CA2731941C - Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase - Google Patents
Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase Download PDFInfo
- Publication number
- CA2731941C CA2731941C CA2731941A CA2731941A CA2731941C CA 2731941 C CA2731941 C CA 2731941C CA 2731941 A CA2731941 A CA 2731941A CA 2731941 A CA2731941 A CA 2731941A CA 2731941 C CA2731941 C CA 2731941C
- Authority
- CA
- Canada
- Prior art keywords
- pyran
- propano
- phenanthro
- dodecahydro
- tetramethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13610108P | 2008-08-12 | 2008-08-12 | |
| US61/136,101 | 2008-08-12 | ||
| PCT/US2009/004560 WO2010019204A1 (en) | 2008-08-12 | 2009-08-07 | Antifungal agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2731941A1 CA2731941A1 (en) | 2010-02-18 |
| CA2731941C true CA2731941C (en) | 2016-09-27 |
Family
ID=41669133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2731941A Active CA2731941C (en) | 2008-08-12 | 2009-08-07 | Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8188085B2 (https=) |
| EP (1) | EP2326181A4 (https=) |
| JP (1) | JP5548875B2 (https=) |
| CN (2) | CN102176827B (https=) |
| AU (1) | AU2009282474B2 (https=) |
| CA (1) | CA2731941C (https=) |
| WO (1) | WO2010019204A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012025506A1 (de) | 2010-08-26 | 2012-03-01 | Bayer Cropscience Ag | 5-iod-triazol-derivate |
| HRP20220544T1 (hr) | 2015-01-19 | 2022-08-05 | Scynexis, Inc. | Nove soli i polimorfi scy-078 |
| MA49889A (fr) * | 2017-04-10 | 2020-06-24 | Scynexis Inc | Agents antifongiques utilisés en association |
| KR102807716B1 (ko) | 2017-08-04 | 2025-05-13 | 싸이넥시스, 인크. | 산성 pH에서 증진된 활성을 갖는 항진균제 |
| CA3087176A1 (en) | 2018-01-02 | 2019-07-11 | Scynexis, Inc. | Injectable compositions of triterpenoid antifungals encapsulated in liposomes |
| US12053486B2 (en) | 2018-03-09 | 2024-08-06 | Therazure LLC | Compositions for the treatment of infections in feet |
| US20220117948A1 (en) * | 2019-01-30 | 2022-04-21 | Scynexis, Inc. | Triterpenoid antifungals for the treatment of fungal osteo-articular infections |
| BR112021016876A2 (pt) | 2019-02-27 | 2021-11-03 | Scynexis Inc | Métodos para tratar e para prevenir pneumonia por pneumocystis, métodos para tratar e para prevenir pneumonia por pneumocystis jirovecii, preparação de um medicamento para tratar ou prevenir pneumonia por pneumocystis jirovecii, e, uso de um composto |
| AU2020276595B2 (en) | 2019-05-16 | 2025-12-04 | Scynexis, Inc. | Antifungal Agents for Candida Auris Decolonization |
| WO2021092349A1 (en) | 2019-11-08 | 2021-05-14 | Scynexis, Inc. | Lipid-based formulations of scy-078 salts |
| WO2021097411A1 (en) * | 2019-11-15 | 2021-05-20 | The Research Foundation For The State University Of New York | Anti-fungal compositions and methods for using same |
| CN118724779B (zh) * | 2024-06-05 | 2025-09-23 | 浙江瑞博制药有限公司 | 一种醛基化合物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756472A (en) * | 1996-01-31 | 1998-05-26 | Merck & Co., Inc. | Antifungal agent obtained from hormonema |
| DE69718141T2 (de) | 1996-01-31 | 2003-08-21 | Merck & Co., Inc. | Fungizid |
| HUP0303249A3 (en) * | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| FR2824324B1 (fr) * | 2001-05-04 | 2003-08-15 | Aventis Pharma Sa | Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques |
| US20050131041A1 (en) | 2002-04-17 | 2005-06-16 | Mohammad Salman | Azole derivatives as antifungal agents |
| JP5245057B2 (ja) | 2006-04-03 | 2013-07-24 | メルク・シャープ・アンド・ドーム・コーポレーション | 抗真菌剤 |
-
2009
- 2009-08-07 WO PCT/US2009/004560 patent/WO2010019204A1/en not_active Ceased
- 2009-08-07 US US12/461,318 patent/US8188085B2/en active Active
- 2009-08-07 CN CN200980140485.1A patent/CN102176827B/zh active Active
- 2009-08-07 JP JP2011522975A patent/JP5548875B2/ja active Active
- 2009-08-07 EP EP09806945A patent/EP2326181A4/en not_active Withdrawn
- 2009-08-07 AU AU2009282474A patent/AU2009282474B2/en active Active
- 2009-08-07 CA CA2731941A patent/CA2731941C/en active Active
- 2009-08-07 CN CN201510182454.XA patent/CN104877001B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1214271A1 (zh) | 2016-07-22 |
| AU2009282474B2 (en) | 2014-03-20 |
| EP2326181A4 (en) | 2012-11-28 |
| JP5548875B2 (ja) | 2014-07-16 |
| CN104877001A (zh) | 2015-09-02 |
| US8188085B2 (en) | 2012-05-29 |
| CN102176827B (zh) | 2015-05-20 |
| AU2009282474A1 (en) | 2010-02-18 |
| CN102176827A (zh) | 2011-09-07 |
| JP2011530593A (ja) | 2011-12-22 |
| CA2731941A1 (en) | 2010-02-18 |
| EP2326181A1 (en) | 2011-06-01 |
| WO2010019204A1 (en) | 2010-02-18 |
| CN104877001B (zh) | 2020-07-03 |
| US20100113439A1 (en) | 2010-05-06 |
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| Publication | Publication Date | Title |
|---|---|---|
| CA2731941C (en) | Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase | |
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| TW200811194A (en) | Antifungal agents | |
| AU2021201355B2 (en) | Seco macrolide compounds | |
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| AU2009282476B2 (en) | Antifungal agents | |
| EP2197447B1 (en) | Antifungal agents | |
| HK1214271B (zh) | 抗真菌製劑 | |
| HK1158017B (en) | Antifungal agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140718 |
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