CA2731941C - Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase - Google Patents

Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase Download PDF

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Publication number
CA2731941C
CA2731941C CA2731941A CA2731941A CA2731941C CA 2731941 C CA2731941 C CA 2731941C CA 2731941 A CA2731941 A CA 2731941A CA 2731941 A CA2731941 A CA 2731941A CA 2731941 C CA2731941 C CA 2731941C
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CA
Canada
Prior art keywords
pyran
propano
phenanthro
dodecahydro
tetramethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2731941A
Other languages
English (en)
French (fr)
Other versions
CA2731941A1 (en
Inventor
Mark L. Greenlee
Robert Wilkening
James Apgar
Donald Sperbeck
Kenneth James Wildonger
Dongfang Meng
Dann L. Parker
Gregory James Pacofsky
Brian Haid Heasley
Ahmed Mamai
Kingsley Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scynexis Inc
Original Assignee
Scynexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2731941(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scynexis Inc filed Critical Scynexis Inc
Publication of CA2731941A1 publication Critical patent/CA2731941A1/en
Application granted granted Critical
Publication of CA2731941C publication Critical patent/CA2731941C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2731941A 2008-08-12 2009-08-07 Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase Active CA2731941C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13610108P 2008-08-12 2008-08-12
US61/136,101 2008-08-12
PCT/US2009/004560 WO2010019204A1 (en) 2008-08-12 2009-08-07 Antifungal agents

Publications (2)

Publication Number Publication Date
CA2731941A1 CA2731941A1 (en) 2010-02-18
CA2731941C true CA2731941C (en) 2016-09-27

Family

ID=41669133

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2731941A Active CA2731941C (en) 2008-08-12 2009-08-07 Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase

Country Status (7)

Country Link
US (1) US8188085B2 (OSRAM)
EP (1) EP2326181A4 (OSRAM)
JP (1) JP5548875B2 (OSRAM)
CN (2) CN102176827B (OSRAM)
AU (1) AU2009282474B2 (OSRAM)
CA (1) CA2731941C (OSRAM)
WO (1) WO2010019204A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103180301B (zh) 2010-08-26 2015-11-25 拜耳知识产权有限责任公司 5-碘代三唑衍生物
RS63234B1 (sr) 2015-01-19 2022-06-30 Scynexis Inc Nove soli i polimorfi scy-078
KR102683355B1 (ko) 2017-04-10 2024-07-10 싸이넥시스, 인크. 조합하여 사용되는 항진균제
LT3661503T (lt) 2017-08-04 2022-12-12 Scynexis, Inc. Priešgrybeliniai agentai, pasižymintys padidintu aktyvumu esant rūgštiniam ph
KR102694692B1 (ko) 2018-01-02 2024-08-14 싸이넥시스, 인크. 리포좀 내에 캡슐화된 트리테르페노이드 항진균제의 주사가능한 조성물
US12053486B2 (en) 2018-03-09 2024-08-06 Therazure LLC Compositions for the treatment of infections in feet
CN113498343A (zh) * 2019-01-30 2021-10-12 西尼克斯公司 用于治疗真菌性骨关节感染的三萜抗真菌剂
JP7581219B2 (ja) 2019-02-27 2024-11-12 サイネクシス，インコーポレーテッド ニューモシスチス属種（Ｐｎｅｕｍｏｃｙｓｔｉｓ ｓｐｐ．）肺炎を治療又は予防するためのトリテルペノイド系抗真菌薬
AU2020276595B2 (en) 2019-05-16 2025-12-04 Scynexis, Inc. Antifungal Agents for Candida Auris Decolonization
WO2021092349A1 (en) 2019-11-08 2021-05-14 Scynexis, Inc. Lipid-based formulations of scy-078 salts
WO2021097411A1 (en) * 2019-11-15 2021-05-20 The Research Foundation For The State University Of New York Anti-fungal compositions and methods for using same
CN118724779B (zh) * 2024-06-05 2025-09-23 浙江瑞博制药有限公司 一种醛基化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE230268T1 (de) 1996-01-31 2003-01-15 Merck & Co Inc Fungizid
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
HUP0303249A3 (en) * 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
FR2824324B1 (fr) * 2001-05-04 2003-08-15 Aventis Pharma Sa Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques
US20050131041A1 (en) 2002-04-17 2005-06-16 Mohammad Salman Azole derivatives as antifungal agents
DK2007396T3 (da) * 2006-04-03 2013-03-18 Merck Sharp & Dohme Enfumafungin-derivat som antimykotika

Also Published As

Publication number Publication date
US8188085B2 (en) 2012-05-29
EP2326181A1 (en) 2011-06-01
CN102176827B (zh) 2015-05-20
JP5548875B2 (ja) 2014-07-16
AU2009282474A1 (en) 2010-02-18
AU2009282474B2 (en) 2014-03-20
EP2326181A4 (en) 2012-11-28
CN104877001B (zh) 2020-07-03
CN102176827A (zh) 2011-09-07
HK1214271A1 (zh) 2016-07-22
CA2731941A1 (en) 2010-02-18
JP2011530593A (ja) 2011-12-22
WO2010019204A1 (en) 2010-02-18
CN104877001A (zh) 2015-09-02
US20100113439A1 (en) 2010-05-06

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Effective date: 20140718