CA2720846A1 - Novel inhibitors of hepatitis c virus replication - Google Patents

Novel inhibitors of hepatitis c virus replication Download PDF

Info

Publication number
CA2720846A1
CA2720846A1 CA2720846A CA2720846A CA2720846A1 CA 2720846 A1 CA2720846 A1 CA 2720846A1 CA 2720846 A CA2720846 A CA 2720846A CA 2720846 A CA2720846 A CA 2720846A CA 2720846 A1 CA2720846 A1 CA 2720846A1
Authority
CA
Canada
Prior art keywords
optionally substituted
compound
ifn
substituted alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2720846A
Other languages
English (en)
French (fr)
Inventor
Leonid Beigelman
Guangyi Wang
Brad O. Buckman
Antitsa Dimitrova Stoycheva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermune Inc
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of CA2720846A1 publication Critical patent/CA2720846A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/30—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hydrocarbon radicals, substituted by hetero atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2720846A 2008-04-15 2009-04-14 Novel inhibitors of hepatitis c virus replication Abandoned CA2720846A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US4521408P 2008-04-15 2008-04-15
US4521908P 2008-04-15 2008-04-15
US61/045,219 2008-04-15
US61/045,214 2008-04-15
US10985608P 2008-10-30 2008-10-30
US61/109,856 2008-10-30
US11791608P 2008-11-25 2008-11-25
US61/117,916 2008-11-25
US14833709P 2009-01-29 2009-01-29
US61/148,337 2009-01-29
PCT/US2009/040567 WO2009134616A2 (en) 2008-04-15 2009-04-14 Novel inhibitors of hepatitis c virus replication

Publications (1)

Publication Number Publication Date
CA2720846A1 true CA2720846A1 (en) 2009-11-05

Family

ID=41078055

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2720846A Abandoned CA2720846A1 (en) 2008-04-15 2009-04-14 Novel inhibitors of hepatitis c virus replication

Country Status (10)

Country Link
US (1) US20090257979A1 (enExample)
EP (1) EP2283002A2 (enExample)
JP (1) JP2011516610A (enExample)
KR (1) KR20110004439A (enExample)
CN (1) CN102026990A (enExample)
AU (1) AU2009241514A1 (enExample)
BR (1) BRPI0911259A2 (enExample)
CA (1) CA2720846A1 (enExample)
MX (1) MX2010011307A (enExample)
WO (1) WO2009134616A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2665984C (en) 2006-10-12 2017-02-28 Activbiotics, Inc. Superoxide dismutase mimetics for the treatment of oral mucositis
US20120232062A1 (en) * 2009-10-20 2012-09-13 Eiger Biopharmaceuticals, Inc. Azaindazoles to treat flaviviridae virus infection
TW201121968A (en) * 2009-11-09 2011-07-01 Intermune Inc Novel inhibitors of hepatitis C virus replication
CA2849456C (en) 2011-09-26 2021-12-07 Galera Therapeutics, Llc Methods for treatment of diseases
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
CA2811203C (en) 2011-10-21 2015-05-05 Abbvie Inc. Methods for treating hcv
CN104023726A (zh) 2011-10-21 2014-09-03 艾伯维公司 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333)
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
WO2015018797A2 (en) * 2013-08-05 2015-02-12 Haplogen Gmbh Antiviral compounds
WO2016148512A1 (ko) * 2015-03-16 2016-09-22 마이크로엑츄에이터(주) 카메라 모듈에 사용되는 필터전환 장치 및 카메라 모듈을 포함하는 모바일 기기
HUE049926T2 (hu) 2015-08-11 2020-11-30 Galera Labs Llc Makrociklusos pentaazagyûrûkomplexek orális biológiai hozzáférhetõséggel
JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
CN109414454A (zh) 2016-05-03 2019-03-01 加莱拉实验室有限责任公司 用于癌症治疗的组合疗法
EP3506907B1 (en) 2016-09-01 2023-06-07 Galera Labs, LLC Combination cancer therapy with a pentaaza macrocyclic ring complex and an ascorbate compound
EA201992431A1 (ru) 2017-10-13 2020-03-13 ГАЛЕРА ЛЭБЗ, ЭлЭлСи Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6025984A (ja) * 1983-07-22 1985-02-08 Tokyo Inst Of Technol ベンゾチアジアジン誘導体の製造方法
JPH0216448A (ja) * 1988-07-04 1990-01-19 Fuji Photo Film Co Ltd 化学物質の分配係数の推算処理方法
CZ220498A3 (cs) * 1996-01-17 1998-11-11 Novo Nordisk A/S Deriváty 1,2,4-thiadiazinu a 1,4-thiazinu, příprava a použití
US6242443B1 (en) * 1996-06-21 2001-06-05 Novo Nordisk Ais 1,2,4-benzothiadiazine derivatives, their preparation and use
US6156700A (en) * 1997-09-17 2000-12-05 American Cyanmid Company 3-(1,2-Benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione herbicidal agents
US6943159B1 (en) * 1998-02-18 2005-09-13 Neurosearch A/S Compounds and their use as positive AMPA receptor modulators
US7902203B2 (en) * 2002-11-01 2011-03-08 Abbott Laboratories, Inc. Anti-infective agents
US20040097492A1 (en) * 2002-11-01 2004-05-20 Pratt John K Anti-infective agents
SI1560827T1 (sl) * 2002-11-01 2011-04-29 Abbott Lab Antiinfekcijska sredstva
US20040162285A1 (en) * 2002-11-01 2004-08-19 Pratt John K. Anti-infective agents
US20050075331A1 (en) * 2003-10-06 2005-04-07 Pratt John K. Anti-infective agents
CA2518465A1 (en) * 2003-03-25 2004-10-14 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7378414B2 (en) * 2003-08-25 2008-05-27 Abbott Laboratories Anti-infective agents
RU2007110531A (ru) * 2004-08-23 2008-09-27 Ф.Хоффманн-Ля Рош Аг (Ch) Гетероциклические противовирусные соединения
CA2584485C (en) * 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
WO2006093801A1 (en) * 2005-02-25 2006-09-08 Abbott Laboratories Thiadiazine derivatives useful as anti-infective agents
CN101189230A (zh) * 2005-05-04 2008-05-28 弗·哈夫曼-拉罗切有限公司 抗病毒的杂环化合物
CN102584649A (zh) * 2006-06-22 2012-07-18 安那迪斯药品股份有限公司 吡咯并[1,2-b]哒嗪酮化合物
JP4199273B2 (ja) * 2006-08-29 2008-12-17 本田技研工業株式会社 車両状態推定装置
TW200840572A (en) * 2006-12-12 2008-10-16 Anadys Pharmaceuticals Inc 5,6-dihydro-1H-pyridin-2-one compounds
US20080188466A1 (en) * 2006-12-21 2008-08-07 Anadys Pharmaceuticals, Inc. Pyridazinone compounds
DK2118074T3 (en) * 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
US20080227774A1 (en) * 2007-03-15 2008-09-18 Frank Ruebsam 5,5-disubstituted-indolizinone compounds
US7834009B2 (en) * 2007-08-27 2010-11-16 Anadys Pharmaceuticals, Inc. 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds
US8097613B2 (en) * 2008-06-10 2012-01-17 Anadys Pharmaceuticals, Inc. [1,2,4]thiadiazine 1,1-dioxide compounds

Also Published As

Publication number Publication date
JP2011516610A (ja) 2011-05-26
AU2009241514A1 (en) 2009-11-05
WO2009134616A8 (en) 2010-05-14
KR20110004439A (ko) 2011-01-13
CN102026990A (zh) 2011-04-20
BRPI0911259A2 (pt) 2015-10-06
EP2283002A2 (en) 2011-02-16
WO2009134616A3 (en) 2010-03-18
WO2009134616A2 (en) 2009-11-05
MX2010011307A (es) 2010-11-09
US20090257979A1 (en) 2009-10-15

Similar Documents

Publication Publication Date Title
US20090257979A1 (en) Novel Inhibitors of Hepatitis C Virus Replication
US7781474B2 (en) Inhibitors of hepatitis C virus replication
US8119592B2 (en) Compounds and methods for inhibiting hepatitis C viral replication
EP2177523A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
US20110312996A1 (en) Novel inhibitors of hepatitis c virus replication
AU2008216382A1 (en) Novel inhibitors hepatitis C virus replication
US20120101032A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
CA2686546A1 (en) Novel peptide inhibitors of hepatitis c virus replication
WO2012087976A2 (en) Novel inhibitors of hepatitis c virus replication
CA2720729A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
CN101304976A (zh) 病毒复制抑制剂
TW201116540A (en) Therapeutic antiviral peptides
AU2005276648A1 (en) Heterocyclic antiviral compounds
US20110110890A1 (en) Novel Inhibitors of Hepatitis C Virus Replication
CN101495457A (zh) C型肝炎病毒复制的新颖抑制剂
HK1125360B (en) Compounds and methods for inhibiting hepatitis c viral replication
HK1144683A (en) Novel macrocyclic inhibitors of hepatitis c virus replication

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140415