CA2720846A1 - Novel inhibitors of hepatitis c virus replication - Google Patents
Novel inhibitors of hepatitis c virus replication Download PDFInfo
- Publication number
- CA2720846A1 CA2720846A1 CA2720846A CA2720846A CA2720846A1 CA 2720846 A1 CA2720846 A1 CA 2720846A1 CA 2720846 A CA2720846 A CA 2720846A CA 2720846 A CA2720846 A CA 2720846A CA 2720846 A1 CA2720846 A1 CA 2720846A1
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- Canada
- Prior art keywords
- optionally substituted
- compound
- ifn
- substituted alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 208000010710 hepatitis C virus infection Diseases 0.000 claims abstract description 8
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- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 125000004385 trihaloalkyl group Chemical group 0.000 description 1
- 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 125000005500 uronium group Chemical group 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
- C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
- C07D285/30—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hydrocarbon radicals, substituted by hetero atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4521408P | 2008-04-15 | 2008-04-15 | |
| US4521908P | 2008-04-15 | 2008-04-15 | |
| US61/045,219 | 2008-04-15 | ||
| US61/045,214 | 2008-04-15 | ||
| US10985608P | 2008-10-30 | 2008-10-30 | |
| US61/109,856 | 2008-10-30 | ||
| US11791608P | 2008-11-25 | 2008-11-25 | |
| US61/117,916 | 2008-11-25 | ||
| US14833709P | 2009-01-29 | 2009-01-29 | |
| US61/148,337 | 2009-01-29 | ||
| PCT/US2009/040567 WO2009134616A2 (en) | 2008-04-15 | 2009-04-14 | Novel inhibitors of hepatitis c virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2720846A1 true CA2720846A1 (en) | 2009-11-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2720846A Abandoned CA2720846A1 (en) | 2008-04-15 | 2009-04-14 | Novel inhibitors of hepatitis c virus replication |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090257979A1 (enExample) |
| EP (1) | EP2283002A2 (enExample) |
| JP (1) | JP2011516610A (enExample) |
| KR (1) | KR20110004439A (enExample) |
| CN (1) | CN102026990A (enExample) |
| AU (1) | AU2009241514A1 (enExample) |
| BR (1) | BRPI0911259A2 (enExample) |
| CA (1) | CA2720846A1 (enExample) |
| MX (1) | MX2010011307A (enExample) |
| WO (1) | WO2009134616A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2056675T1 (sl) | 2006-10-12 | 2019-08-30 | Galera Labs, Llc | Postopki za zdravljenje oralnega mukozitisa |
| WO2011049988A2 (en) * | 2009-10-20 | 2011-04-28 | Eiger Biopharmaceuticals, Inc. | Indazoles to treat flaviviridae virus infection |
| TW201121968A (en) * | 2009-11-09 | 2011-07-01 | Intermune Inc | Novel inhibitors of hepatitis C virus replication |
| CA3120505C (en) * | 2011-09-26 | 2024-11-12 | Galera Labs, Llc | METHODS OF TREATING DISEASES |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| SE1450131A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | DAA-kombinationsbehandling (t.ex. med ABT-072 eller ABT-333)för användning vid behandling av HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| SE1450130A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon |
| WO2015018797A2 (en) * | 2013-08-05 | 2015-02-12 | Haplogen Gmbh | Antiviral compounds |
| CN105991908B (zh) * | 2015-03-16 | 2019-06-07 | 迈科威特株式会社 | 摄像机模块用滤光器转换装置及包含该模块的移动设备 |
| EP3738967A1 (en) | 2015-08-11 | 2020-11-18 | Galera Labs, LLC | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
| CN109689063A (zh) | 2016-04-28 | 2019-04-26 | 埃默里大学 | 含有炔烃的核苷酸和核苷治疗组合物及其相关用途 |
| EP3452060A4 (en) | 2016-05-03 | 2020-01-01 | Galera Labs, LLC | Combination therapy for cancer treatment |
| CN109906081A (zh) | 2016-09-01 | 2019-06-18 | 加莱拉实验室有限责任公司 | 利用五氮杂大环络合物和抗坏血酸类化合物的联合癌症疗法 |
| EA201992431A1 (ru) | 2017-10-13 | 2020-03-13 | ГАЛЕРА ЛЭБЗ, ЭлЭлСи | Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS6025984A (ja) * | 1983-07-22 | 1985-02-08 | Tokyo Inst Of Technol | ベンゾチアジアジン誘導体の製造方法 |
| JPH0216448A (ja) * | 1988-07-04 | 1990-01-19 | Fuji Photo Film Co Ltd | 化学物質の分配係数の推算処理方法 |
| CZ220498A3 (cs) * | 1996-01-17 | 1998-11-11 | Novo Nordisk A/S | Deriváty 1,2,4-thiadiazinu a 1,4-thiazinu, příprava a použití |
| US6242443B1 (en) * | 1996-06-21 | 2001-06-05 | Novo Nordisk Ais | 1,2,4-benzothiadiazine derivatives, their preparation and use |
| US6156700A (en) * | 1997-09-17 | 2000-12-05 | American Cyanmid Company | 3-(1,2-Benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione herbicidal agents |
| US6943159B1 (en) * | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
| US7902203B2 (en) * | 2002-11-01 | 2011-03-08 | Abbott Laboratories, Inc. | Anti-infective agents |
| US20040162285A1 (en) * | 2002-11-01 | 2004-08-19 | Pratt John K. | Anti-infective agents |
| ATE493408T1 (de) * | 2002-11-01 | 2011-01-15 | Abbott Lab | Antiinfektiöse mittel |
| US20040097492A1 (en) * | 2002-11-01 | 2004-05-20 | Pratt John K | Anti-infective agents |
| US20050075331A1 (en) * | 2003-10-06 | 2005-04-07 | Pratt John K. | Anti-infective agents |
| JP4887139B2 (ja) * | 2003-03-25 | 2012-02-29 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| US7378414B2 (en) * | 2003-08-25 | 2008-05-27 | Abbott Laboratories | Anti-infective agents |
| RU2007110531A (ru) * | 2004-08-23 | 2008-09-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Гетероциклические противовирусные соединения |
| US8093273B2 (en) * | 2004-10-20 | 2012-01-10 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
| WO2006093801A1 (en) * | 2005-02-25 | 2006-09-08 | Abbott Laboratories | Thiadiazine derivatives useful as anti-infective agents |
| CN101189230A (zh) * | 2005-05-04 | 2008-05-28 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的杂环化合物 |
| KR101384266B1 (ko) * | 2006-06-22 | 2014-04-24 | 애나디스 파마슈티칼스, 인코포레이티드 | 파이로［1,2-ｂ］파이리다지논 화합물 |
| JP4199273B2 (ja) * | 2006-08-29 | 2008-12-17 | 本田技研工業株式会社 | 車両状態推定装置 |
| CL2007003587A1 (es) * | 2006-12-12 | 2008-07-04 | Anadys Pharmaceuticals Inc | Compuestos derivados de pirimidinas sustituidas; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para tratar o prevenir la infeccion de la hepatitis c. |
| US20080188466A1 (en) * | 2006-12-21 | 2008-08-07 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
| KR101444489B1 (ko) * | 2007-02-01 | 2014-09-24 | 리스버로직스 코퍼레이션 | 심혈관 질환을 예방 및 치료하기 위한 화합물 |
| US20080227774A1 (en) * | 2007-03-15 | 2008-09-18 | Frank Ruebsam | 5,5-disubstituted-indolizinone compounds |
| US7834009B2 (en) * | 2007-08-27 | 2010-11-16 | Anadys Pharmaceuticals, Inc. | 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds |
| TWI438206B (zh) * | 2008-06-10 | 2014-05-21 | Anadys Pharmaceuticals Inc | 〔１，２，４〕噻二１，１二氧化物化合物 |
-
2009
- 2009-04-14 US US12/423,720 patent/US20090257979A1/en not_active Abandoned
- 2009-04-14 BR BRPI0911259A patent/BRPI0911259A2/pt not_active IP Right Cessation
- 2009-04-14 WO PCT/US2009/040567 patent/WO2009134616A2/en not_active Ceased
- 2009-04-14 AU AU2009241514A patent/AU2009241514A1/en not_active Abandoned
- 2009-04-14 MX MX2010011307A patent/MX2010011307A/es not_active Application Discontinuation
- 2009-04-14 CN CN2009801168384A patent/CN102026990A/zh active Pending
- 2009-04-14 KR KR1020107025281A patent/KR20110004439A/ko not_active Withdrawn
- 2009-04-14 EP EP09739418A patent/EP2283002A2/en not_active Withdrawn
- 2009-04-14 JP JP2011505149A patent/JP2011516610A/ja active Pending
- 2009-04-14 CA CA2720846A patent/CA2720846A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110004439A (ko) | 2011-01-13 |
| AU2009241514A1 (en) | 2009-11-05 |
| WO2009134616A2 (en) | 2009-11-05 |
| WO2009134616A3 (en) | 2010-03-18 |
| WO2009134616A8 (en) | 2010-05-14 |
| EP2283002A2 (en) | 2011-02-16 |
| MX2010011307A (es) | 2010-11-09 |
| US20090257979A1 (en) | 2009-10-15 |
| CN102026990A (zh) | 2011-04-20 |
| BRPI0911259A2 (pt) | 2015-10-06 |
| JP2011516610A (ja) | 2011-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140415 |