CA2742377C - Low total salt reagent compositions and systems for biosensors - Google Patents
Low total salt reagent compositions and systems for biosensors Download PDFInfo
- Publication number
- CA2742377C CA2742377C CA2742377A CA2742377A CA2742377C CA 2742377 C CA2742377 C CA 2742377C CA 2742377 A CA2742377 A CA 2742377A CA 2742377 A CA2742377 A CA 2742377A CA 2742377 C CA2742377 C CA 2742377C
- Authority
- CA
- Canada
- Prior art keywords
- reagent composition
- per
- nmol
- mediator
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 296
- 239000000203 mixture Substances 0.000 title claims description 281
- 150000003839 salts Chemical class 0.000 title description 57
- 239000012491 analyte Substances 0.000 claims abstract description 97
- 102000004190 Enzymes Human genes 0.000 claims abstract description 69
- 108090000790 Enzymes Proteins 0.000 claims abstract description 69
- 239000000337 buffer salt Substances 0.000 claims abstract description 61
- 239000004020 conductor Substances 0.000 claims abstract description 60
- 239000011230 binding agent Substances 0.000 claims abstract description 47
- -1 transition metal salt Chemical class 0.000 claims abstract description 44
- 238000005259 measurement Methods 0.000 claims abstract description 39
- 229910052723 transition metal Inorganic materials 0.000 claims abstract description 35
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- 238000006479 redox reaction Methods 0.000 claims abstract description 12
- 238000012360 testing method Methods 0.000 claims description 105
- 239000002736 nonionic surfactant Substances 0.000 claims description 32
- 239000003945 anionic surfactant Substances 0.000 claims description 18
- 239000004094 surface-active agent Substances 0.000 claims description 18
- 239000002563 ionic surfactant Substances 0.000 claims description 7
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 6
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 6
- 235000019800 disodium phosphate Nutrition 0.000 claims description 6
- 239000000523 sample Substances 0.000 description 130
- 229940088598 enzyme Drugs 0.000 description 60
- 238000004458 analytical method Methods 0.000 description 42
- 239000012530 fluid Substances 0.000 description 42
- 230000005284 excitation Effects 0.000 description 27
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 19
- 239000008103 glucose Substances 0.000 description 19
- 230000027756 respiratory electron transport chain Effects 0.000 description 17
- 239000000463 material Substances 0.000 description 16
- 238000000151 deposition Methods 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 239000013060 biological fluid Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 238000003556 assay Methods 0.000 description 10
- 230000002596 correlated effect Effects 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 238000006722 reduction reaction Methods 0.000 description 8
- 230000004044 response Effects 0.000 description 8
- 230000008021 deposition Effects 0.000 description 7
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 6
- VBLYLVNRHJELKI-YBFXNURJSA-N OS(=O)(=O)C1=CC=C(S(O)(=O)=O)C(\N=C/2C=C3SC4=CC=CC=C4N=C3C=C\2)=C1 Chemical compound OS(=O)(=O)C1=CC=C(S(O)(=O)=O)C(\N=C/2C=C3SC4=CC=CC=C4N=C3C=C\2)=C1 VBLYLVNRHJELKI-YBFXNURJSA-N 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 5
- SBWGZAXBCCNRTM-CTHBEMJXSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]octanamide Chemical compound CCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SBWGZAXBCCNRTM-CTHBEMJXSA-N 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 108090000854 Oxidoreductases Proteins 0.000 description 4
- 102000004316 Oxidoreductases Human genes 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- ILBONRFSLATCRE-UHFFFAOYSA-N Phosfolan Chemical compound CCOP(=O)(OCC)N=C1SCCS1 ILBONRFSLATCRE-UHFFFAOYSA-N 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 229920000847 nonoxynol Polymers 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 description 3
- 101710088194 Dehydrogenase Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 3
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 3
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 229940116269 uric acid Drugs 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 2
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 description 2
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 description 2
- 239000011714 flavin adenine dinucleotide Substances 0.000 description 2
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 150000002990 phenothiazines Chemical class 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- AFENDNXGAFYKQO-GSVOUGTGSA-N (R)-2-hydroxybutyric acid Chemical compound CC[C@@H](O)C(O)=O AFENDNXGAFYKQO-GSVOUGTGSA-N 0.000 description 1
- 150000005208 1,4-dihydroxybenzenes Chemical class 0.000 description 1
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- NECRQCBKTGZNMH-UHFFFAOYSA-N 3,5-dimethylhex-1-yn-3-ol Chemical compound CC(C)CC(C)(O)C#C NECRQCBKTGZNMH-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- 102100039702 Alcohol dehydrogenase class-3 Human genes 0.000 description 1
- 108010025188 Alcohol oxidase Proteins 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 108010006591 Apoenzymes Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 102000002794 Glucosephosphate Dehydrogenase Human genes 0.000 description 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 229920001730 Moisture cure polyurethane Polymers 0.000 description 1
- BWUHFIMIYXLIIO-FYJGNVAPSA-N OC(=O)C1=CC(C(=O)O)=CC(\N=C/2C=C3SC4=CC=CC=C4N=C3C=C\2)=C1 Chemical compound OC(=O)C1=CC(C(=O)O)=CC(\N=C/2C=C3SC4=CC=CC=C4N=C3C=C\2)=C1 BWUHFIMIYXLIIO-FYJGNVAPSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000840 electrochemical analysis Methods 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 108010051015 glutathione-independent formaldehyde dehydrogenase Proteins 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 210000002977 intracellular fluid Anatomy 0.000 description 1
- 238000001540 jet deposition Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- BRTPYBXQVFNPCB-UHFFFAOYSA-N n-phenyl-3h-phenoxazin-3-amine Chemical class C1=CC2=NC3=CC=CC=C3OC2=CC1NC1=CC=CC=C1 BRTPYBXQVFNPCB-UHFFFAOYSA-N 0.000 description 1
- DLZPPUIHGWXDNJ-UHFFFAOYSA-N n-phenylphenothiazin-3-imine Chemical class C1=CC=CC=C1N=C1C=C2SC3=CC=CC=C3N=C2C=C1 DLZPPUIHGWXDNJ-UHFFFAOYSA-N 0.000 description 1
- LJXXBBCNKKOAHS-UHFFFAOYSA-N n-phenylphenoxazin-3-imine Chemical class C1=CC=CC=C1N=C1C=C2OC3=CC=CC=C3N=C2C=C1 LJXXBBCNKKOAHS-UHFFFAOYSA-N 0.000 description 1
- 229950006238 nadide Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 229950000688 phenothiazine Drugs 0.000 description 1
- 125000001644 phenoxazinyl group Chemical class C1(=CC=CC=2OC3=CC=CC=C3NC12)* 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229960002796 polystyrene sulfonate Drugs 0.000 description 1
- 239000011970 polystyrene sulfonate Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 150000004053 quinones Chemical class 0.000 description 1
- YAYGSLOSTXKUBW-UHFFFAOYSA-N ruthenium(2+) Chemical compound [Ru+2] YAYGSLOSTXKUBW-UHFFFAOYSA-N 0.000 description 1
- BPEVHDGLPIIAGH-UHFFFAOYSA-N ruthenium(3+) Chemical compound [Ru+3] BPEVHDGLPIIAGH-UHFFFAOYSA-N 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- LGORLCOUTMVEAC-UHFFFAOYSA-M sodium;2-nonylphenolate Chemical compound [Na+].CCCCCCCCCC1=CC=CC=C1[O-] LGORLCOUTMVEAC-UHFFFAOYSA-M 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20124208P | 2008-12-08 | 2008-12-08 | |
| US61/201,242 | 2008-12-08 | ||
| PCT/US2009/066963 WO2010077598A1 (en) | 2008-12-08 | 2009-12-07 | Low total salt reagent compositions and systems for biosensors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2742377A1 CA2742377A1 (en) | 2010-07-08 |
| CA2742377C true CA2742377C (en) | 2018-05-22 |
Family
ID=41800700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2742377A Expired - Fee Related CA2742377C (en) | 2008-12-08 | 2009-12-07 | Low total salt reagent compositions and systems for biosensors |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8871069B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2373805B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5773883B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102227505B (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0923340A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2742377C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2373805T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2555215T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20151237T1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011006046A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2373805T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2373805E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2546862C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010077598A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9233788B2 (en) | 2010-01-22 | 2016-01-12 | Bayer Healthcare Llc | Biosensor desiccant system having enhanced measurement performance |
| TWI565943B (zh) * | 2011-07-22 | 2017-01-11 | 拜耳保健公司 | 具有增進測量性能之生物感測器乾燥劑系統 |
| CA2949906C (en) * | 2013-03-15 | 2019-04-02 | F. Hoffmann-La Roche Ag | Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same |
| ES2685978T3 (es) * | 2014-03-13 | 2018-10-15 | PAL Finland Oy | Tira reactiva y aparato para medir el contenido de alcohol en sangre, y un método para medir el contenido de alcohol en sangre |
| GB2531728A (en) * | 2014-10-27 | 2016-05-04 | Cilag Gmbh Int | Method for determining diffusion |
| WO2018147862A1 (en) * | 2017-02-10 | 2018-08-16 | Hewlett-Packard Development Company, L.P. | Determine viscosity of fluids using a capillary channel |
| US20210076991A1 (en) * | 2018-01-16 | 2021-03-18 | The Regents Of The University Of California | In-situ sweat rate monitoring for normalization of sweat analyte concentrations |
| RU197895U1 (ru) * | 2020-02-05 | 2020-06-04 | Общество с ограниченной ответственностью "МедТехПродукт" | Электрохимический биосенсор для определения концентрации глюкозы в крови |
| RU209089U1 (ru) * | 2021-10-22 | 2022-02-01 | Кирилл Владимирович Романенко | Электрохимический биосенсор для определения концентрации глюкозы в крови |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713165A (en) * | 1986-07-02 | 1987-12-15 | Ilex Corporation | Sensor having ion-selective electrodes |
| DE68924026T3 (de) | 1988-03-31 | 2008-01-10 | Matsushita Electric Industrial Co., Ltd., Kadoma | Biosensor und dessen herstellung. |
| KR0171222B1 (ko) * | 1989-12-15 | 1999-02-18 | 스티브 올드함 | 산화 환원 조정시약 및 바이오센서 |
| US5508171A (en) | 1989-12-15 | 1996-04-16 | Boehringer Mannheim Corporation | Assay method with enzyme electrode system |
| US5393615A (en) | 1994-02-03 | 1995-02-28 | Miles Inc. | Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof |
| US5498542A (en) | 1994-09-29 | 1996-03-12 | Bayer Corporation | Electrode mediators for regeneration of NADH and NADPH |
| US6153069A (en) | 1995-02-09 | 2000-11-28 | Tall Oak Ventures | Apparatus for amperometric Diagnostic analysis |
| US5520786A (en) | 1995-06-06 | 1996-05-28 | Bayer Corporation | Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof |
| AUPN661995A0 (en) * | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| US5798031A (en) | 1997-05-12 | 1998-08-25 | Bayer Corporation | Electrochemical biosensor |
| EP1042667B1 (en) * | 1997-12-22 | 2009-06-17 | Roche Diagnostics Operations, Inc. | Meter |
| JP4256588B2 (ja) * | 1998-05-20 | 2009-04-22 | アークレイ株式会社 | 統計的手法を用いた電気化学的測定方法および測定装置 |
| JP2000039416A (ja) * | 1998-05-21 | 2000-02-08 | Matsushita Electric Ind Co Ltd | バイオセンサ |
| US6287451B1 (en) * | 1999-06-02 | 2001-09-11 | Handani Winarta | Disposable sensor and method of making |
| CA2305922C (en) | 1999-08-02 | 2005-09-20 | Bayer Corporation | Improved electrochemical sensor design |
| US7163616B2 (en) | 2001-09-14 | 2007-01-16 | Bayer Corporation | Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes |
| DE10243599A1 (de) * | 2002-09-19 | 2004-04-01 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Messvorrichtung und -verfahren für ein Screening bei auf Elektroden immobilisierten Zellen |
| JP4619359B2 (ja) | 2003-06-20 | 2011-01-26 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | フレア状に形成された試料受入チャンバーを持つ試験片 |
| DE602004028267D1 (de) * | 2003-10-30 | 2010-09-02 | Arkray Inc | Biosensor und verfahren zu dessen herstellung |
| JP4449431B2 (ja) * | 2003-11-19 | 2010-04-14 | パナソニック株式会社 | 基質濃度の測定方法 |
| KR101503072B1 (ko) | 2005-07-20 | 2015-03-16 | 바이엘 헬스케어 엘엘씨 | 게이트형 전류 측정법 |
| US8404100B2 (en) | 2005-09-30 | 2013-03-26 | Bayer Healthcare Llc | Gated voltammetry |
| US7955484B2 (en) * | 2005-12-14 | 2011-06-07 | Nova Biomedical Corporation | Glucose biosensor and method |
| CA2643163C (en) * | 2006-02-27 | 2020-01-28 | Bayer Healthcare Llc | Temperature-adjusted analyte determination for biosensor systems |
| US8163162B2 (en) * | 2006-03-31 | 2012-04-24 | Lifescan, Inc. | Methods and apparatus for analyzing a sample in the presence of interferents |
| JP5395665B2 (ja) | 2006-09-22 | 2014-01-22 | バイエル・ヘルスケア・エルエルシー | 改善された安定性およびヘマトクリット性能（ｐｅｒｆｏｒｍａｎｃｅ）を有するバイオセンサー系 |
| US8163146B2 (en) * | 2007-10-12 | 2012-04-24 | Abbott Diabetes Care Inc. | Mediator stabilized reagent compositions for use in biosensor electrodes |
| WO2009076402A1 (en) * | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Porous particle reagent compositions, devices, and methods for biosensors |
| JP5812603B2 (ja) | 2007-12-10 | 2015-11-17 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ | 勾配ベース補正 |
| EP2222867B1 (en) | 2007-12-10 | 2018-07-11 | Ascensia Diabetes Care Holdings AG | Rapid-read gated amperometry |
| JP5583594B2 (ja) | 2007-12-10 | 2014-09-03 | バイエル・ヘルスケア・エルエルシー | 試験センサ内に試薬物質を被着させる方法 |
| CA2708156C (en) * | 2007-12-10 | 2018-01-23 | Bayer Healthcare Llc | Reagents and methods for detecting analytes |
| CN105353013B (zh) | 2008-07-10 | 2020-01-14 | 安晟信医疗科技控股公司 | 识别样本中的电离物质的方法 |
| CN102239406A (zh) | 2008-12-08 | 2011-11-09 | 拜尔健康护理有限责任公司 | 具有信号调节功能的生物传感器系统 |
-
2009
- 2009-12-07 HR HRP20151237TT patent/HRP20151237T1/hr unknown
- 2009-12-07 BR BRPI0923340A patent/BRPI0923340A2/pt not_active Application Discontinuation
- 2009-12-07 PT PT97754378T patent/PT2373805E/pt unknown
- 2009-12-07 DK DK09775437.8T patent/DK2373805T3/en active
- 2009-12-07 CA CA2742377A patent/CA2742377C/en not_active Expired - Fee Related
- 2009-12-07 WO PCT/US2009/066963 patent/WO2010077598A1/en not_active Ceased
- 2009-12-07 EP EP09775437.8A patent/EP2373805B1/en active Active
- 2009-12-07 RU RU2011128002/10A patent/RU2546862C2/ru not_active IP Right Cessation
- 2009-12-07 JP JP2011540801A patent/JP5773883B2/ja active Active
- 2009-12-07 PL PL09775437T patent/PL2373805T3/pl unknown
- 2009-12-07 MX MX2011006046A patent/MX2011006046A/es active IP Right Grant
- 2009-12-07 CN CN200980147993.2A patent/CN102227505B/zh active Active
- 2009-12-07 ES ES09775437.8T patent/ES2555215T3/es active Active
-
2011
- 2011-06-06 US US13/154,088 patent/US8871069B2/en active Active
-
2014
- 2014-08-01 JP JP2014157974A patent/JP6081414B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20151237T1 (hr) | 2015-12-18 |
| JP6081414B2 (ja) | 2017-02-15 |
| CA2742377A1 (en) | 2010-07-08 |
| EP2373805B1 (en) | 2015-11-04 |
| JP2012511159A (ja) | 2012-05-17 |
| JP2014224828A (ja) | 2014-12-04 |
| DK2373805T3 (en) | 2015-12-07 |
| CN102227505B (zh) | 2016-05-11 |
| PT2373805E (pt) | 2015-12-30 |
| JP5773883B2 (ja) | 2015-09-02 |
| RU2011128002A (ru) | 2013-01-20 |
| CN102227505A (zh) | 2011-10-26 |
| US8871069B2 (en) | 2014-10-28 |
| ES2555215T3 (es) | 2015-12-29 |
| MX2011006046A (es) | 2011-07-20 |
| RU2546862C2 (ru) | 2015-04-10 |
| US20110297540A1 (en) | 2011-12-08 |
| WO2010077598A1 (en) | 2010-07-08 |
| EP2373805A1 (en) | 2011-10-12 |
| PL2373805T3 (pl) | 2016-03-31 |
| BRPI0923340A2 (pt) | 2018-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2006272909B2 (en) | Gated amperometry | |
| EP2535703B1 (en) | Multi-electrode biosensor system | |
| EP2679150B1 (en) | Transient decay amperometry | |
| CA2742377C (en) | Low total salt reagent compositions and systems for biosensors | |
| US8617835B2 (en) | Porous particle reagent compositions, devices, and methods for biosensors | |
| JP2014224828A5 (cg-RX-API-DMAC7.html) | ||
| AU2013200069B2 (en) | Gated amperometry | |
| HK1229422A1 (en) | Test sensor for determining the concentration of an analyte in a sample |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20141127 |
|
| MKLA | Lapsed |
Effective date: 20211207 |