CA2680792A1 - Traitement de troubles auto-immuns - Google Patents

Traitement de troubles auto-immuns Download PDF

Info

Publication number
CA2680792A1
CA2680792A1 CA002680792A CA2680792A CA2680792A1 CA 2680792 A1 CA2680792 A1 CA 2680792A1 CA 002680792 A CA002680792 A CA 002680792A CA 2680792 A CA2680792 A CA 2680792A CA 2680792 A1 CA2680792 A1 CA 2680792A1
Authority
CA
Canada
Prior art keywords
beta
ltbr
seq
amino acid
extracellular domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002680792A
Other languages
English (en)
Inventor
Graham K. Farrington
Evan Beckman
Jeffrey L. Browning
Werner Meier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen MA Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2680792A1 publication Critical patent/CA2680792A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002680792A 2007-03-15 2008-03-17 Traitement de troubles auto-immuns Abandoned CA2680792A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91851807P 2007-03-15 2007-03-15
US60/918,518 2007-03-15
PCT/US2008/003548 WO2008112325A2 (fr) 2007-03-15 2008-03-17 Traitement de troubles auto-immuns

Publications (1)

Publication Number Publication Date
CA2680792A1 true CA2680792A1 (fr) 2008-09-18

Family

ID=39630536

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002680792A Abandoned CA2680792A1 (fr) 2007-03-15 2008-03-17 Traitement de troubles auto-immuns

Country Status (5)

Country Link
EP (1) EP2139509A2 (fr)
JP (1) JP5431171B2 (fr)
CN (1) CN101951940A (fr)
CA (1) CA2680792A1 (fr)
WO (1) WO2008112325A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2311481A3 (fr) * 2006-10-20 2013-10-16 Biogen Idec MA Inc. Traitement de maladies démyélinisantes avec le recepteur soluble de la lymphotoxine beta
WO2009111347A1 (fr) * 2008-02-29 2009-09-11 Biogen Idec Ma Inc. Protéines hybrides purifiées d’immunoglobuline et leurs procédés de purification
CA2737379A1 (fr) * 2008-09-30 2010-04-08 Genentech, Inc. Marqueurs biologiques predictifs de la sensibilite d'une polyarthrite rhumatoide a des antagonistes de lymphotoxine
MX2011007647A (es) 2009-01-21 2011-09-01 Amgen Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes.
CA2817015A1 (fr) * 2010-11-09 2012-05-18 Altimab Therapeutics, Inc. Complexes proteiques pour la liaison a un antigene, et leurs procedes d'utilisation
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
MX2017012966A (es) 2015-04-10 2018-06-06 Amgen Inc Muteinas de interleuquina 2 para la expansion de celulas t regulatorias.
EP3900716A1 (fr) * 2020-04-21 2021-10-27 Dompe' Farmaceutici S.P.A. Co-cristal de gabapentine, de kétoprofène et de lysine, compositions pharmaceutiques et leur utilisation médicale

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925351A (en) * 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6013631A (en) * 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
TR200504220T2 (tr) * 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
EP1608730B1 (fr) * 2003-03-28 2013-11-06 Biogen Idec MA Inc. Recepteurs baff tronques
JP4629047B2 (ja) * 2003-06-12 2011-02-09 イーライ リリー アンド カンパニー Glp−1アナログ複合タンパク質
WO2005003175A2 (fr) * 2003-06-13 2005-01-13 Biogen Idec Ma Inc. Anticorps d'aglycosyle anti-cd154 (ligand cd40) et utilisations correspondantes
EP1664116A4 (fr) * 2003-08-22 2009-06-03 Biogen Idec Inc Anticorps ameliores possedant une fonction d'effecteur modifiee et procedes de fabrication associes
WO2006007853A2 (fr) * 2004-07-20 2006-01-26 Symphogen A/S Procedure de caracterisation structurelle d'une proteine polyclonale recombinee ou d'une lignee de cellules polyclonales
EP2311481A3 (fr) * 2006-10-20 2013-10-16 Biogen Idec MA Inc. Traitement de maladies démyélinisantes avec le recepteur soluble de la lymphotoxine beta
AU2008254951A1 (en) * 2007-05-14 2008-11-27 Biogen Idec Ma Inc. Single-chain Fc (ScFc) regions, binding polypeptides comprising same, and methods related thereto
WO2009111347A1 (fr) * 2008-02-29 2009-09-11 Biogen Idec Ma Inc. Protéines hybrides purifiées d’immunoglobuline et leurs procédés de purification

Also Published As

Publication number Publication date
CN101951940A (zh) 2011-01-19
WO2008112325A3 (fr) 2009-12-23
JP5431171B2 (ja) 2014-03-05
EP2139509A2 (fr) 2010-01-06
WO2008112325A2 (fr) 2008-09-18
JP2010521472A (ja) 2010-06-24

Similar Documents

Publication Publication Date Title
JP6810190B2 (ja) Fgf21突然変異体及びその使用
EP2260054B1 (fr) Protéines hybrides purifiées d immunoglobuline et leurs procédés de purification
KR101378194B1 (ko) 안정한 단백질 제제
CA2680792A1 (fr) Traitement de troubles auto-immuns
CA2681728C (fr) Combinaison d'inhibition de blys ou d'april et immunosuppresseurs destines au traitement de maladies auto-immunes
US11717558B2 (en) Nucleic acid molecules encoding activin receptor type IIA variants
US8722615B2 (en) Compositions and methods for increasing serum half-life
US20130259861A1 (en) Treatment of autoimmune disorders
CA2795823C (fr) Proteines cd24 et leur utilisation dans le traitement de l'arthrite rhumatoide
WO2014078627A1 (fr) Formulations liquides pour des protéines de fusion tnfr:fc
US7557084B2 (en) IL-18 specific polypeptides and therapeutic uses thereof
US20180280474A1 (en) Treatment of bile acid disorders
US7732167B2 (en) Interferon-α/β binding fusion proteins and therapeutic uses thereof
CN117915937A (zh) 使用TACI-Fc融合免疫调节蛋白的给药和治疗方法
KR20240053675A (ko) sBCMA 변이체 및 이의 FC 융합 단백질을 이용한 IgA, IgM 및/또는 IgG의 생산 감소 방법
AU2013204512A1 (en) Purified Immunoglobulin Fusion Proteins and Methods of Their Purification

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130315

FZDE Dead

Effective date: 20150908