CA2703154A1 - Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (vegf) - Google Patents
Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (vegf) Download PDFInfo
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- CA2703154A1 CA2703154A1 CA2703154A CA2703154A CA2703154A1 CA 2703154 A1 CA2703154 A1 CA 2703154A1 CA 2703154 A CA2703154 A CA 2703154A CA 2703154 A CA2703154 A CA 2703154A CA 2703154 A1 CA2703154 A1 CA 2703154A1
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- Prior art keywords
- antibody
- vegf
- angiogenic
- antibodies
- pro
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98243807P | 2007-10-25 | 2007-10-25 | |
| US60/982,438 | 2007-10-25 | ||
| PCT/IL2008/001410 WO2009053987A1 (en) | 2007-10-25 | 2008-10-26 | Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (vegf) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2703154A1 true CA2703154A1 (en) | 2009-04-30 |
Family
ID=40385456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2703154A Abandoned CA2703154A1 (en) | 2007-10-25 | 2008-10-26 | Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (vegf) |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8592563B2 (enExample) |
| EP (1) | EP2203480A1 (enExample) |
| JP (1) | JP2011504092A (enExample) |
| CN (1) | CN101970486A (enExample) |
| AU (1) | AU2008315414A1 (enExample) |
| CA (1) | CA2703154A1 (enExample) |
| WO (1) | WO2009053987A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7750124B2 (en) | 2006-09-29 | 2010-07-06 | Oncomed Pharmaceuticals, Inc. | Anti-human DLL4 antibodies and compositions |
| CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| AU2010339723B2 (en) * | 2009-12-21 | 2014-11-06 | Mayo Foundation For Medical Education And Research | Early marker of proteinuria in patients treated with an anti-VEGF treatment |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| MX343117B (es) * | 2011-06-15 | 2016-10-25 | Hoffmann La Roche | Anticuerpos del receptor eritropoyetina (epo) anti-humana y metodos de uso. |
| HRP20190044T1 (hr) | 2011-09-23 | 2019-02-22 | Oncomed Pharmaceuticals, Inc. | Agensi koji vežu vegf/dll4 i njihove uporabe |
| AU2013337811A1 (en) | 2012-10-31 | 2015-05-14 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
| US20150353617A1 (en) * | 2013-01-27 | 2015-12-10 | The Cleveland Clinic Foundation | Anti-angiogenic vegf-ax isoform |
| MX382902B (es) | 2014-10-31 | 2025-03-13 | Oncomed Pharm Inc | Inhibidor de la vía noth en combinación con un agente inmunoterapéutico para usarse en el tratamiento de cáncer. |
| WO2016194708A1 (ja) * | 2015-05-29 | 2016-12-08 | 国立大学法人名古屋大学 | 尿中VEGF-A165bを指標とした腎機能の検査方法及び検査装置、腎機能の検査装置として機能させるためのプログラム及び記録媒体 |
| WO2017053705A1 (en) | 2015-09-23 | 2017-03-30 | Oncomed Pharmaceuticals, Inc. | Methods and compositions for treatment of cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6022541A (en) * | 1991-10-18 | 2000-02-08 | Beth Israel Deaconess Medical Center | Immunological preparation for concurrent specific binding to spatially exposed regions of vascular permeability factor bound in-vivo to a tumor associated blood vessel |
| US7667004B2 (en) | 2001-04-17 | 2010-02-23 | Abmaxis, Inc. | Humanized antibodies against vascular endothelial growth factor |
| JP4689956B2 (ja) * | 2001-08-01 | 2011-06-01 | ユニバーシティ オブ ブリストル | 増殖因子イソ型 |
| US20050009110A1 (en) * | 2003-07-08 | 2005-01-13 | Xiao-Jia Chang | Methods of producing antibodies for diagnostics and therapeutics |
| US20060286636A1 (en) * | 2005-04-29 | 2006-12-21 | Shima David T | VEGF variants |
| US20080031815A1 (en) * | 2006-07-27 | 2008-02-07 | Xiaoyuan Chen | Pet imaging of vascular endothelial growth factor receptor (VEGFR), compositions for VEGF cancer imaging, and methods of VEGF cancer imaging |
| GB0704678D0 (en) | 2007-03-09 | 2007-04-18 | Univ Bristol | Pro- and anti-angiogenic treatments |
-
2008
- 2008-10-26 AU AU2008315414A patent/AU2008315414A1/en not_active Abandoned
- 2008-10-26 JP JP2010530629A patent/JP2011504092A/ja active Pending
- 2008-10-26 WO PCT/IL2008/001410 patent/WO2009053987A1/en not_active Ceased
- 2008-10-26 US US12/739,619 patent/US8592563B2/en not_active Expired - Fee Related
- 2008-10-26 CA CA2703154A patent/CA2703154A1/en not_active Abandoned
- 2008-10-26 CN CN2008801226493A patent/CN101970486A/zh active Pending
- 2008-10-26 EP EP08842953A patent/EP2203480A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008315414A1 (en) | 2009-04-30 |
| CN101970486A (zh) | 2011-02-09 |
| US8592563B2 (en) | 2013-11-26 |
| EP2203480A1 (en) | 2010-07-07 |
| JP2011504092A (ja) | 2011-02-03 |
| WO2009053987A1 (en) | 2009-04-30 |
| US20100272733A1 (en) | 2010-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20141028 |