CA2708559C - Treatment of colon diseases or prevention of colorectal carcinoma with imidazoquinoline derivatives - Google Patents
Treatment of colon diseases or prevention of colorectal carcinoma with imidazoquinoline derivatives Download PDFInfo
- Publication number
- CA2708559C CA2708559C CA2708559A CA2708559A CA2708559C CA 2708559 C CA2708559 C CA 2708559C CA 2708559 A CA2708559 A CA 2708559A CA 2708559 A CA2708559 A CA 2708559A CA 2708559 C CA2708559 C CA 2708559C
- Authority
- CA
- Canada
- Prior art keywords
- imiquimod
- prevention
- colorectal
- sotirimod
- resiquimod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010009944 Colon cancer Diseases 0.000 title claims abstract description 14
- 208000001333 Colorectal Neoplasms Diseases 0.000 title claims abstract description 12
- 230000002265 prevention Effects 0.000 title claims abstract description 12
- RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical class C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 title claims description 10
- 201000010989 colorectal carcinoma Diseases 0.000 title claims description 7
- 238000011282 treatment Methods 0.000 title description 11
- 208000019399 Colonic disease Diseases 0.000 title description 2
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229960002751 imiquimod Drugs 0.000 claims abstract description 35
- ZXBCLVSLRUWISJ-UHFFFAOYSA-N 2-methyl-1-(2-methylpropyl)imidazo[4,5-c][1,5]naphthyridin-4-amine Chemical compound C1=CC=NC2=C3N(CC(C)C)C(C)=NC3=C(N)N=C21 ZXBCLVSLRUWISJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229950010550 resiquimod Drugs 0.000 claims abstract description 12
- BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229950008380 sotirimod Drugs 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims description 11
- 208000022131 polyp of large intestine Diseases 0.000 claims description 6
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- 229940124669 imidazoquinoline Drugs 0.000 abstract description 4
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- 208000014081 polyp of colon Diseases 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
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- WSIZDLIFQIDDKA-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinolin-2-amine Chemical compound C1=CC=NC2=C(NC(N)=N3)C3=CC=C21 WSIZDLIFQIDDKA-UHFFFAOYSA-N 0.000 description 1
- 208000004804 Adenomatous Polyps Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010048832 Colon adenoma Diseases 0.000 description 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
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- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US645908P | 2008-01-15 | 2008-01-15 | |
| US61/006,459 | 2008-01-15 | ||
| PCT/EP2008/011088 WO2009089900A1 (en) | 2008-01-15 | 2008-12-23 | Treatment of colon diseases or prevention of colorectal carcinoma with imidazoquinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2708559A1 CA2708559A1 (en) | 2009-07-23 |
| CA2708559C true CA2708559C (en) | 2015-10-06 |
Family
ID=40419193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2708559A Expired - Fee Related CA2708559C (en) | 2008-01-15 | 2008-12-23 | Treatment of colon diseases or prevention of colorectal carcinoma with imidazoquinoline derivatives |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8008319B2 (enExample) |
| EP (1) | EP2237780A1 (enExample) |
| JP (1) | JP2011509956A (enExample) |
| CN (1) | CN101909624A (enExample) |
| AU (1) | AU2008347400B2 (enExample) |
| BR (1) | BRPI0822002A2 (enExample) |
| CA (1) | CA2708559C (enExample) |
| EA (1) | EA018579B1 (enExample) |
| GE (1) | GEP20125605B (enExample) |
| IL (1) | IL205819A (enExample) |
| MX (1) | MX2010007699A (enExample) |
| NZ (1) | NZ586161A (enExample) |
| UA (1) | UA101339C2 (enExample) |
| WO (1) | WO2009089900A1 (enExample) |
| ZA (1) | ZA201003906B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA020488B1 (ru) | 2009-10-22 | 2014-11-28 | Джилид Сайэнс, Инк. | Производные пурина или деазапурина для применения при лечении вирусных инфекций и других заболеваний |
| CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| SG11201605449YA (en) | 2014-01-10 | 2016-08-30 | Birdie Biopharmaceuticals Inc | Compounds and compositions for immunotherapy |
| EP4001311B1 (en) | 2014-07-09 | 2025-11-05 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1/pd-1 combinations for treating tumors |
| CN112546238A (zh) | 2014-09-01 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CN106943597A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN118515666A (zh) | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| US11517567B2 (en) * | 2017-06-23 | 2022-12-06 | Birdie Biopharmaceuticals, Inc. | Pharmaceutical compositions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2078547C1 (ru) * | 1995-11-28 | 1997-05-10 | Центральный научно-исследовательский рентгено-радиологический институт МЗМП РФ | Способ лечения полипоза желудка и двенадцатиперстной кишки |
| UA74852C2 (en) * | 2000-12-08 | 2006-02-15 | 3M Innovative Properties Co | Urea-substituted imidazoquinoline ethers |
| AU2002219472A1 (en) * | 2001-01-02 | 2002-07-16 | Elisabeth Shanahan-Prendergast | Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens |
| US20060193789A1 (en) * | 2002-10-25 | 2006-08-31 | Foamix Ltd. | Film forming foamable composition |
| BRPI0416801A (pt) * | 2003-11-21 | 2007-01-09 | Novartis Ag | derivados de 1h-imidazoquinolina como inibidores de proteìna sinase |
-
2008
- 2008-12-23 MX MX2010007699A patent/MX2010007699A/es active IP Right Grant
- 2008-12-23 JP JP2010542534A patent/JP2011509956A/ja active Pending
- 2008-12-23 EA EA201001164A patent/EA018579B1/ru not_active IP Right Cessation
- 2008-12-23 AU AU2008347400A patent/AU2008347400B2/en not_active Ceased
- 2008-12-23 UA UAA201006372A patent/UA101339C2/ru unknown
- 2008-12-23 CA CA2708559A patent/CA2708559C/en not_active Expired - Fee Related
- 2008-12-23 EP EP08871156A patent/EP2237780A1/en not_active Withdrawn
- 2008-12-23 NZ NZ586161A patent/NZ586161A/en unknown
- 2008-12-23 BR BRPI0822002A patent/BRPI0822002A2/pt not_active IP Right Cessation
- 2008-12-23 CN CN2008801223531A patent/CN101909624A/zh active Pending
- 2008-12-23 GE GEAP200811913A patent/GEP20125605B/en unknown
- 2008-12-23 WO PCT/EP2008/011088 patent/WO2009089900A1/en not_active Ceased
-
2009
- 2009-01-14 US US12/353,683 patent/US8008319B2/en not_active Expired - Fee Related
-
2010
- 2010-05-17 IL IL205819A patent/IL205819A/en not_active IP Right Cessation
- 2010-06-01 ZA ZA2010/03906A patent/ZA201003906B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GEP20125605B (en) | 2012-08-10 |
| JP2011509956A (ja) | 2011-03-31 |
| AU2008347400A1 (en) | 2009-07-23 |
| EA201001164A1 (ru) | 2010-12-30 |
| IL205819A (en) | 2013-02-28 |
| UA101339C2 (ru) | 2013-03-25 |
| CN101909624A (zh) | 2010-12-08 |
| NZ586161A (en) | 2012-05-25 |
| ZA201003906B (en) | 2011-03-30 |
| BRPI0822002A2 (pt) | 2015-10-13 |
| US8008319B2 (en) | 2011-08-30 |
| MX2010007699A (es) | 2010-08-04 |
| US20090182005A1 (en) | 2009-07-16 |
| CA2708559A1 (en) | 2009-07-23 |
| AU2008347400B2 (en) | 2014-12-11 |
| EP2237780A1 (en) | 2010-10-13 |
| EA018579B1 (ru) | 2013-09-30 |
| WO2009089900A1 (en) | 2009-07-23 |
| IL205819A0 (en) | 2010-11-30 |
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| Publication | Publication Date | Title |
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| CA2708559C (en) | Treatment of colon diseases or prevention of colorectal carcinoma with imidazoquinoline derivatives | |
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