CA2659463A1

CA2659463A1 - Combination therapy

Combination therapy Download PDF

Info

Publication number: CA2659463A1
Authority: CA; Canada
Prior art keywords: pyridinylmethyl; benzenedimethanamine; tetrahydro; bis; methyl
Prior art date: 2006-08-02
Legal status : Abandoned

Application number

CA002659463A

Other languages

English (en)

French (fr)

Inventor

Gary Bridger

Louis M. Pelus

Current Assignee

Genzyme Corp

Original Assignee

Individual

Priority date

2006-08-02

Filing date

2007-08-02

Publication date

2008-02-07

2007-08-02 Application filed by Individual filed Critical Individual

2008-02-07 Publication of CA2659463A1 publication Critical patent/CA2659463A1/en

Status Abandoned legal-status Critical Current

Links

238000002648 combination therapy Methods 0.000 title description 4
210000000130 stem cell Anatomy 0.000 claims abstract description 91
238000000034 method Methods 0.000 claims abstract description 52
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239000003112 inhibitor Substances 0.000 claims abstract description 30
206010035226 Plasma cell myeloma Diseases 0.000 claims abstract description 29
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101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims abstract description 28
208000034578 Multiple myelomas Diseases 0.000 claims abstract description 10
210000004027 cell Anatomy 0.000 claims description 75
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238000011282 treatment Methods 0.000 claims description 18
239000000203 mixture Substances 0.000 claims description 17
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MNQBPRHHZPXCKZ-ZDCRTTOTSA-N (2s)-2-[[(2s)-1-(3,5-dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-4-[[(2s)-4-methyl-2-[methyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]butanoic acid Chemical group CN([C@@H](CC(C)C)C(=O)NCC[C@H](NC(=O)[C@H]1N(CCC1)S(=O)(=O)C=1C=C(Cl)C=C(Cl)C=1)C(O)=O)C(=O)CC(C=C1)=CC=C1NC(=O)NC1=CC=CC=C1C MNQBPRHHZPXCKZ-ZDCRTTOTSA-N 0.000 claims description 7
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