CA2712897A1 - Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands - Google Patents
Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands Download PDFInfo
- Publication number
- CA2712897A1 CA2712897A1 CA2712897A CA2712897A CA2712897A1 CA 2712897 A1 CA2712897 A1 CA 2712897A1 CA 2712897 A CA2712897 A CA 2712897A CA 2712897 A CA2712897 A CA 2712897A CA 2712897 A1 CA2712897 A1 CA 2712897A1
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 45
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Classifications
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Landscapes
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- Obesity (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6290708P | 2008-01-30 | 2008-01-30 | |
| US61/062,907 | 2008-01-30 | ||
| PCT/US2009/032709 WO2009097567A1 (en) | 2008-01-30 | 2009-01-30 | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2712897A1 true CA2712897A1 (en) | 2009-08-06 |
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| CA2712897A Abandoned CA2712897A1 (en) | 2008-01-30 | 2009-01-30 | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands |
Country Status (7)
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| US (1) | US8513232B2 (https=) |
| EP (1) | EP2250176B1 (https=) |
| JP (1) | JP5524083B2 (https=) |
| CA (1) | CA2712897A1 (https=) |
| ES (1) | ES2390004T3 (https=) |
| MX (1) | MX2010008375A (https=) |
| WO (1) | WO2009097567A1 (https=) |
Families Citing this family (21)
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| UA95644C2 (ru) * | 2006-07-25 | 2011-08-25 | Сефалон, Инк. | Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний |
| CA2712885A1 (en) | 2008-01-30 | 2009-08-06 | Cephalon, Inc. | Substituted pyridazine derivatives which have histamine h3 antagonist activity |
| MX2010008375A (es) | 2008-01-30 | 2011-03-04 | Cephalon Inc Star | Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3). |
| WO2009142732A2 (en) * | 2008-05-20 | 2009-11-26 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| UY32730A (es) * | 2009-06-26 | 2011-01-31 | Novartis Ag | Inhibidores de cyp17 |
| WO2011020193A1 (en) * | 2009-08-18 | 2011-02-24 | Merck Frosst Canada Ltd. | Renin inhibitors |
| EP2488530A4 (en) * | 2009-10-13 | 2014-03-19 | Merck Canada Inc | SPIROCYCLIC PIPERIDINE DERIVATIVES AS RENIN INHIBITORS |
| TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
| TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
| AU2012249421B9 (en) | 2011-04-28 | 2015-10-22 | Novartis Ag | 17alpha-hydroxylase/C17,20-lyase inhibitors |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP3290407B1 (en) | 2013-10-18 | 2020-01-01 | Celgene Quanticel Research, Inc | Bromodomain inhibitors |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| AU2017252276A1 (en) | 2016-04-18 | 2018-11-15 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2018083171A1 (en) * | 2016-11-02 | 2018-05-11 | AbbVie Deutschland GmbH & Co. KG | Spiro-compounds as s1p modulators |
| WO2018112204A1 (en) * | 2016-12-14 | 2018-06-21 | Cephalon, Inc. | Spiropiperidine derivatives |
| CN114728982A (zh) | 2019-10-31 | 2022-07-08 | 逃逸生物有限公司 | 固体形式的s1p-受体调节剂 |
| GB201917101D0 (en) * | 2019-11-25 | 2020-01-08 | Uea Enterprises Ltd | Method for digesting nucleic acid in a sample |
| EP4725946A1 (en) * | 2023-06-09 | 2026-04-15 | Guangzhou Unirise Pharmaceutical Co., Ltd. | Irak4 degradation agent and use thereof |
Family Cites Families (15)
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|---|---|---|---|---|
| US4166120A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines |
| CZ2003686A3 (cs) | 2000-08-08 | 2003-08-13 | Ortho Mcneil Pharmaceutical, Inc. | Neimidazolové aryloxypiperidiny |
| KR101011657B1 (ko) * | 2002-03-01 | 2011-01-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 항우울제 |
| SE0202133D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| EP1642898B1 (en) | 2003-06-27 | 2013-03-27 | Msd K.K. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
| CN100418948C (zh) | 2003-07-15 | 2008-09-17 | 麦克公司 | 羟基吡啶cgrp受体抗拮抗剂 |
| CN101921279A (zh) * | 2003-10-01 | 2010-12-22 | 阿得罗公司 | 螺环杂环衍生物及其应用方法 |
| SE0403160D0 (sv) | 2004-12-23 | 2004-12-23 | Biovitrum Ab | New compounds |
| CA2602336A1 (en) | 2005-03-31 | 2006-10-05 | Ucb Pharma S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
| EP1707203A1 (en) | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| EP1717235A3 (en) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
| WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| WO2007088462A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
| US20100317679A1 (en) * | 2007-09-21 | 2010-12-16 | Ligand Pharmaceuticals, Inc. | Substituted aryl-fused spirocyclic amines |
| MX2010008375A (es) | 2008-01-30 | 2011-03-04 | Cephalon Inc Star | Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3). |
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- 2009-01-30 EP EP09707104A patent/EP2250176B1/en not_active Not-in-force
- 2009-01-30 JP JP2010545227A patent/JP5524083B2/ja not_active Expired - Fee Related
- 2009-01-30 WO PCT/US2009/032709 patent/WO2009097567A1/en not_active Ceased
- 2009-01-30 CA CA2712897A patent/CA2712897A1/en not_active Abandoned
- 2009-01-30 ES ES09707104T patent/ES2390004T3/es active Active
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2010
- 2010-07-29 US US12/846,100 patent/US8513232B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5524083B2 (ja) | 2014-06-18 |
| EP2250176B1 (en) | 2012-08-01 |
| EP2250176A1 (en) | 2010-11-17 |
| WO2009097567A1 (en) | 2009-08-06 |
| US8513232B2 (en) | 2013-08-20 |
| WO2009097567A4 (en) | 2009-10-29 |
| HK1149555A1 (en) | 2011-10-07 |
| US20110071131A1 (en) | 2011-03-24 |
| JP2011511001A (ja) | 2011-04-07 |
| MX2010008375A (es) | 2011-03-04 |
| ES2390004T3 (es) | 2012-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140121 |
|
| FZDE | Discontinued |
Effective date: 20160706 |