CA2747602A1 - 3.1.0 bicyclic glyt1 inhibitors and methods of making and using same - Google Patents
3.1.0 bicyclic glyt1 inhibitors and methods of making and using same Download PDFInfo
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- CA2747602A1 CA2747602A1 CA2747602A CA2747602A CA2747602A1 CA 2747602 A1 CA2747602 A1 CA 2747602A1 CA 2747602 A CA2747602 A CA 2747602A CA 2747602 A CA2747602 A CA 2747602A CA 2747602 A1 CA2747602 A1 CA 2747602A1
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- optionally substituted
- hydrogen
- organic residue
- independently selected
- carbons
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- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (3)
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| US14103008P | 2008-12-29 | 2008-12-29 | |
| US61/141,030 | 2008-12-29 | ||
| PCT/US2009/069716 WO2010078348A1 (en) | 2008-12-29 | 2009-12-29 | 3.1.0 bicyclic glyt1 inhibitors and methods of making and using same |
Publications (1)
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| CA2747602A1 true CA2747602A1 (en) | 2010-07-08 |
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| EP (1) | EP2381941A4 (enExample) |
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| US9012489B2 (en) * | 2011-08-03 | 2015-04-21 | Boehringer Ingelheim International Gmbh | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament |
| BR112016025910A8 (pt) * | 2014-05-06 | 2021-07-13 | Univ Northwestern | uso de uma quantidade eficaz de glyx-13, uso de glyx-13 e um antagonista de nmdar e composição farmaceuticamente aceitável compreendendo os mesmos |
| US9987242B2 (en) | 2015-05-05 | 2018-06-05 | Northwestern University | Treatment of Levodopa-induced Dyskinesias |
| CR20210545A (es) * | 2019-05-01 | 2021-12-23 | Boehringer Ingelheim Int | Formas sólidas de un inhibidor de glyt1 |
| CA3188340A1 (en) | 2020-08-13 | 2022-02-17 | Boehringer Ingelheim International Gmbh | Treatment of cognitive impairement associated with schizophrenia |
| KR20230088761A (ko) | 2020-10-13 | 2023-06-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 재가공하는 방법 |
| JP2025528779A (ja) | 2022-08-09 | 2025-09-02 | シーザン ハイスーク ファーマシューティカル カンパニー リミテッド | Ｐｄｅ４ｂ阻害剤及びその用途 |
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| US5981168A (en) * | 1998-05-15 | 1999-11-09 | The University Of British Columbia | Method and composition for modulating amyloidosis |
| EA009903B1 (ru) * | 2003-10-14 | 2008-04-28 | Пфайзер Продактс Инк. | Бициклические [3.1.0] производные в качестве ингибиторов переносчиков глицина |
| AU2005317846B2 (en) * | 2004-12-21 | 2011-12-08 | Merck Sharp & Dohme Limited | Piperidine and azetidine derivatives as GlyT1 inhibitors |
| US20080319043A1 (en) * | 2005-05-03 | 2008-12-25 | Mohammad Salman | 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists |
| GB0523998D0 (en) * | 2005-11-25 | 2006-01-04 | Merck Sharp & Dohme | Therapeutic agents |
| CL2007002809A1 (es) * | 2006-09-29 | 2008-04-18 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 3-aza biciclo [3.1.0]hexano; y su uso en el tratamiento de enfermedades tales como desordenes psicoticos y de ansiedad, desordenes del sueno, uso y abuso de sustancias psicoactivas, demencia y deterioro de funciones cognitivas |
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Also Published As
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| RU2011124709A (ru) | 2013-02-10 |
| JP2012514006A (ja) | 2012-06-21 |
| KR20110117087A (ko) | 2011-10-26 |
| US20100256192A1 (en) | 2010-10-07 |
| BRPI0923878A2 (pt) | 2015-07-28 |
| IL213541A0 (en) | 2011-07-31 |
| AU2009335120A1 (en) | 2011-07-07 |
| WO2010078348A1 (en) | 2010-07-08 |
| CN102271677A (zh) | 2011-12-07 |
| US8497289B2 (en) | 2013-07-30 |
| MX2011006845A (es) | 2011-08-04 |
| EP2381941A4 (en) | 2012-08-01 |
| EP2381941A1 (en) | 2011-11-02 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20141230 |