CA2660283C - 2-acylaminothiazole compositions and methods for increasing blood platlelet levels in humans - Google Patents

2-acylaminothiazole compositions and methods for increasing blood platlelet levels in humans Download PDF

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Publication number
CA2660283C
CA2660283C CA2660283A CA2660283A CA2660283C CA 2660283 C CA2660283 C CA 2660283C CA 2660283 A CA2660283 A CA 2660283A CA 2660283 A CA2660283 A CA 2660283A CA 2660283 C CA2660283 C CA 2660283C
Authority
CA
Canada
Prior art keywords
dosage form
dose
pharmaceutically acceptable
thrombocytopenia
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
CA2660283A
Other languages
English (en)
French (fr)
Other versions
CA2660283A1 (en
Inventor
Robert E. Desjardins
Rudolph Lucek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AkaRx Inc
Original Assignee
AkaRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AkaRx Inc filed Critical AkaRx Inc
Publication of CA2660283A1 publication Critical patent/CA2660283A1/en
Application granted granted Critical
Publication of CA2660283C publication Critical patent/CA2660283C/en
Active legal-status Critical Current
Adjusted expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2660283A 2006-08-08 2007-08-08 2-acylaminothiazole compositions and methods for increasing blood platlelet levels in humans Active 2029-08-08 CA2660283C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83633406P 2006-08-08 2006-08-08
US60/836,334 2006-08-08
PCT/US2007/017860 WO2008021283A2 (en) 2006-08-08 2007-08-08 Compositions and methods for increasing blood platelet levels in humans

Publications (2)

Publication Number Publication Date
CA2660283A1 CA2660283A1 (en) 2008-02-21
CA2660283C true CA2660283C (en) 2014-11-18

Family

ID=39082656

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2660283A Active 2029-08-08 CA2660283C (en) 2006-08-08 2007-08-08 2-acylaminothiazole compositions and methods for increasing blood platlelet levels in humans

Country Status (8)

Country Link
US (2) US20080039475A1 (https=)
EP (2) EP2452674B1 (https=)
JP (3) JP2010500361A (https=)
AU (2) AU2007284644B2 (https=)
CA (1) CA2660283C (https=)
ES (2) ES2470333T3 (https=)
IL (4) IL196897A (https=)
WO (1) WO2008021283A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1466912T3 (da) 2002-01-18 2013-07-01 Astellas Pharma Inc 2-acylaminothiazolderivat eller salt deraf
EP2464352A1 (en) * 2009-08-14 2012-06-20 Eisai Inc. Use of e5501 for stimulating platelet production
CN112022825B (zh) * 2020-08-24 2024-03-22 瑞阳制药股份有限公司 马来酸阿伐曲泊帕片剂及其制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330998A (en) * 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
US5256675A (en) * 1989-08-07 1993-10-26 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
FR2677356B1 (fr) * 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
US5250732A (en) * 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
GB9126677D0 (en) * 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
EP0620403B1 (de) * 1993-04-08 1996-12-04 ABB Management AG Misch- und Flammenstabilisierungseinrichtung in einer Brennkammer mit Vormischverbrennung
EP0768311B1 (en) * 1995-03-09 2003-08-06 Kyowa Hakko Kogyo Co., Ltd. Pyrrolocarbazole derivatives
EP0823423B1 (en) * 1995-04-28 2004-06-16 Banyu Pharmaceutical Co., Ltd. 1,4-disubstituted piperidine derivatives
TR199701526T1 (xx) * 1995-06-07 1998-03-21 Glaxo Group Limited Bir trombopoietin resept�r�ne ba�lanan peptitler ve bile�ikler.
US5963666A (en) * 1995-08-18 1999-10-05 International Business Machines Corporation Confusion matrix mediated word prediction
AU702751B2 (en) * 1995-10-17 1999-03-04 Daiichi Suntory Pharma Co., Ltd Therapeutics for thrombocytopenia
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
WO2000017175A1 (en) * 1998-09-18 2000-03-30 Vertex Pharmaceuticals Incorporated INHIBITORS OF p38
JP2002529502A (ja) * 1998-11-17 2002-09-10 スミスクライン・ビーチャム・コーポレイション 血小板減少症の治療法
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
GB0028383D0 (en) * 2000-11-21 2001-01-03 Novartis Ag Organic compounds
CA2437248A1 (en) * 2001-02-02 2002-08-15 Takeda Chemical Industries, Ltd. Jnk inhibitor
JPWO2002062775A1 (ja) * 2001-02-02 2004-06-10 山之内製薬株式会社 ２−アシルアミノチアゾール誘導体又はその塩
DK1466912T3 (da) * 2002-01-18 2013-07-01 Astellas Pharma Inc 2-acylaminothiazolderivat eller salt deraf
BR0312023A (pt) * 2002-06-27 2005-03-22 Novo Nordisk As Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica
WO2004029049A1 (ja) * 2002-09-30 2004-04-08 Yamanouchi Pharmaceutical Co., Ltd. 2-アシルアミノチアゾール誘導体の新規な塩
US20040235834A1 (en) * 2003-03-25 2004-11-25 Farmer Luc J. Thiazoles useful as inhibitors of protein kinases
CA2529686C (en) * 2003-07-17 2010-06-15 Astellas Pharma Inc. 2-acylaminothiazole derivative or salt thereof
WO2005014561A1 (ja) * 2003-08-12 2005-02-17 Shionogi & Co., Ltd. トロンボポエチン受容体アゴニスト作用を有する化合物
CA2628848A1 (en) * 2005-11-08 2007-05-18 Astellas Pharma Inc. Compositions and methods for treating thrombocytopenia

Also Published As

Publication number Publication date
AU2007284644B2 (en) 2011-09-01
EP2452674B1 (en) 2014-03-26
AU2007284644A1 (en) 2008-02-21
EP2056826A2 (en) 2009-05-13
IL240323A (en) 2016-05-31
JP2013047257A (ja) 2013-03-07
WO2008021283A3 (en) 2008-12-11
JP2010500361A (ja) 2010-01-07
EP2056826B1 (en) 2014-01-08
AU2011253775B2 (en) 2014-02-13
IL196897A (en) 2015-08-31
AU2011253775A1 (en) 2011-12-22
HK1170673A1 (en) 2013-03-08
JP2015221806A (ja) 2015-12-10
IL240323A0 (en) 2015-09-24
EP2452674A2 (en) 2012-05-16
IL245911A0 (en) 2016-07-31
IL196897A0 (en) 2011-08-01
IL240322A0 (en) 2015-09-24
JP6258264B2 (ja) 2018-01-10
ES2470333T3 (es) 2014-06-23
US20080039475A1 (en) 2008-02-14
CA2660283A1 (en) 2008-02-21
US20110224226A1 (en) 2011-09-15
EP2452674A3 (en) 2012-05-30
EP2056826A4 (en) 2009-09-09
WO2008021283A2 (en) 2008-02-21
ES2452032T3 (es) 2014-03-31

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Legal Events

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EEER Examination request
FZDC Discontinued application reinstated