CA2723270C - Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease - Google Patents
Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US6116308P | 2008-06-13 | 2008-06-13 | |
| US61/061,163 | 2008-06-13 | ||
| PCT/EP2009/057263 WO2009150214A2 (en) | 2008-06-13 | 2009-06-12 | Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease |
Publications (2)
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| CA2723270A1 CA2723270A1 (en) | 2009-12-17 |
| CA2723270C true CA2723270C (en) | 2018-03-13 |
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| CA2723270A Expired - Fee Related CA2723270C (en) | 2008-06-13 | 2009-06-12 | Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease |
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| Country | Link |
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| US (2) | US8476408B2 (enExample) |
| EP (1) | EP2310041B1 (enExample) |
| JP (1) | JP5481473B2 (enExample) |
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| AU (1) | AU2009256558B2 (enExample) |
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| MX (1) | MX2010013677A (enExample) |
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| US9651708B2 (en) * | 2011-04-21 | 2017-05-16 | Baker Hughes Incorporated | Method of mapping reservoir fluid movement using gravity sensors |
| US20140336109A1 (en) * | 2011-12-15 | 2014-11-13 | Alize Pharma Sas | Modulation of ghrelin levels and ghrelin/unacylated ghrelin ratio using unacylated ghrelin |
| US10016458B2 (en) | 2012-04-16 | 2018-07-10 | Baystate Health, Inc. | p53 silenced endothelial progenitor cells for diabetes |
| WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
| US20160151458A1 (en) * | 2013-06-21 | 2016-06-02 | Alize Pharma Sas | Use Of Unacylated Ghrelin, Fragments And Analogs Thereof As Antioxidant |
| EP3137098A4 (en) * | 2014-04-29 | 2017-11-01 | Mayo Foundation for Medical Education and Research | Butyrylcholinesterases having an enhanced ability to hydrolyze acyl ghrelin |
| WO2018053216A1 (en) | 2016-09-15 | 2018-03-22 | Mayo Foundation For Medical Education And Research | Methods and materials for using butyrylcholinesterases to treat cancer |
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| US5643872A (en) * | 1989-10-23 | 1997-07-01 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
| US5747296A (en) * | 1992-05-11 | 1998-05-05 | Corvas International, Inc. | Method of detecting neutophil inhibitory factor mimics |
| WO1994013692A1 (en) * | 1992-12-10 | 1994-06-23 | Regents Of The University Of Minnesota | Polypeptides useful for treating inflammatory disorders |
| US5786332A (en) * | 1995-03-06 | 1998-07-28 | Trega Biosciences, Inc. | Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels |
| WO1995014787A1 (en) * | 1993-11-22 | 1995-06-01 | Centocor, Inc. | Peptide inhibitors of selecting binding |
| US5695761A (en) * | 1993-12-23 | 1997-12-09 | Rutgers University | Suppression of nitric oxide production by osteopontin |
| DE69533704D1 (de) * | 1994-03-09 | 2004-12-02 | Cortech Inc | Bradykinin-antagonist peptide mit n-substituierten glycinen |
| US5958875A (en) * | 1996-03-29 | 1999-09-28 | The Regents Of The University Of California | Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
| US6627729B1 (en) | 1997-03-24 | 2003-09-30 | Zymogenetics, Inc. | TML peptides |
| US5932548A (en) * | 1998-06-03 | 1999-08-03 | Deghenghi; Romano | Lysine containing peptides for treatment of heart disease |
| AU6515499A (en) * | 1998-10-16 | 2000-05-08 | Musc Foundation For Research Development | Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof |
| WO2001056592A1 (en) | 2000-02-01 | 2001-08-09 | Novo Nordisk A/S | Use of compounds for the regulation of food intake |
| EP1286697A2 (en) | 2000-05-17 | 2003-03-05 | Eli Lilly And Company | Method for selectively inhibiting ghrelin action |
| EP1353683A4 (en) | 2000-05-30 | 2004-05-12 | Merck & Co Inc | ANALOGS BY GHRELIN |
| US6872548B2 (en) | 2001-01-31 | 2005-03-29 | Human Genome Sciences, Inc. | Scaffolded fusion polypeptides and compositions and methods for making the same |
| WO2002060472A1 (fr) | 2001-01-31 | 2002-08-08 | Chugai Seiyaku Kabushiki Kaisha | Remedes pour des etats d'hyponutrition |
| ATE552031T1 (de) | 2001-12-18 | 2012-04-15 | Alize Pharma Sas | Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz |
| US7666833B2 (en) | 2001-12-18 | 2010-02-23 | Alizé Pharma SAS | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
| CA2470235C (en) | 2001-12-18 | 2012-02-07 | Theratechnologies Inc. | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
| AU2002364586A1 (en) * | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| JP5000848B2 (ja) | 2002-05-21 | 2012-08-15 | 第一三共株式会社 | グレリン含有医薬組成物 |
| JP2006527738A (ja) * | 2003-06-18 | 2006-12-07 | ディレボ・ビオテク・アーゲー | 新規生物学的実体およびその薬学的または診断的使用 |
| US7517269B2 (en) | 2003-08-12 | 2009-04-14 | Parvia Corp. | Building element for constructing a modular substructure |
| US7825090B2 (en) | 2003-10-24 | 2010-11-02 | Alizé Pharma SAS | Use of ghrelin and unacylated ghrelin compositions for treating insulin resistance |
| US8076288B2 (en) * | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| WO2006019577A1 (en) * | 2004-07-14 | 2006-02-23 | Eli Lilly And Company | Anti-ghrelin antibodies |
| WO2006045319A2 (en) | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| JP2008520204A (ja) * | 2004-11-15 | 2008-06-19 | イーライ リリー アンド カンパニー | 非アシル化グレリン抗体及びその治療への使用 |
| JP5147827B2 (ja) | 2006-03-28 | 2013-02-20 | リアット・ミンツ | 高コレステロール血症および／または高コレステロールおよび／または高コレステロール関連疾患および／または脂血症および／または脂血症関連疾患および／または冠動脈疾患および／または体重管理および／または糖尿病および／または高血糖の治療のためのグレリンスプライス変種の使用 |
| MX2009012969A (es) | 2007-05-31 | 2010-04-27 | Alize Pharma Sas | Grelina no acilada como agente terapeutico en el tratamiento de trastornos metabolicos. |
| EP2067481A1 (en) | 2007-12-03 | 2009-06-10 | Charité-Universitätsmedizin Berlin | Therapeutic use of desacyl ghrelin |
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- 2009-06-12 US US12/996,244 patent/US20110160121A1/en not_active Abandoned
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- 2009-06-12 AU AU2009256558A patent/AU2009256558B2/en not_active Ceased
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- 2009-06-12 WO PCT/EP2009/057263 patent/WO2009150214A2/en not_active Ceased
- 2009-06-12 CA CA2723270A patent/CA2723270C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
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| JP2011522864A (ja) | 2011-08-04 |
| US20100016226A1 (en) | 2010-01-21 |
| WO2009150214A2 (en) | 2009-12-17 |
| AU2009256558B2 (en) | 2014-03-06 |
| CN102065883A (zh) | 2011-05-18 |
| JP5481473B2 (ja) | 2014-04-23 |
| US8476408B2 (en) | 2013-07-02 |
| EP2310041B1 (en) | 2013-02-13 |
| MX2010013677A (es) | 2011-05-23 |
| AU2009256558A1 (en) | 2009-12-17 |
| EP2310041A2 (en) | 2011-04-20 |
| WO2009150214A3 (en) | 2010-03-11 |
| CA2723270A1 (en) | 2009-12-17 |
| US20110160121A1 (en) | 2011-06-30 |
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