CA2667983A1 - Le dmae en tant qu'agent unique pour le traitement de deficit cognitif leger - Google Patents
Le dmae en tant qu'agent unique pour le traitement de deficit cognitif leger Download PDFInfo
- Publication number
- CA2667983A1 CA2667983A1 CA002667983A CA2667983A CA2667983A1 CA 2667983 A1 CA2667983 A1 CA 2667983A1 CA 002667983 A CA002667983 A CA 002667983A CA 2667983 A CA2667983 A CA 2667983A CA 2667983 A1 CA2667983 A1 CA 2667983A1
- Authority
- CA
- Canada
- Prior art keywords
- dmae
- use according
- dimethylaminoethanol
- administration
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 12
- 208000010877 cognitive disease Diseases 0.000 title description 37
- 208000027061 mild cognitive impairment Diseases 0.000 title description 27
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 claims abstract description 26
- 206010012289 Dementia Diseases 0.000 claims abstract description 15
- 230000003109 amnesic effect Effects 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 12
- 229960002887 deanol Drugs 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 150000002148 esters Chemical class 0.000 claims abstract description 9
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 9
- 230000000971 hippocampal effect Effects 0.000 claims abstract description 7
- 150000004677 hydrates Chemical class 0.000 claims abstract description 5
- 239000012453 solvate Substances 0.000 claims abstract description 5
- 230000007278 cognition impairment Effects 0.000 claims abstract description 4
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 5
- 229940043131 pyroglutamate Drugs 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 230000036470 plasma concentration Effects 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 claims description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims description 2
- 229940072107 ascorbate Drugs 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 claims description 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims description 2
- 229940049953 phenylacetate Drugs 0.000 claims description 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- DAEHWWVKPWBXGD-DFWYDOINSA-N 2-(dimethylamino)ethanol;(2s)-5-oxopyrrolidine-2-carboxylic acid Chemical compound CN(C)CCO.OC(=O)[C@@H]1CCC(=O)N1 DAEHWWVKPWBXGD-DFWYDOINSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- -1 pyroglutamate dimethylaminoethanol Chemical compound 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 21
- 230000000694 effects Effects 0.000 description 13
- 208000024827 Alzheimer disease Diseases 0.000 description 10
- 230000001149 cognitive effect Effects 0.000 description 10
- 230000015654 memory Effects 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000026139 Memory disease Diseases 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 5
- 206010027175 memory impairment Diseases 0.000 description 5
- 208000028698 Cognitive impairment Diseases 0.000 description 4
- 230000006866 deterioration Effects 0.000 description 4
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000007000 age related cognitive decline Effects 0.000 description 3
- 238000000848 angular dependent Auger electron spectroscopy Methods 0.000 description 3
- 230000001713 cholinergic effect Effects 0.000 description 3
- 230000006999 cognitive decline Effects 0.000 description 3
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 2
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 2
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 2
- 230000036626 alertness Effects 0.000 description 2
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000544 cholinesterase inhibitor Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 229960003530 donepezil Drugs 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960003980 galantamine Drugs 0.000 description 2
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000007787 long-term memory Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000003557 neuropsychological effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 2
- 229960002646 scopolamine Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 description 1
- 102100034112 Alkyldihydroxyacetonephosphate synthase, peroxisomal Human genes 0.000 description 1
- 101000799143 Homo sapiens Alkyldihydroxyacetonephosphate synthase, peroxisomal Proteins 0.000 description 1
- 241000234479 Narcissus Species 0.000 description 1
- GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 description 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 description 1
- 101000767160 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Intracellular protein transport protein USO1 Proteins 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000003931 cognitive performance Effects 0.000 description 1
- 208000030251 communication disease Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 1
- 229960004640 memantine Drugs 0.000 description 1
- 230000006993 memory improvement Effects 0.000 description 1
- 230000007334 memory performance Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229960004526 piracetam Drugs 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229960004136 rivastigmine Drugs 0.000 description 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
- 229960000371 rofecoxib Drugs 0.000 description 1
- 230000011273 social behavior Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000016978 synaptic transmission, cholinergic Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0609548A FR2907679B1 (fr) | 2006-10-31 | 2006-10-31 | Utilisation de dmae pour le traitement de deficit cognitif leger |
| FR0609548 | 2006-10-31 | ||
| PCT/EP2007/061737 WO2008053011A1 (fr) | 2006-10-31 | 2007-10-31 | Le dmae en tant qu'agent unique pour le traitement de deficit cognitif leger |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2667983A1 true CA2667983A1 (fr) | 2008-05-08 |
Family
ID=38050144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002667983A Abandoned CA2667983A1 (fr) | 2006-10-31 | 2007-10-31 | Le dmae en tant qu'agent unique pour le traitement de deficit cognitif leger |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8207218B2 (https=) |
| EP (1) | EP2083814B1 (https=) |
| JP (1) | JP2010508253A (https=) |
| KR (1) | KR20090082428A (https=) |
| CN (1) | CN101528220A (https=) |
| AR (1) | AR063764A1 (https=) |
| AU (1) | AU2007316137A1 (https=) |
| BR (1) | BRPI0718263A2 (https=) |
| CA (1) | CA2667983A1 (https=) |
| FR (1) | FR2907679B1 (https=) |
| IL (1) | IL198463A0 (https=) |
| MA (1) | MA30925B1 (https=) |
| MX (1) | MX2009004682A (https=) |
| NO (1) | NO20092099L (https=) |
| RU (1) | RU2009120137A (https=) |
| TN (1) | TN2009000159A1 (https=) |
| WO (1) | WO2008053011A1 (https=) |
| ZA (1) | ZA200903626B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150157046A1 (en) * | 2013-12-10 | 2015-06-11 | Lifewave, Inc. | Nutritional product composition for the mind |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002320251A1 (en) * | 2001-07-05 | 2003-01-21 | Vital Basics, Inc. | Compositions for improving mental performance |
| US20060211721A1 (en) * | 2005-03-21 | 2006-09-21 | Roberts Alan R | Nutraceutical formulation of a cognitive enhancement system |
-
2006
- 2006-10-31 FR FR0609548A patent/FR2907679B1/fr not_active Expired - Fee Related
-
2007
- 2007-10-31 CA CA002667983A patent/CA2667983A1/fr not_active Abandoned
- 2007-10-31 CN CNA2007800401804A patent/CN101528220A/zh active Pending
- 2007-10-31 EP EP07822084A patent/EP2083814B1/fr active Active
- 2007-10-31 US US12/447,816 patent/US8207218B2/en not_active Expired - Fee Related
- 2007-10-31 MX MX2009004682A patent/MX2009004682A/es not_active Application Discontinuation
- 2007-10-31 RU RU2009120137/15A patent/RU2009120137A/ru not_active Application Discontinuation
- 2007-10-31 AR ARP070104851A patent/AR063764A1/es not_active Application Discontinuation
- 2007-10-31 KR KR1020097010586A patent/KR20090082428A/ko not_active Withdrawn
- 2007-10-31 BR BRPI0718263-5A patent/BRPI0718263A2/pt not_active IP Right Cessation
- 2007-10-31 AU AU2007316137A patent/AU2007316137A1/en not_active Abandoned
- 2007-10-31 JP JP2009533884A patent/JP2010508253A/ja not_active Withdrawn
- 2007-10-31 WO PCT/EP2007/061737 patent/WO2008053011A1/fr not_active Ceased
-
2009
- 2009-04-24 TN TNP2009000159A patent/TN2009000159A1/fr unknown
- 2009-04-30 IL IL198463A patent/IL198463A0/en unknown
- 2009-05-26 ZA ZA200903626A patent/ZA200903626B/xx unknown
- 2009-05-27 MA MA31926A patent/MA30925B1/fr unknown
- 2009-05-28 NO NO20092099A patent/NO20092099L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL198463A0 (en) | 2010-02-17 |
| US20090298908A1 (en) | 2009-12-03 |
| BRPI0718263A2 (pt) | 2014-01-07 |
| CN101528220A (zh) | 2009-09-09 |
| FR2907679A1 (fr) | 2008-05-02 |
| MA30925B1 (fr) | 2009-11-02 |
| TN2009000159A1 (fr) | 2010-10-18 |
| AU2007316137A1 (en) | 2008-05-08 |
| US8207218B2 (en) | 2012-06-26 |
| AR063764A1 (es) | 2009-02-18 |
| FR2907679B1 (fr) | 2009-10-30 |
| WO2008053011A1 (fr) | 2008-05-08 |
| KR20090082428A (ko) | 2009-07-30 |
| RU2009120137A (ru) | 2010-12-10 |
| NO20092099L (no) | 2009-07-17 |
| EP2083814A1 (fr) | 2009-08-05 |
| MX2009004682A (es) | 2009-09-28 |
| JP2010508253A (ja) | 2010-03-18 |
| ZA200903626B (en) | 2010-07-28 |
| EP2083814B1 (fr) | 2013-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20121031 |