CA2659429A1 - 4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp) - Google Patents

4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp) Download PDF

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Publication number
CA2659429A1
CA2659429A1 CA002659429A CA2659429A CA2659429A1 CA 2659429 A1 CA2659429 A1 CA 2659429A1 CA 002659429 A CA002659429 A CA 002659429A CA 2659429 A CA2659429 A CA 2659429A CA 2659429 A1 CA2659429 A1 CA 2659429A1
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CA
Canada
Prior art keywords
compound
6alkyl
pharmaceutically acceptable
ring containing
compounds
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Abandoned
Application number
CA002659429A
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English (en)
French (fr)
Inventor
Philip Jones
Uwe Koch
Jesus Maria Ontoria Ontoria
Rita Scarpelli
Carsten Schultz-Fademrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
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Individual
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Publication of CA2659429A1 publication Critical patent/CA2659429A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
CA002659429A 2006-08-09 2007-08-06 4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp) Abandoned CA2659429A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0615809.1 2006-08-09
GBGB0615809.1A GB0615809D0 (en) 2006-08-09 2006-08-09 Therapeutic compounds
PCT/GB2007/050472 WO2008017883A2 (en) 2006-08-09 2007-08-06 4-oxo-4,5-dihydropyrrolo[1,2-a] quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp)

Publications (1)

Publication Number Publication Date
CA2659429A1 true CA2659429A1 (en) 2008-02-14

Family

ID=37056069

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002659429A Abandoned CA2659429A1 (en) 2006-08-09 2007-08-06 4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp)

Country Status (7)

Country Link
US (1) US20100152180A1 (OSRAM)
EP (1) EP2057161A2 (OSRAM)
JP (1) JP2010500334A (OSRAM)
AU (1) AU2007283212A1 (OSRAM)
CA (1) CA2659429A1 (OSRAM)
GB (1) GB0615809D0 (OSRAM)
WO (1) WO2008017883A2 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2032140A1 (en) 2006-05-31 2009-03-11 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
CA2672860C (en) * 2006-12-28 2013-01-29 Abbott Laboratories Inhibitors of poly(adp-ribose)polymerase
GB0804755D0 (en) * 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
BRPI1007358A2 (pt) 2009-01-23 2018-03-06 Takeda Pharmaceutical Company Limited inibidores de poli (adp-ribose) polimerase (parp)
US8541417B2 (en) * 2009-07-30 2013-09-24 Takeda Pharmaceutical Company Limited Poly (ADP-ribose) polymerase (PARP) inhibitors
ES2562903T3 (es) * 2011-07-13 2016-03-09 Santen Pharmaceutical Co., Ltd Nuevo compuesto que tiene actividad inhibidora de PARP
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
BR112014032053A2 (pt) * 2012-06-20 2017-06-27 Hoffmann La Roche composto, composição farmacêutica, utilização de um composto, método para o tratamento de câncer e invenção
CN103936735B (zh) * 2014-04-04 2015-11-11 沈阳工业大学 氮杂苯并薁衍生物及其制备方法和用途
CN116075512A (zh) 2020-06-11 2023-05-05 Chdi基金会股份有限公司 用于对亨廷顿蛋白成像的杂环化合物和显像剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
GB0017508D0 (en) * 2000-07-17 2000-08-30 Novartis Ag Antimicrobials
ITMI20002358A1 (it) * 2000-10-31 2002-05-01 Flavio Moroni Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi
JP2008526715A (ja) * 2005-01-03 2008-07-24 ユニベルシタ デグリ ストゥディ ディ シエナ 神経精神障害の治療のためのアリールピペラジン誘導体
EP1798233A1 (en) * 2005-12-19 2007-06-20 Faust Pharmaceuticals Pyrrolo[1,2-a]quinoxaline derivatives as Adenosine A3 receptor modulators and uses thereof

Also Published As

Publication number Publication date
GB0615809D0 (en) 2006-09-20
JP2010500334A (ja) 2010-01-07
WO2008017883A2 (en) 2008-02-14
WO2008017883A3 (en) 2008-04-03
US20100152180A1 (en) 2010-06-17
EP2057161A2 (en) 2009-05-13
AU2007283212A1 (en) 2008-02-14

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