CA2657269A1 - New indications for direct thrombin inhibitors - Google Patents
New indications for direct thrombin inhibitors Download PDFInfo
- Publication number
- CA2657269A1 CA2657269A1 CA002657269A CA2657269A CA2657269A1 CA 2657269 A1 CA2657269 A1 CA 2657269A1 CA 002657269 A CA002657269 A CA 002657269A CA 2657269 A CA2657269 A CA 2657269A CA 2657269 A1 CA2657269 A1 CA 2657269A1
- Authority
- CA
- Canada
- Prior art keywords
- disease
- compound
- methyl
- dabigatran
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06117345 | 2006-07-17 | ||
| EP06117345.6 | 2006-07-17 | ||
| EP07102513.4 | 2007-02-15 | ||
| EP07102513 | 2007-02-15 | ||
| PCT/EP2007/057256 WO2008009639A2 (en) | 2006-07-17 | 2007-07-13 | New indications for direct thrombin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2657269A1 true CA2657269A1 (en) | 2008-01-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002657269A Abandoned CA2657269A1 (en) | 2006-07-17 | 2007-07-13 | New indications for direct thrombin inhibitors |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20080200514A1 (enExample) |
| EP (1) | EP2043632A2 (enExample) |
| JP (1) | JP2009543843A (enExample) |
| AR (1) | AR062057A1 (enExample) |
| CA (1) | CA2657269A1 (enExample) |
| TW (1) | TW200813012A (enExample) |
| WO (1) | WO2008009639A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2716642C (en) * | 2008-03-28 | 2017-02-28 | Boehringer Ingelheim International Gmbh | Method for manufacturing acid pellets |
| RU2010143901A (ru) * | 2008-03-28 | 2012-05-10 | Бёрингер Ингельхайм Интернациональ Гмбх (De) | Способ получения композиций дабигатрана для перорального введения |
| RU2529798C2 (ru) | 2008-07-14 | 2014-09-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ получения лекарственных соединений, содержащих дабигатран |
| US20110306640A1 (en) * | 2008-08-19 | 2011-12-15 | Boehringer Ingelheim International Gmbh | Dabigatran in tumour therapy |
| EP2358368A1 (en) | 2008-11-11 | 2011-08-24 | Boehringer Ingelheim International GmbH | Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy |
| NZ593787A (en) * | 2009-02-02 | 2013-09-27 | Boehringer Ingelheim Int | Lyophilised dabigatran |
| WO2010130758A1 (en) * | 2009-05-14 | 2010-11-18 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of cancer and fibrotic diseases |
| EP2429520A1 (en) * | 2009-05-14 | 2012-03-21 | Boehringer Ingelheim International GmbH | New combination therapy in treatment of oncological and fibrotic diseases |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| EA201201202A1 (ru) * | 2010-03-01 | 2013-04-30 | Рациофарм Гмбх | Пероральная фармацевтическая композиция, содержащая этексилат дабигатрана |
| EP2550966B1 (de) * | 2011-07-25 | 2016-10-19 | Dritte Patentportfolio Beteiligungsgesellschaft mbH & Co. KG | Dabigatran-Amidoximsäureesters als Prodrugs und ihre Verwendung als Arzneimittel |
| US20130345262A1 (en) | 2012-06-25 | 2013-12-26 | Boehringer Ingelheim International Gmbh | Method for prevention of stroke |
| CN105440017B (zh) * | 2014-08-19 | 2018-03-02 | 天津药物研究院 | 达比加群酯香草酸盐及其制备方法和应用 |
| CN104628733A (zh) * | 2015-03-02 | 2015-05-20 | 中国药科大学 | 四氢苯并[4,5]咪唑并[1,2-a]吡嗪类凝血酶抑制剂 |
| WO2025136810A1 (en) * | 2023-12-19 | 2025-06-26 | The Research Institute At Nationwide Children's Hospital | Anticoagulants for treating nephrotic syndrome |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000514788A (ja) * | 1996-06-25 | 2000-11-07 | イーライ・リリー・アンド・カンパニー | 抗凝固剤 |
| US5863292A (en) * | 1996-09-26 | 1999-01-26 | Tosic; Aleksandar | Articulated external orthopedic fixation system and method of use |
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| GB0014136D0 (en) * | 2000-06-10 | 2000-08-02 | Astrazeneca Ab | Combination therapy |
| US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
| DE10235639A1 (de) * | 2002-08-02 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel |
| WO2004026252A2 (en) * | 2002-09-23 | 2004-04-01 | The Regents Of The University Of Michigan | Glioma treatments |
| KR20040076203A (ko) * | 2003-02-24 | 2004-08-31 | 주식회사 엘지생명과학 | 음식물-약물 상호작용을 방지하기 위한 경구 투여용약제학적 조성물 및 방법 |
| CA2523157A1 (en) * | 2003-04-24 | 2004-11-04 | Boehringer Ingelheim International Gmbh | Use of dipyridamole or mopidamole for treatment and prevention of thrombo-embolic diseases and disorders caused by excessive formation of thrombin and/or by elevated expression ofthrombin receptors |
| US20060198836A1 (en) * | 2003-07-17 | 2006-09-07 | Smithkline Beecham Corporation | Method of treating hit patients with argatroban |
| US20060222640A1 (en) * | 2005-03-29 | 2006-10-05 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for treatment of thrombosis |
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2007
- 2007-07-13 CA CA002657269A patent/CA2657269A1/en not_active Abandoned
- 2007-07-13 WO PCT/EP2007/057256 patent/WO2008009639A2/en not_active Ceased
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- 2007-07-13 AR ARP070103124A patent/AR062057A1/es not_active Application Discontinuation
- 2007-07-13 EP EP07787524A patent/EP2043632A2/en not_active Withdrawn
- 2007-07-16 TW TW096125876A patent/TW200813012A/zh unknown
- 2007-07-17 US US11/778,748 patent/US20080200514A1/en not_active Abandoned
-
2010
- 2010-03-22 US US12/728,732 patent/US20100173947A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR062057A1 (es) | 2008-10-15 |
| WO2008009639A2 (en) | 2008-01-24 |
| JP2009543843A (ja) | 2009-12-10 |
| TW200813012A (en) | 2008-03-16 |
| EP2043632A2 (en) | 2009-04-08 |
| WO2008009639A3 (en) | 2008-06-26 |
| US20080200514A1 (en) | 2008-08-21 |
| US20100173947A1 (en) | 2010-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |