CA2672526C - Spectrometre de masse - Google Patents
Spectrometre de masse Download PDFInfo
- Publication number
- CA2672526C CA2672526C CA2672526A CA2672526A CA2672526C CA 2672526 C CA2672526 C CA 2672526C CA 2672526 A CA2672526 A CA 2672526A CA 2672526 A CA2672526 A CA 2672526A CA 2672526 C CA2672526 C CA 2672526C
- Authority
- CA
- Canada
- Prior art keywords
- time
- ions
- release
- ion
- packet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 471
- 230000001133 acceleration Effects 0.000 claims abstract description 168
- 238000013467 fragmentation Methods 0.000 claims description 46
- 238000006062 fragmentation reaction Methods 0.000 claims description 46
- 238000006243 chemical reaction Methods 0.000 claims description 38
- 230000001052 transient effect Effects 0.000 claims description 23
- 230000001965 increasing effect Effects 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 10
- 230000004323 axial length Effects 0.000 claims description 8
- 230000003247 decreasing effect Effects 0.000 claims description 8
- 230000005405 multipole Effects 0.000 claims description 7
- 238000005192 partition Methods 0.000 claims description 6
- 238000005040 ion trap Methods 0.000 abstract description 65
- 238000011144 upstream manufacturing Methods 0.000 abstract description 24
- 238000005070 sampling Methods 0.000 description 15
- 238000010884 ion-beam technique Methods 0.000 description 13
- 238000010494 dissociation reaction Methods 0.000 description 6
- 230000005593 dissociations Effects 0.000 description 6
- 238000010265 fast atom bombardment Methods 0.000 description 6
- 238000001819 mass spectrum Methods 0.000 description 6
- 238000003795 desorption Methods 0.000 description 4
- 230000005684 electric field Effects 0.000 description 4
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000001698 laser desorption ionisation Methods 0.000 description 4
- 230000009021 linear effect Effects 0.000 description 4
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 2
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 description 2
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 2
- 238000000451 chemical ionisation Methods 0.000 description 2
- 238000001360 collision-induced dissociation Methods 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 238000000688 desorption electrospray ionisation Methods 0.000 description 2
- 238000000132 electrospray ionisation Methods 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001211 electron capture detection Methods 0.000 description 1
- 238000001077 electron transfer detection Methods 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/401—Time-of-flight spectrometers characterised by orthogonal acceleration, e.g. focusing or selecting the ions, pusher electrode
Abstract
La présente invention concerne un spectromètre de masse comportant un analyseur de masse à temps de vol de l'accélération orthogonale. Une impulsion ou un paquets d'ions est libéré(e) soit à partir d'une piège à ions (7) soit à partir d'un guide d'ions ionique par ondes en amont d'une électrode d'accélération orthogonale (2) formant partie de l'analyseur de masse de temps de vol d'accélération orthogonale. Des ions dans l'impulsion ou le paquet d'ions qui est libéré(e) sont dispersés dans le temps et l'électrode d'accélération orthogonale (2) est excitée plusieurs fois préalablement à la libération d'une impulsion ou d'un paquet d'ions ultérieur(e).
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0624993.2 | 2006-12-14 | ||
| GBGB0624993.2A GB0624993D0 (en) | 2006-12-14 | 2006-12-14 | Mass spectrometer |
| US88450907P | 2007-01-11 | 2007-01-11 | |
| US60/884,509 | 2007-01-11 | ||
| PCT/GB2007/004820 WO2008071993A2 (fr) | 2006-12-14 | 2007-12-14 | Spectromètre de masse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2672526A1 CA2672526A1 (fr) | 2008-06-19 |
| CA2672526C true CA2672526C (fr) | 2016-08-23 |
Family
ID=39384818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2672526A Active CA2672526C (fr) | 2006-12-14 | 2007-12-14 | Spectrometre de masse |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2092549B1 (fr) |
| JP (1) | JP5175859B2 (fr) |
| CA (1) | CA2672526C (fr) |
| WO (1) | WO2008071993A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012084299A (ja) * | 2010-10-08 | 2012-04-26 | Jeol Ltd | タンデム型飛行時間型質量分析計 |
| GB201104220D0 (en) * | 2011-03-14 | 2011-04-27 | Micromass Ltd | Ion guide with orthogonal sampling |
| GB201808894D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
| GB201808892D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
| GB201808936D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808912D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB2602188B (en) | 2018-05-31 | 2023-01-11 | Micromass Ltd | Mass spectrometer |
| WO2019229463A1 (fr) | 2018-05-31 | 2019-12-05 | Micromass Uk Limited | Spectromètre de masse comportant une région de fragmentation |
| GB201808949D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808890D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5689111A (en) * | 1995-08-10 | 1997-11-18 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
| AU2002303853A1 (en) * | 2001-05-25 | 2002-12-09 | Ionwerks, Inc. | A time-of-flight mass spectrometer for monitoring of fast processes |
| JP3990889B2 (ja) * | 2001-10-10 | 2007-10-17 | 株式会社日立ハイテクノロジーズ | 質量分析装置およびこれを用いる計測システム |
| US6794641B2 (en) * | 2002-05-30 | 2004-09-21 | Micromass Uk Limited | Mass spectrometer |
| US7095013B2 (en) * | 2002-05-30 | 2006-08-22 | Micromass Uk Limited | Mass spectrometer |
| GB0424426D0 (en) * | 2004-11-04 | 2004-12-08 | Micromass Ltd | Mass spectrometer |
-
2007
- 2007-12-14 EP EP07848560.4A patent/EP2092549B1/fr active Active
- 2007-12-14 CA CA2672526A patent/CA2672526C/fr active Active
- 2007-12-14 WO PCT/GB2007/004820 patent/WO2008071993A2/fr active Application Filing
- 2007-12-14 JP JP2009540869A patent/JP5175859B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5175859B2 (ja) | 2013-04-03 |
| EP2092549A2 (fr) | 2009-08-26 |
| JP2010514095A (ja) | 2010-04-30 |
| EP2092549B1 (fr) | 2013-08-14 |
| CA2672526A1 (fr) | 2008-06-19 |
| WO2008071993A2 (fr) | 2008-06-19 |
| WO2008071993A3 (fr) | 2009-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |