CA2693735A1 - Diagnosis and treatment of varicocele and prostate disorders - Google Patents

Diagnosis and treatment of varicocele and prostate disorders Download PDF

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Publication number
CA2693735A1
CA2693735A1 CA2693735A CA2693735A CA2693735A1 CA 2693735 A1 CA2693735 A1 CA 2693735A1 CA 2693735 A CA2693735 A CA 2693735A CA 2693735 A CA2693735 A CA 2693735A CA 2693735 A1 CA2693735 A1 CA 2693735A1
Authority
CA
Canada
Prior art keywords
wire
catheter
reflux
vein
guide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2693735A
Other languages
French (fr)
Inventor
Yigal Gat
Menachem Goren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/826,283 external-priority patent/US20090018486A1/en
Application filed by Individual filed Critical Individual
Publication of CA2693735A1 publication Critical patent/CA2693735A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1011Multiple balloon catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02Dilators made of swellable material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09175Guide wires having specific characteristics at the distal tip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09175Guide wires having specific characteristics at the distal tip
    • A61M2025/09183Guide wires having specific characteristics at the distal tip having tools at the distal tip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/1052Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/1095Balloon catheters with special features or adapted for special applications with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft

Abstract

A method for forestalling or therapy, at least partially, of BPH or prostate cancer comprising identifying a reflux of venous blood to the prostate and impeding the reflux by treating veins effecting or conveying the reflux, and related apparatus and kit.

Claims (60)

1. A method for forestalling or therapy, at least partially, of BPH or prostate cancer comprising:
(a) identifying a reflux of venous blood to the prostate; and (b) impeding the reflux by treating veins causing or conveying the reflux.
2. A method according to claim 1, wherein causing or conveying comprises having incompetent valves resulting in hydrostatic pressure that prevents upstream venous drainage.
3. A method according to claim 1, wherein treating comprises occlusion one or more veins.
4. A method according to claim 3, wherein occlusion comprises utilizing a sclerosant.
5. A method according to claim 3, wherein occlusion comprises utilizing an element that blocks the vein passage or induces thrombosis.
6. A method according to claim 3, wherein occlusion comprises radiation or thermal or ultrasonic or cryogenic ablation, or a combination thereof.
7. A method according to claim 1, wherein treating comprises a combination of methods.
8. A method according to claim 1, wherein a vein comprises at least one of an internal spermatic vein or a deferential vein or a by-pass vein.
9. A method according to claim 1, wherein the venous blood is rich in testosterone relative to a normal concentration range in the blood circulation.
10. A method for assessing a degree of venous reflux to the prostate comprising:
(a) palpating the prostate for hypertrophy; and (b) inferring a degree of the reflux responsive to the degree of hypertrophy.
11. A method according to claim 10, wherein the reflux degree is responsive to a unilateral or bilateral reflux or a combination thereof.
12. A method according to claim 10, wherein assessing the degree of the reflux comprises assessing a degree of a malfunction of a spermatic vein valves.
13. A method for assessing a degree of venous reflux to the prostate comprising:
(a) measuring testosterone concentration; and (b) determining a degree of the reflux responsive to the testosterone concentration.
14. A method according to claim 13, wherein the testosterone comprises at least one of free or bound testosterone.
15. A method according to claim 13, wherein assessing the degree of the reflux is responsive to the anatomical location of the measurement.
16. A method according to claim 13, wherein assessing the degree of the reflux comprises assessing a degree of a malfunction of a spermatic vein valves.
17. A method according to claim 13, wherein the measurement comprises a measurement of at least one of a venous blood or arterial blood.
18. A method according to claim 17, wherein the measurement comprises a measurement in a blood vessel at an anatomical location near the prostate before the blood drain to the vena cava.
19. A method for reducing aging symptoms comprising effecting a cause that decreased testosterone supply to the blood stream.
20. A method according to claim 19, wherein effecting comprises impeding a reflux of venous blood.
21. A method according to claim 20, wherein impeding the reflux comprises treating veins effecting or conveying the reflux.
22. A method according to claim 21, wherein treating comprises occlusion.
23. A method according to claim 22, wherein occlusion comprises utilizing at least one of a sclerosant, an element that blocks the vein passage, an element that induces thrombosis, a material that induces thrombosis, ablation or medication.
24. A method according to claim 21, wherein the vein comprises an internal spermatic vein or a deferential vein or a by-pass vein.
25. A method of passing a wire or a catheter through a venous valve, comprising (a) expanding a vein such that a valve orifice is opened; and (b) moving the wire or catheter through the opened orifice.
26. A method according to claim 25, wherein the vein comprises one of an internal spermatic vein, a deferential vein or a by-pass vein in the groin.
27. A method according to claim 25, wherein expanding comprises utilizing an expandable element.
28. A method according to claim 27, wherein the expandable element is contractible.
29. A method according to claim 27, wherein the expandable element comprises a wire mesh.
30. A method according to claim 27, wherein the expandable element comprises an inflatable balloon.
31. A method according to claim 27, wherein the expandable element comprises an elastic element.
32. A guide-wire for passing a catheter through a venous valve comprising:
(a) an expandable element near a distal end of the guide-wire; and (b) an extension at the distal end of the element, forming a flexible tip.
33. A guide-wire according to claim 32, wherein the expandable elements is contractible.
34. A guide-wire according to claim 32, wherein the guide-wire comprises a lumen.
35. A guide-wire according to claim 34, wherein a control wire passes through the lumen.
36. A guide-wire according to claim 35, wherein the control wire effects at least one of expanding or contracting the element.
37. A guide-wire according to claim 36, wherein (a) pulling the control wire expands the element; and (b) pushing the control wire retracts the element.
38. A guide-wire according to claim 32, wherein the element comprises a wire mesh.
39. A guide-wire according to claim 32, wherein the element comprises an inflatable balloon.
40. A guide-wire according to claim 32 wherein the element comprises an elastic element.
41. A guide-wire according to claim 32, wherein the element comprises a shape memory material (SMA) expanding or retracting responsive to temperature, or a piezoelectric element expanding or retracting responsive to voltage.
42. A vascular catheter for occluding a region of a blood vessel comprising:
(a) one or more inflatable elements; and (b) one or more perforations along at least part of the catheter for a material application.
43. A catheter according to claim 42, wherein the material is a sclerosant injected into the catheter.
44. A catheter according to claim 42, wherein the material is a mechanical element removably attached to the catheter.
45. A catheter according to claim 42, wherein the length of an interval between the inflatable elements is modifiable.
46. A catheter according to claim 42, wherein the material is a glue.
47. A catheter according to claim 42, wherein the catheter applies electric field to induce sclerosis.
48. A catheter according to claim 42, wherein at least some of the perforations are closable.
49. A kit for forestalling or therapy, at least partially, of BPH or prostate cancer, comprising:
(a) a guide-wire for passing a catheter through a venous valve;
(b) a vascular catheter for occluding a region of a blood vessel; and (c) an occlusion material or element.
50. A kit according to claim 49, wherein the material comprises at least one of a glue, a sclerosant, or an embolization material.
51. A kit according to claim 49, wherein the element is a coil or an elastic element.
52. A kit according to claim 49, comprising a plurality of the guide-wire or a plurality of the vascular catheters.
53. A kit according to claim 49, wherein the material or elements are sufficient for at least one treatment.
54. A kit according to claim 49, comprising an auxiliary device.
55. A kit according to claim 54, wherein the auxiliary device comprises one of a catheter port, a syringe, or other devices used with the guide-wire or the catheter or the occlusion material or the occlusion element.
56. Use of a sclerosant for the manufacture of medicament for treating BPH or prostate cancer in a subject.
57. A method according to claim 56, wherein said subject age is about 40 or over, 50 or over or 60 or older.
58. A method according to claim 56, wherein said subject was not diagnosed as infertile or not diagnosed for varicocele.
59. Use of a sclerosant for treating prostate hyperplasia or prostate cancer.
60. Use of a vascular cement for treating prostate hyperplasia or prostate cancer.
CA2693735A 2007-07-13 2008-07-13 Diagnosis and treatment of varicocele and prostate disorders Abandoned CA2693735A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/826,283 US20090018486A1 (en) 2007-07-13 2007-07-13 Diagnosis and treatment of vericocele and prostate disorders
US11/826,283 2007-07-13
US6451108P 2008-03-10 2008-03-10
US61/064,511 2008-03-10
PCT/IL2008/000971 WO2009010962A2 (en) 2007-07-13 2008-07-13 Diagnosis and treatment of varicocele and prostate disorders

Publications (1)

Publication Number Publication Date
CA2693735A1 true CA2693735A1 (en) 2009-01-22

Family

ID=40260179

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2693735A Abandoned CA2693735A1 (en) 2007-07-13 2008-07-13 Diagnosis and treatment of varicocele and prostate disorders
CA2693225A Abandoned CA2693225A1 (en) 2007-07-13 2008-07-13 Methods and apparatuses for vascular and prostate treatment
CA2693227A Abandoned CA2693227A1 (en) 2007-07-13 2008-07-13 Methods and apparatus for treating the prostate

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2693225A Abandoned CA2693225A1 (en) 2007-07-13 2008-07-13 Methods and apparatuses for vascular and prostate treatment
CA2693227A Abandoned CA2693227A1 (en) 2007-07-13 2008-07-13 Methods and apparatus for treating the prostate

Country Status (6)

Country Link
EP (2) EP2178594A4 (en)
JP (1) JP2010533052A (en)
CN (1) CN101801289A (en)
AU (2) AU2008277252A1 (en)
CA (3) CA2693735A1 (en)
WO (3) WO2009010963A2 (en)

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Also Published As

Publication number Publication date
EP2170180A2 (en) 2010-04-07
EP2178594A4 (en) 2011-02-23
WO2009010964A3 (en) 2010-02-25
CA2693227A1 (en) 2009-01-22
EP2170180A4 (en) 2011-02-23
WO2009010963A2 (en) 2009-01-22
AU2008277252A1 (en) 2009-01-22
CA2693225A1 (en) 2009-01-22
AU2008277251A1 (en) 2009-01-22
WO2009010962A2 (en) 2009-01-22
WO2009010962A3 (en) 2010-09-16
WO2009010963A3 (en) 2010-01-14
EP2178594A2 (en) 2010-04-28
CN101801289A (en) 2010-08-11
WO2009010964A2 (en) 2009-01-22
JP2010533052A (en) 2010-10-21

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Effective date: 20130715