CA2737695C - Conversion of nitrogen dioxide (no2) to nitric oxide (no) - Google Patents
Conversion of nitrogen dioxide (no2) to nitric oxide (no) Download PDFInfo
- Publication number
- CA2737695C CA2737695C CA2737695A CA2737695A CA2737695C CA 2737695 C CA2737695 C CA 2737695C CA 2737695 A CA2737695 A CA 2737695A CA 2737695 A CA2737695 A CA 2737695A CA 2737695 C CA2737695 C CA 2737695C
- Authority
- CA
- Canada
- Prior art keywords
- nitric oxide
- nitrogen dioxide
- conversion
- delivery system
- therapeutic gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 11
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 title abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 title abstract 3
- 238000006243 chemical reaction Methods 0.000 title 1
- 239000007789 gas Substances 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J12/00—Chemical processes in general for reacting gaseous media with gaseous media; Apparatus specially adapted therefor
- B01J12/007—Chemical processes in general for reacting gaseous media with gaseous media; Apparatus specially adapted therefor in the presence of catalytically active bodies, e.g. porous plates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
- A61M16/122—Preparation of respiratory gases or vapours by mixing different gases with dilution
-
- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
- A62B7/00—Respiratory apparatus
- A62B7/08—Respiratory apparatus containing chemicals producing oxygen
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
- A61M2016/1025—Measuring a parameter of the content of the delivered gas the O2 concentration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0078—Special media to be introduced, removed or treated changed by chemical action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Business, Economics & Management (AREA)
- Emergency Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9897408P | 2008-09-22 | 2008-09-22 | |
| US61/098,974 | 2008-09-22 | ||
| PCT/US2009/057687 WO2010033916A1 (en) | 2008-09-22 | 2009-09-21 | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2737695A1 CA2737695A1 (en) | 2010-03-25 |
| CA2737695C true CA2737695C (en) | 2018-10-23 |
Family
ID=42039905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2737695A Active CA2737695C (en) | 2008-09-22 | 2009-09-21 | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US8173072B2 (enExample) |
| EP (1) | EP2362810A4 (enExample) |
| JP (2) | JP5611955B2 (enExample) |
| AU (1) | AU2009292963B2 (enExample) |
| CA (1) | CA2737695C (enExample) |
| WO (1) | WO2010033916A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7560076B2 (en) | 2004-08-18 | 2009-07-14 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| WO2009097343A1 (en) | 2008-01-28 | 2009-08-06 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US8434475B2 (en) * | 2008-01-31 | 2013-05-07 | Genosys, Inc. | Nitric oxide reactor and distributor apparatus and method |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| EP2362810A4 (en) * | 2008-09-22 | 2013-09-11 | Geno Llc | CONVERSION OF NITROGEN DIOXIDE (NO2) TO NITROGEN MONOXIDE (NO) |
| JP5878866B2 (ja) | 2009-06-22 | 2016-03-08 | ゲノ エルエルシー | 一酸化窒素治療 |
| AU2011245476B2 (en) | 2010-04-26 | 2016-05-12 | VERO Biotech LLC. | Delivery of ultra pure nitric oxide (NO) |
| AU2011336358B2 (en) * | 2010-12-03 | 2016-09-29 | VERO Biotech LLC. | Nitric oxide treatments |
| JP2014527025A (ja) | 2011-05-27 | 2014-10-09 | ゲノ エルエルシー | 吸入用一酸化窒素を用いて血管反応性を決定する方法 |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| US10525226B2 (en) * | 2014-05-14 | 2020-01-07 | Mallinckrodt Hospital Products IP Limited | Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| US10384031B1 (en) | 2014-06-20 | 2019-08-20 | Mallinckrodt Hospital Products IP Limited | Systems and methods for manufacturing and safety of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| EP4180078A1 (en) | 2014-10-20 | 2023-05-17 | VERO Biotech LLC | Nitrogen dioxide storage cassette |
| US20160121071A1 (en) * | 2014-10-30 | 2016-05-05 | Nu-Med Plus | Controlled delivery of medical gases using diffusion membranes |
| EP3108920A1 (en) * | 2015-06-22 | 2016-12-28 | Linde AG | Device for delivering nitric oxide and oxygen to a patient |
| EP4400101A1 (en) | 2016-01-27 | 2024-07-17 | SYK Technologies, LLC | Nitric oxide topical application apparatus and methods |
| JP2019528868A (ja) * | 2016-09-10 | 2019-10-17 | ベロ バイオテック エルエルシー | 移動式一酸化窒素送達システム及び方法 |
| TWI619539B (zh) | 2016-10-14 | 2018-04-01 | 財團法人工業技術研究院 | 淨化含氮氧化物氣體的組成物及裝置 |
| EP4095094A1 (en) | 2017-02-27 | 2022-11-30 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| BR112019016708B1 (pt) | 2017-02-27 | 2024-01-30 | Third Pole, Inc | Sistemas de geração de óxido nítrico |
| US11672938B1 (en) | 2018-07-18 | 2023-06-13 | Vero Biotech LLC | Start-up protocols for nitric oxide delivery device |
| US11754538B1 (en) * | 2018-07-18 | 2023-09-12 | Vero Biotech Inc. | Method and apparatus for automatic calibration |
| EP3837523A4 (en) | 2018-08-14 | 2022-05-11 | SaNOtize Research and Development Corp. | DEVICES AND METHODS FOR QUANTIFYING NITRIC OXIDE |
| WO2020232419A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| WO2021142472A1 (en) | 2020-01-11 | 2021-07-15 | Third Pole, Inc. | Systems and methods for nitric oxide generation with humidity control |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| JP2024534608A (ja) | 2021-09-23 | 2024-09-20 | サード ポール，インコーポレイテッド | 一酸化窒素を送達するシステム及び方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674429A (en) * | 1971-01-06 | 1972-07-04 | Union Carbide Corp | Adsorption process for water and nitrogen oxides |
| JP2895977B2 (ja) * | 1991-04-12 | 1999-05-31 | 株式会社日本紙パルプ研究所 | リグノセルロース材料の漂白方法 |
| DE69403342T2 (de) * | 1993-09-13 | 1997-08-28 | Aga Ab | Verfahren und vorrichtung zum erzeugen von stickstoffoxyde |
| US5670125A (en) * | 1993-09-30 | 1997-09-23 | The Boc Group, Inc. | Process for the purification of nitric oxide |
| JPH07187622A (ja) * | 1993-12-22 | 1995-07-25 | Osaka Gas Co Ltd | 低濃度ｎｏの製造方法及びｎｏ２の測定方法 |
| US5417950A (en) | 1994-07-07 | 1995-05-23 | The Boc Group, Inc. | Process for the purification of nitric oxide |
| IN192791B (enExample) * | 1996-06-28 | 2004-05-22 | Johnson & Johnson Medical | |
| US6187937B1 (en) | 1998-01-16 | 2001-02-13 | Flexsys America L.P. | Preparation of N-phenyl-benzoquinoneimine from hydroxydiphenylamines |
| JP2003505507A (ja) | 1999-07-28 | 2003-02-12 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 治療的血管新生および脈管形成におけるニコチン |
| US6689810B2 (en) * | 2001-08-21 | 2004-02-10 | Cellular Sciences, Inc. | Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide |
| EP1429829B1 (en) * | 2001-09-05 | 2013-11-27 | Geno LLC | Nitric oxide generation |
| US7560076B2 (en) * | 2004-08-18 | 2009-07-14 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| JP4641255B2 (ja) * | 2005-12-22 | 2011-03-02 | 住友精化株式会社 | 一酸化窒素精製方法 |
| US8790715B2 (en) * | 2006-02-16 | 2014-07-29 | Ino Therapeutics Llc | Method and apparatus for generating nitric oxide for medical use |
| CA2681308C (en) * | 2007-03-23 | 2015-11-24 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| EP2362810A4 (en) * | 2008-09-22 | 2013-09-11 | Geno Llc | CONVERSION OF NITROGEN DIOXIDE (NO2) TO NITROGEN MONOXIDE (NO) |
-
2009
- 2009-09-21 EP EP09815334.9A patent/EP2362810A4/en not_active Withdrawn
- 2009-09-21 JP JP2011528036A patent/JP5611955B2/ja active Active
- 2009-09-21 AU AU2009292963A patent/AU2009292963B2/en not_active Ceased
- 2009-09-21 WO PCT/US2009/057687 patent/WO2010033916A1/en not_active Ceased
- 2009-09-21 US US12/563,662 patent/US8173072B2/en active Active
- 2009-09-21 CA CA2737695A patent/CA2737695C/en active Active
-
2012
- 2012-03-30 US US13/436,018 patent/US8715577B2/en active Active
-
2014
- 2014-05-05 US US14/270,260 patent/US9408994B2/en active Active
- 2014-09-03 JP JP2014178701A patent/JP2015006422A/ja active Pending
-
2016
- 2016-08-04 US US15/229,105 patent/US10086352B2/en active Active
-
2018
- 2018-10-01 US US16/149,092 patent/US20190209993A1/en not_active Abandoned
-
2019
- 2019-10-01 US US16/590,093 patent/US11511252B2/en active Active
-
2022
- 2022-11-28 US US18/059,309 patent/US12059661B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9408994B2 (en) | 2016-08-09 |
| EP2362810A1 (en) | 2011-09-07 |
| JP2015006422A (ja) | 2015-01-15 |
| US11511252B2 (en) | 2022-11-29 |
| US20120251399A1 (en) | 2012-10-04 |
| US20200282375A1 (en) | 2020-09-10 |
| US8715577B2 (en) | 2014-05-06 |
| JP2012502770A (ja) | 2012-02-02 |
| EP2362810A4 (en) | 2013-09-11 |
| US20230294060A1 (en) | 2023-09-21 |
| US12059661B2 (en) | 2024-08-13 |
| US20100104667A1 (en) | 2010-04-29 |
| AU2009292963B2 (en) | 2016-08-18 |
| CA2737695A1 (en) | 2010-03-25 |
| US20170182471A1 (en) | 2017-06-29 |
| AU2009292963A1 (en) | 2010-03-25 |
| US10086352B2 (en) | 2018-10-02 |
| US20150007814A1 (en) | 2015-01-08 |
| US8173072B2 (en) | 2012-05-08 |
| US20190209993A1 (en) | 2019-07-11 |
| WO2010033916A1 (en) | 2010-03-25 |
| JP5611955B2 (ja) | 2014-10-22 |
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| 关闭 | Neuroscience Bulletin Copyright Assignment and Submission Declaration Form |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140919 |