CA2661700C - Nanoparticles for delivering immunotherapeutics to antigen presenting cells in lymph nodes - Google Patents

Nanoparticles for delivering immunotherapeutics to antigen presenting cells in lymph nodes Download PDF

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Publication number
CA2661700C
CA2661700C CA2661700A CA2661700A CA2661700C CA 2661700 C CA2661700 C CA 2661700C CA 2661700 A CA2661700 A CA 2661700A CA 2661700 A CA2661700 A CA 2661700A CA 2661700 C CA2661700 C CA 2661700C
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Canada
Prior art keywords
nanoparticles
particles
antigen
polymer
dcs
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CA2661700A
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English (en)
French (fr)
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CA2661700A1 (en
Inventor
Sai T. Reddy
Jeffrey A. Hubbell
Melody A. Swartz
Andre van Der Vlies
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Ecole Polytechnique Federale de Lausanne EPFL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2661700A 2006-02-21 2007-02-21 Nanoparticles for delivering immunotherapeutics to antigen presenting cells in lymph nodes Active CA2661700C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77513206P 2006-02-21 2006-02-21
US60/775,132 2006-02-21
US11/707,627 2007-02-19
US11/707,627 US8021689B2 (en) 2006-02-21 2007-02-19 Nanoparticles for immunotherapy
PCT/US2007/004671 WO2007098254A2 (en) 2006-02-21 2007-02-21 Nanoparticles for immunotherapy

Publications (2)

Publication Number Publication Date
CA2661700A1 CA2661700A1 (en) 2007-08-30
CA2661700C true CA2661700C (en) 2020-07-07

Family

ID=38438002

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2661700A Active CA2661700C (en) 2006-02-21 2007-02-21 Nanoparticles for delivering immunotherapeutics to antigen presenting cells in lymph nodes

Country Status (8)

Country Link
US (1) US8021689B2 (https=)
EP (1) EP1993511B1 (https=)
JP (1) JP5506196B2 (https=)
CN (1) CN101437491B (https=)
AU (1) AU2007217514B2 (https=)
CA (1) CA2661700C (https=)
ES (1) ES2709391T3 (https=)
WO (1) WO2007098254A2 (https=)

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Also Published As

Publication number Publication date
WO2007098254A3 (en) 2008-09-25
EP1993511A4 (en) 2014-11-05
EP1993511B1 (en) 2018-10-31
CN101437491A (zh) 2009-05-20
EP1993511A2 (en) 2008-11-26
JP2009527566A (ja) 2009-07-30
ES2709391T3 (es) 2019-04-16
US20080031899A1 (en) 2008-02-07
CN101437491B (zh) 2013-01-02
AU2007217514A1 (en) 2007-08-30
WO2007098254A2 (en) 2007-08-30
CA2661700A1 (en) 2007-08-30
AU2007217514B2 (en) 2013-02-21
JP5506196B2 (ja) 2014-05-28
US8021689B2 (en) 2011-09-20

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