BRPI0718263A2 - Dmae como agente único para o tratamento de déficit cognitivo leve - Google Patents
Dmae como agente único para o tratamento de déficit cognitivo leve Download PDFInfo
- Publication number
- BRPI0718263A2 BRPI0718263A2 BRPI0718263-5A BRPI0718263A BRPI0718263A2 BR PI0718263 A2 BRPI0718263 A2 BR PI0718263A2 BR PI0718263 A BRPI0718263 A BR PI0718263A BR PI0718263 A2 BRPI0718263 A2 BR PI0718263A2
- Authority
- BR
- Brazil
- Prior art keywords
- use according
- dmae
- medicament
- dimethyl amino
- reminder
- Prior art date
Links
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 title claims description 25
- 238000011282 treatment Methods 0.000 title claims description 11
- 230000007278 cognition impairment Effects 0.000 title claims description 3
- 206010012289 Dementia Diseases 0.000 claims description 14
- 230000003109 amnesic effect Effects 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 11
- 229960002887 deanol Drugs 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 208000011580 syndromic disease Diseases 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 8
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 150000004677 hydrates Chemical class 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 claims description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims description 2
- 229940072107 ascorbate Drugs 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims description 2
- 229940049953 phenylacetate Drugs 0.000 claims description 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 2
- 229940043131 pyroglutamate Drugs 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 2
- PXKVCJOCQWPPDT-MLWJPKLSSA-N 1-(dimethylamino)ethyl (2S)-5-oxopyrrolidine-2-carboxylate Chemical compound N1[C@@H](CCC1=O)C(=O)OC(C)N(C)C PXKVCJOCQWPPDT-MLWJPKLSSA-N 0.000 claims 1
- DAEHWWVKPWBXGD-DFWYDOINSA-N 2-(dimethylamino)ethanol;(2s)-5-oxopyrrolidine-2-carboxylic acid Chemical compound CN(C)CCO.OC(=O)[C@@H]1CCC(=O)N1 DAEHWWVKPWBXGD-DFWYDOINSA-N 0.000 claims 1
- 108010020346 Polyglutamic Acid Proteins 0.000 claims 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 1
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 description 32
- 208000027061 mild cognitive impairment Diseases 0.000 description 22
- 238000012360 testing method Methods 0.000 description 22
- 230000000694 effects Effects 0.000 description 13
- 230000001149 cognitive effect Effects 0.000 description 10
- 208000024827 Alzheimer disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000015654 memory Effects 0.000 description 7
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 6
- 206010027175 memory impairment Diseases 0.000 description 6
- 208000028698 Cognitive impairment Diseases 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000006866 deterioration Effects 0.000 description 4
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000007000 age related cognitive decline Effects 0.000 description 3
- 238000000848 angular dependent Auger electron spectroscopy Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000001713 cholinergic effect Effects 0.000 description 3
- 230000006999 cognitive decline Effects 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 2
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 2
- 208000026139 Memory disease Diseases 0.000 description 2
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000036626 alertness Effects 0.000 description 2
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 2
- 229940055075 anticholinesterase parasympathomimetics Drugs 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000000544 cholinesterase inhibitor Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229960003530 donepezil Drugs 0.000 description 2
- 229960003980 galantamine Drugs 0.000 description 2
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000007787 long-term memory Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 2
- 229960002646 scopolamine Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 description 1
- 102100034112 Alkyldihydroxyacetonephosphate synthase, peroxisomal Human genes 0.000 description 1
- 101000799143 Homo sapiens Alkyldihydroxyacetonephosphate synthase, peroxisomal Proteins 0.000 description 1
- 244000223072 Narcissus jonquilla Species 0.000 description 1
- 235000013862 Narcissus jonquilla Nutrition 0.000 description 1
- GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 description 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003931 cognitive performance Effects 0.000 description 1
- 208000030251 communication disease Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 1
- 229960004640 memantine Drugs 0.000 description 1
- 230000006993 memory improvement Effects 0.000 description 1
- 230000007334 memory performance Effects 0.000 description 1
- 230000001343 mnemonic effect Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000003557 neuropsychological effect Effects 0.000 description 1
- 238000010855 neuropsychological testing Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229960004526 piracetam Drugs 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229960004136 rivastigmine Drugs 0.000 description 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
- 229960000371 rofecoxib Drugs 0.000 description 1
- 230000011273 social behavior Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000016978 synaptic transmission, cholinergic Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0609548A FR2907679B1 (fr) | 2006-10-31 | 2006-10-31 | Utilisation de dmae pour le traitement de deficit cognitif leger |
| FR0609548 | 2006-10-31 | ||
| PCT/EP2007/061737 WO2008053011A1 (fr) | 2006-10-31 | 2007-10-31 | Le dmae en tant qu'agent unique pour le traitement de deficit cognitif leger |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0718263A2 true BRPI0718263A2 (pt) | 2014-01-07 |
Family
ID=38050144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0718263-5A BRPI0718263A2 (pt) | 2006-10-31 | 2007-10-31 | Dmae como agente único para o tratamento de déficit cognitivo leve |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8207218B2 (https=) |
| EP (1) | EP2083814B1 (https=) |
| JP (1) | JP2010508253A (https=) |
| KR (1) | KR20090082428A (https=) |
| CN (1) | CN101528220A (https=) |
| AR (1) | AR063764A1 (https=) |
| AU (1) | AU2007316137A1 (https=) |
| BR (1) | BRPI0718263A2 (https=) |
| CA (1) | CA2667983A1 (https=) |
| FR (1) | FR2907679B1 (https=) |
| IL (1) | IL198463A0 (https=) |
| MA (1) | MA30925B1 (https=) |
| MX (1) | MX2009004682A (https=) |
| NO (1) | NO20092099L (https=) |
| RU (1) | RU2009120137A (https=) |
| TN (1) | TN2009000159A1 (https=) |
| WO (1) | WO2008053011A1 (https=) |
| ZA (1) | ZA200903626B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150157046A1 (en) * | 2013-12-10 | 2015-06-11 | Lifewave, Inc. | Nutritional product composition for the mind |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002320251A1 (en) * | 2001-07-05 | 2003-01-21 | Vital Basics, Inc. | Compositions for improving mental performance |
| US20060211721A1 (en) * | 2005-03-21 | 2006-09-21 | Roberts Alan R | Nutraceutical formulation of a cognitive enhancement system |
-
2006
- 2006-10-31 FR FR0609548A patent/FR2907679B1/fr not_active Expired - Fee Related
-
2007
- 2007-10-31 CA CA002667983A patent/CA2667983A1/fr not_active Abandoned
- 2007-10-31 CN CNA2007800401804A patent/CN101528220A/zh active Pending
- 2007-10-31 EP EP07822084A patent/EP2083814B1/fr active Active
- 2007-10-31 US US12/447,816 patent/US8207218B2/en not_active Expired - Fee Related
- 2007-10-31 MX MX2009004682A patent/MX2009004682A/es not_active Application Discontinuation
- 2007-10-31 RU RU2009120137/15A patent/RU2009120137A/ru not_active Application Discontinuation
- 2007-10-31 AR ARP070104851A patent/AR063764A1/es not_active Application Discontinuation
- 2007-10-31 KR KR1020097010586A patent/KR20090082428A/ko not_active Withdrawn
- 2007-10-31 BR BRPI0718263-5A patent/BRPI0718263A2/pt not_active IP Right Cessation
- 2007-10-31 AU AU2007316137A patent/AU2007316137A1/en not_active Abandoned
- 2007-10-31 JP JP2009533884A patent/JP2010508253A/ja not_active Withdrawn
- 2007-10-31 WO PCT/EP2007/061737 patent/WO2008053011A1/fr not_active Ceased
-
2009
- 2009-04-24 TN TNP2009000159A patent/TN2009000159A1/fr unknown
- 2009-04-30 IL IL198463A patent/IL198463A0/en unknown
- 2009-05-26 ZA ZA200903626A patent/ZA200903626B/xx unknown
- 2009-05-27 MA MA31926A patent/MA30925B1/fr unknown
- 2009-05-28 NO NO20092099A patent/NO20092099L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL198463A0 (en) | 2010-02-17 |
| US20090298908A1 (en) | 2009-12-03 |
| CN101528220A (zh) | 2009-09-09 |
| FR2907679A1 (fr) | 2008-05-02 |
| MA30925B1 (fr) | 2009-11-02 |
| CA2667983A1 (fr) | 2008-05-08 |
| TN2009000159A1 (fr) | 2010-10-18 |
| AU2007316137A1 (en) | 2008-05-08 |
| US8207218B2 (en) | 2012-06-26 |
| AR063764A1 (es) | 2009-02-18 |
| FR2907679B1 (fr) | 2009-10-30 |
| WO2008053011A1 (fr) | 2008-05-08 |
| KR20090082428A (ko) | 2009-07-30 |
| RU2009120137A (ru) | 2010-12-10 |
| NO20092099L (no) | 2009-07-17 |
| EP2083814A1 (fr) | 2009-08-05 |
| MX2009004682A (es) | 2009-09-28 |
| JP2010508253A (ja) | 2010-03-18 |
| ZA200903626B (en) | 2010-07-28 |
| EP2083814B1 (fr) | 2013-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sahakian et al. | A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease | |
| Myers et al. | Out-patient compliance with antidepressant medication | |
| Swanson et al. | Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation | |
| GARFINKEL et al. | Tricyclic antidepressant and methylphenidate treatment of attention deficit disorder in children | |
| McKeith et al. | Operational criteria for senile dementia of Lewy body type (SDLT) | |
| Hollister | Clinical use of psychotherapeutic drugs | |
| SCHAIN et al. | Carbamazepine as an anticonvulsant in children | |
| Davis et al. | Physostigmine: improvement of long-term memory processes in normal humans | |
| Forette et al. | A phase II study in patients with Alzheimer's disease to assess the preliminary efficacy and maximum tolerated dose of rivastigmine (Exelon®) | |
| Curran et al. | Memory and psychomotor effects of oxcarbazepine in healthy human volunteers | |
| Lang et al. | Anticholinergics in adult-onset focal dystonia | |
| Leppik | Epilepsy in the elderly: scope of the problem | |
| Santaguida et al. | Pharmacological treatment of dementia: summary | |
| BRPI0718263A2 (pt) | Dmae como agente único para o tratamento de déficit cognitivo leve | |
| Brown et al. | Methylphenidate and adolescents hospitalized with conduct disorder: Dose effects on classroom behavior, academic performance, and impulsivity | |
| Ropper | A rational approach to dementia | |
| Livingston et al. | Acetyl‐l‐carnitine in dementia | |
| Craft et al. | Psychiatric disturbance in mentally handicapped patients: A prospective study of current clinical usage of depot fluphenazine in hospitals for the mentally handicapped | |
| Gauthier | Managing Expectations in the Long-Term Treatment of Alzheimer’s | |
| Mohs et al. | Cholinergic drug effects on memory and cognition in humans. | |
| Thal | Physostigmine in Alzheimer’s disease | |
| Wilson | Ill-health due to drugs | |
| Minhas et al. | Impact of Vortioxetine on severity, cognitive dysfunctions, and functionality in patients with major depression: a real world experience from Pakistan | |
| Tison et al. | Parkinsonism and exposure to neuroleptic drugs in elderly people living in institutions | |
| HK1135909A (en) | Dmae as sole agent for the treatment of mild cognitive impairment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 5A E 6A ANUIDADES. |
|
| B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A, 8A, 9A, 10A, 11A, 12A E 13A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |