CA2703563A1 - Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level - Google Patents
Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level Download PDFInfo
- Publication number
- CA2703563A1 CA2703563A1 CA2703563A CA2703563A CA2703563A1 CA 2703563 A1 CA2703563 A1 CA 2703563A1 CA 2703563 A CA2703563 A CA 2703563A CA 2703563 A CA2703563 A CA 2703563A CA 2703563 A1 CA2703563 A1 CA 2703563A1
- Authority
- CA
- Canada
- Prior art keywords
- dopamine transporter
- patient
- lewy body
- body dementia
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nuclear Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98419407P | 2007-10-31 | 2007-10-31 | |
| US60/984,194 | 2007-10-31 | ||
| PCT/US2008/081569 WO2009058851A2 (en) | 2007-10-31 | 2008-10-29 | Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2703563A1 true CA2703563A1 (en) | 2009-05-07 |
Family
ID=40591729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2703563A Abandoned CA2703563A1 (en) | 2007-10-31 | 2008-10-29 | Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20100312105A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2211911A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2011502966A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2703563A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2009058851A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2010540512A (ja) | 2007-09-26 | 2010-12-24 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 異なるタイプの認知症を特異的に診断する方法 |
| AU2014240105B2 (en) * | 2013-03-15 | 2019-10-31 | Cerora, Inc. | Multi-modal pharmaco-diagnostic assessment of brain health |
| US10779747B2 (en) | 2013-03-15 | 2020-09-22 | Cerora, Inc. | System and signatures for the multi-modal physiological stimulation and assessment of brain health |
| GB201313291D0 (en) * | 2013-07-25 | 2013-09-11 | Ge Healthcare Ltd | Imaging neurological disease |
| CN104720840A (zh) * | 2015-02-11 | 2015-06-24 | 清华大学深圳研究生院 | 基于多巴胺转运体显像特异性摄取比的半自动量化方法 |
| WO2018148509A1 (en) * | 2017-02-10 | 2018-08-16 | Likeminds, Inc. | Methods for in vivo monitoring of dopaminergic disorders and efficacy of treatment agents therefor |
| CN112805038A (zh) * | 2018-07-18 | 2021-05-14 | 悦智有限公司 | 用于使化合物加速组织穿透到脑内的方法 |
| CN113271985A (zh) * | 2018-08-07 | 2021-08-17 | 悦智有限公司 | 用于诊断多巴胺能和运动障碍的方法 |
| TWI686178B (zh) * | 2019-10-09 | 2020-03-01 | 中原大學 | 自動化定位核子醫學腦部影像紋狀體與計算紋狀體專一性攝取率的方法與系統 |
| WO2021092096A1 (en) * | 2019-11-06 | 2021-05-14 | Likeminds, Inc. | Individualized dosing of radioactive tracers for imaging |
| WO2022240817A1 (en) * | 2021-05-13 | 2022-11-17 | Likeminds, Inc. | Methods of visualizing dopamine transporters |
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| US7081238B2 (en) * | 1995-11-03 | 2006-07-25 | The President And Fellows Of Harvard College | Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level |
| JP2001517617A (ja) * | 1997-09-24 | 2001-10-09 | ノヴァ モレキュラー インク． | 神経変性疾患の治療を目的としてａｐｏｅレベルを増加させる方法 |
| DE60124730T2 (de) * | 2000-03-03 | 2007-10-04 | Eisai R&D Management Co., Ltd. | Neue methoden unter verwendung von cholinesteraseinhibitoren |
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| MXPA05004828A (es) * | 2002-11-07 | 2006-01-27 | Applied Neurosolutions Inc | Metodos para predecir si sujetos con deterioro cognoscitivo leve (mci) desarrollaran o no la enfermedad de alzheimer. |
| US20080302950A1 (en) * | 2005-08-11 | 2008-12-11 | The Brigham And Women's Hospital, Inc. | System and Method for Performing Single Photon Emission Computed Tomography (Spect) with a Focal-Length Cone-Beam Collimation |
| US8150629B2 (en) * | 2005-11-10 | 2012-04-03 | In Silico Biosciences | Method and apparatus for computer modeling of the interaction between and among cortical and subcortical areas in the human brain for the purpose of predicting the effect of drugs in psychiatric and cognitive diseases |
| ES2525932T3 (es) * | 2006-05-02 | 2015-01-02 | The Trustees Of The University Of Pennsylvania | Derivados de dihidrotetrabenazina radiomarcados y su uso como agentes de imagenología |
| JP2010540512A (ja) * | 2007-09-26 | 2010-12-24 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 異なるタイプの認知症を特異的に診断する方法 |
| US8084018B2 (en) * | 2007-10-31 | 2011-12-27 | Alseres Pharmaceuticals, Inc. | Methods for imaging dopamine transporter level |
| US8557222B2 (en) * | 2008-04-04 | 2013-10-15 | Avid Radiopharmaceuticals, Inc. | Radiopharmaceutical imaging of neurodegenerative diseases |
| HRP20150831T1 (hr) * | 2008-12-19 | 2015-10-09 | Biogen International Neuroscience Gmbh | Humana anti-alfa- sinuklein auto-protutijela |
| SG176628A1 (en) * | 2009-06-05 | 2012-01-30 | Link Medicine Corp | Aminopyrrolidinone derivatives and uses thereof |
| GB0922304D0 (en) * | 2009-12-22 | 2010-02-03 | Ge Healthcare Ltd | Radioiodinated compounds |
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| US20100312105A1 (en) | 2010-12-09 |
| WO2009058851A2 (en) | 2009-05-07 |
| US20160121003A1 (en) | 2016-05-05 |
| JP2011502966A (ja) | 2011-01-27 |
| WO2009058851A3 (en) | 2010-01-14 |
| EP2211911A2 (en) | 2010-08-04 |
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