CA2757240A1 - Formulation for inducing broadly reactive neutralizing anti-hiv antibodies - Google Patents
Formulation for inducing broadly reactive neutralizing anti-hiv antibodies Download PDFInfo
- Publication number
- CA2757240A1 CA2757240A1 CA2757240A CA2757240A CA2757240A1 CA 2757240 A1 CA2757240 A1 CA 2757240A1 CA 2757240 A CA2757240 A CA 2757240A CA 2757240 A CA2757240 A CA 2757240A CA 2757240 A1 CA2757240 A1 CA 2757240A1
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- ligand
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- hiv
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- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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| US16662509P | 2009-04-03 | 2009-04-03 | |
| US61/166,625 | 2009-04-03 | ||
| PCT/US2010/001017 WO2010114628A2 (en) | 2009-04-03 | 2010-04-05 | Formulation for inducing broadly reactive neutralizing anti-hiv antibodies |
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| CA2757240A1 true CA2757240A1 (en) | 2010-10-07 |
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| WO2006110831A2 (en) * | 2005-04-12 | 2006-10-19 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| CA2683752A1 (en) * | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20140322262A1 (en) * | 2007-09-28 | 2014-10-30 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20120070488A1 (en) * | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| JP2013505201A (ja) | 2009-04-03 | 2013-02-14 | デューク ユニバーシティー | 広域反応性中和抗ｈｉｖ抗体を誘導するための配合物 |
| CA2791025A1 (en) | 2010-02-25 | 2011-09-01 | Duke University | Method of inducing the production of protective anti-hiv-1 antibodies |
| WO2012101509A2 (en) * | 2011-01-28 | 2012-08-02 | Sanofi Pasteur Sa | Immunological compositions against hiv |
| WO2014020205A2 (es) * | 2012-07-31 | 2014-02-06 | Universidad De Granada | Inmunógenos anti-vih mejorados |
| AU2013332272B2 (en) | 2012-10-19 | 2018-12-20 | The Council Of The Queensland Institute Of Medical Research | Improved human herpesvirus immunotherapy |
| US10076567B2 (en) | 2013-09-27 | 2018-09-18 | Duke University | MPER-liposome conjugates and uses thereof |
| WO2024097957A1 (en) * | 2022-11-03 | 2024-05-10 | Duke University | Novel antibodies for hiv and methods of making and using the same |
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| CN1122576A (zh) | 1993-03-11 | 1996-05-15 | 南加利福尼亚大学 | 免疫感染簇病毒感染的治疗策略 |
| DK0702563T3 (da) | 1993-05-27 | 2003-11-10 | Entremed Inc | Sammensætninger og fremgangsmåder til behandling af cancer og hyperproliferative sygdomme |
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| US6156337A (en) | 1994-07-08 | 2000-12-05 | Opperbas Holding B.V. | Method for high loading of vesicles with biopolymeric substances |
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| CA2511538C (en) | 2002-12-30 | 2013-11-26 | 3M Innovative Properties Company | Immunostimulatory combinations |
| EP1613643A4 (en) | 2003-03-27 | 2009-10-28 | Sudhir Paul | LUPUS ANTIBODIES FOR THE PASSIVE IMMUNE THERAPY OF HIV / AIDS |
| WO2006110831A2 (en) | 2005-04-12 | 2006-10-19 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20080057075A1 (en) | 2005-04-12 | 2008-03-06 | Haynes Barton F | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| CA2683752A1 (en) * | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| DK2148697T3 (da) | 2007-05-24 | 2012-12-17 | Glaxosmithkline Biolog Sa | Lyofiliseret CPG indeholdende WT-1-sammensætning |
| US20120070488A1 (en) | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20140322262A1 (en) | 2007-09-28 | 2014-10-30 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| WO2009111304A2 (en) | 2008-02-29 | 2009-09-11 | President And Fellows Of Harvard College | A fusion-intermediate state of hiv-1 gp41 targeted by broadly neutralizing antibodies |
| SMT202000101T1 (it) | 2008-10-10 | 2020-03-13 | Childrens Medical Center | Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente |
| EP2334329A1 (en) | 2008-10-16 | 2011-06-22 | New York Blood Center | Immunoenhancer-linked oligomeric hiv vaccines |
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| EP2413951A4 (en) | 2015-05-20 |
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| WO2010114628A9 (en) | 2010-11-25 |
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