CA2750844A1 - Triptolide c-ring derivatives as anticancer agents and immune modulators - Google Patents
Triptolide c-ring derivatives as anticancer agents and immune modulators Download PDFInfo
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- CA2750844A1 CA2750844A1 CA2750844A CA2750844A CA2750844A1 CA 2750844 A1 CA2750844 A1 CA 2750844A1 CA 2750844 A CA2750844 A CA 2750844A CA 2750844 A CA2750844 A CA 2750844A CA 2750844 A1 CA2750844 A1 CA 2750844A1
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- compound
- triptolide
- disease
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15020709P | 2009-02-05 | 2009-02-05 | |
| US61/150,207 | 2009-02-05 | ||
| PCT/US2010/023220 WO2010091193A2 (en) | 2009-02-05 | 2010-02-04 | Triptolide c-ring derivatives as anticancer agents and immune modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2750844A1 true CA2750844A1 (en) | 2010-08-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2750844A Abandoned CA2750844A1 (en) | 2009-02-05 | 2010-02-04 | Triptolide c-ring derivatives as anticancer agents and immune modulators |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8268882B2 (OSRAM) |
| EP (1) | EP2393818A4 (OSRAM) |
| JP (1) | JP5653939B2 (OSRAM) |
| CN (2) | CN102307881B (OSRAM) |
| AU (1) | AU2010210594B2 (OSRAM) |
| CA (1) | CA2750844A1 (OSRAM) |
| WO (1) | WO2010091193A2 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI480040B (zh) * | 2012-06-11 | 2015-04-11 | Univ Kaohsiung Medical | 雷公藤甲素用於製備治療與運動神經元存活蛋白質表現相關之疾病的藥物的用途 |
| WO2014031979A1 (en) | 2012-08-23 | 2014-02-27 | Dyer, Cheryl, A. | Reducing the reproductive capacity of mammals |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| CN1027371C (zh) * | 1989-09-08 | 1995-01-11 | 中国医学科学院皮肤病研究所 | 二萜内酯化合物的合成方法 |
| AU7570191A (en) | 1990-03-14 | 1991-10-10 | Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
| NZ500762A (en) * | 1997-05-23 | 2001-08-31 | Aventis Pharma Inc | Triptolide derivatives substituted with amino acids, useful in the treatment of autoimmune diseases |
| US6004999A (en) * | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| EP1109789B1 (en) * | 1998-09-02 | 2003-07-16 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| JP2001081030A (ja) * | 1999-07-13 | 2001-03-27 | Mitsuhiro Hatta | 免疫抑制剤の副作用防御剤 |
| WO2002017931A1 (fr) | 2000-09-01 | 2002-03-07 | Xiaomin Wang | Utilisation d'un ou de plusieurs extraits de tripterygium wilfordii hook.f pour la preparation de medicaments destines a prevenir et a traiter des troubles du systeme nerveux |
| US6620843B2 (en) * | 2001-01-19 | 2003-09-16 | Pharmagenesis | Anticancer treatment using triptolide prodrugs |
| US6569893B2 (en) * | 2001-03-15 | 2003-05-27 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents |
| US7847109B2 (en) * | 2002-05-31 | 2010-12-07 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| JP2004168713A (ja) * | 2002-11-20 | 2004-06-17 | St Marianna Univ School Of Medicine | アポトーシス誘導剤 |
| CN1726025A (zh) * | 2002-12-17 | 2006-01-25 | 泛华医药公司 | 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物 |
| CN100408583C (zh) * | 2003-02-25 | 2008-08-06 | 美国泛华医药公司 | 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| WO2005000291A1 (en) | 2003-06-27 | 2005-01-06 | Pharmagenesis, Inc. | Method for treatment of idiopathic pulmonary fibrosis using triptolide derivatives |
| WO2005062913A2 (en) * | 2003-12-24 | 2005-07-14 | Pharmagenesis, Inc. | Triplide 5,6-derivatives as immunomodulators and anticancer agents |
| US7863464B2 (en) * | 2004-03-02 | 2011-01-04 | Pharmagenesis, Inc. | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
| CN100374443C (zh) * | 2004-03-29 | 2008-03-12 | 北京键凯科技有限公司 | 亲水性聚合物-雷公藤提取物的结合物及其药物组合物 |
| WO2009023201A1 (en) * | 2007-08-16 | 2009-02-19 | Myelorx Llc | Rigid derivatives of triptolide as anticancer, immune suppressant, anti-fibrosis, and cns protectant agents |
-
2010
- 2010-02-04 US US13/147,587 patent/US8268882B2/en not_active Expired - Fee Related
- 2010-02-04 EP EP10739131.0A patent/EP2393818A4/en not_active Withdrawn
- 2010-02-04 CN CN201080006751.4A patent/CN102307881B/zh not_active Expired - Fee Related
- 2010-02-04 AU AU2010210594A patent/AU2010210594B2/en not_active Ceased
- 2010-02-04 WO PCT/US2010/023220 patent/WO2010091193A2/en not_active Ceased
- 2010-02-04 CA CA2750844A patent/CA2750844A1/en not_active Abandoned
- 2010-02-04 CN CN201410448310.XA patent/CN104387406A/zh active Pending
- 2010-02-04 JP JP2011549263A patent/JP5653939B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2393818A2 (en) | 2011-12-14 |
| AU2010210594A1 (en) | 2011-08-18 |
| WO2010091193A2 (en) | 2010-08-12 |
| CN102307881A (zh) | 2012-01-04 |
| US20110288166A1 (en) | 2011-11-24 |
| EP2393818A4 (en) | 2013-09-04 |
| JP2012516899A (ja) | 2012-07-26 |
| WO2010091193A3 (en) | 2011-02-03 |
| AU2010210594B2 (en) | 2015-02-12 |
| US8268882B2 (en) | 2012-09-18 |
| JP5653939B2 (ja) | 2015-01-14 |
| CN104387406A (zh) | 2015-03-04 |
| CN102307881B (zh) | 2014-12-24 |
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| Publication | Publication Date | Title |
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| US8426616B2 (en) | Triptolide lactone ring derivatives as immunomodulators and anticancer agents | |
| US6569893B2 (en) | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents | |
| EP1603555B1 (en) | Halogenated triptolide derivatives as immunomodulators and anticancer agents | |
| US7019151B2 (en) | Triptolide derivatives as immunomodulators and anticancer agents | |
| US7820834B2 (en) | Triptolide 5,6-derivatives as immunomodulators and anticancer agents | |
| US8268882B2 (en) | Triptolide C-ring derivatives as anticancer agents and immune modulators |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20160204 |