CA2686157A1 - Traitement des maladies cardiovasculaires et de la dyslipidemie au moyen d'inhibiteurs de la phospholipase a<sb>2</sb> secretoire (spla<sb>2</sb>) et therapies combinees impliquant des inhibiteurs de la spla<sb>2</sb> - Google Patents
Traitement des maladies cardiovasculaires et de la dyslipidemie au moyen d'inhibiteurs de la phospholipase a<sb>2</sb> secretoire (spla<sb>2</sb>) et therapies combinees impliquant des inhibiteurs de la spla<sb>2</sb> Download PDFInfo
- Publication number
- CA2686157A1 CA2686157A1 CA002686157A CA2686157A CA2686157A1 CA 2686157 A1 CA2686157 A1 CA 2686157A1 CA 002686157 A CA002686157 A CA 002686157A CA 2686157 A CA2686157 A CA 2686157A CA 2686157 A1 CA2686157 A1 CA 2686157A1
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- Prior art keywords
- inhibitors
- administration
- plus
- spla2
- cvd
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- Abandoned
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- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
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- 229940068965 polysorbates Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
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- 229920003124 powdered cellulose Polymers 0.000 description 1
- 235000019814 powdered cellulose Nutrition 0.000 description 1
- VWBQYTRBTXKKOG-IYNICTALSA-M pravastatin sodium Chemical compound [Na+].C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 VWBQYTRBTXKKOG-IYNICTALSA-M 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- XOTCNYPJDCKTCB-UHFFFAOYSA-N propylphosphonic acid Chemical compound OP(O)(=O)CC=[CH] XOTCNYPJDCKTCB-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003331 prothrombotic effect Effects 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
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- 230000004043 responsiveness Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VQGXCRIVHHXZIG-UHFFFAOYSA-N tert-butyl 4-(1-benzyl-2-ethyl-3-oxamoylindol-5-yl)oxybutanoate Chemical compound CCC1=C(C(=O)C(N)=O)C2=CC(OCCCC(=O)OC(C)(C)C)=CC=C2N1CC1=CC=CC=C1 VQGXCRIVHHXZIG-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003595 thromboxanes Chemical class 0.000 description 1
- 229960004929 tirofiban hydrochloride Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 229940100615 topical ointment Drugs 0.000 description 1
- 229950004514 torcetrapib Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
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- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
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- 229940045854 xanthinol niacinate Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91591007P | 2007-05-03 | 2007-05-03 | |
| US60/915,910 | 2007-05-03 | ||
| US96959107P | 2007-08-31 | 2007-08-31 | |
| US60/969,591 | 2007-08-31 | ||
| US87486907A | 2007-10-18 | 2007-10-18 | |
| US11/874,869 | 2007-10-18 | ||
| PCT/US2008/062577 WO2008137803A1 (fr) | 2007-05-03 | 2008-05-02 | Traitement des maladies cardiovasculaires et de la dyslipidémie au moyen d'inhibiteurs de la phospholipase a2 sécrétoire (spla2) et thérapies combinées impliquant des inhibiteurs de la spla2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2686157A1 true CA2686157A1 (fr) | 2008-11-13 |
Family
ID=39943969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002686157A Abandoned CA2686157A1 (fr) | 2007-05-03 | 2008-05-02 | Traitement des maladies cardiovasculaires et de la dyslipidemie au moyen d'inhibiteurs de la phospholipase a<sb>2</sb> secretoire (spla<sb>2</sb>) et therapies combinees impliquant des inhibiteurs de la spla<sb>2</sb> |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2154958A4 (fr) |
| JP (1) | JP2010526152A (fr) |
| CN (1) | CN101742907A (fr) |
| AU (1) | AU2008247451A1 (fr) |
| BR (1) | BRPI0811486A2 (fr) |
| CA (1) | CA2686157A1 (fr) |
| EA (1) | EA200971020A1 (fr) |
| WO (1) | WO2008137803A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2483707C1 (ru) * | 2012-05-04 | 2013-06-10 | Лира Талгатовна Гильмутдинова | Способ санаторной терапии больных с метаболическим синдромом и артериальной гипертензией с применением сульфидных ванн |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2395837A1 (fr) * | 2009-01-08 | 2011-12-21 | Anthera Pharmaceuticals, Inc. | Inhibiteur de phospholipase a2 (spla2) sécrétoire, compositions de médicament à base de niacine et méthodes de traitement des maladies cardiovasculaires et de la dyslipidémie |
| CN115040508A (zh) * | 2022-07-28 | 2022-09-13 | 上海市同仁医院 | 吲哚-3-乙醛在制备新型抗肥胖活性制剂中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT199800127A (es) * | 1997-08-29 | 2000-02-01 | Combinaciones terapeuticas. | |
| DE69921314T2 (de) * | 1998-05-01 | 2006-02-09 | Eli Lilly And Co., Indianapolis | INHIBITORISCHE ESTER FÜR sPLA 2 |
| AU2001236440A1 (en) * | 2000-01-25 | 2001-08-07 | Eli Lilly And Company | Method for the treatment of inflammation with spla2 inhibitors |
| CA2417127A1 (fr) * | 2000-07-24 | 2002-01-31 | The University Of Queensland | Composes et inhibiteurs de phospholipases |
| TWI314457B (fr) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| US20060094693A1 (en) * | 2004-09-21 | 2006-05-04 | Point Therapeutics, Inc. | Methods and compositions for treating glucose-associated conditions, metabolic syndrome, dyslipidemias and other conditions |
| CA2627043A1 (fr) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Composes d'indole multivalents et leur utilisation en tant qu'inhibiteurs de phospholipases a2 |
-
2008
- 2008-05-02 CA CA002686157A patent/CA2686157A1/fr not_active Abandoned
- 2008-05-02 CN CN200880023061A patent/CN101742907A/zh active Pending
- 2008-05-02 EP EP08747605A patent/EP2154958A4/fr not_active Withdrawn
- 2008-05-02 BR BRPI0811486-2A2A patent/BRPI0811486A2/pt not_active IP Right Cessation
- 2008-05-02 WO PCT/US2008/062577 patent/WO2008137803A1/fr active Application Filing
- 2008-05-02 EA EA200971020A patent/EA200971020A1/ru unknown
- 2008-05-02 AU AU2008247451A patent/AU2008247451A1/en not_active Abandoned
- 2008-05-02 JP JP2010507578A patent/JP2010526152A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2483707C1 (ru) * | 2012-05-04 | 2013-06-10 | Лира Талгатовна Гильмутдинова | Способ санаторной терапии больных с метаболическим синдромом и артериальной гипертензией с применением сульфидных ванн |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101742907A (zh) | 2010-06-16 |
| EP2154958A4 (fr) | 2011-05-04 |
| EA200971020A1 (ru) | 2010-10-29 |
| EP2154958A1 (fr) | 2010-02-24 |
| BRPI0811486A2 (pt) | 2014-09-30 |
| AU2008247451A1 (en) | 2008-11-13 |
| WO2008137803A1 (fr) | 2008-11-13 |
| JP2010526152A (ja) | 2010-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |
Effective date: 20130502 |