia és domináns optikus atrofia kezelése tokotrienol kinonokkal |
| CN102548548B (zh) * | 2009-06-10 | 2017-09-01 | 米拓科技有限公司（卢森堡） | 用于医学和兽医学的眼科药物组合物 |
| US20110207828A1 (en) * | 2009-08-26 | 2011-08-25 | Miller Guy M | Methods for the prevention and treatment of cerebral ischemia |
| CA2797644A1 (en) * | 2009-12-31 | 2011-07-07 | Edison Pharmaceuticals, Inc. | Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones |
| JP2013523816A (ja) * | 2010-04-06 | 2013-06-17 | エジソン ファーマシューティカルズ， インコーポレイテッド | 毛細血管拡張性運動失調症の治療 |
| US20120295985A1 (en) * | 2010-11-19 | 2012-11-22 | Miller Guy M | Methods for improving blood glucose control |
| EP2714024B1 (en) | 2011-06-03 | 2018-10-03 | Mitotech SA | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
| WO2012174286A1 (en) | 2011-06-14 | 2012-12-20 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| WO2013006736A1 (en) * | 2011-07-06 | 2013-01-10 | Edison Pharmaceuticals, Inc | Treatment of leigh syndrome and leigh-like syndrome, including complications of sucla2 mutations, with tocotrienol quinones |
| WO2013006737A1 (en) * | 2011-07-06 | 2013-01-10 | Edison Pharmaceuticals, Inc. | Treatment of methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones |
| WO2013013078A1 (en) | 2011-07-19 | 2013-01-24 | Edison Pharmeceuticals, Inc. | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| EP2573063A1 (en) | 2011-09-23 | 2013-03-27 | DSM IP Assets B.V. | Process for preparing chiral quinone |
| US9629815B2 (en) | 2012-09-07 | 2017-04-25 | Bioelectron Technology Corporation | Benzoquinone derivatives for treating oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| CA2906145A1 (en) | 2013-03-15 | 2014-09-18 | Edison Pharmaceuticals, Inc. | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
| WO2015183963A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including redox-active parabenzoquinones and uses thereof |
| NZ733528A (en) | 2014-12-16 | 2021-07-30 | Ptc Therapeutics Inc | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| JP7117241B2 (ja) | 2015-12-16 | 2022-08-12 | ピーティーシー セラピューティクス， インコーポレイテッド | 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法 |
| CA3008849A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| US20190365705A1 (en) * | 2017-01-20 | 2019-12-05 | Ohio State Innovation Foundation | Topical tocotrienol compositions and methods of increasing skin stem cells |
| HUE066196T2 (hu) | 2018-10-17 | 2024-07-28 | Ptc Therapeutics Inc | 2,3,5-trimetil-6-nonilciklohexa-2,5-dién-1,4-dion alfa-szinukleinopátiák, tauopátiák és egyéb rendellenességek szuppresszálására és kezelésére |
| CA3225266A1 (en) | 2021-07-08 | 2023-01-12 | Swathi PINNAMANENI | Pharmaceutical compositions comprising 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione |
| WO2024259130A1 (en) * | 2023-06-16 | 2024-12-19 | Ptc Therapeutics, Inc. | Methods for increasing vatiquinone plasma exposure with food |
| WO2025024247A1 (en) * | 2023-07-21 | 2025-01-30 | Stealth Biotherapeutics Inc. | Methods, compositions and uses related to the treatment and prevention of leigh's syndrome |
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| US5318993A (en) * | 1993-04-16 | 1994-06-07 | Bristol-Myers Squibb Company | Antihyperlipidemic benzoquinones |
| EP1378753B1 (en) * | 2002-07-01 | 2006-05-31 | Santhera Pharmaceuticals (Schweiz) GmbH | A screening method and compounds for treating Friedreich Ataxia |
| US7015243B2 (en) * | 2003-08-28 | 2006-03-21 | Allergan, Inc. | Cyclohexyl prostaglandin analogs as EP4-receptor agonists |
| WO2005033093A1 (en) * | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| US20050074447A1 (en) * | 2003-10-01 | 2005-04-07 | Papas Andreas M. | Treatment for diabetic microvascular and macrovascular complications |
| US8182990B2 (en) * | 2004-03-18 | 2012-05-22 | Rusk Intellectual Reserve Ag | Method for diagnosing or predicting susceptibility to optic neuropathy |
| DK2471530T3 (en) * | 2005-06-01 | 2017-04-10 | Edison Pharmaceuticals Inc | REDOXACTIVE THERAPEUTIC AGENTS FOR THE TREATMENT OF MITOCONDARY DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS |
| EP1986636B1 (en) * | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
| WO2008157747A1 (en) * | 2007-06-21 | 2008-12-24 | The Jackson Laboratory | Use of inhibition of exonuclease 1 in methods for therapy and diagnostic of neurodegenerative diseases, eye diseases, and mitochondrial disorders |
-
2010
- 2010-04-27 EA EA201101576A patent/EA201101576A1/ru unknown
- 2010-04-27 JP JP2012508606A patent/JP2012525397A/ja not_active Withdrawn
- 2010-04-27 WO PCT/US2010/032621 patent/WO2010126909A1/en not_active Ceased
- 2010-04-27 BR BRPI1013377A patent/BRPI1013377A2/pt not_active Application Discontinuation
- 2010-04-27 MX MX2011011310A patent/MX2011011310A/es not_active Application Discontinuation
- 2010-04-27 US US12/768,554 patent/US20100273892A1/en not_active Abandoned
- 2010-04-27 EP EP10715649A patent/EP2424494A1/en not_active Withdrawn
- 2010-04-27 CA CA2759984A patent/CA2759984A1/en not_active Abandoned
-
2013
- 2013-01-10 US US13/738,827 patent/US20140031433A1/en not_active Abandoned
-
2014
- 2014-11-20 JP JP2014235405A patent/JP2015038154A/ja not_active Withdrawn
-
2016
- 2016-04-11 JP JP2016078793A patent/JP2016128523A/ja active Pending
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2017
- 2017-08-07 JP JP2017152470A patent/JP2017193594A/ja active Pending
- 2017-12-20 US US15/849,557 patent/US20180116978A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016128523A (ja) | 2016-07-14 |
| JP2012525397A (ja) | 2012-10-22 |
| US20140031433A1 (en) | 2014-01-30 |
| US20180116978A1 (en) | 2018-05-03 |
| WO2010126909A1 (en) | 2010-11-04 |
| EP2424494A1 (en) | 2012-03-07 |
| BRPI1013377A2 (pt) | 2017-03-21 |
| JP2017193594A (ja) | 2017-10-26 |
| JP2015038154A (ja) | 2015-02-26 |
| MX2011011310A (es) | 2011-11-18 |
| US20100273892A1 (en) | 2010-10-28 |
| EA201101576A1 (ru) | 2012-04-30 |
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