CA2747000C - Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine - Google Patents

Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine Download PDF

Info

Publication number
CA2747000C
CA2747000C CA2747000A CA2747000A CA2747000C CA 2747000 C CA2747000 C CA 2747000C CA 2747000 A CA2747000 A CA 2747000A CA 2747000 A CA2747000 A CA 2747000A CA 2747000 C CA2747000 C CA 2747000C
Authority
CA
Canada
Prior art keywords
eszopiclone
besylate
maleate
zopiclone
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2747000A
Other languages
English (en)
Other versions
CA2747000A1 (fr
Inventor
H. Scott Wilkinson
Richard Hsia
Tushar Misra
Kostas Saranteas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sunovion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunovion Pharmaceuticals Inc filed Critical Sunovion Pharmaceuticals Inc
Priority to CA2812705A priority Critical patent/CA2812705C/fr
Publication of CA2747000A1 publication Critical patent/CA2747000A1/fr
Application granted granted Critical
Publication of CA2747000C publication Critical patent/CA2747000C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2747000A 2007-12-19 2008-12-18 Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine Expired - Fee Related CA2747000C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2812705A CA2812705C (fr) 2007-12-19 2008-12-18 Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US836307P 2007-12-19 2007-12-19
US836407P 2007-12-19 2007-12-19
US836507P 2007-12-19 2007-12-19
US61/008,363 2007-12-19
US61/008,364 2007-12-19
US61/008,365 2007-12-19
PCT/US2008/087461 WO2009085972A1 (fr) 2007-12-19 2008-12-18 Sels de maléate, de bésylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-méthyl-1-pipérazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2812705A Division CA2812705C (fr) 2007-12-19 2008-12-18 Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine

Publications (2)

Publication Number Publication Date
CA2747000A1 CA2747000A1 (fr) 2009-07-09
CA2747000C true CA2747000C (fr) 2013-09-03

Family

ID=40404919

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2812705A Expired - Fee Related CA2812705C (fr) 2007-12-19 2008-12-18 Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine
CA2747000A Expired - Fee Related CA2747000C (fr) 2007-12-19 2008-12-18 Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2812705A Expired - Fee Related CA2812705C (fr) 2007-12-19 2008-12-18 Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine

Country Status (4)

Country Link
AR (1) AR069867A1 (fr)
CA (2) CA2812705C (fr)
TW (1) TW200940543A (fr)
WO (1) WO2009085972A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8269005B2 (en) 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8212036B2 (en) 2007-12-19 2012-07-03 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
TW202241853A (zh) 2009-01-16 2022-11-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA04285A (fr) * 1972-01-07 1979-12-31 Rhone Poulenc Sa Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
FR2671800B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) * 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
WO1993010787A1 (fr) * 1991-12-02 1993-06-10 Sepracor, Inc. Procedes et compositions therapeutiques de troubles du sommeil, d'attaques epileptiques et d'autres troubles au moyen de zopiclone (+) optiquement pure
PT1691811E (pt) * 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
WO2005063248A1 (fr) * 2003-12-22 2005-07-14 Sepracor Inc. Therapie combinatoire avec la modafinile pour ameliorer la qualite du sommeil
US7776858B2 (en) * 2004-04-05 2010-08-17 Sepracor Inc. Methods of treatment of chronic pain using eszopiclone
US20080293726A1 (en) * 2005-07-06 2008-11-27 Sepracor Inc. Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders

Also Published As

Publication number Publication date
WO2009085972A1 (fr) 2009-07-09
CA2812705C (fr) 2015-08-18
TW200940543A (en) 2009-10-01
CA2747000A1 (fr) 2009-07-09
AR069867A1 (es) 2010-02-24
CA2812705A1 (fr) 2009-07-09

Similar Documents

Publication Publication Date Title
US8889685B2 (en) Method for treating a sleep disorder with eszopiclone maleate
US8889686B2 (en) Method of decreasing the bitterness of a pharmaceutical dosage form containing zopiclone
US8809332B2 (en) Method for treating anxiety with a dosage form of besylate salts of zopiclone or eszopiclone
US8268832B2 (en) Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8269005B2 (en) L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US7456173B2 (en) Compositions comprising zopiclone derivatives and methods of making and using the same
CA2747000C (fr) Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine
CA2747008C (fr) Sels de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b] pyrazine
JP2004517852A (ja) インドール誘導体および５−ｈｔ２ｂおよび５−ｈｔ２ｃ受容体リガンドとしてのそれらの使用
EA009042B1 (ru) Соль фосфорной кислоты ингибитора дипептидилпептидазы-iv
TW200811181A (en) Purinone derivatives as HM74a agonists
MXPA01011534A (es) Metodos de preparar y utilizar n-desmetilzopiclona.
EP0430201B1 (fr) Aminocarbonylcarbamates apparentés à la physostigmine, leur procédé de préparation et leur utilisation comme médicaments
KR20140111044A (ko) 구연산아일데나필 결정 형태 o 및 그의 제조방법과 용도
EP2981538B1 (fr) Pipérazino[1,2-a]indol-1-ones et [1,4]diazépino[1,2-a]indol-1-one
CN116535390A (zh) pH敏感型4-酰胺哌啶类衍生物、药物组合物及其制备方法和应用
JPH01165588A (ja) ５，６，７，８‐テトラハイドロ‐４ｈ‐イソオキサゾロ〔４，５‐ｃ〕アゼピン誘導体、異性体およびそれらの酸付加塩
CA2485869A1 (fr) Medicaments preventifs ou therapeutiques par voie orale contre la pollakiurie et l'incontinence urinaire, ou inducteurs de sommeil, contenant des derives de tropolone

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20181218