CA2675754A1 - Mutated netrin 4, fragments thereof and uses thereof as drugs - Google Patents

Mutated netrin 4, fragments thereof and uses thereof as drugs Download PDF

Info

Publication number
CA2675754A1
CA2675754A1 CA002675754A CA2675754A CA2675754A1 CA 2675754 A1 CA2675754 A1 CA 2675754A1 CA 002675754 A CA002675754 A CA 002675754A CA 2675754 A CA2675754 A CA 2675754A CA 2675754 A1 CA2675754 A1 CA 2675754A1
Authority
CA
Canada
Prior art keywords
seq
protein
cells
represented
netrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002675754A
Other languages
English (en)
French (fr)
Inventor
Jean Plouet (Deceased)
Laurence Leconte
Esma Lejmi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
IVS Institut des Vaisseaux et du Sang
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2675754A1 publication Critical patent/CA2675754A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
CA002675754A 2007-01-19 2008-01-21 Mutated netrin 4, fragments thereof and uses thereof as drugs Abandoned CA2675754A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290075A EP1947114A1 (en) 2007-01-19 2007-01-19 Mutated netrin 4, fragments thereof and uses thereof as drugs
EP07290075.6 2007-01-19
PCT/EP2008/050662 WO2008087224A2 (en) 2007-01-19 2008-01-21 Mutated netrin 4, fragments thereof and uses thereof as drugs

Publications (1)

Publication Number Publication Date
CA2675754A1 true CA2675754A1 (en) 2008-07-24

Family

ID=38123893

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002675754A Abandoned CA2675754A1 (en) 2007-01-19 2008-01-21 Mutated netrin 4, fragments thereof and uses thereof as drugs

Country Status (5)

Country Link
US (1) US8420780B2 (OSRAM)
EP (2) EP1947114A1 (OSRAM)
JP (1) JP2010516237A (OSRAM)
CA (1) CA2675754A1 (OSRAM)
WO (1) WO2008087224A2 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355666B1 (en) 2000-12-22 2012-06-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of repulsive guidance molecule (RGM) and its modulators
JP5089397B2 (ja) * 2004-11-22 2012-12-05 サントル ナシオナル ドゥ ラ ルシェルシェ シアンティフィク 変異ネトリン4、その断片及びこれらの薬剤としての使用
WO2007039256A2 (de) 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
WO2010007144A2 (en) * 2008-07-18 2010-01-21 Centre National De La Recherche Scientifique New mutated netrin 4 proteins, fragments thereof and their uses as drugs
WO2010142040A1 (en) * 2009-06-09 2010-12-16 The Royal Institution For The Advancement Of Learning/Mcgill University Novel netrin derivatives and uses thereof
CA2780069C (en) 2009-12-08 2018-07-17 Abbott Gmbh & Co. Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
MX391536B (es) 2012-01-27 2025-03-21 Abbvie Deutschland Composicion y metodo para el diagnostico y tratamiento de enfermedades asociadas con la degeneracion de neuritas.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402660B2 (en) * 2000-08-02 2008-07-22 The Johns Hopkins University Endothelial cell expression patterns
JP5089397B2 (ja) * 2004-11-22 2012-12-05 サントル ナシオナル ドゥ ラ ルシェルシェ シアンティフィク 変異ネトリン4、その断片及びこれらの薬剤としての使用

Also Published As

Publication number Publication date
US20100247520A1 (en) 2010-09-30
EP1947114A1 (en) 2008-07-23
WO2008087224A2 (en) 2008-07-24
WO2008087224A3 (en) 2008-09-25
US8420780B2 (en) 2013-04-16
JP2010516237A (ja) 2010-05-20
EP2102233A2 (en) 2009-09-23

Similar Documents

Publication Publication Date Title
US20110262432A1 (en) mutated netrin 4 proteins, fragments thereof and their uses as drugs
US8420780B2 (en) Mutated netrin 4, fragments thereof and uses thereof as drugs
JP4524340B2 (ja) 血管内皮増殖因子c(vegf−c)タンパク質およびその遺伝子、変異体、ならびにその使用
US20110280876A1 (en) Mutated netrin - 4, fragments thereof and their use as medicines
EP1469878B1 (en) Fgfr agonists
US20050106674A1 (en) Ligands for EPH-like receptors
JP5341311B2 (ja) Nogoレセプター結合タンパク質
US20120071406A1 (en) Modified vegf-a with improved angiogenic properties
EP0909316B1 (en) Glial cell line-derived neurotrophic factor receptor
US20020147329A1 (en) Method of modulating tissue growth using Frzb protein
JP2004344175A (ja) 新規な神経栄養因子
US20050032697A1 (en) Heparin binding VEGFR-3 ligands
US8138148B2 (en) GDNF derived peptides
JP2002505576A (ja) 神経栄養因子レセプター
US20030009023A1 (en) Isolation and method of using tissue growth-inducing Frzb protein
US7138251B1 (en) Polynucleotides encoding a neurotrophic factor receptor
JP2010527627A (ja) Vegf−d突然変異体およびそれらの使用
WO2012088563A1 (en) Vegfr-2-specific forms of vegf-d and vegf-c and uses thereof
KR20010012826A (ko) 신경교 세포주-유래 향신경성 인자 수용체
KR100399377B1 (ko) Gdnf 단백질의 분석방법 및 검정 기구
MXPA98003767A (en) Receivers of the neurotrophic factor derived from cell line gl

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130121

FZDE Dead

Effective date: 20161229