CA2700441A1 - C5a binding nucleic acids - Google Patents

C5a binding nucleic acids Download PDF

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Publication number
CA2700441A1
CA2700441A1 CA2700441A CA2700441A CA2700441A1 CA 2700441 A1 CA2700441 A1 CA 2700441A1 CA 2700441 A CA2700441 A CA 2700441A CA 2700441 A CA2700441 A CA 2700441A CA 2700441 A1 CA2700441 A1 CA 2700441A1
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CA
Canada
Prior art keywords
stretch
nucleic acid
absent
nucleotides
acid according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2700441A
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English (en)
French (fr)
Inventor
Werner Purschke
Florian Jarosch
Dirk Eulberg
Sven Klussmann
Klaus Buchner
Christian Maasch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TME Pharma AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CA2700441A1 publication Critical patent/CA2700441A1/en
Abandoned legal-status Critical Current

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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
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    • A61P33/06Antimalarials
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    • A61P37/02Immunomodulators
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183Diol linkers, e.g. glycols or propanediols
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
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  • Virology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
CA2700441A 2007-09-24 2008-09-24 C5a binding nucleic acids Abandoned CA2700441A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07018750.5 2007-09-24
EP07018750 2007-09-24
PCT/EP2008/008097 WO2009040113A2 (en) 2007-09-24 2008-09-24 C5a BINDING NUCLEIC ACIDS

Publications (1)

Publication Number Publication Date
CA2700441A1 true CA2700441A1 (en) 2009-04-02

Family

ID=40174751

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2700441A Abandoned CA2700441A1 (en) 2007-09-24 2008-09-24 C5a binding nucleic acids

Country Status (11)

Country Link
US (1) US8507456B2 (cg-RX-API-DMAC7.html)
EP (2) EP2562256A3 (cg-RX-API-DMAC7.html)
JP (1) JP5798320B2 (cg-RX-API-DMAC7.html)
KR (1) KR20100072185A (cg-RX-API-DMAC7.html)
CN (1) CN101809154A (cg-RX-API-DMAC7.html)
AU (1) AU2008303775A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0817260A2 (cg-RX-API-DMAC7.html)
CA (1) CA2700441A1 (cg-RX-API-DMAC7.html)
MX (1) MX2010003109A (cg-RX-API-DMAC7.html)
RU (1) RU2010116245A (cg-RX-API-DMAC7.html)
WO (1) WO2009040113A2 (cg-RX-API-DMAC7.html)

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US20120065254A1 (en) * 2009-03-23 2012-03-15 Noxxon Pharma Ag C5A binding nucleic acids and the use thereof
EP2480888B1 (en) * 2009-09-25 2016-11-30 XOMA Technology Ltd. Screening methods
JP2014514329A (ja) * 2011-04-26 2014-06-19 リガド・バイオサイエンシーズ・インコーポレーテツド Peg化オリゴヌクレオチドの製造方法
CN103582887B (zh) * 2011-06-07 2017-07-04 皇家飞利浦有限公司 提供核苷酸序列数据的方法和测序装置
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
PT2802660T (pt) 2012-01-10 2020-04-21 Aptarion Biotech Ag Novos ácidos nucleicos que se ligam a c5a
WO2015066027A2 (en) 2013-10-28 2015-05-07 Dots Devices, Inc. Allergen detection
WO2015103438A2 (en) 2014-01-02 2015-07-09 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
CN106860867A (zh) * 2017-02-23 2017-06-20 中山大学 己糖激酶2特异性抑制剂在急性中枢神经系统损伤疾病中的应用
EP3553521A1 (en) * 2018-04-12 2019-10-16 Koninklijke Philips N.V. Gingivitis diagnostic methods, uses and kits
WO2025196240A1 (en) 2024-03-20 2025-09-25 Aptarion Biotech Ag Method of treating a disorder with a c5a inhibitor
EP4620474A1 (en) 2024-03-20 2025-09-24 APTARION biotech AG Method of treating a disorder with a c5a inhibitor

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Also Published As

Publication number Publication date
JP2010539893A (ja) 2010-12-24
AU2008303775A1 (en) 2009-04-02
CN101809154A (zh) 2010-08-18
EP2562256A2 (en) 2013-02-27
JP5798320B2 (ja) 2015-10-21
MX2010003109A (es) 2010-04-01
BRPI0817260A2 (pt) 2014-10-14
WO2009040113A2 (en) 2009-04-02
US8507456B2 (en) 2013-08-13
RU2010116245A (ru) 2011-11-10
US20110046207A1 (en) 2011-02-24
WO2009040113A3 (en) 2009-06-11
EP2205734A2 (en) 2010-07-14
EP2562256A3 (en) 2013-06-19
KR20100072185A (ko) 2010-06-30

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