CA2664631A1 - Quinoline derivatives for modulating dna methylation - Google Patents
Quinoline derivatives for modulating dna methylation Download PDFInfo
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- CA2664631A1 CA2664631A1 CA002664631A CA2664631A CA2664631A1 CA 2664631 A1 CA2664631 A1 CA 2664631A1 CA 002664631 A CA002664631 A CA 002664631A CA 2664631 A CA2664631 A CA 2664631A CA 2664631 A1 CA2664631 A1 CA 2664631A1
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- acid
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US92150206P | 2006-10-12 | 2006-10-12 | |
| US60/921,502 | 2006-10-12 | ||
| US91185007P | 2007-04-13 | 2007-04-13 | |
| US60/911,850 | 2007-04-13 | ||
| PCT/US2007/081321 WO2008046085A2 (en) | 2006-10-12 | 2007-10-12 | Quinoline derivatives for modulating dna methylation |
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| CA2664631A1 true CA2664631A1 (en) | 2008-04-17 |
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| US (2) | US20080175814A1 (https=) |
| EP (2) | EP2174938A1 (https=) |
| JP (1) | JP2010506856A (https=) |
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| CA (1) | CA2664631A1 (https=) |
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| US7939546B2 (en) | 2007-10-12 | 2011-05-10 | Supergen, Inc. | Quinoline derivatives for modulating DNA methylation |
| US20110245156A1 (en) * | 2008-12-09 | 2011-10-06 | Cytokine Pharmasciences, Inc. | Novel antiviral compounds, compositions, and methods of use |
| WO2012079079A1 (en) * | 2010-12-10 | 2012-06-14 | President And Fellows Of Harvard College | Production of induced pluripotent stem cells |
| US20140309257A1 (en) * | 2011-11-11 | 2014-10-16 | The Regents Of The University Of Colorado, A Body Corporate | Topoisomerase inhibitors and methods of making and use as therapeutic agents |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
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| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
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| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
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| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| EP4119947A1 (en) | 2012-12-21 | 2023-01-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3-targeting drug which is administered to patient responsive to gpc3-targeting drug therapy |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| DE69220468T2 (de) | 1991-07-23 | 1997-10-16 | Fujitsu Ltd | Gerät zur feineinstellung eines kopfes |
| FR2705099B1 (fr) | 1993-05-12 | 1995-08-04 | Centre Nat Rech Scient | Oligonucléotides phosphorothioates triesters et procédé de préparation. |
| US5773449A (en) | 1994-10-07 | 1998-06-30 | Zenyaku Kogyo Kabushiki Kaisha | Thioquinolone compounds which have useful pharmaceutical activity |
| US7709479B1 (en) * | 1999-09-21 | 2010-05-04 | Astrazeneca | Quinazoline derivatives and their use as pharmaceuticals |
| US7378524B2 (en) * | 2003-04-11 | 2008-05-27 | Taigen Biotechnology Co., Ltd. | Aminoquinoline compounds |
| AU2005250224A1 (en) * | 2004-06-04 | 2005-12-15 | Astrazeneca Ab | Quinazoline derivatives as ERBB receptor tyrosine kinases |
| US7790746B2 (en) * | 2007-10-12 | 2010-09-07 | Supergen, Inc. | Quinoline derivatives for modulating DNA methylation |
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2007
- 2007-10-12 EP EP10000636A patent/EP2174938A1/en not_active Withdrawn
- 2007-10-12 KR KR1020097009745A patent/KR20090089854A/ko not_active Withdrawn
- 2007-10-12 EP EP07854027A patent/EP2078008A2/en not_active Withdrawn
- 2007-10-12 WO PCT/US2007/081321 patent/WO2008046085A2/en not_active Ceased
- 2007-10-12 US US11/871,762 patent/US20080175814A1/en not_active Abandoned
- 2007-10-12 CA CA002664631A patent/CA2664631A1/en not_active Abandoned
- 2007-10-12 JP JP2009532619A patent/JP2010506856A/ja active Pending
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2009
- 2009-09-09 US US12/556,510 patent/US20100129320A1/en not_active Abandoned
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| EP2078008A2 (en) | 2009-07-15 |
| US20100129320A1 (en) | 2010-05-27 |
| JP2010506856A (ja) | 2010-03-04 |
| KR20090089854A (ko) | 2009-08-24 |
| US20080175814A1 (en) | 2008-07-24 |
| EP2174938A1 (en) | 2010-04-14 |
| WO2008046085A2 (en) | 2008-04-17 |
| WO2008046085A3 (en) | 2008-06-05 |
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