CA2689504A1 - Procedes de fabrication d'acides bisphosphoniques - Google Patents

Procedes de fabrication d'acides bisphosphoniques Download PDF

Info

Publication number
CA2689504A1
CA2689504A1 CA002689504A CA2689504A CA2689504A1 CA 2689504 A1 CA2689504 A1 CA 2689504A1 CA 002689504 A CA002689504 A CA 002689504A CA 2689504 A CA2689504 A CA 2689504A CA 2689504 A1 CA2689504 A1 CA 2689504A1
Authority
CA
Canada
Prior art keywords
phosphorous
acid
reaction mixture
mixture
stream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002689504A
Other languages
English (en)
Inventor
Yunqi Liu
Aaron J. Delaup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albemarle Corp
Original Assignee
Albemarle Corporation
Yunqi Liu
Aaron J. Delaup
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albemarle Corporation, Yunqi Liu, Aaron J. Delaup filed Critical Albemarle Corporation
Publication of CA2689504A1 publication Critical patent/CA2689504A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
CA002689504A 2007-06-19 2008-06-05 Procedes de fabrication d'acides bisphosphoniques Abandoned CA2689504A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94483407P 2007-06-19 2007-06-19
US60/944,834 2007-06-19
PCT/US2008/065842 WO2008157050A1 (fr) 2007-06-19 2008-06-05 Procédés de fabrication d'acides bisphosphoniques

Publications (1)

Publication Number Publication Date
CA2689504A1 true CA2689504A1 (fr) 2008-12-24

Family

ID=38664439

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002689504A Abandoned CA2689504A1 (fr) 2007-06-19 2008-06-05 Procedes de fabrication d'acides bisphosphoniques

Country Status (2)

Country Link
CA (1) CA2689504A1 (fr)
WO (1) WO2008157050A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE041846T2 (hu) 2014-08-13 2019-05-28 Albemarle Corp Nagy sûrûségû vizes kútfolyadék
MY188299A (en) 2016-11-17 2021-11-25 Albemarle Corp High density aqueous well fluids

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
ES2262145T3 (es) * 1994-12-28 2006-11-16 Gador S.A. Composicion anabolica para la masa osea que comprende olpadronato.
CA2197267C (fr) * 1997-02-11 2000-02-08 Yong Tao Procede pour la preparation de l'acide 4-amino-1-hydroxybutylidene-1,1-bisphosphonique ou de ses sels
JP3385208B2 (ja) * 1998-03-23 2003-03-10 山之内製薬株式会社 ヘテロ環ビス（フォスフォン酸）誘導体の新規製造法
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
MX2007000087A (es) * 2004-06-23 2007-11-06 Teva Pharma Acido ibandronico solido y cristalino.
WO2007013097A1 (fr) * 2005-07-25 2007-02-01 Natco Pharma Limited Procédé amélioré pour la préparation d'ibandronate de sodium
CN101443341A (zh) * 2006-03-21 2009-05-27 雅宝公司 制造二膦酸的方法

Also Published As

Publication number Publication date
WO2008157050A1 (fr) 2008-12-24

Similar Documents

Publication Publication Date Title
EP1476451B1 (fr) Utilisation de certains diluants pour l'elaboration d'acides bisphosphoniques
EP1656386B1 (fr) Procede d'elaboration de composes d'acide bisphosphonique
US7872144B2 (en) Process for producing biphosphonic acids and forms thereof
EP1504012B9 (fr) Preparation d'acides biphosphoniques et de leurs sels
CA2646418A1 (fr) Procede de fabrication d'acides bisphosphoniques
CN102639545B (zh) 制备氨基羟基二膦酸的方法
US20090281320A1 (en) Process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid and hemipentahydrate monosodium salt thereof
US7361761B2 (en) Process for the preparation of bisphosphonic acid
EP1390373B9 (fr) Procede de preparation d'acide 4-amino-1-hydroxybutylidene-1, 1-biphosphonique
RU2425049C2 (ru) Способ получения бифосфоновых кислот и их солей
CA2689504A1 (fr) Procedes de fabrication d'acides bisphosphoniques
EP1798236A1 (fr) Procédé de préparation d' acide 3-pyridyl-1-hydroxyethylidene-1,1-biphosphonique et leurs formes hydratées
Schull et al. Synthesis of symmetrical triarylphosphines from aryl fluorides and red phosphorus: scope and limitations
WO2008035131A1 (fr) Procédé amélioré pour la préparation d'un acide bisphosphonique
JP5258370B2 (ja) リセドロン酸の工業的製造方法

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead