CA2664800A1 - Ketoconazole enantiomer in humans - Google Patents
Ketoconazole enantiomer in humans Download PDFInfo
- Publication number
- CA2664800A1 CA2664800A1 CA002664800A CA2664800A CA2664800A1 CA 2664800 A1 CA2664800 A1 CA 2664800A1 CA 002664800 A CA002664800 A CA 002664800A CA 2664800 A CA2664800 A CA 2664800A CA 2664800 A1 CA2664800 A1 CA 2664800A1
- Authority
- CA
- Canada
- Prior art keywords
- patient
- ketoconazole
- enantiomer
- ketoconazole enantiomer
- reduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- XMAYWYJOQHXEEK-ZEQKJWHPSA-N (2S,4R)-ketoconazole Chemical class C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@H]1O[C@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-ZEQKJWHPSA-N 0.000 claims abstract description 194
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/33—Heterocyclic compounds
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Emergency Medicine (AREA)
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- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US84896306P | 2006-10-02 | 2006-10-02 | |
| US60/848,963 | 2006-10-02 | ||
| PCT/US2007/080186 WO2008042898A2 (en) | 2006-10-02 | 2007-10-02 | Ketoconazole enantiomer in humans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2664800A1 true CA2664800A1 (en) | 2008-04-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002664800A Abandoned CA2664800A1 (en) | 2006-10-02 | 2007-10-02 | Ketoconazole enantiomer in humans |
Country Status (12)
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| US (4) | US9198906B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2076265A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010505866A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007303219A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0719835A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2664800A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL197986A0 (cg-RX-API-DMAC7.html) |
| NO (1) | NO20091593L (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2008042898A2 (cg-RX-API-DMAC7.html) |
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| US20090233843A1 (en) * | 2005-01-10 | 2009-09-17 | Cortendo Invest Ab | Methods and compositions for treating diabetes, metabolic syndrome and other conditions |
| AU2007204969A1 (en) * | 2006-01-10 | 2007-07-19 | Cortendo Invest Ab | Methods and compositions for treating prostate cancer |
| AU2007303219A1 (en) | 2006-10-02 | 2008-04-10 | Cortendo Ab (Publ) | Ketoconazole enantiomer in humans |
| US20160244436A1 (en) * | 2013-09-25 | 2016-08-25 | Cortendo Ab (Publ) | Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome p450 inhibition and their method of use |
| WO2016048984A1 (en) * | 2014-09-25 | 2016-03-31 | Cortendo Ab (Publ) | Methods and compositions for the treatment of cushing's syndrome using 2s, 4r ketoconazole |
| CN113710250A (zh) | 2019-03-04 | 2021-11-26 | 斯特朗布里奇都柏林有限公司 | 用左旋酮康唑治疗疾病的方法 |
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| US4144346A (en) | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| US4503055A (en) | 1979-03-26 | 1985-03-05 | Janssen Pharmaceutica, N.V. | Derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| US4814333A (en) | 1987-07-28 | 1989-03-21 | The Trustees Of Dartmouth College | Method for treatment of hypercortisolemic, depressed patients |
| US5432176A (en) | 1988-11-29 | 1995-07-11 | The John Hopkins University | Method of retarding the progression of chronic renal failure |
| WO1994014446A1 (en) | 1992-12-22 | 1994-07-07 | Sepracor, Inc. | Methods and compositions of (+) ketoconazole for treating fungal, yeast and dermatophyte infections |
| WO1994014447A1 (en) * | 1992-12-22 | 1994-07-07 | Sepracor, Inc. | Methods and compositions of (-) ketoconazole for treating fungal yeast and dermatophyte infections |
| IL109728A0 (en) | 1993-05-28 | 1994-08-26 | Pfizer Res & Dev | Indoles |
| US5869255A (en) * | 1994-02-01 | 1999-02-09 | The Regents Of The University Of California | Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis |
| US6642236B1 (en) * | 1998-12-14 | 2003-11-04 | Cortendo Ab | Methods for prophylactic treatment of cardiovascular disease with inhibitor of cortisol synthesis |
| CA2196174C (en) * | 1994-08-09 | 2005-03-01 | Per Marin | Use of ketoconazole and related substances in medicaments for treatment of type ii diabetes |
| US5584790A (en) * | 1995-09-08 | 1996-12-17 | Beckman Instruments, Inc. | Variable inclination centrifugation assembly for rapid separation of blood |
| JP3092947B2 (ja) | 1995-12-14 | 2000-09-25 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモン拮抗剤 |
| WO1997028149A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
| US5994334A (en) * | 1997-02-05 | 1999-11-30 | University Of Maryland | Androgen synthesis inhibitors |
| SE9700642D0 (sv) | 1997-02-24 | 1997-02-24 | Kronvall Stefan Med Ab | Medel och sätt för förebyggande och behandling av det metabola syndromet |
| US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| WO1999001423A1 (en) | 1997-07-01 | 1999-01-14 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| AU3033500A (en) | 1999-01-15 | 2000-08-01 | Agouron Pharmaceuticals, Inc. | Non-peptide glp-1 agonists |
| AU3441400A (en) | 1999-03-29 | 2000-10-16 | Uutech Limited | Peptide |
| WO2000059887A1 (en) | 1999-04-02 | 2000-10-12 | Neurogen Corporation | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives and their use as antidiabetics |
| BR0010651A (pt) | 1999-05-17 | 2002-03-19 | Novo Nordisk As | Composto, uso de um composto, composição farmacêutica, e, método para o tratamento e/ou prevenção de distúrbios ou de doenças mediadas por uma ação antagonìstica de glucagon |
| GB9915625D0 (en) | 1999-07-02 | 1999-09-01 | Cortendo Ab | Method |
| ES2307534T3 (es) | 1999-09-28 | 2008-12-01 | Bayer Corporation | Agonistas de receptores 3 (r3) del peptido activador de la adenilato ciclasa hipofisiaria (pacap) y sus metodos de uso farmacologicos. |
| GB0001449D0 (en) | 2000-01-21 | 2000-03-08 | Cortendo Ab | Compositions |
| US20020055512A1 (en) * | 2000-01-21 | 2002-05-09 | Cortendo Ab. | Compositions for delivery of a cortisol antagonist |
| EP1409512A1 (en) | 2000-06-27 | 2004-04-21 | Aventis Pharma S.A. | 20-fluoro-17(20)-vinyl steroids as inhibitors of c17-20-lyase and 5-alpha reductase |
| GB0118300D0 (en) | 2001-07-26 | 2001-09-19 | Cortendo Ab | Formulations |
| US20040265827A1 (en) | 2001-09-21 | 2004-12-30 | Zhimin Zhu | Regulation of human steroid 5-alpha reductase |
| EP1465667A4 (en) * | 2001-09-24 | 2007-06-27 | Merck & Co Inc | SCREENING AND SELECTION PROCEDURE FOR STATIN COMBINATIONS |
| JP2005528325A (ja) | 2001-09-26 | 2005-09-22 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Ｃ１７，２０リアーゼ阻害剤としての置換３−ピリジルインドール類およびインダゾール類 |
| EP1471917A1 (en) * | 2002-02-07 | 2004-11-03 | Pfizer Limited | Use of pde5 inhibitors such as sildenafil in the treatment of polycystic ovary syndrome |
| WO2004052390A1 (en) | 2002-12-11 | 2004-06-24 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating polycystic ovary syndrome |
| WO2004080414A2 (en) * | 2003-03-12 | 2004-09-23 | Mullally John P | Composition and method for treating inflammations by reducing c-reactive protein |
| WO2005113516A1 (en) | 2004-05-14 | 2005-12-01 | Neurocrine Biosciences, Inc. | Uracil-type gonadotropin-releasing hormone receptor antagonists and methods related thereto |
| US20060002999A1 (en) * | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
| US20090233843A1 (en) | 2005-01-10 | 2009-09-17 | Cortendo Invest Ab | Methods and compositions for treating diabetes, metabolic syndrome and other conditions |
| US20070116839A1 (en) * | 2005-11-23 | 2007-05-24 | The Coca-Cola Company | High-Potency Sweetener Composition With C-Reactive Protein Reducing Substance and Compositions Sweetened Therewith |
| AU2007204969A1 (en) * | 2006-01-10 | 2007-07-19 | Cortendo Invest Ab | Methods and compositions for treating prostate cancer |
| AU2007303219A1 (en) | 2006-10-02 | 2008-04-10 | Cortendo Ab (Publ) | Ketoconazole enantiomer in humans |
| JP2013540145A (ja) | 2010-10-21 | 2013-10-31 | ウニベルシテート デス ザールランデス | コルチゾール依存性疾患の治療用の選択的ｃｙｐ１１ｂ１阻害剤 |
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2007
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- 2007-10-02 CA CA002664800A patent/CA2664800A1/en not_active Abandoned
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- 2007-10-02 BR BRPI0719835-3A2A patent/BRPI0719835A2/pt not_active IP Right Cessation
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2009
- 2009-04-05 IL IL197986A patent/IL197986A0/en unknown
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2015
- 2015-11-18 US US14/944,258 patent/US20160067243A1/en not_active Abandoned
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2018
- 2018-01-09 US US15/865,631 patent/US20180125841A1/en not_active Abandoned
-
2019
- 2019-03-13 US US16/351,797 patent/US20190209555A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100093755A1 (en) | 2010-04-15 |
| US20180125841A1 (en) | 2018-05-10 |
| EP2076265A4 (en) | 2010-09-22 |
| WO2008042898A9 (en) | 2008-09-04 |
| WO2008042898A2 (en) | 2008-04-10 |
| BRPI0719835A2 (pt) | 2014-05-06 |
| ZA200902127B (en) | 2010-07-28 |
| EP2076265A2 (en) | 2009-07-08 |
| AU2007303219A1 (en) | 2008-04-10 |
| RU2009116632A (ru) | 2010-11-10 |
| WO2008042898A3 (en) | 2008-10-23 |
| US20190209555A1 (en) | 2019-07-11 |
| NO20091593L (no) | 2009-04-22 |
| NZ576569A (en) | 2012-05-25 |
| JP2010505866A (ja) | 2010-02-25 |
| US9198906B2 (en) | 2015-12-01 |
| IL197986A0 (en) | 2009-12-24 |
| US20160067243A1 (en) | 2016-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20141002 |