CA2703563A1 - Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level - Google Patents
Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level Download PDFInfo
- Publication number
- CA2703563A1 CA2703563A1 CA2703563A CA2703563A CA2703563A1 CA 2703563 A1 CA2703563 A1 CA 2703563A1 CA 2703563 A CA2703563 A CA 2703563A CA 2703563 A CA2703563 A CA 2703563A CA 2703563 A1 CA2703563 A1 CA 2703563A1
- Authority
- CA
- Canada
- Prior art keywords
- dopamine transporter
- patient
- lewy body
- body dementia
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nuclear Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98419407P | 2007-10-31 | 2007-10-31 | |
| US60/984,194 | 2007-10-31 | ||
| PCT/US2008/081569 WO2009058851A2 (en) | 2007-10-31 | 2008-10-29 | Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2703563A1 true CA2703563A1 (en) | 2009-05-07 |
Family
ID=40591729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2703563A Abandoned CA2703563A1 (en) | 2007-10-31 | 2008-10-29 | Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20100312105A1 (https=) |
| EP (1) | EP2211911A4 (https=) |
| JP (1) | JP2011502966A (https=) |
| CA (1) | CA2703563A1 (https=) |
| WO (1) | WO2009058851A2 (https=) |
Families Citing this family (11)
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|---|---|---|---|---|
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| WO2014152110A1 (en) * | 2013-03-15 | 2014-09-25 | Simon Adam J | Multi-modal pharmaco-diagnostic assessment of brian helath |
| KR20160055103A (ko) | 2013-03-15 | 2016-05-17 | 아담 제이 사이먼 | 뇌 건강의 다중-모드 생리적 자극 및 평가를 위한 시스템 및 시그너처 |
| GB201313291D0 (en) * | 2013-07-25 | 2013-09-11 | Ge Healthcare Ltd | Imaging neurological disease |
| CN104720840A (zh) * | 2015-02-11 | 2015-06-24 | 清华大学深圳研究生院 | 基于多巴胺转运体显像特异性摄取比的半自动量化方法 |
| EP3579887A4 (en) * | 2017-02-10 | 2020-09-16 | Likeminds, Inc. | PROCEDURE FOR IN VIVO MONITORING OF DOPAMINER DISORDERS AND EFFECTIVENESS OF TREATMENT PRODUCTS THEREFORE |
| KR20210034008A (ko) * | 2018-07-18 | 2021-03-29 | 라이크마인즈, 인크. | 뇌로의 화합물의 가속화된 조직 침투를 위한 방법 |
| CN113271985A (zh) * | 2018-08-07 | 2021-08-17 | 悦智有限公司 | 用于诊断多巴胺能和运动障碍的方法 |
| TWI686178B (zh) * | 2019-10-09 | 2020-03-01 | 中原大學 | 自動化定位核子醫學腦部影像紋狀體與計算紋狀體專一性攝取率的方法與系統 |
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| WO2022240817A1 (en) * | 2021-05-13 | 2022-11-17 | Likeminds, Inc. | Methods of visualizing dopamine transporters |
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| US8084018B2 (en) * | 2007-10-31 | 2011-12-27 | Alseres Pharmaceuticals, Inc. | Methods for imaging dopamine transporter level |
| JP5603855B2 (ja) * | 2008-04-04 | 2014-10-08 | アビッド レディオファーマシューティカルズ、インク． | 神経変成疾患の放射性薬剤による画像化 |
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| US20100312105A1 (en) | 2010-12-09 |
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| EP2211911A2 (en) | 2010-08-04 |
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